Population Pharmacokinetic and Exposure-Response Analyses of Baloxavir Marboxil in Adults and Adolescents Including Patients With Influenza

• Published in: Journal of pharmaceutical sciences Vol. 108; no. 5; pp. 1896 - 1904
• Main Authors: Koshimichi, Hiroki, Tsuda, Yoshiyuki, Ishibashi, Toru, Wajima, Toshihiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019
• Subjects: baloxavir marboxil; cap-dependent endonuclease inhibitor; influenza; population pharmacokinetics; S-033188; influenza; cap-dependent endonuclease inhibitor; baloxavir marboxil; S-033188; population pharmacokinetics

Baloxavir marboxil, a prodrug that is metabolized to baloxavir acid, suppresses viral replication by inhibiting cap-dependent endonuclease. Our aim is to characterize its pharmacokinetics and exposure-response relationships. Population pharmacokinetic analysis of the baloxavir acid was performed usi...