Shear-mediated ALK5 expression regulates endothelial activation

• Published in: Biochemical and biophysical research communications Vol. 642; pp. 90 - 96
• Main Authors: Pang, Kuin Tian, Ghim, Mean, Sarathchandra, Padmini, Warboys, Christina M., Yacoub, Magdi H., Chester, Adrian H., Weinberg, Peter D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.01.2023
• Subjects: Animals; Cardiovascular disease; Endothelial cells; Endothelial-to-mesenchymal transition; Humans; Mechanosensing; Monocyte adhesion; Paracellular transport; Phosphorylation; Protein Serine-Threonine Kinases - metabolism; Receptor, Transforming Growth Factor-beta Type I - metabolism; Receptors, Transforming Growth Factor beta - metabolism; Shear stress; Signal Transduction; Swine; TGF-β; Signal transduction; Paracellular transport; Shear stress; TGF-β; Monocyte adhesion; Cardiovascular disease; Endothelial-to-mesenchymal transition; Mechanosensing; Endothelial cells

Calcific aortic valve disease affects the aortic side of the valve, exposed to low magnitude multidirectional (“disturbed) blood flow, more than it affects the ventricular side, exposed to high magnitude uniaxial flow. Overt disease is preceded by endothelial dysfunction and inflammation. Here we in...