Investigating the origin of high efficiency in confined multienzyme catalysis

• Published in: Nanoscale Vol. 11; no. 45; pp. 2218 - 22117
• Main Authors: Cao, Yufei, Li, Xiaoyang, Xiong, Jiarong, Wang, Licheng, Yan, Li-Tang, Ge, Jun
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 21.11.2019
• Subjects: Biomimetic Materials - chemistry; Biomimetics; Catalysis; Coarsening; Efficiency; Enzymes; Enzymes, Immobilized - chemistry; Kinetics; Metal-organic frameworks; Metal-Organic Frameworks - chemistry; Models, Chemical; Multienzyme Complexes - chemistry; Nanocrystals; Reaction intermediates; Reaction kinetics

Biomimetic strategies have successfully been applied to confine multiple enzymes on scaffolds to obtain higher catalytic efficiency of enzyme cascades than freely distributed enzymes. However, the origin of high efficiency is poorly understood. We developed a coarse-grained, particle-based model to...