Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers

• Published in: Advanced drug delivery reviews Vol. 182; p. 114097
• Main Authors: Haddadzadegan, Soheil, Dorkoosh, Farid, Bernkop-Schnürch, Andreas
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2022
• Subjects: Administration, Oral; Drug Carriers - chemistry; Drug Liberation; Drug Stability; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Mucosa - metabolism; Lipid-based nanocarriers; Liposomes; Liposomes - chemistry; Micelles; Mucus - metabolism; Nanoparticle Drug Delivery System - chemistry; Nanoparticles - chemistry; NLC; Oral drug delivery; Peptide Hydrolases - metabolism; Peptides - administration & dosage; Peptides - pharmacokinetics; Proteins - administration & dosage; Proteins - pharmacokinetics; SEDDS; Self-emulsifying drug delivery systems; SLN; Therapeutic peptides; Therapeutic peptides; SEDDS; Self-emulsifying drug delivery systems; SLN; NLC; Micelles; Oral drug delivery; Lipid-based nanocarriers; Liposomes

[Display omitted] The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers including the enzymatic, sulfhydryl, mucus and...