Anticholinergic drug exposure at intensive care unit admission affects the occurrence of delirium. A prospective cohort study

• Published in: European journal of internal medicine Vol. 78; pp. 121 - 126
• Main Authors: Vondeling, Ariël M., Knol, Wilma, Egberts, Toine C.G., Slooter, Arjen J.C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2020
• Subjects: Anticholinergics; Cholinergic Antagonists - adverse effects; Cohort studies; Critical care; Critical Illness; Delirium; Delirium - chemically induced; Delirium - epidemiology; Humans; Intensive care; Intensive Care Units; Netherlands - epidemiology; Pharmaceutical Preparations; Prospective Studies; Survival analysis; Netherlands; Delirium; APACHE IV; Intensive care; ARS; CAM-ICU; CSHR; ACH; Critical care; IQR; ADS; Anticholinergics; Survival analysis; SD; SOFA; Cohort studies; ICU; SHR

•Exposure to drugs with anticholinergic effects before ICU admission increases the risk of developing delirium.•The effect is more pronounced in the first days of the ICU admission.•Advanced age and septic shock increases the risk for delirium in ICU patients.•The ADS scale can be effectively used t...