Sulphation of hydroxybiphenyls in human tissues

1. Sulphotransferase is an important detoxication pathway of hydroxybiphenyls and the kinetics of sulphotransferase activity were studied in human liver, ileum and colon mucosae, lung, kidney, urinary bladder mucosa and brain using o-, m- and p-hydroxybiphenyl as substrates. 2. Sulphotransferase act...

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Bibliographic Details
Published inXenobiotica Vol. 21; no. 9; pp. 1113 - 1118
Main Authors Pacifici, G.M, Vannucci, L, Bencini, C, Tusini, G, Mosca, F
Format Journal Article
LanguageEnglish
Published England 1991
Subjects
Adult
Aged
animal tissues
biphenyl
Biphenyl Compounds - metabolism
derivatives
enzyme activity
Female
Humans
liver
Male
men
metabolic detoxification
Middle Aged
Proteins - metabolism
Sulfates - metabolism
sulfotransferase
Sulfotransferases - metabolism
transferases
women
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Summary:1. Sulphotransferase is an important detoxication pathway of hydroxybiphenyls and the kinetics of sulphotransferase activity were studied in human liver, ileum and colon mucosae, lung, kidney, urinary bladder mucosa and brain using o-, m- and p-hydroxybiphenyl as substrates. 2. Sulphotransferase activity was detectable in all tissues studied, although it showed marked tissue-dependence. The rate of sulphation ranged > 100-fold in different tissues and the highest and lowest activities of sulphotransferase were found in liver and brain, respectively. 3. The Km of sulphotransferase was not tissue-dependent but was dependent on the isomer of hydroxybiphenyl. The Km varied over a 500-fold range and the highest and lowest values of Km were found with p-hydroxybiphenyl and m-hydroxybiphenyl, respectively.
ISSN:0049-8254
1366-5928
DOI:10.3109/00498259109039551