Sulphation of hydroxybiphenyls in human tissues

• Published in: Xenobiotica Vol. 21; no. 9; pp. 1113 - 1118
• Main Authors: Pacifici, G.M, Vannucci, L, Bencini, C, Tusini, G, Mosca, F
• Format: Journal Article
• Language: English
• Published: England 1991
• Subjects: Adult; Aged; animal tissues; biphenyl; Biphenyl Compounds - metabolism; derivatives; enzyme activity; Female; Humans; liver; Male; men; metabolic detoxification; Middle Aged; Proteins - metabolism; Sulfates - metabolism; sulfotransferase; Sulfotransferases - metabolism; transferases; women

1. Sulphotransferase is an important detoxication pathway of hydroxybiphenyls and the kinetics of sulphotransferase activity were studied in human liver, ileum and colon mucosae, lung, kidney, urinary bladder mucosa and brain using o-, m- and p-hydroxybiphenyl as substrates. 2. Sulphotransferase act...