Optimal dose regimens of esomeprazole for gastric acid suppression with minimal influence of the CYP2C19 polymorphism - Lou, Horng-Yuan; Chang, Chun-Chao; Sheu, Ming-Thau; Chen, Ying-Chen; Ho, Hsiu-O (European journal of clinical pharmacology, 2009)
Keywords: Adult; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Biomedical and Life Sciences; Biomedicine; Clinical trials; Cytochrome P-450 CYP2C19; Down-Regulation; Drug Administration Schedule; Drug dosages; Esomeprazole - administration & dosage; Esomeprazole - blood; Esomeprazole - pharmacokinetics; Gastric Acid - secretion; Gastric Acidity Determination; Gastroesophageal reflux; Gastroesophageal Reflux - drug therapy; Gastroesophageal Reflux - enzymology; Gastroesophageal Reflux - genetics; Gene Frequency; Heterozygote; Homozygote; Humans; Pharmaceuticals; Pharmacogenetics; Pharmacology; Pharmacology/Toxicology; Phenotype; Pilot Projects; polymorphism; Polymorphism, Genetic; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - blood; Proton Pump Inhibitors - pharmacokinetics; Taiwan; Treatment Outcome; Young Adult; GERD; CYP2C19; Esomeprazole; Intragastric pH; Polymorphism