Calculation of drug-polymer mixing enthalpy as a new screening method of precipitation inhibitors for supersaturating pharmaceutical formulations

• Published in: European journal of pharmaceutical sciences Vol. 132; pp. 142 - 156
• Main Authors: Price, Daniel J., Nair, Anita, Kuentz, Martin, Dressman, Jennifer, Saal, Christoph
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.04.2019
• Subjects: Bioenabling formulations; Enthalpy; in silico tools; Precipitation inhibition; Screening; Supersaturation; in silico tools; Screening; Supersaturation; Bioenabling formulations; Precipitation inhibition; Enthalpy

Supersaturating formulations are widely used to improve the oral bioavailability of poorly soluble drugs. However, supersaturated solutions are thermodynamically unstable and such formulations often must include a precipitation inhibitor (PI) to sustain the increased concentrations to ensure that su...