Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers
[Display omitted] The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers including the enzymatic, sulfhydryl, mucus and...
Saved in:
| Published in | Advanced drug delivery reviews Vol. 182; p. 114097 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.03.2022
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | [Display omitted]
The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers including the enzymatic, sulfhydryl, mucus and epithelial barrier. The development of oral formulations for therapeutic peptides and proteins is therefore necessary. Among the most promising formulation approaches are lipid-based nanocarriers such as oil-in-water nanoemulsions, self-emulsifying drug delivery systems (SEDDS), solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), liposomes and micelles. As the lipophilic character of therapeutic peptides and proteins can be tremendously increased such as by the formation of hydrophobic ion pairs (HIP) with hydrophobic counter ions, they can be incorporated in the lipophilic phase of these carriers. Since gastrointestinal (GI) peptidases as well as sulfhydryl compounds such as glutathione and dietary proteins are too hydrophilic to enter the lipophilic phase of these carriers, the incorporated therapeutic peptide or protein is protected towards enzymatic degradation as well as unintended thiol/disulfide exchange reactions. Stability of lipid-based nanocarriers towards lipases can be provided by the use to excipients that are not or just poorly degraded by these enzymes. Nanocarriers with a size <200 nm and a mucoinert surface such as PEG or zwitterionic surfaces exhibit high mucus permeating properties. Having reached the underlying absorption membrane, lipid-based nanocarriers enable paracellular and lymphatic drug uptake, induce endocytosis and transcytosis or simply fuse with the cell membrane releasing their payload into the systemic circulation. Numerous in vivo studies provide evidence for the potential of these delivery systems. Within this review we provide an overview about the different barriers for oral peptide and protein delivery, highlight the progress made on lipid-based nanocarriers in order to overcome them and discuss strengths and weaknesses of these delivery systems in comparison to other technologies. |
|---|---|
| AbstractList | The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers including the enzymatic, sulfhydryl, mucus and epithelial barrier. The development of oral formulations for therapeutic peptides and proteins is therefore necessary. Among the most promising formulation approaches are lipid-based nanocarriers such as oil-in-water nanoemulsions, self-emulsifying drug delivery systems (SEDDS), solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), liposomes and micelles. As the lipophilic character of therapeutic peptides and proteins can be tremendously increased such as by the formation of hydrophobic ion pairs (HIP) with hydrophobic counter ions, they can be incorporated in the lipophilic phase of these carriers. Since gastrointestinal (GI) peptidases as well as sulfhydryl compounds such as glutathione and dietary proteins are too hydrophilic to enter the lipophilic phase of these carriers, the incorporated therapeutic peptide or protein is protected towards enzymatic degradation as well as unintended thiol/disulfide exchange reactions. Stability of lipid-based nanocarriers towards lipases can be provided by the use to excipients that are not or just poorly degraded by these enzymes. Nanocarriers with a size <200 nm and a mucoinert surface such as PEG or zwitterionic surfaces exhibit high mucus permeating properties. Having reached the underlying absorption membrane, lipid-based nanocarriers enable paracellular and lymphatic drug uptake, induce endocytosis and transcytosis or simply fuse with the cell membrane releasing their payload into the systemic circulation. Numerous in vivo studies provide evidence for the potential of these delivery systems. Within this review we provide an overview about the different barriers for oral peptide and protein delivery, highlight the progress made on lipid-based nanocarriers in order to overcome them and discuss strengths and weaknesses of these delivery systems in comparison to other technologies.The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers including the enzymatic, sulfhydryl, mucus and epithelial barrier. The development of oral formulations for therapeutic peptides and proteins is therefore necessary. Among the most promising formulation approaches are lipid-based nanocarriers such as oil-in-water nanoemulsions, self-emulsifying drug delivery systems (SEDDS), solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), liposomes and micelles. As the lipophilic character of therapeutic peptides and proteins can be tremendously increased such as by the formation of hydrophobic ion pairs (HIP) with hydrophobic counter ions, they can be incorporated in the lipophilic phase of these carriers. Since gastrointestinal (GI) peptidases as well as sulfhydryl compounds such as glutathione and dietary proteins are too hydrophilic to enter the lipophilic phase of these carriers, the incorporated therapeutic peptide or protein is protected towards enzymatic degradation as well as unintended thiol/disulfide exchange reactions. Stability of lipid-based nanocarriers towards lipases can be provided by the use to excipients that are not or just poorly degraded by these enzymes. Nanocarriers with a size <200 nm and a mucoinert surface such as PEG or zwitterionic surfaces exhibit high mucus permeating properties. Having reached the underlying absorption membrane, lipid-based nanocarriers enable paracellular and lymphatic drug uptake, induce endocytosis and transcytosis or simply fuse with the cell membrane releasing their payload into the systemic circulation. Numerous in vivo studies provide evidence for the potential of these delivery systems. Within this review we provide an overview about the different barriers for oral peptide and protein delivery, highlight the progress made on lipid-based nanocarriers in order to overcome them and discuss strengths and weaknesses of these delivery systems in comparison to other technologies. The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers including the enzymatic, sulfhydryl, mucus and epithelial barrier. The development of oral formulations for therapeutic peptides and proteins is therefore necessary. Among the most promising formulation approaches are lipid-based nanocarriers such as oil-in-water nanoemulsions, self-emulsifying drug delivery systems (SEDDS), solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), liposomes and micelles. As the lipophilic character of therapeutic peptides and proteins can be tremendously increased such as by the formation of hydrophobic ion pairs (HIP) with hydrophobic counter ions, they can be incorporated in the lipophilic phase of these carriers. Since gastrointestinal (GI) peptidases as well as sulfhydryl compounds such as glutathione and dietary proteins are too hydrophilic to enter the lipophilic phase of these carriers, the incorporated therapeutic peptide or protein is protected towards enzymatic degradation as well as unintended thiol/disulfide exchange reactions. Stability of lipid-based nanocarriers towards lipases can be provided by the use to excipients that are not or just poorly degraded by these enzymes. Nanocarriers with a size <200 nm and a mucoinert surface such as PEG or zwitterionic surfaces exhibit high mucus permeating properties. Having reached the underlying absorption membrane, lipid-based nanocarriers enable paracellular and lymphatic drug uptake, induce endocytosis and transcytosis or simply fuse with the cell membrane releasing their payload into the systemic circulation. Numerous in vivo studies provide evidence for the potential of these delivery systems. Within this review we provide an overview about the different barriers for oral peptide and protein delivery, highlight the progress made on lipid-based nanocarriers in order to overcome them and discuss strengths and weaknesses of these delivery systems in comparison to other technologies. [Display omitted] The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers including the enzymatic, sulfhydryl, mucus and epithelial barrier. The development of oral formulations for therapeutic peptides and proteins is therefore necessary. Among the most promising formulation approaches are lipid-based nanocarriers such as oil-in-water nanoemulsions, self-emulsifying drug delivery systems (SEDDS), solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), liposomes and micelles. As the lipophilic character of therapeutic peptides and proteins can be tremendously increased such as by the formation of hydrophobic ion pairs (HIP) with hydrophobic counter ions, they can be incorporated in the lipophilic phase of these carriers. Since gastrointestinal (GI) peptidases as well as sulfhydryl compounds such as glutathione and dietary proteins are too hydrophilic to enter the lipophilic phase of these carriers, the incorporated therapeutic peptide or protein is protected towards enzymatic degradation as well as unintended thiol/disulfide exchange reactions. Stability of lipid-based nanocarriers towards lipases can be provided by the use to excipients that are not or just poorly degraded by these enzymes. Nanocarriers with a size <200 nm and a mucoinert surface such as PEG or zwitterionic surfaces exhibit high mucus permeating properties. Having reached the underlying absorption membrane, lipid-based nanocarriers enable paracellular and lymphatic drug uptake, induce endocytosis and transcytosis or simply fuse with the cell membrane releasing their payload into the systemic circulation. Numerous in vivo studies provide evidence for the potential of these delivery systems. Within this review we provide an overview about the different barriers for oral peptide and protein delivery, highlight the progress made on lipid-based nanocarriers in order to overcome them and discuss strengths and weaknesses of these delivery systems in comparison to other technologies. |
| ArticleNumber | 114097 |
| Author | Haddadzadegan, Soheil Bernkop-Schnürch, Andreas Dorkoosh, Farid |
| Author_xml | – sequence: 1 givenname: Soheil surname: Haddadzadegan fullname: Haddadzadegan, Soheil organization: Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria – sequence: 2 givenname: Farid surname: Dorkoosh fullname: Dorkoosh, Farid organization: Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran – sequence: 3 givenname: Andreas surname: Bernkop-Schnürch fullname: Bernkop-Schnürch, Andreas email: andreas.bernkop@uibk.ac.at organization: Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34999121$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kMtKxDAUQIMoOj5-wIVk6aZjknbaRtzI4AsENwruwm1yqxk6SU0ywvy9GUZduHAVSM4J955Dsuu8Q0JOOZtyxuuLxRSMCVPBBJ9yXjHZ7JAJbxtRtEJWu2SSIVnk-9cDchjjgjEumprtk4OyklJywSfEPAUYqMHBfmJYU9_T9I4BRlwlq-mIY7IGIwVn6Bh8QuviJX1G_e784N_WdMgvUWd-ow52tKboIKKhDpzXEILFEI_JXg9DxJPv84i83N48z--Lx6e7h_n1Y6ErxlIhe9HVJciZ1CCrZtYa08lSatlA2bas6TSUrKugFsaYvm5mohGAmRKYVytleUTOt__mUT9WGJNa2qhxyEOiX0Ulat7OBGs5z-jZN7rqlmjUGOwSwlr9lMmA2AI6-BgD9r8IZ2qTXy3UJr_a5Ffb_Flq_0jaJkjWuxTADv-rV1sVc6DPXE1FbdFpNDagTsp4-5_-BRIeoNs |
| CitedBy_id | crossref_primary_10_1080_17425247_2023_2269092 crossref_primary_10_1021_acs_molpharmaceut_3c00877 crossref_primary_10_1016_j_actbio_2023_06_005 crossref_primary_10_1016_j_jcis_2024_02_076 crossref_primary_10_1016_j_jconrel_2022_08_041 crossref_primary_10_1021_acsami_3c05692 crossref_primary_10_3389_fphar_2024_1476739 crossref_primary_10_3390_pharmaceutics17020148 crossref_primary_10_1007_s41664_024_00302_5 crossref_primary_10_3390_ph15091072 crossref_primary_10_1016_j_jconrel_2023_06_034 crossref_primary_10_3390_molecules27113507 crossref_primary_10_1016_j_fbio_2024_105802 crossref_primary_10_2147_IJN_S494224 crossref_primary_10_1007_s00210_023_02683_3 crossref_primary_10_1016_j_biopha_2024_117029 crossref_primary_10_1016_j_phymed_2024_155484 crossref_primary_10_1039_D4MA00720D crossref_primary_10_1042_CS20220261 crossref_primary_10_1002_adhm_202302034 crossref_primary_10_1111_1750_3841_17672 crossref_primary_10_1021_acsnano_4c12434 crossref_primary_10_1007_s12033_022_00624_8 crossref_primary_10_1016_j_apsb_2024_08_027 crossref_primary_10_1016_j_ijpharm_2022_121979 crossref_primary_10_1016_j_jconrel_2024_12_008 crossref_primary_10_3389_fonc_2023_1142111 crossref_primary_10_1080_87559129_2022_2062772 crossref_primary_10_1016_j_ijbiomac_2024_133680 crossref_primary_10_1002_ange_202214795 crossref_primary_10_1080_17425247_2024_2364651 crossref_primary_10_1039_D4TB00837E crossref_primary_10_1016_j_dental_2024_10_002 crossref_primary_10_1080_17435889_2025_2457315 crossref_primary_10_1016_j_ijbiomac_2024_135849 crossref_primary_10_1021_acsbiomaterials_3c01207 crossref_primary_10_1007_s13346_025_01810_2 crossref_primary_10_1002_cmdc_202400938 crossref_primary_10_1016_j_jddst_2024_106285 crossref_primary_10_1021_acsanm_4c04262 crossref_primary_10_2174_0126673878299775240719061653 crossref_primary_10_1016_j_matt_2024_101948 crossref_primary_10_1016_j_ijpharm_2024_124812 crossref_primary_10_3389_fnut_2022_1050647 crossref_primary_10_1016_j_cej_2024_154232 crossref_primary_10_1016_j_jconrel_2022_12_043 crossref_primary_10_1016_j_jconrel_2025_01_013 crossref_primary_10_3390_ph16091285 crossref_primary_10_1007_s00203_023_03629_2 crossref_primary_10_1016_j_cis_2022_102757 crossref_primary_10_1016_j_jddst_2023_104368 crossref_primary_10_1016_j_jconrel_2023_09_011 crossref_primary_10_3390_molecules29174193 crossref_primary_10_1002_jbt_70233 crossref_primary_10_1002_smtd_202402249 crossref_primary_10_1002_med_22046 crossref_primary_10_1080_10408398_2025_2450543 crossref_primary_10_2147_IJN_S434908 crossref_primary_10_1016_j_nantod_2024_102602 crossref_primary_10_1016_j_ijbiomac_2023_125918 crossref_primary_10_1116_6_0004159 crossref_primary_10_1002_smll_202307618 crossref_primary_10_1016_j_ijpharm_2024_124786 crossref_primary_10_1080_10717544_2023_2181744 crossref_primary_10_1080_17425247_2022_2147505 crossref_primary_10_3390_pharmaceutics14040805 crossref_primary_10_1016_j_ejps_2022_106363 crossref_primary_10_1016_j_foodchem_2022_134059 crossref_primary_10_3390_pharmaceutics16070886 crossref_primary_10_1021_acsptsci_3c00269 crossref_primary_10_3390_pharmaceutics14122808 crossref_primary_10_1002_prp2_1053 crossref_primary_10_1080_1061186X_2023_2247583 crossref_primary_10_1016_j_ijpharm_2023_123726 crossref_primary_10_1002_adhm_202403698 crossref_primary_10_1007_s13346_024_01729_0 crossref_primary_10_1021_acs_jafc_3c06518 crossref_primary_10_3390_jnt5040012 crossref_primary_10_3390_pharmaceutics17010012 crossref_primary_10_1089_hum_2023_016 crossref_primary_10_1016_j_fbio_2024_104641 crossref_primary_10_1021_acs_nanolett_2c02948 crossref_primary_10_1097_st9_0000000000000054 crossref_primary_10_1208_s12249_024_02794_x crossref_primary_10_1007_s11259_023_10161_7 crossref_primary_10_1016_j_cclet_2023_108662 crossref_primary_10_2147_IJN_S416706 crossref_primary_10_1111_1541_4337_13386 crossref_primary_10_1016_j_jcis_2023_10_001 crossref_primary_10_1080_10408398_2023_2294164 crossref_primary_10_3390_molecules27185854 crossref_primary_10_3390_jfb14090453 crossref_primary_10_1080_02652048_2024_2376116 crossref_primary_10_1016_j_jddst_2024_105664 crossref_primary_10_1007_s13346_023_01454_0 crossref_primary_10_3390_nano12132147 crossref_primary_10_1080_10717544_2022_2118399 crossref_primary_10_3390_vaccines12010026 crossref_primary_10_3390_futurepharmacol3040047 crossref_primary_10_1002_smsc_202400112 crossref_primary_10_1039_D3TB01612A crossref_primary_10_3390_nano13071166 crossref_primary_10_1016_j_ejmech_2024_117131 crossref_primary_10_1124_pharmrev_123_001159 crossref_primary_10_1016_j_apsb_2024_02_019 crossref_primary_10_1080_17425247_2022_2051476 crossref_primary_10_1016_j_biotechadv_2023_108213 crossref_primary_10_1016_j_foodchem_2023_136680 crossref_primary_10_1016_j_ijpharm_2022_122476 crossref_primary_10_3389_fbioe_2023_1272850 crossref_primary_10_1016_j_ejmech_2024_116168 crossref_primary_10_1016_j_ijbiomac_2023_126000 crossref_primary_10_1002_smtd_202401355 crossref_primary_10_1016_j_scib_2025_02_003 crossref_primary_10_3390_pharmaceutics14081668 crossref_primary_10_3390_pharmaceutics17040397 crossref_primary_10_1016_j_jconrel_2023_08_044 crossref_primary_10_1007_s12274_023_5645_7 crossref_primary_10_1016_j_ijbiomac_2024_138990 crossref_primary_10_1016_j_jconrel_2024_02_023 crossref_primary_10_1021_acs_biomac_2c00699 crossref_primary_10_1016_j_addr_2023_115117 crossref_primary_10_3390_pharmaceutics15010205 crossref_primary_10_1039_D3LC00515A crossref_primary_10_2147_DDDT_S461969 crossref_primary_10_1080_17425247_2023_2237408 crossref_primary_10_1002_wnan_1952 crossref_primary_10_1039_D4BM01210K crossref_primary_10_3390_ijms24087548 crossref_primary_10_1016_j_carbpol_2023_120838 crossref_primary_10_1016_j_jconrel_2023_12_045 crossref_primary_10_3390_ijms252011206 crossref_primary_10_1515_ntrev_2022_0517 crossref_primary_10_1002_anie_202214795 crossref_primary_10_1186_s12951_023_01991_3 crossref_primary_10_1016_j_chembiol_2024_10_013 crossref_primary_10_1186_s12951_025_03190_8 crossref_primary_10_1038_s41392_024_02107_5 crossref_primary_10_1016_j_colsurfb_2022_112816 crossref_primary_10_1016_j_actbio_2022_03_013 crossref_primary_10_1080_17425247_2024_2410951 crossref_primary_10_3390_pharmaceutics16060804 crossref_primary_10_1002_adfm_202404549 crossref_primary_10_1021_acs_langmuir_4c04896 crossref_primary_10_1007_s10989_024_10592_z crossref_primary_10_2478_acph_2023_0009 crossref_primary_10_3390_foods14030500 crossref_primary_10_1080_17425247_2023_2231343 crossref_primary_10_59761_RCR5150 crossref_primary_10_1021_acsnano_4c11172 crossref_primary_10_1080_10717544_2022_2058646 crossref_primary_10_1002_smll_202206968 crossref_primary_10_1021_acsami_4c06110 crossref_primary_10_1016_j_actbio_2025_02_039 crossref_primary_10_3390_pharmaceutics15082168 crossref_primary_10_1016_j_jddst_2025_106628 crossref_primary_10_1088_1748_605X_ada85e crossref_primary_10_1016_j_xphs_2024_08_007 crossref_primary_10_1016_j_biopha_2024_117577 crossref_primary_10_2147_IJN_S434626 crossref_primary_10_3390_ph18030310 crossref_primary_10_1016_j_apsb_2024_09_015 crossref_primary_10_1016_j_ijpharm_2023_123578 crossref_primary_10_3390_ph16020214 crossref_primary_10_1002_INMD_20220005 crossref_primary_10_3390_ph16101377 crossref_primary_10_1016_j_addr_2023_115159 crossref_primary_10_1016_j_addr_2023_114862 crossref_primary_10_1016_j_colsurfb_2023_113205 crossref_primary_10_1080_07391102_2023_2248513 crossref_primary_10_1007_s13346_022_01246_y crossref_primary_10_3390_pharmaceutics15030995 crossref_primary_10_1016_j_jddst_2023_104903 crossref_primary_10_1016_j_addr_2024_115304 crossref_primary_10_1016_j_nbt_2025_02_003 crossref_primary_10_1021_acsnano_3c11315 crossref_primary_10_1016_j_ijpharm_2023_123683 crossref_primary_10_1021_acsami_4c01165 crossref_primary_10_1016_j_jddst_2023_104467 crossref_primary_10_1021_acs_bioconjchem_4c00480 crossref_primary_10_1016_j_jddst_2023_104344 crossref_primary_10_3390_mi13101780 crossref_primary_10_1016_j_actbio_2024_06_026 crossref_primary_10_26599_NR_2025_94907082 crossref_primary_10_1016_j_ijpharm_2022_122505 crossref_primary_10_1208_s12249_022_02311_y crossref_primary_10_1016_j_jconrel_2023_08_024 crossref_primary_10_1016_j_addr_2023_115139 crossref_primary_10_1016_j_ijpharm_2023_123598 crossref_primary_10_1021_acs_langmuir_2c01089 crossref_primary_10_1016_j_ijpharm_2024_124844 crossref_primary_10_1166_sam_2023_4540 crossref_primary_10_1016_j_ajps_2025_101019 crossref_primary_10_3390_ijms242317056 crossref_primary_10_3390_pharmaceutics15041288 crossref_primary_10_1016_j_addr_2023_115133 crossref_primary_10_3390_pharmaceutics16060694 crossref_primary_10_1016_j_onano_2022_100064 crossref_primary_10_1007_s13346_025_01832_w crossref_primary_10_1016_j_ab_2024_115699 crossref_primary_10_1186_s11671_023_03823_7 crossref_primary_10_1007_s13346_023_01398_5 crossref_primary_10_1016_j_ijpharm_2025_125311 crossref_primary_10_1016_j_jconrel_2024_12_039 crossref_primary_10_1016_j_ijbiomac_2024_139447 crossref_primary_10_1007_s13346_023_01511_8 crossref_primary_10_3390_molecules27103085 crossref_primary_10_1016_j_ijpharm_2024_124059 crossref_primary_10_1016_j_jddst_2024_105717 crossref_primary_10_1016_j_biomaterials_2023_122312 crossref_primary_10_2147_IJN_S502490 crossref_primary_10_1016_j_ejps_2023_106374 crossref_primary_10_1016_j_jddst_2023_104686 crossref_primary_10_1039_D3TB02643D crossref_primary_10_3390_pharmaceutics16081022 |
| Cites_doi | 10.1007/s12247-009-9064-4 10.1080/17425247.2021.1942838 10.1073/pnas.0502416102 10.1211/0022357991776976 10.1021/bi00267a011 10.1021/acsnano.5b00028 10.1166/jcsb.2012.1020 10.1016/j.xphs.2020.07.024 10.1016/j.colsurfb.2014.02.045 10.1016/S0168-3659(97)00204-6 10.1016/j.jddst.2019.101394 10.1021/acsami.7b16524 10.3109/02652040903031279 10.1517/13543776.2011.561784 10.1016/j.ejps.2021.105737 10.1166/jbn.2015.1971 10.1016/j.jconrel.2009.02.018 10.1016/j.ijpharm.2017.12.009 10.1038/nrd.2018.183 10.1016/j.ejps.2017.12.002 10.1016/j.ejpb.2019.08.011 10.1016/j.ejpb.2012.02.009 10.1016/j.addr.2016.06.005 10.1021/acscentsci.6b00172 10.1016/j.ejps.2013.06.011 10.3390/pharmaceutics12111026 10.1016/j.jconrel.2017.12.027 10.1016/j.ijpharm.2015.10.078 10.1016/j.ijpharm.2014.05.047 10.5958/0975-4377.2020.00035.X 10.1016/j.ijpharm.2019.02.014 10.1016/j.addr.2017.10.001 10.1016/j.colsurfb.2010.12.014 10.1021/acs.molpharmaceut.9b00861 10.1016/j.ijpharm.2008.05.018 10.1016/j.ijpharm.2019.03.001 10.1016/j.ejps.2010.01.006 10.2217/nnm.12.141 10.1007/s00726-020-02926-0 10.1039/C9NR03025E 10.4155/tde.14.5 10.1016/j.jconrel.2021.08.060 10.4292/wjgpt.v6.i4.213 10.1021/acsami.6b08183 10.1016/j.nano.2015.06.013 10.1007/s11095-021-03004-0 10.1021/acsami.8b00507 10.1517/17425247.2016.1167034 10.1016/j.apsb.2013.10.001 10.1080/10408690590956710 10.1021/acsnano.5b03876 10.1016/j.jconrel.2014.10.026 10.1021/je00019a019 10.1016/j.supflu.2020.104782 10.1016/j.lfs.2004.05.027 10.1016/0304-4165(78)90305-7 10.1021/acs.molpharmaceut.7b00824 10.1111/cbdd.12055 10.1016/j.ijpharm.2020.119918 10.1081/LPR-120039794 10.1089/dia.2019.0185 10.2147/IJN.S124703 10.1126/sciadv.abe2620 10.2174/2211738507666190321110721 10.1177/0091270010372625 10.1177/193229680900300323 10.1016/j.xphs.2018.04.011 10.1016/S0378-5173(97)04885-0 10.3109/10717544.2016.1143056 10.1016/j.ijpharm.2019.01.039 10.1016/j.jconrel.2019.01.023 10.1002/jps.10573 10.1016/j.jconrel.2012.12.021 10.1155/2011/458128 10.1016/S0928-0987(02)00051-9 10.1016/j.nano.2013.07.011 10.1016/j.ijpharm.2013.11.028 10.1016/j.ijpharm.2008.11.013 10.1016/j.ejpb.2016.12.019 10.1038/s41565-020-0693-6 10.1016/j.jddst.2016.10.012 10.1016/S0142-9612(00)00039-9 10.1016/j.jconrel.2021.08.013 10.1126/scitranslmed.aar7047 10.1021/ja204043b 10.1016/0378-5173(93)90150-E 10.1016/j.ijpharm.2013.05.021 10.1016/j.ijpharm.2020.119371 10.1016/j.ejpb.2019.07.002 10.1016/j.numecd.2020.09.020 10.1016/j.ejpb.2015.01.022 10.1016/j.jconrel.2013.10.011 10.1080/10408398.2011.559558 10.1016/j.biomaterials.2012.08.047 10.1016/j.ijpharm.2020.120148 10.1016/j.ijpharm.2017.02.019 10.1136/gutjnl-2019-319146 10.1039/C9NA00308H 10.1016/j.addr.2018.11.006 10.1016/j.ijpharm.2006.07.026 10.1021/acsnano.8b04315 10.1016/j.jsps.2011.04.001 10.1021/mp300649z 10.1016/j.xphs.2017.05.029 10.1002/jps.24215 10.1016/j.cis.2014.10.013 10.1016/j.ijpharm.2018.01.018 10.1016/j.biomaterials.2010.12.029 10.1111/j.1745-7254.2006.00424.x 10.1016/j.jcis.2014.07.045 10.1016/j.ijpharm.2016.04.044 10.1016/j.jconrel.2018.12.028 10.3109/10837450.2013.829093 10.1038/s41573-019-0053-0 10.1016/j.jconrel.2017.03.008 10.1016/j.cbpa.2016.08.022 10.1021/la300394c 10.1016/S0378-3782(01)00211-0 10.3109/03639049309062992 10.1016/j.apsb.2017.11.007 10.1016/S0378-5173(00)00526-3 10.1016/j.jcis.2020.12.019 10.1016/j.jconrel.2018.03.018 10.2147/IJN.S168310 10.1016/j.apsb.2021.03.003 10.1016/S1773-2247(10)50028-5 10.1016/j.ijpharm.2014.10.039 10.1016/j.colsurfb.2018.03.034 10.2165/00003495-199550050-00009 10.3390/pharmaceutics12020099 10.1007/s00726-005-0241-6 10.1016/j.ejps.2015.10.005 10.3109/03639045.2011.645834 10.1038/mt.2013.124 10.1002/jps.23757 10.3109/1061186X.2015.1086359 10.1517/17425247.2015.1068287 10.1080/1061186X.2019.1584200 10.1016/j.ijpharm.2017.05.042 10.1080/03639045.2020.1851241 10.1016/S0016-5085(76)80318-6 10.1021/acsbiomaterials.0c00637 10.1007/s00592-019-01403-9 10.3390/ph13110408 10.1021/acs.molpharmaceut.0c00343 10.1016/S0006-3495(01)75844-4 10.1023/A:1018945902276 10.2217/nnm-2020-0127 10.4103/2230-973X.167676 10.1517/17425247.2011.604311 10.1016/j.ijpharm.2019.118863 10.3109/1061186X.2014.950664 10.1016/j.ejpb.2015.04.013 10.1016/j.jconrel.2014.07.037 10.1016/j.ejps.2010.07.005 10.3390/nano10010135 10.1039/C5NR07474F 10.1016/j.ijpharm.2011.05.066 10.1016/j.ejpb.2020.04.025 10.1016/j.ejpb.2020.03.004 10.1016/j.ijpharm.2019.03.010 10.1021/acs.molpharmaceut.0c00610 10.1023/A:1018936806278 10.1042/bj1240058P 10.1016/j.jddst.2019.05.045 10.1016/j.scp.2017.07.002 10.1080/03639045.2017.1338722 10.1177/193229681300700228 10.1023/A:1011975120776 10.3390/ph14010014 10.1016/j.addr.2021.03.011 10.3389/fendo.2018.00613 10.1016/j.ejpb.2007.07.006 10.3390/pharmaceutics10040203 10.1002/adma.201901935 10.5530/jyp.2021.13.10 10.1021/jf401548r 10.1208/s12248-013-9481-7 10.1080/10717544.2018.1551441 10.1016/j.addr.2007.04.007 10.1016/j.addr.2020.05.007 10.1016/S1359-6446(01)02010-4 10.1016/j.plipres.2013.04.008 10.1016/j.addr.2016.01.010 10.1016/j.ejpb.2020.03.016 10.1016/j.jconrel.2005.02.001 10.2174/1381612033455206 10.1016/j.drudis.2021.01.020 10.1210/jendso/bvab048.1054 10.1016/j.ijpharm.2017.03.027 10.1016/j.ejps.2020.105272 10.1021/acs.molpharmaceut.0c00305 10.1021/bm0503165 10.1016/j.bpj.2009.07.009 10.1039/C7NR07736J 10.1002/jps.20150 10.1016/j.addr.2021.113899 10.1016/j.ijpharm.2003.12.016 10.1038/s41578-019-0156-6 10.2174/156720107780362339 10.1136/archdischild-2019-318225 10.1139/y59-099 10.1211/0022357055434 10.1016/j.ijpharm.2015.05.039 10.1016/j.ijpharm.2008.05.015 10.1007/s43441-019-00036-y 10.1359/JBMR.040715 10.1007/s11095-014-1337-z 10.1016/j.ijbiomac.2013.08.002 10.1177/1932296817691303 10.1016/j.jcis.2020.08.045 10.1080/03639040601155665 10.1016/0378-5173(95)04388-8 10.1016/j.xphs.2017.05.019 10.1016/j.jconrel.2003.05.001 10.3390/pharmaceutics13081312 10.1016/j.addr.2018.07.001 10.1016/j.jconrel.2018.01.012 10.1517/17425247.2011.547469 10.3109/02652048.2015.1035685 10.1016/j.ijpharm.2007.03.009 10.3390/pharmaceutics13040565 10.1016/j.ejpb.2009.06.001 10.1016/S0169-409X(00)00103-4 10.1016/j.ijpharm.2015.04.075 10.1016/j.ijpharm.2012.03.032 10.1016/j.colsurfb.2008.12.031 10.1021/acs.molpharmaceut.6b01027 10.3109/1061186X.2012.716845 10.1002/jps.20555 10.1002/jps.21993 10.1016/j.bone.2012.01.009 10.1016/j.ajps.2015.04.005 10.1073/pnas.1722338115 10.2217/nnm-2016-0047 10.1111/j.1463-1326.2009.01150.x 10.1016/j.ijpharm.2017.11.067 10.1016/j.drudis.2018.11.010 10.1016/j.jconrel.2005.05.016 10.2147/IJN.S125047 10.2147/IJN.S318092 10.1055/s-0031-1295487 10.3109/00365529409090437 10.1016/j.colsurfb.2013.01.009 10.3390/pharmaceutics13040459 10.1016/j.addr.2009.09.006 10.1016/j.ijpharm.2006.02.045 10.1038/mi.2013.30 10.2147/DDDT.S95905 10.1111/j.1749-6632.1978.tb22027.x 10.1016/j.coph.2017.07.011 10.1023/A:1015921101465 10.1080/01932691.2020.1773849 10.1126/scitranslmed.3003453 10.1166/jbn.2013.1572 10.1155/2011/132435 10.1016/j.jcis.2019.05.057 10.1016/j.ddtec.2011.11.006 10.1016/S1383-5866(03)00092-3 10.1016/j.jcis.2020.11.051 10.1211/0022357001774813 10.1080/17425247.2016.1213236 10.1016/j.jconrel.2017.04.038 10.1517/17425247.2014.917077 10.1016/j.bbamem.2010.07.013 10.1016/j.ejpb.2020.04.004 10.1039/c2sm25847a |
| ContentType | Journal Article |
| Copyright | 2022 The Authors Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2022 The Authors – notice: Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.addr.2021.114097 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1872-8294 |
| ExternalDocumentID | 34999121 10_1016_j_addr_2021_114097 S0169409X21004907 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23M 4.4 457 4G. 53G 5GY 5VS 6I. 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABFNM ABGSF ABJNI ABMAC ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HX~ HZ~ IHE J1W KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SPT SSP SSU SSZ T5K TEORI WUQ Y6R ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO ADVLN AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH CGR CUY CVF ECM EFKBS EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c400t-9f2b63a959ca94758ddb939c97a38807bca30b4a62dddf675272ae8dd2e001393 |
| IEDL.DBID | .~1 |
| ISSN | 0169-409X 1872-8294 |
| IngestDate | Fri Jul 11 09:28:49 EDT 2025 Mon Jul 21 06:08:14 EDT 2025 Tue Jul 01 03:36:08 EDT 2025 Thu Apr 24 23:02:48 EDT 2025 Fri Feb 23 02:40:13 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Therapeutic peptides SEDDS Self-emulsifying drug delivery systems SLN NLC Micelles Oral drug delivery Lipid-based nanocarriers Liposomes |
| Language | English |
| License | This is an open access article under the CC BY license. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c400t-9f2b63a959ca94758ddb939c97a38807bca30b4a62dddf675272ae8dd2e001393 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0169409X21004907 |
| PMID | 34999121 |
| PQID | 2618520811 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2618520811 pubmed_primary_34999121 crossref_primary_10_1016_j_addr_2021_114097 crossref_citationtrail_10_1016_j_addr_2021_114097 elsevier_sciencedirect_doi_10_1016_j_addr_2021_114097 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | March 2022 2022-03-00 20220301 |
| PublicationDateYYYYMMDD | 2022-03-01 |
| PublicationDate_xml | – month: 03 year: 2022 text: March 2022 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Advanced drug delivery reviews |
| PublicationTitleAlternate | Adv Drug Deliv Rev |
| PublicationYear | 2022 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Wu, Zheng, Liu, Shan, Zhang, Huang (b0910) 2018; 10 Lane, O'Driscoll, Corrigan (b0055) 2005; 57 Craik, Fairlie, Liras, Price (b0015) 2013; 81 Khatri, Shao (b0525) 2018; 536 Wang, Jiang, Wang, Liao, Yin (b0665) 2015; 10 Shailubhai, Palejwala, Arjunan, Saykhedkar, Nefsky, Foss, Comiskey, Jacob, Plevy (b0185) 2015; 6 Stano, Bufali, Pisano, Bucci, Barbarino, Santaniello, Carminati, Luisi (b1155) 2004; 14 Esparza, Jayawardena, Onyuksel (b1400) 2019 Li, Tan, Prestidge, Nielsen, Müllertz (b0930) 2014; 477 Ma, Ma, Liu, Zheng, Duan (b1235) 2006; 27 Flanagan, Singh (b1100) 2006; 46 Li, Xia, Tao, Shen, He, Gan, Wang (b0870) 2017; 106 Shahzadi, Nazir, Phan, Bernkop-Schnürch (b0475) 2020; 151 Prüfert, Hering, Zaichik, Le, Bernkop-Schnürch (b0715) 2020; 583 Wang, Shi, Gan, Dai (b0535) 2004; 35 Vass, Démuth, Hirsch, Nagy, Andersen, Vigh, Verreck, Csontos, Nagy, Marosi (b0210) 2019; 296 Parmentier, Thewes, Gropp, Fricker (b1300) 2011; 415 A. Yadav, S. Mohite, Recent advances in protein and peptide drug delivery, Research journal of pharmaceutical dosage forms and technology 12(3) (2020) 205 (212 (2020)). Le, Steinbring, Le-Vinh, Jalil, Matuszczak, Bernkop-Schnürch (b1510) 2021; 587 Maher, Brayden (b0155) 2012; 9 Martins, Costa-Lima, Carneiro, Cordeiro-da-Silva, Souto, Ferreira (b0865) 2012; 430 Hintzen, Perera, Hauptstein, Müller, Laffleur, Bernkop-Schnürch (b0345) 2014; 472 Gregoriadis, Ryman (b0835) 1971; 124 Bucheit, Pamulapati, Carter, Malloy, Dixon, Sisson (b0140) 2020; 22 Adjei, Rao, Garren, Menon, Vadnere (b0295) 1993; 90 Banerjee, Ibsen, Brown, Chen, Agatemor, Mitragotri (b1470) 2018; 115 . Noble, Markham (b0150) 1995; 50 Müller, Runge, Ravelli, Mehnert, Thünemann, Souto (b1275) 2006; 317 Chen, Fan, Jin, Zhou, Yang, Zhu, Zhang, Zhang, Huang (b1290) 2013; 8 Bashyal, Seo, Keum, Noh, Lamichhane, Lee (b0385) 2021; 13 Üner (b1265) 2006; 61 Ansari, Anwer, Jamil, Al-Shdefat, Ali, Ahmad, Ansari (b0575) 2016; 23 Maisel, Ensign, Reddy, Cone, Hanes (b0800) 2015; 197 McClements, Rao (b1055) 2011; 51 Tokunaga, Tashiro, Ono, Sharmin, Kato, Irie, Mishima, Satho, Aida, Mishima (b1090) 2020; 160 Ganesan, Narayanasamy (b1050) 2017; 6 Michaelsen, Jørgensen, Abdi, Wasan, Rades, Müllertz (b0750) 2019; 142 Speranza, Corradini, Hartman, Ribnicky, Oren, Rogers (b0745) 2013; 61 Wu, Shan, Zhang, Huang (b0805) 2018; 124 Samson, Nachtigall, Fleseriu, Molitch, Giustina, Ludlam, Patou, Haviv, Biermasz, Kennedy (b0170) 2021; 5 O’Driscoll (b0890) 2002; 15 Degim, Ünal, Eşsiz, Abbasoglu (b0450) 2004; 75 Ramaldes, Pereira, Castro, Vieira, Cardoso (b1020) 2002; 38 FDA, Novel Excipient Review Pilot Program, FDA. Miller, Dahan, Gupta, Varghese, Amidon (b0550) 2009; 137 Liang, Harries, Wong (b0320) 2005; 102 Senior (b0590) 2001; 6 Dünnhaupt, Kammona, Waldner, Kiparissides, Bernkop-Schnürch (b0815) 2015; 96 Maji, Mahajan, Sriram, Medtiya, Vasave, Khatri, Kumar, Singh, Madan, Singh (b1160) 2021 Serrano, Kochergina, Albors, Diaz, Oroval, Hueso, Serrano (b1370) 2020; 8 Buckley, Hubálek, Rahbek (b1490) 2016; 4 Zupančič, Bernkop-Schnürch (b0275) 2017; 255 Balata, Essa, Shamardl, Zaidan, Abourehab (b0695) 2016; 10 Vaishya, Mandal, Gokulgandhi, Patel, Mitra (b0440) 2015; 489 Yuan, Chen, Chai, Du, Hu (b0820) 2013; 10 Bashyal, Seo, Keum, Noh, Lamichhane, Kim, Kim, Choi, Lee (b0480) 2021; 16 Yang, Bahreman, Daudey, Bussmann, Olsthoorn, Kros (b0990) 2016; 2 Muntoni, Marini, Ahmadi, Milla, Ghè, Bargoni, Capucchio, Biasibetti, Battaglia (b0045) 2019; 56 Tomizawa, Aramaki, Fujii, Kara, Suzuki, Yachi, Kikuchi, Tsuchiya (b1030) 1993; 10 Zupančič, Rohrer, Thanh Lam, Grießinger, Bernkop-Schnürch (b0425) 2017; 43 Singh, Meher, Raval, Khan, Chaurasia, Jain, Chourasia (b1105) 2017; 252 Almeida, Runge, Müller (b1250) 1997; 149 Bashyal, Seo, Keum, Noh, Choi, Lee (b0445) 2018; 13 Anil, Kannan (b1195) 2018; 10 Shrestha, Bouttefeux, Vanvarenberg, Lundquist, Cunarro, Tovar, Khodus, Andersson, Keita, Dieguez (b0970) 2018; 10 Anchan, Koland (b0950) 2021; 13 Werle, Takeuchi (b1305) 2009; 370 Gleeson, Fein, Whitehead (b0115) 2021; 173 S. Faulkner, EnterisBioPharma touts more Phase II data for oral endometriosis therapy, Drug Delivery Business, 201/8. Hui, Huang (b1320) 2021 Iqbal, Md, Sahni, Baboota, Dang, Ali (b1085) 2012; 20 Anselmo, Gokarn, Mitragotri (b0125) 2019; 18 Yu, Fan, Wang, Qi, Lu, Wu (b0850) 2019; 16 Donovan, Flynn, Amidon (b0260) 1990; 7 Tekeli, Aktas, Celebi (b0920) 2021; 53 Francis, Cristea, Winnik (b0975) 2005; 6 Lo, Chen, Lee, Han, Li (b0685) 2010; 99 Keum, Noh, Seo, Bashyal, Lee (b0395) 2020; 13 Kauss, Gaubert, Tabaran, Tonelli, Phoeung, Langlois, White, Cartwright, Gomes, Gaudin (b0680) 2018; 536 Chintalapudi, Murthy, Lakshmi, Manohar (b0720) 2015; 5 Huo, Tao, Zhang, Liu, Lin, Liu, Zhang, Zhang, Yang, Wu (b0725) 2018; 114 Heinemann, Jacques (b0160) 2009; 3 Griesser, Hetényi, Moser, Demarne, Jannin, Bernkop-Schnürch (b0040) 2017; 520 Arnold, Imanidis, Kuentz (b0655) 2012; 38 Amoabediny, Haghiralsadat, Naderinezhad, Helder, Akhoundi Kharanaghi, Mohammadnejad Arough, Zandieh-Doulabi (b1070) 2018; 67 Mudshinge, Deore, Patil, Bhalgat (b1130) 2011; 19 Leonaviciute, Bernkop-Schnürch (b1180) 2015; 12 Shahzadi, Fürst, Knoll, Bernkop-Schnürch (b0735) 2021; 13 Li, Li, Zhou, Li, Zhao, Ma, Li, Gao, Liu, Wang (b0960) 2012; 33 Vukovic, Khatib, Drake, Madriaga, Brandenburg, Král, Onyuksel (b1390) 2011; 133 Hämmerle, Mindeholm, Launonen, Kiese, Loeffler, Harfst, Azria, Arnold, John (b0100) 2012; 50 Karamanidou, Karidi, Bourganis, Kontonikola, Kammona, Kiparissides (b0565) 2015; 97 Müller, Runge, Ravelli, Thünemann, Mehnert, Souto (b1270) 2008; 68 Jørgensen, Jepsen, Nielsen, Dufva, Nielsen, Rades, Boisen, Müllertz (b1455) 2019; 143 FDA, Applications Covered by Section 505(b)(2), 1999. Zhang, Zhao, Chu, Han, Zhai (b1145) 2014; 434 Ramakrishna, Mathan, Mathan (b0460) 1994; 29 Suzuki, Kim, Bae (b1330) 2019; 294 Sang Yoo, Gwan Park (b0350) 2004; 93 Christiansen, Backensfeld, Weitschies (b0740) 2010; 41 Meaney, O'Driscoll (b0050) 2000; 207 Kalepu, Manthina, Padavala (b0900) 2013; 3 Han, Lu, Xie, Zhang, Zhu, Du, Wang, Song, Yang, Shi, Cao (b1415) 2020; 15 Friedl, Dünnhaupt, Hintzen, Waldner, Parikh, Pearson, Wilcox, Bernkop-Schnürch (b0825) 2013; 102 Sakloetsakun, Dünnhaupt, Barthelmes, Perera, Bernkop-Schnürch (b1190) 2013; 61 Freije, Lamouche, Tanguay (b0285) 2020; 54 Moroz (b0025) 2016; 101 He, Lu, Qi, Zhao, Dong, Wu (b1355) 2018; 8 Campione, Lanna, Cosio, Rosa, Conte, Iacovelli, Romeo, Falconi, Del Vecchio, Franchin (b1365) 2020 Bernkop-Schnürch (b1430) 2013; 50 Wang, Luo (b0875) 2019; 11 Harde, Das, Jain (b1035) 2011; 8 Woodley (b0230) 1994; 11 Bonengel, Jelkmann, Abdulkarim, Gumbleton, Reinstadler, Oberacher, Prüfert, Bernkop-Schnürch (b0370) 2018; 273 Byeon, Lee, Kim, Ahn, Kim, Choi, Park (b1335) 2019; 26 Shan, Zhu, Liu, Li, Zhong, Sun, Zhang, Huang (b0775) 2015; 9 FDA, Inactive Ingredient Search for Approved Drug Products, FDA. Bernkop-Schnürch, Kast, Guggi (b0215) 2003; 93 Chattopadhyay, Huff, Shekunov (b1125) 2006; 95 Dobry, Settell, Baumann, Ray, Graham, Beyerinck (b1165) 2009; 4 Darge, Hanurry, Birhan, Mekonnen, Andrgie, Chou, Lai, Tsai (b1465) 2021; 406 Chamieh, Tarrat, Doudou, Jannin, Demarne, Cottet (b0755) 2019; 559 Lee, Schlesinger, Wickline, Lanza, Baker (b0980) 2012; 8 Muranushi, Mack, Kim (b0340) 1993; 19 Chakraborty, Shukla, Mishra, Singh (b0240) 2009; 73 Singh, Bajpai, Mishra (b0690) 2020; 37 Bernkop-Schnürch, Jalil (b0765) 2018; 271 Brayden, Maher (b0175) 2021; 5 Aramaki, Tomizawa, Hara, Yachi, Kikuchi, Tsuchiya (b1015) 1993; 10 Niu, Tan, Guan, Hovgaard, Lu, Qi, Lian, Li, Wu (b1315) 2014; 460 Almeida, Souto (b1245) 2007; 59 Zhang, Ping, Huang, Xu, Cheng, Han (b1280) 2006; 327 Deamer (b1150) 1978; 308 Mahmood, Prüfert, Efiana, Ashraf, Hermann, Hussain, Bernkop-Schnürch (b1500) 2016; 13 Tankó, Bagger, Alexandersen, Devogelaer, Reginster, Chick, Olson, Benmammar, Mindeholm, Azria (b0105) 2004; 19 Mabbott, Donaldson, Ohno, Williams, Mahajan (b1010) 2013; 6 Niu, Lu, Hovgaard, Guan, Tan, Lian, Qi, Wu (b1345) 2012; 81 Rao, Yajurvedi, Shao (b0965) 2008; 362 Dossche, Michelet, De Bruyne, Van Herzeele, Gasthuys, Rittig, Vermeulen, Walle (b0190) 2021; 106 Alqahtani, Alayoubi, Nazzal, Sylvester, Kaddoumi (b0860) 2013; 15 Rao, Shao (b0325) 2008; 362 Karsdal, Henriksen, Bay-Jensen, Molloy, Arnold, John, Byrjalsen, Azria, Riis, Qvist (b0110) 2011; 51 U.S.F.a.D. Administration, Human insulin receives FDA approval, FDA Drug Bull 12 (1982) 18–19. Kalhapure, Mocktar, Sikwal, Sonawane, Kathiravan, Skelton, Govender (b0465) 2014; 117 Liu, Hirschberg, Fanø, Mu, Müllertz (b0570) 2020; 147 Pujara (b0710) 2012; 4 Prajapati, Verma, Patel (b1040) 2018; 13 Zhang, Gao, Jiang, Chen, Liu, Yu, Li (b0615) 2013; 452 Lewis, McEntee, Holland, Patel (b0135) 2021 Brayden, Stuettgen (b0400) 2021; 159 Kurpiers, Wolf, Spleis, Steinbring, Jörgensen, Matuszczak, Bernkop-Schnürch (b0310) 2021; 110 Wang, Wang, Zhang, Fu, Gao, Zhang (b1285) 2019; 52 McClements (b0645) 2013; 52 Smart, Gaisford, Basit (b0265) 2014; 11 Bordes, Holmberg (b0315) 2015; 222 Krishnadas, Onyuksel, Rubinstein (b1395) 2003; 9 Beloqui, Solinís, Gascón, del Pozo-Rodríguez, des Rieux, Préat (b0880) 2013; 166 Zhang, Qi, Lu, He, Li, Wu (b1350) 2014; 10 Morales, Brayden (b0165) 2017; 36 Wahlang, Kabra, Pawar, Tikoo, Bansal (b1000) 2012; 62 Wu, Lin, Wang, Chen, Chang (b0830) 2012; 28 Drucker (b1450) 2020; 19 Mahmood, Bernkop-Schnürch (b0020) 2019; 142 Olmsted, Padgett, Yudin, Whaley, Moench, Cone (b0790) 2001; 81 Pavoni, Perinelli, Bonacucina, Cespi, Palmieri (b1095) 2020; 10 Gradauer, Barthelmes, Vonach, Almer, Mangge, Teubl, Roblegg, Dünnhaupt, Fröhlich, Bernkop-Schnürch, Prassl (b1325) 2013; 172 Bahman, Taurin, Altayeb, Taha, Bakhiet, Greish (b0940) 2020; 12 Liu, Werner, Funke, Besenius, Saaby, Fanø, Mu, Müllertz (b1240) 2019; 560 Ghosh, Saranya, Mukherjee, Chandrasekaran (b1060) 2013; 105 Mahjub, Dorkoosh, Rafiee-Tehrani, Bernkop Schnürch (b0625) 2015; 32 Zhu, Chen, Paul, Lu, Wu, Qi (b1435) 2021 Battaglia, Gallarate, Cavalli, Trotta (b1110) 2010; 27 Koehl, Holm, Kuentz, Jannin, Griffin (b0660) 2020; 17 Yuan, Jiang, Du, Miao, Zhang, Hu (b0600) 2009; 70 Xu, Van Hul, Suriano, Préat, Cani, Beloqui (b0515) 2020; 69 Niu, Iqbal (10.1016/j.addr.2021.114097_b1085) 2012; 20 Maher (10.1016/j.addr.2021.114097_b0130) 2016; 106 Flanagan (10.1016/j.addr.2021.114097_b1100) 2006; 46 Alqahtani (10.1016/j.addr.2021.114097_b0860) 2013; 15 Wibel (10.1016/j.addr.2021.114097_b0485) 2020; 151 Gregoriadis (10.1016/j.addr.2021.114097_b0835) 1971; 124 Dumont (10.1016/j.addr.2021.114097_b1255) 2019; 54 McClements (10.1016/j.addr.2021.114097_b1055) 2011; 51 Mudshinge (10.1016/j.addr.2021.114097_b1130) 2011; 19 Bernkop-Schnürch (10.1016/j.addr.2021.114097_b0235) 1998; 52 Krishnadas (10.1016/j.addr.2021.114097_b1395) 2003; 9 Fonte (10.1016/j.addr.2021.114097_b0030) 2013; 7 Uchiyama (10.1016/j.addr.2021.114097_b0405) 1999; 51 10.1016/j.addr.2021.114097_b0090 Chaudhary (10.1016/j.addr.2021.114097_b0895) 2014; 22 Muntoni (10.1016/j.addr.2021.114097_b0045) 2019; 56 Yuan (10.1016/j.addr.2021.114097_b0600) 2009; 70 Pinsuwan (10.1016/j.addr.2021.114097_b0760) 1995; 40 Wu (10.1016/j.addr.2021.114097_b0910) 2018; 10 Tekeli (10.1016/j.addr.2021.114097_b0920) 2021; 53 Sakloetsakun (10.1016/j.addr.2021.114097_b1190) 2013; 61 Zupančič (10.1016/j.addr.2021.114097_b0425) 2017; 43 Beauchesne (10.1016/j.addr.2021.114097_b0145) 2007; 33 Etezadi (10.1016/j.addr.2021.114097_b1205) 2020; 590 Degim (10.1016/j.addr.2021.114097_b0450) 2004; 75 Cholkar (10.1016/j.addr.2021.114097_b1375) 2012; 2 Richards (10.1016/j.addr.2021.114097_b0605) 1978; 543 Xu (10.1016/j.addr.2021.114097_b0785) 2015; 9 El-Laithy (10.1016/j.addr.2021.114097_b0905) 2015; 490 Durán-Lobato (10.1016/j.addr.2021.114097_b0180) 2020; 32 Tomizawa (10.1016/j.addr.2021.114097_b1030) 1993; 10 Zhu (10.1016/j.addr.2021.114097_b1435) 2021 Schmitz (10.1016/j.addr.2021.114097_b0245) 2006; 30 Hetényi (10.1016/j.addr.2021.114097_b0560) 2017; 523 Morel (10.1016/j.addr.2021.114097_b1295) 1996; 132 Bucheit (10.1016/j.addr.2021.114097_b0140) 2020; 22 Deamer (10.1016/j.addr.2021.114097_b1150) 1978; 308 Mabbott (10.1016/j.addr.2021.114097_b1010) 2013; 6 Ansari (10.1016/j.addr.2021.114097_b0575) 2016; 23 Ghosh (10.1016/j.addr.2021.114097_b1060) 2013; 105 Wang (10.1016/j.addr.2021.114097_b0875) 2019; 11 Akhtar (10.1016/j.addr.2021.114097_b0700) 2011; 21 10.1016/j.addr.2021.114097_b0075 Pavoni (10.1016/j.addr.2021.114097_b1095) 2020; 10 Shahzadi (10.1016/j.addr.2021.114097_b1420) 2020; 17 Parmentier (10.1016/j.addr.2021.114097_b1340) 2014; 103 Joyce (10.1016/j.addr.2021.114097_b1200) 2019; 142 Bordes (10.1016/j.addr.2021.114097_b0315) 2015; 222 Xue (10.1016/j.addr.2021.114097_b0630) 2011; 32 Müller (10.1016/j.addr.2021.114097_b1275) 2006; 317 Werle (10.1016/j.addr.2021.114097_b1305) 2009; 370 Kintzing (10.1016/j.addr.2021.114097_b0200) 2016; 34 Heinemann (10.1016/j.addr.2021.114097_b0160) 2009; 3 Lane (10.1016/j.addr.2021.114097_b0055) 2005; 57 Olmsted (10.1016/j.addr.2021.114097_b0790) 2001; 81 Balata (10.1016/j.addr.2021.114097_b0695) 2016; 10 Dobbins (10.1016/j.addr.2021.114097_b0335) 1976; 70 Lieleg (10.1016/j.addr.2021.114097_b0840) 2009; 97 Gaudana (10.1016/j.addr.2021.114097_b0495) 2011; 2011 Bahman (10.1016/j.addr.2021.114097_b0205) 2019; 7 Li (10.1016/j.addr.2021.114097_b0870) 2017; 106 Khan (10.1016/j.addr.2021.114097_b1005) 2013; 8 10.1016/j.addr.2021.114097_b1425 Drucker (10.1016/j.addr.2021.114097_b1450) 2020; 19 Üner (10.1016/j.addr.2021.114097_b1265) 2006; 61 Griesser (10.1016/j.addr.2021.114097_b0040) 2017; 520 Liang (10.1016/j.addr.2021.114097_b0320) 2005; 102 Woodley (10.1016/j.addr.2021.114097_b0230) 1994; 11 McClements (10.1016/j.addr.2021.114097_b0645) 2013; 52 Francis (10.1016/j.addr.2021.114097_b0975) 2005; 6 Dossche (10.1016/j.addr.2021.114097_b0190) 2021; 106 Xie (10.1016/j.addr.2021.114097_b0595) 2011; 83 Maisel (10.1016/j.addr.2021.114097_b0800) 2015; 197 Campione (10.1016/j.addr.2021.114097_b1365) 2020 Battaglia (10.1016/j.addr.2021.114097_b1110) 2010; 27 Ganesan (10.1016/j.addr.2021.114097_b1050) 2017; 6 Wolf (10.1016/j.addr.2021.114097_b1505) 2020; 150 Mahmood (10.1016/j.addr.2021.114097_b0020) 2019; 142 Friedl (10.1016/j.addr.2021.114097_b0610) 2020; 15 Zupančič (10.1016/j.addr.2021.114097_b0275) 2017; 255 Vukovic (10.1016/j.addr.2021.114097_b1390) 2011; 133 Stano (10.1016/j.addr.2021.114097_b1155) 2004; 14 Ramakrishna (10.1016/j.addr.2021.114097_b0460) 1994; 29 Friedl (10.1016/j.addr.2021.114097_b0825) 2013; 102 Zhang (10.1016/j.addr.2021.114097_b1145) 2014; 434 Samiei (10.1016/j.addr.2021.114097_b0545) 2017; 527 Anchan (10.1016/j.addr.2021.114097_b0950) 2021; 13 AboulFotouh (10.1016/j.addr.2021.114097_b1220) 2018; 167 Brayden (10.1016/j.addr.2021.114097_b0175) 2021; 5 Bashyal (10.1016/j.addr.2021.114097_b0480) 2021; 16 Shukla (10.1016/j.addr.2021.114097_b1075) 2011; 8 Parmentier (10.1016/j.addr.2021.114097_b1300) 2011; 415 Yu (10.1016/j.addr.2021.114097_b0850) 2019; 16 Song (10.1016/j.addr.2021.114097_b0455) 2005; 106 Bashyal (10.1016/j.addr.2021.114097_b0415) 2021; 338 Chamieh (10.1016/j.addr.2021.114097_b0755) 2019; 559 Hu (10.1016/j.addr.2021.114097_b1260) 2004; 273 Niu (10.1016/j.addr.2021.114097_b1315) 2014; 460 Shalaby (10.1016/j.addr.2021.114097_b1360) 2018; 107 Iyer (10.1016/j.addr.2021.114097_b0195) 2010; 12 Senior (10.1016/j.addr.2021.114097_b0590) 2001; 6 10.1016/j.addr.2021.114097_b0280 Niu (10.1016/j.addr.2021.114097_b1345) 2012; 81 10.1016/j.addr.2021.114097_b1445 Lo (10.1016/j.addr.2021.114097_b0685) 2010; 99 Vaishya (10.1016/j.addr.2021.114097_b0440) 2015; 489 Prüfert (10.1016/j.addr.2021.114097_b0715) 2020; 583 Martins (10.1016/j.addr.2021.114097_b0865) 2012; 430 Chattopadhyay (10.1016/j.addr.2021.114097_b1125) 2006; 95 Christiansen (10.1016/j.addr.2021.114097_b0740) 2010; 41 Menzel (10.1016/j.addr.2021.114097_b1225) 2018; 277 Speranza (10.1016/j.addr.2021.114097_b0745) 2013; 61 Hoekstra (10.1016/j.addr.2021.114097_b0985) 1982; 21 Bernkop-Schnürch (10.1016/j.addr.2021.114097_b1430) 2013; 50 Arnold (10.1016/j.addr.2021.114097_b0655) 2012; 38 Anselmo (10.1016/j.addr.2021.114097_b0125) 2019; 18 10.1016/j.addr.2021.114097_b0035 Zhang (10.1016/j.addr.2021.114097_b0615) 2013; 452 Asfour (10.1016/j.addr.2021.114097_b1480) 2020 Lu (10.1016/j.addr.2021.114097_b0355) 2018; 15 Yang (10.1016/j.addr.2021.114097_b0990) 2016; 2 Katsuda (10.1016/j.addr.2021.114097_b1405) 2010; 1798 Niu (10.1016/j.addr.2021.114097_b0580) 2011; 6 Maji (10.1016/j.addr.2021.114097_b1160) 2021 Kubackova (10.1016/j.addr.2021.114097_b1185) 2021; 13 Gaidhani (10.1016/j.addr.2021.114097_b1175) 2015; 4 Karsdal (10.1016/j.addr.2021.114097_b0110) 2011; 51 Wang (10.1016/j.addr.2021.114097_b0520) 2010; 39 Jörgensen (10.1016/j.addr.2021.114097_b0770) 2020; 17 Rao (10.1016/j.addr.2021.114097_b0965) 2008; 362 Caffarel-Salvador (10.1016/j.addr.2021.114097_b1485) 2021; 7 Lupo (10.1016/j.addr.2021.114097_b0585) 2021; 47 Guarini (10.1016/j.addr.2021.114097_b0410) 1984; 271 Liu (10.1016/j.addr.2021.114097_b0570) 2020; 147 O’Driscoll (10.1016/j.addr.2021.114097_b0890) 2002; 15 Li (10.1016/j.addr.2021.114097_b0960) 2012; 33 Arbit (10.1016/j.addr.2021.114097_b0080) 2017; 11 Brown (10.1016/j.addr.2021.114097_b0120) 2020; 5 Luzio (10.1016/j.addr.2021.114097_b0065) 2007; 56 Yildiz (10.1016/j.addr.2021.114097_b0795) 2015; 23 Chen (10.1016/j.addr.2021.114097_b1290) 2013; 8 Shahzadi (10.1016/j.addr.2021.114097_b0475) 2020; 151 Cagel (10.1016/j.addr.2021.114097_b1140) 2017; 113 Ensign (10.1016/j.addr.2021.114097_b0780) 2012; 4 Shan (10.1016/j.addr.2021.114097_b0775) 2015; 9 Karamanidou (10.1016/j.addr.2021.114097_b0565) 2015; 97 Ismail (10.1016/j.addr.2021.114097_b0330) 2020; 152 Esparza (10.1016/j.addr.2021.114097_b1400) 2019 Amoabediny (10.1016/j.addr.2021.114097_b1070) 2018; 67 Almeida (10.1016/j.addr.2021.114097_b1245) 2007; 59 Chintalapudi (10.1016/j.addr.2021.114097_b0720) 2015; 5 Shailubhai (10.1016/j.addr.2021.114097_b0185) 2015; 6 Zupančič (10.1016/j.addr.2021.114097_b0380) 2016; 23 Mahmood (10.1016/j.addr.2021.114097_b1500) 2016; 13 Donovan (10.1016/j.addr.2021.114097_b0260) 1990; 7 Leonaviciute (10.1016/j.addr.2021.114097_b0650) 2016; 508 Singh (10.1016/j.addr.2021.114097_b1105) 2017; 252 Volpi (10.1016/j.addr.2021.114097_b1460) 2021; 14 Sun (10.1016/j.addr.2021.114097_b0490) 2011; 6 10.1016/j.addr.2021.114097_b0010 Hu (10.1016/j.addr.2021.114097_b0620) 2015; 11 Chakraborty (10.1016/j.addr.2021.114097_b0240) 2009; 73 Zhou (10.1016/j.addr.2021.114097_b0915) 2014; 19 Anil (10.1016/j.addr.2021.114097_b1195) 2018; 10 Mahjub (10.1016/j.addr.2021.114097_b0625) 2015; 32 Aramaki (10.1016/j.addr.2021.114097_b1015) 1993; 10 Le (10.1016/j.addr.2021.114097_b1510) 2021; 587 Kim (10.1016/j.addr.2021.114097_b0885) 2018; 12 Prajapati (10.1016/j.addr.2021.114097_b1040) 2018; 13 Dahlgren (10.1016/j.addr.2021.114097_b0420) 2020; 12 Lewis (10.1016/j.addr.2021.114097_b0135) 2021 Noble (10.1016/j.addr.2021.114097_b0150) 1995; 50 Bahman (10.1016/j.addr.2021.114097_b0940) 2020; 12 Banerjee (10.1016/j.addr.2021.114097_b1470) 2018; 115 Durán-Lobato (10.1016/j.addr.2021.114097_b0085) 2021 10.1016/j.addr.2021.114097_b0365 Christophersen (10.1016/j.addr.2021.114097_b0640) 2014; 31 Ijaz (10.1016/j.addr.2021.114097_b0250) 2016; 13 Kurpiers (10.1016/j.addr.2021.114097_b0310) 2021; 110 Bashyal (10.1016/j.addr.2021.114097_b0445) 2018; 13 Gallarate (10.1016/j.addr.2021.114097_b1115) 2011; 2011 Serrano (10.1016/j.addr.2021.114097_b1370) 2020; 8 Kalhapure (10.1016/j.addr.2021.114097_b0465) 2014; 117 Laouini (10.1016/j.addr.2021.114097_b1135) 2012; 1 Feeney (10.1016/j.addr.2021.114097_b0730) 2014; 192 Bligh (10.1016/j.addr.2021.114097_b0500) 1959; 37 Bernkop-Schnürch (10.1016/j.addr.2021.114097_b0765) 2018; 271 Li (10.1016/j.addr.2021.114097_b1495) 2017; 12 Megwa (10.1016/j.addr.2021.114097_b0555) 2000; 52 Morales (10.1016/j.addr.2021.114097_b0165) 2017; 36 Pupo (10.1016/j.addr.2021.114097_b1080) 2005; 104 Pujara (10.1016/j.addr.2021.114097_b0710) 2012; 4 Tankó (10.1016/j.addr.2021.114097_b0105) 2004; 19 Bashyal (10.1016/j.addr.2021.114097_b0385) 2021; 13 Müller (10.1016/j.addr.2021.114097_b1270) 2008; 68 Tokunaga (10.1016/j.addr.2021.114097_b1090) 2020; 160 Dobry (10.1016/j.addr.2021.114097_b1165) 2009; 4 Liu (10.1016/j.addr.2021.114097_b1475) 2021 Marschütz (10.1016/j.addr.2021.114097_b0225) 2000; 21 Lee (10.1016/j.addr.2021.114097_b0980) 2012; 8 Phan (10.1016/j.a |
| References_xml | – volume: 151 start-page: 73 year: 2020 end-page: 80 ident: b0485 article-title: Hydrophobic ion pairing (HIP) of (poly) peptide drugs: Benefits and drawbacks of different preparation methods publication-title: Eur. J. Pharm. Biopharm. – volume: 149 start-page: 255 year: 1997 end-page: 265 ident: b1250 article-title: Peptide-loaded solid lipid nanoparticles (SLN): influence of production parameters publication-title: Int. J. Pharm. – volume: 47 start-page: 22 year: 2021 end-page: 35 ident: b0585 article-title: Impact of bile salts and a medium chain fatty acid on the physical properties of self-emulsifying drug delivery systems publication-title: Drug Dev. Ind. Pharm. – volume: 90 start-page: 141 year: 1993 end-page: 149 ident: b0295 article-title: Effect of ion-pairing on 1-octanol-water partitioning of peptide drugs. I: the nonapeptide leuprolide acetate publication-title: Int. J. Pharm. – volume: 294 start-page: 259 year: 2019 end-page: 267 ident: b1330 article-title: Long-term oral administration of Exendin-4 to control type 2 diabetes in a rat model publication-title: J. Control. Release – start-page: 1 year: 2021 end-page: 13 ident: b0510 article-title: Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide publication-title: Pharm. Res. – volume: 15 start-page: 1829 year: 2020 end-page: 1841 ident: b0610 article-title: Cellular uptake of self-emulsifying drug-delivery systems: polyethylene glycol versus polyglycerol surface publication-title: Nanomedicine (Lond) – volume: 430 start-page: 216 year: 2012 end-page: 227 ident: b0865 article-title: Solid lipid nanoparticles as intracellular drug transporters: an investigation of the uptake mechanism and pathway publication-title: Int. J. Pharm. – volume: 560 start-page: 377 year: 2019 end-page: 384 ident: b1240 article-title: SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats publication-title: Int. J. Pharm. – volume: 9 start-page: 1005 year: 2003 end-page: 1012 ident: b1395 article-title: Interactions of VIP, secretin and PACAP1-38 with phospholipids: a biological paradox revisited publication-title: Curr. Pharm. Des. – volume: 30 start-page: 35 year: 2006 end-page: 42 ident: b0245 article-title: Characterisation of the thiol-disulphide chemistry of desmopressin by LC, mu-LC, LC-ESI-MS and Maldi-Tof publication-title: Amino Acids – volume: 99 start-page: 2320 year: 2010 end-page: 2332 ident: b0685 article-title: Self-emulsifying O/W formulations of paclitaxel prepared from mixed nonionic surfactants publication-title: J. Pharm. Sci. – volume: 52 start-page: 838 year: 2019 end-page: 845 ident: b1285 article-title: Preparation and characterization of solid lipid nanoparticles loaded with salmon calcitonin phospholipid complex publication-title: J. Drug Delivery Sci. Technol. – volume: 8 start-page: 1085 year: 2013 end-page: 1100 ident: b1290 article-title: Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle–double emulsion method via the combined use of different solid lipids publication-title: Nanomedicine – volume: 587 start-page: 279 year: 2021 end-page: 289 ident: b1510 article-title: Polyphosphate coatings: A promising strategy to overcome the polycation dilemma publication-title: J. Colloid Interface Sci. – volume: 12 start-page: 179 year: 2010 end-page: 185 ident: b0195 article-title: Oral insulin–a review of current status publication-title: Diabetes Obes. Metab. – volume: 52 start-page: 1 year: 1998 end-page: 16 ident: b0235 article-title: The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins publication-title: J. Control. Release – volume: 11 start-page: 825 year: 2017 end-page: 832 ident: b0080 article-title: Oral insulin delivery in a physiologic context publication-title: J. Diabetes Sci. Technol. – volume: 296 start-page: 162 year: 2019 end-page: 178 ident: b0210 article-title: Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals publication-title: J. Control. Release – volume: 273 start-page: 29 year: 2004 end-page: 35 ident: b1260 article-title: Preparation and characterization of solid lipid nanoparticles containing peptide publication-title: Int. J. Pharm. – volume: 8 start-page: 8 year: 2020 end-page: 15 ident: b1370 article-title: Liposomal lactoferrin as potential preventative and cure for COVID-19 publication-title: Int. J. Res. Health Sci. – volume: 8 start-page: 3024 year: 2012 end-page: 3035 ident: b0980 article-title: Simulation of fusion-mediated nanoemulsion interactions with model lipid bilayers publication-title: Soft Matter – volume: 13 start-page: 1503 year: 2016 end-page: 1512 ident: b1500 article-title: Cell-penetrating self-nanoemulsifying drug delivery systems (SNEDDS) for oral gene delivery publication-title: Exp. Opin. Drug Deliv. – volume: 573 year: 2020 ident: b0530 article-title: Hydrophobic H-bond pairing: a novel approach to improve membrane permeability publication-title: Int. J. Pharm. – volume: 21 start-page: 561 year: 2011 end-page: 576 ident: b0700 article-title: The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review publication-title: Expert Opin. Ther. Pat. – volume: 15 start-page: 605 year: 2020 end-page: 614 ident: b1415 article-title: Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions publication-title: Nat. Nanotechnol. – volume: 81 start-page: 265 year: 2012 end-page: 272 ident: b1345 article-title: Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose publication-title: Eur. J. Pharm. Biopharm. – volume: 57 start-page: 169 year: 2005 end-page: 175 ident: b0055 article-title: Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model publication-title: J. Pharm. Pharmacol. – volume: 10 start-page: 117 year: 2016 ident: b0695 article-title: Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol publication-title: Drug Des. Devel. Therapy – volume: 104 start-page: 379 year: 2005 end-page: 396 ident: b1080 article-title: Preparation of plasmid DNA-containing liposomes using a high-pressure homogenization–extrusion technique publication-title: J. Control. Release – volume: 1798 start-page: 2090 year: 2010 end-page: 2093 ident: b1405 article-title: Specific formation of trypsin-resistant micelles on a hydrophobic peptide observed with Triton X-100 but not with octylglucoside publication-title: Biochim. Biophys. Acta (BBA)-Biomembr. – volume: 19 start-page: 929 year: 1993 end-page: 941 ident: b0340 article-title: The effects of fatty acids and their derivatives on the intestinal absorption of insulin in rat publication-title: Drug Dev. Ind. Pharm. – volume: 559 start-page: 228 year: 2019 end-page: 234 ident: b0755 article-title: Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis publication-title: Int. J. Pharm. – volume: 95 start-page: 667 year: 2006 end-page: 679 ident: b1125 article-title: Drug encapsulation using supercritical fluid extraction of emulsions publication-title: J. Pharm. Sci. – volume: 10 start-page: 9315 year: 2018 end-page: 9324 ident: b0935 article-title: Novel solid lipid nanoparticle with endosomal escape function for oral delivery of insulin publication-title: ACS Appl. Mater. Interfaces – volume: 81 start-page: 129 year: 2016 end-page: 136 ident: b0300 article-title: Development and in vitro characterisation of an oral self-emulsifying delivery system for daptomycin publication-title: Eur. J. Pharm. Sci. – volume: 27 start-page: 1017 year: 2019 end-page: 1024 ident: b0470 article-title: Oral self-emulsifying delivery systems for systemic administration of therapeutic proteins: science fiction? publication-title: J. Drug Target. – volume: 97 start-page: 223 year: 2015 end-page: 229 ident: b0565 article-title: Effective incorporation of insulin in mucus permeating self-nanoemulsifying drug delivery systems publication-title: Eur. J. Pharm. Biopharm. – volume: 538 start-page: 159 year: 2018 end-page: 166 ident: b0375 article-title: Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating publication-title: Int. J. Pharm. – volume: 167 start-page: 82 year: 2018 end-page: 92 ident: b1220 article-title: Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability publication-title: Colloids Surf., B – volume: 1 start-page: 4207 year: 2019 end-page: 4237 ident: b0290 article-title: Hydrophobic ion pairing: encapsulating small molecules, peptides, and proteins into nanocarriers publication-title: Nanosc. Adv. – volume: 15 start-page: 216 year: 2018 end-page: 225 ident: b0355 article-title: Hydrophobic ion pairing of peptide antibiotics for processing into controlled release nanocarrier formulations publication-title: Mol. Pharm. – volume: 338 start-page: 644 year: 2021 end-page: 661 ident: b0415 article-title: Bile acid transporter-mediated oral absorption of insulin via hydrophobic ion-pairing approach publication-title: J. Control. Release – volume: 24 start-page: 440 year: 2019 end-page: 451 ident: b0070 article-title: A review of non-invasive insulin delivery systems for diabetes therapy in clinical trials over the past decade publication-title: Drug Discov. Today – volume: 9 start-page: 2345 year: 2015 end-page: 2356 ident: b0775 article-title: Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-assembled nanoparticles for oral delivery of insulin publication-title: ACS Nano – volume: 97 start-page: 1569 year: 2009 end-page: 1577 ident: b0840 article-title: Selective filtering of particles by the extracellular matrix: an electrostatic bandpass publication-title: Biophys. J. – volume: 327 start-page: 153 year: 2006 end-page: 159 ident: b1280 article-title: Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin publication-title: Int. J. Pharm. – volume: 4 year: 2012 ident: b0780 article-title: Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus publication-title: Sci. Transl. Med. – volume: 39 start-page: 373 year: 2010 end-page: 379 ident: b0520 article-title: Lyophilization of water-in-oil emulsions to prepare phospholipid-based anhydrous reverse micelles for oral peptide delivery publication-title: Eur. J. Pharm. Sci. – volume: 496 start-page: 993 year: 2015 end-page: 1005 ident: b1410 article-title: Goblet cell targeting nanoparticle containing drug-loaded micelle cores for oral delivery of insulin publication-title: Int. J. Pharm. – volume: 160 year: 2020 ident: b1090 article-title: Rapid production of liposomes using high pressure carbon dioxide and direct ultrasonication publication-title: J. Supercrit. Fluids – volume: 33 start-page: 8881 year: 2012 end-page: 8892 ident: b0960 article-title: The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier publication-title: Biomaterials – volume: 6 start-page: 666 year: 2013 end-page: 677 ident: b1010 article-title: Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium publication-title: Mucosal Immunol. – volume: 61 start-page: 6505 year: 2013 end-page: 6515 ident: b0745 article-title: Influence of emulsifier structure on lipid bioaccessibility in oil–water nanoemulsions publication-title: J. Agric. Food. Chem. – volume: 107 start-page: 203 year: 2018 end-page: 216 ident: b0505 article-title: Transformation of biopharmaceutical classification system class I and III drugs into ionic liquids and lipophilic salts for enhanced developability using lipid formulations publication-title: J. Pharm. Sci. – start-page: 43 year: 2019 end-page: 57 ident: b1400 article-title: Phospholipid micelles for peptide drug delivery – volume: 13 start-page: 459 year: 2021 ident: b1185 article-title: Oligonucleotide Delivery across the Caco-2 Monolayer: The Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS) publication-title: Pharmaceutics – volume: 277 start-page: 165 year: 2018 end-page: 172 ident: b1225 article-title: In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide publication-title: J. Control. Release – volume: 252 start-page: 28 year: 2017 end-page: 49 ident: b1105 article-title: Nanoemulsion: Concepts, development and applications in drug delivery publication-title: J. Control Release – volume: 23 start-page: 2074 year: 2016 end-page: 2083 ident: b0380 article-title: Development and in vitro evaluation of an oral SEDDS for desmopressin publication-title: Drug Deliv. – volume: 102 start-page: 4406 year: 2013 end-page: 4413 ident: b0825 article-title: Development and evaluation of a novel mucus diffusion test system approved by self-nanoemulsifying drug delivery systems publication-title: J. Pharm. Sci. – volume: 107 start-page: 2136 year: 2018 end-page: 2143 ident: b1360 article-title: Bioadhesive chitosan-coated cationic nanoliposomes with improved insulin encapsulation and prolonged oral hypoglycemic effect in diabetic mice publication-title: J. Pharm. Sci. – start-page: 113899 year: 2021 ident: b0085 article-title: Nanotechnologies for the delivery of biologicals: historical perspective and current landscape publication-title: Adv. Drug Deliv. Rev. – volume: 102 start-page: 11173 year: 2005 end-page: 11178 ident: b0320 article-title: Polymorphism of DNA–anionic liposome complexes reveals hierarchy of ion-mediated interactions publication-title: Proc. Natl. Acad. Sci. – volume: 452 start-page: 374 year: 2013 end-page: 381 ident: b0615 article-title: Bile salts enhance the intestinal absorption of lipophilic drug loaded lipid nanocarriers: mechanism and effect in rats publication-title: Int. J. Pharm. – volume: 4 start-page: 18 year: 2012 end-page: 23 ident: b0710 article-title: Self emulsifying drug delivery system: A Novel approach publication-title: Int. J. Curr. Pharmaceut. Res. – volume: 271 start-page: 4 year: 1984 end-page: 10 ident: b0410 article-title: Structural restriction in bile acids and non-ionic detergents for promotion of heparin absorption from rat gastro-intestinal tract publication-title: Archives Internationales de Pharmacodynamie et de Thérapie – volume: 8 start-page: 25444 year: 2016 end-page: 25453 ident: b0845 article-title: Enhanced Oral Delivery of Protein Drugs Using Zwitterion-Functionalized Nanoparticles to Overcome both the Diffusion and Absorption Barriers publication-title: ACS Appl. Mater. Interfaces – volume: 61 start-page: 375 year: 2006 end-page: 386 ident: b1265 article-title: Preparation, characterization and physico-chemical properties of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC): their benefits as colloidal drug carrier systems publication-title: Die Pharmazie-Int. J. Pharmaceut. Sci. – volume: 543 start-page: 508 year: 1978 end-page: 522 ident: b0605 article-title: Effects of bile salts on the structural integrity of liposomes publication-title: Biochim. Biophys. Acta (BBA)-Gen. Sub. – volume: 31 start-page: 2420 year: 2014 end-page: 2428 ident: b0640 article-title: Solid lipid particles for oral delivery of peptide and protein drugs II–the digestion of trilaurin protects desmopressin from proteolytic degradation publication-title: Pharm. Res. – volume: 13 start-page: 923 year: 2016 end-page: 929 ident: b0250 article-title: Development of oral self nano-emulsifying delivery system (s) of lanreotide with improved stability against presystemic thiol-disulfide exchange reactions publication-title: Exp. Opin. Drug Deliv. – volume: 12 start-page: 1673 year: 2017 ident: b1495 article-title: Mechanism of hepatic targeting via oral administration of DSPE–PEG–cholic acid-modified nanoliposomes publication-title: Int. J. Nanomed. – volume: 6 start-page: 37 year: 2017 end-page: 56 ident: b1050 article-title: Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery publication-title: Sustain. Chem. Pharm. – volume: 143 start-page: 98 year: 2019 end-page: 105 ident: b1455 article-title: Microcontainers for oral insulin delivery–in vitro studies of permeation enhancement publication-title: Eur. J. Pharm. Biopharm. – volume: 10 start-page: 9916 year: 2018 end-page: 9928 ident: b0910 article-title: Biomimetic viruslike and charge reversible nanoparticles to sequentially overcome mucus and epithelial barriers for oral insulin delivery publication-title: ACS Appl. Mater. Interfaces – volume: 2 start-page: 621 year: 2016 end-page: 630 ident: b0990 article-title: Drug delivery via cell membrane fusion using lipopeptide modified liposomes publication-title: ACS Cent. Sci. – volume: 13 start-page: 408 year: 2020 ident: b0395 article-title: In vitro and ex vivo evaluation of penetratin as a non-invasive permeation enhancer in the penetration of salmon calcitonin through TR146 buccal cells and porcine buccal tissues publication-title: Pharmaceuticals – volume: 584 start-page: 684 year: 2021 end-page: 697 ident: b1210 article-title: Solidification of self-emulsifying drug delivery systems (SEDDS): Impact on storage stability of a therapeutic protein publication-title: J. Colloid Interface Sci. – volume: 19 start-page: 743 year: 2014 end-page: 747 ident: b0915 article-title: Lymphatic transport of puerarin occurs after oral administration of different lipid-based formulations to unconscious lymph duct-cannulated rats publication-title: Pharm. Dev. Technol. – start-page: 1 year: 2021 end-page: 10 ident: b1320 article-title: A study on chitosan-coated liposomes as a carrier of bovine serum albumin as oral protein drug publication-title: J. Dispersion Sci. Technol. – volume: 197 start-page: 48 year: 2015 end-page: 57 ident: b0800 article-title: Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse publication-title: J. Control. Release – volume: 192 start-page: 219 year: 2014 end-page: 227 ident: b0730 article-title: ‘Stealth’lipid-based formulations: Poly (ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug publication-title: J. Control. Release – volume: 46 start-page: 221 year: 2006 end-page: 237 ident: b1100 article-title: Microemulsions: a potential delivery system for bioactives in food publication-title: Crit. Rev. Food Sci. Nutr. – volume: 43 start-page: 1694 year: 2017 end-page: 1702 ident: b0425 article-title: Development and in vitro characterization of self-emulsifying drug delivery system (SEDDS) for oral opioid peptide delivery publication-title: Drug Dev. Ind. Pharm. – volume: 3 start-page: 568 year: 2009 end-page: 584 ident: b0160 article-title: Oral insulin and buccal insulin: a critical reappraisal publication-title: J. Diabetes Sci. Technol. – start-page: 155 year: 2019 end-page: 193 ident: b0705 article-title: The role of excipients in the microstructure of Topical semisolid drug products, The Role of Microstructure in Topical Drug Product Development publication-title: Springer – reference: E. Shefter, M. Manning, Ion-pairing of drugs for improved efficacy and delivery, WO9408599, 1994. – volume: 23 start-page: 1972 year: 2016 end-page: 1979 ident: b0575 article-title: Enhanced oral bioavailability of insulin-loaded solid lipid nanoparticles: pharmacokinetic bioavailability of insulin-loaded solid lipid nanoparticles in diabetic rats publication-title: Drug Delivery – volume: 10 start-page: 549 year: 1993 end-page: 552 ident: b1030 article-title: Uptake of phosphatidylserine liposomes by rat Peyer's patches following intraluminal administration publication-title: Pharm. Res. – volume: 12 start-page: 8893 year: 2018 end-page: 8900 ident: b0885 article-title: Oral Nanoparticles Exhibit Specific High-Efficiency Intestinal Uptake and Lymphatic Transport publication-title: ACS Nano – volume: 477 start-page: 390 year: 2014 end-page: 398 ident: b0930 article-title: Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading publication-title: Int. J. Pharm. – volume: 9 start-page: 601 year: 2013 end-page: 609 ident: b0955 article-title: N-octyl-N-arginine chitosan micelles as an oral delivery system of insulin publication-title: J. Biomed. Nanotechnol. – volume: 9 start-page: 613 year: 2018 ident: b0005 article-title: The discovery of insulin: an important milestone in the history of medicine publication-title: Front. Endocrinol. – volume: 1 start-page: 147 year: 2012 end-page: 168 ident: b1135 article-title: Preparation, characterization and applications of liposomes: state of the art publication-title: J. Coll. Sci. Biotechnol. – volume: 6 start-page: 1031 year: 2001 end-page: 1032 ident: b0590 article-title: Bilosomes: the answer to oral vaccine delivery? publication-title: Drug Discov. Today – volume: 583 year: 2020 ident: b0715 article-title: Synthesis and in vitro characterization of a preactivated thiolated acrylic acid/acrylamide-methylpropane sulfonic acid copolymer as a mucoadhesive sprayable polymer publication-title: Int. J. Pharm. – volume: 460 start-page: 119 year: 2014 end-page: 130 ident: b1315 article-title: Enhanced oral absorption of insulin-loaded liposomes containing bile salts: a mechanistic study publication-title: Int. J. Pharm. – volume: 4 start-page: 141 year: 2007 end-page: 151 ident: b1440 article-title: Recent advances in protein and peptide drug delivery systems publication-title: Curr. Drug Deliv. – volume: 142 start-page: 102 year: 2019 end-page: 117 ident: b1200 article-title: Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges publication-title: Adv. Drug Deliv. Rev. – volume: 273 start-page: 21 year: 2018 end-page: 29 ident: b0370 article-title: Impact of different hydrophobic ion pairs of octreotide on its oral bioavailability in pigs publication-title: J. Control. Release – volume: 62 start-page: 88 year: 2012 end-page: 93 ident: b1000 article-title: Contribution of formulation and excipients towards enhanced permeation of curcumin publication-title: Arzneimittelforschung – volume: 527 start-page: 184 year: 2017 end-page: 190 ident: b0545 article-title: An investigation into the ability of alendronate ion pairs to increase oral absorption publication-title: Int. J. Pharm. – volume: 50 start-page: 965 year: 2012 end-page: 973 ident: b0100 article-title: The single dose pharmacokinetic profile of a novel oral human parathyroid hormone formulation in healthy postmenopausal women publication-title: Bone – volume: 536 start-page: 353 year: 2018 end-page: 359 ident: b0525 article-title: Impact of digestion on the transport of dextran-loaded self-emulsified nanoemulsion through MDCK epithelial cell monolayer and rat intestines publication-title: Int. J. Pharm. – volume: 10 start-page: 203 year: 2018 ident: b1170 article-title: Advanced pharmaceutical applications of hot-melt extrusion coupled with fused deposition modelling (FDM) 3D printing for personalised drug delivery publication-title: Pharmaceutics – volume: 69 start-page: 911 year: 2020 end-page: 919 ident: b0515 article-title: Novel strategy for oral peptide delivery in incretin-based diabetes treatment publication-title: Gut – volume: 8 start-page: 1407 year: 2011 end-page: 1424 ident: b1035 article-title: Solid lipid nanoparticles: an oral bioavailability enhancer vehicle publication-title: Exp. Opin. Drug Deliv. – start-page: 237 year: 2015 end-page: 271 ident: b0670 article-title: Solid lipid excipients as matrix agents for sustained drug delivery publication-title: Excip. Appl. Formul. Des. Drug Deliv. – volume: 434 start-page: 40 year: 2014 end-page: 47 ident: b1145 article-title: Preparation, optimization, characterization and cytotoxicity in vitro of Baicalin-loaded mixed micelles publication-title: J. Colloid Interface Sci. – volume: 26 year: 2009 ident: b1215 article-title: Self-emulsifying drug delivery systems (SEDDS): formulation development, characterization, and applications publication-title: Crit. Rev.™ Therap. Drug Carr. Syst. – volume: 15 start-page: 405 year: 2002 end-page: 415 ident: b0890 article-title: Lipid-based formulations for intestinal lymphatic delivery publication-title: Eur. J. Pharm. Sci. – volume: 36 start-page: 192 year: 2016 end-page: 200 ident: b0945 article-title: Development and evaluation of insulin-loaded cationic solid lipid nanoparticles for oral delivery publication-title: J. Drug Delivery Sci. Technol. – volume: 81 start-page: 136 year: 2013 end-page: 147 ident: b0015 article-title: The future of peptide-based drugs publication-title: Chem. Biol. Drug Des. – volume: 8 start-page: 2733 year: 2013 ident: b1005 article-title: Advanced drug delivery to the lymphatic system: lipid-based nanoformulations publication-title: Int. J. Nanomed. – volume: 21 start-page: 1570 year: 2013 end-page: 1578 ident: b0635 article-title: Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics publication-title: Mol. Ther. – volume: 61 start-page: 1427 year: 2009 end-page: 1449 ident: b0060 article-title: Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic publication-title: Adv. Drug Deliv. Rev. – volume: 19 start-page: 277 year: 2020 end-page: 289 ident: b1450 article-title: Advances in oral peptide therapeutics publication-title: Nat. Rev. Drug Discovery – volume: 490 start-page: 146 year: 2015 end-page: 154 ident: b0905 article-title: Novel self-nanoemulsifying self-nanosuspension (SNESNS) for enhancing oral bioavailability of diacerein: simultaneous portal blood absorption and lymphatic delivery publication-title: Int. J. Pharm. – volume: 16 start-page: 4677 year: 2021 ident: b0480 article-title: Facilitated Buccal Insulin Delivery via Hydrophobic Ion-Pairing Approach: In vitro and ex vivo Evaluation publication-title: Int. J. Nanomed. – volume: 4 start-page: 516 year: 2015 end-page: 543 ident: b1175 article-title: Lyophilization/freeze drying–a review publication-title: World J. Pharm. Res. – start-page: 2326 year: 2021 end-page: 2343 ident: b1475 article-title: Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs publication-title: Acta Pharmaceut. Sin. B – volume: 7 start-page: eabe2620 year: 2021 ident: b1485 article-title: A microneedle platform for buccal macromolecule delivery publication-title: Sci. Adv. – volume: 8 start-page: 7024 year: 2016 end-page: 7035 ident: b0855 article-title: Evidence does not support absorption of intact solid lipid nanoparticles via oral delivery publication-title: Nanoscale – volume: 173 start-page: 112 year: 2021 end-page: 124 ident: b0115 article-title: Oral delivery of peptide therapeutics in infants: Challenges and opportunities publication-title: Adv. Drug Deliv. Rev. – volume: 10 start-page: 167 year: 2014 end-page: 176 ident: b1350 article-title: Biotinylated liposomes as potential carriers for the oral delivery of insulin publication-title: Nanomedicine – reference: FDA, Novel Excipient Review Pilot Program, FDA. – reference: FDA, Inactive Ingredient Search for Approved Drug Products, FDA. – volume: 103 start-page: 3985 year: 2014 end-page: 3993 ident: b1340 article-title: Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole publication-title: J. Pharm. Sci. – volume: 8 start-page: 207 year: 2011 end-page: 224 ident: b1075 article-title: Lipid-based oral multiparticulate formulations–advantages, technological advances and industrial applications publication-title: Exp. Opin. Drug Deliv. – volume: 7 start-page: 520 year: 2013 end-page: 531 ident: b0030 article-title: Oral insulin delivery: how far are we? publication-title: J. Diabetes Sci. Technol. – volume: 27 start-page: 1382 year: 2006 end-page: 1388 ident: b1235 article-title: In vitro and in vivo evaluation of a novel oral insulin formulation publication-title: Acta Pharmacol. Sin. – volume: 11 start-page: 1939 year: 2015 end-page: 1948 ident: b0620 article-title: Environment-responsive aza-BODIPY dyes quenching in water as potential probes to visualize the in vivo fate of lipid-based nanocarriers publication-title: Nanomedicine – volume: 13 start-page: 565 year: 2021 ident: b0385 article-title: Development, Characterization, and Ex Vivo Assessment of Elastic Liposomes for Enhancing the Buccal Delivery of Insulin publication-title: Pharmaceutics – volume: 142 start-page: 91 year: 2019 end-page: 101 ident: b0020 article-title: SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs publication-title: Adv. Drug Deliv. Rev. – reference: . – volume: 10 year: 2018 ident: b0220 article-title: Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist publication-title: Sci. Transl. Med. – reference: A. Yadav, S. Mohite, Recent advances in protein and peptide drug delivery, Research journal of pharmaceutical dosage forms and technology 12(3) (2020) 205 (212 (2020)). – volume: 37 start-page: 911 year: 1959 end-page: 917 ident: b0500 article-title: A rapid method of total lipid extraction and purification publication-title: Can. J. Biochem. Physiol. – volume: 11 start-page: 11048 year: 2019 end-page: 11063 ident: b0875 article-title: Biological fate of ingested lipid-based nanoparticles: current understanding and future directions publication-title: Nanoscale – volume: 105 start-page: 152 year: 2013 end-page: 157 ident: b1060 article-title: Antibacterial microemulsion prevents sepsis and triggers healing of wound in wistar rats publication-title: Colloids Surf., B – volume: 520 start-page: 267 year: 2017 end-page: 274 ident: b0040 article-title: Hydrophobic ion pairing: key to highly payloaded self-emulsifying peptide drug delivery systems publication-title: Int. J. Pharm. – volume: 308 start-page: 250 year: 1978 end-page: 258 ident: b1150 article-title: Preparation and properties of ether-injection liposomes publication-title: Ann. N. Y. Acad. Sci. – volume: 117 start-page: 303 year: 2014 end-page: 311 ident: b0465 article-title: Ion pairing with linoleic acid simultaneously enhances encapsulation efficiency and antibacterial activity of vancomycin in solid lipid nanoparticles publication-title: Colloids Surf., B – volume: 65 start-page: S95 year: 2001 end-page: S101 ident: b1045 article-title: Absorption and distribution of dietary fatty acids from different sources publication-title: Early Human Dev. – volume: 52 start-page: 409 year: 2013 end-page: 423 ident: b0645 article-title: Edible lipid nanoparticles: digestion, absorption, and potential toxicity publication-title: Prog. Lipid Res. – reference: U.S.F.a.D. Administration, Human insulin receives FDA approval, FDA Drug Bull 12 (1982) 18–19. – volume: 75 start-page: 2819 year: 2004 end-page: 2827 ident: b0450 article-title: The effect of various liposome formulations on insulin penetration across Caco-2 cell monolayer publication-title: Life Sci. – volume: 9 start-page: 9217 year: 2015 end-page: 9227 ident: b0785 article-title: Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo publication-title: ACS Nano – volume: 271 start-page: 55 year: 2018 end-page: 59 ident: b0765 article-title: Do drug release studies from SEDDS make any sense? publication-title: J. Control. Release – volume: 40 start-page: 623 year: 1995 end-page: 626 ident: b0760 article-title: Correlation of octanol/water solubility ratios and partition coefficients publication-title: J. Chem. Eng. Data – volume: 2 start-page: 361 year: 1996 end-page: 363 ident: b0255 article-title: Investigations into the diffusion behaviour of polypeptides in native intestinal mucus with regard to their peroral administration publication-title: Pharm. Pharmacol. Commun. – reference: FDA, Applications Covered by Section 505(b)(2), 1999. – volume: 70 start-page: 1096 year: 1976 end-page: 1100 ident: b0335 article-title: Effect of bile salts and fatty acids on the colonic absorption of oxalate publication-title: Gastroenterology – volume: 222 start-page: 79 year: 2015 end-page: 91 ident: b0315 article-title: Amino acid-based surfactants–do they deserve more attention? publication-title: Adv. Colloid Interface Sci. – volume: 31 start-page: 691 year: 2021 end-page: 698 ident: b0435 article-title: Glargine insulin loaded lipid nanoparticles: Oral delivery of liquid and solid oral dosage forms publication-title: Nutrit. Metabol. Cardiovasc. Dis. – volume: 132 start-page: 259 year: 1996 end-page: 261 ident: b1295 article-title: Thymopentin in solid lipid nanoparticles publication-title: Int. J. Pharm. – volume: 93 start-page: 488 year: 2004 end-page: 495 ident: b0350 article-title: Biodegradable nanoparticles containing protein-fatty acid complexes for oral delivery of salmon calcitonin publication-title: J. Pharm. Sci. – volume: 124 start-page: 150 year: 2018 end-page: 163 ident: b0805 article-title: Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties publication-title: Adv. Drug Deliv. Rev. – volume: 12 start-page: 1026 year: 2020 ident: b0940 article-title: Oral Insulin Delivery Using Poly (Styrene Co-Maleic Acid) Micelles in a Diabetic Mouse Model publication-title: Pharmaceutics – volume: 83 start-page: 382 year: 2011 end-page: 387 ident: b0595 article-title: Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: influences of fatty acids publication-title: Colloids Surf., B – volume: 207 start-page: 21 year: 2000 end-page: 30 ident: b0050 article-title: A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt: fatty acid micellar systems using the CaCo-2 cell culture model publication-title: Int. J. Pharm. – volume: 22 start-page: 10 year: 2020 end-page: 18 ident: b0140 article-title: Oral semaglutide: a review of the first oral glucagon-like peptide 1 receptor agonist publication-title: Diab. Technol. Ther. – volume: 12 start-page: 99 year: 2020 ident: b0420 article-title: The in vivo effect of transcellular permeation enhancers on the intestinal permeability of two peptide drugs enalaprilat and hexarelin publication-title: Pharmaceutics – volume: 14 start-page: 14 year: 2021 ident: b1460 article-title: Multifunctional Delivery Systems for Peptide Nucleic Acids publication-title: Pharmaceuticals – volume: 51 start-page: 460 year: 2011 end-page: 471 ident: b0110 article-title: Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials publication-title: J. Clin. Pharmacol. – volume: 110 start-page: 124 year: 2021 end-page: 134 ident: b0310 article-title: Lysine-Based Biodegradable Surfactants: Increasing the Lipophilicity of Insulin by Hydrophobic Ion Paring publication-title: J. Pharm. Sci. – volume: 4 start-page: 133 year: 2009 end-page: 142 ident: b1165 article-title: A model-based methodology for spray-drying process development publication-title: J. Pharmaceut. Innov. – year: 2020 ident: b1365 article-title: Pleiotropic effect of Lactoferrin in the prevention and treatment of COVID-19 infection: randomized clinical trial, in vitro and in silico preliminary evidences publication-title: BioRxiv – volume: 5 start-page: A515 year: 2021 ident: b0170 article-title: One-Year Outcomes of the Open-Label Extension of CHIASMA OPTIMAL, a Phase 3 Study of Oral Octreotide Capsules in Acromegaly publication-title: J. Endocr. Soc. – volume: 523 start-page: 357 year: 2017 end-page: 365 ident: b0560 article-title: Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione publication-title: Int. J. Pharm. – volume: 27 start-page: 78 year: 2010 end-page: 85 ident: b1110 article-title: Solid lipid nanoparticles produced through a coacervation method publication-title: J. Microencapsul. – volume: 35 start-page: 1 year: 2004 end-page: 9 ident: b0535 article-title: Separation of amino acids by polymeric reversed micelle extraction publication-title: Sep. Purif. Technol. – volume: 14 start-page: 1325 year: 2017 end-page: 1338 ident: b0675 article-title: Lipid-Drug Conjugate for Enhancing Drug Delivery publication-title: Mol. Pharm. – volume: 115 start-page: 7296 year: 2018 end-page: 7301 ident: b1470 article-title: Ionic liquids for oral insulin delivery publication-title: Proc. Natl. Acad. Sci. – volume: 13 year: 2021 ident: b0950 article-title: Oral Insulin Delivery by Chitosan Coated Solid Lipid Nanoparticles: Ex vivo and in vivo Studies publication-title: J. Young Pharm. – volume: 33 start-page: 211 year: 2007 end-page: 220 ident: b0145 article-title: Cyclosporine A: a review of current oral and intravenous delivery systems publication-title: Drug Dev. Ind. Pharm. – volume: 5 start-page: 1501 year: 2021 end-page: 1511 ident: b0175 article-title: Transient Permeation Enhancer®(TPE®) technology for oral delivery of octreotide: a technological evaluation publication-title: Exp. Opin. Drug Deliv. – volume: 6 start-page: 1155 year: 2011 ident: b0580 article-title: Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation publication-title: Int. J. Nanomed. – volume: 6 start-page: 213 year: 2015 ident: b0185 article-title: Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis publication-title: World J. Gastroint. Pharmacol. Therap. – volume: 157 start-page: 2 year: 2020 end-page: 36 ident: b0270 article-title: Systemic delivery of peptides by the oral route: formulation and medicinal chemistry approaches publication-title: Adv. Drug Deliv. Rev. – volume: 17 start-page: 3129 year: 2020 end-page: 3139 ident: b1420 article-title: Lipophilic arginine esters: The gateway to preservatives without side effects publication-title: Mol. Pharm. – volume: 362 start-page: 2 year: 2008 end-page: 9 ident: b0325 article-title: Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs: I. Formulation development publication-title: Int. J. Pharm. – volume: 10 start-page: 16 year: 2018 end-page: 25 ident: b1195 article-title: Microemulsion as drug delivery system for Peptides and Proteins publication-title: J. Pharmaceut. Sci. Res. – volume: 20 start-page: 813 year: 2012 end-page: 830 ident: b1085 article-title: Nanostructured lipid carriers system: recent advances in drug delivery publication-title: J. Drug Target. – volume: 2011 year: 2011 ident: b1115 article-title: Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique publication-title: Int. J. Chem. Eng. – volume: 124 year: 1971 ident: b0835 article-title: Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases publication-title: Biochem. J – volume: 50 start-page: 2 year: 2013 end-page: 7 ident: b1430 article-title: Reprint of: Nanocarrier systems for oral drug delivery: Do we really need them? publication-title: Eur. J. Pharm. Sci. – volume: 7 start-page: 863 year: 1990 end-page: 868 ident: b0260 article-title: Absorption of polyethylene glycols 600 through 2000: the molecular weight dependence of gastrointestinal and nasal absorption publication-title: Pharm. Res. – volume: 508 start-page: 102 year: 2016 end-page: 108 ident: b0650 article-title: Impact of lipases on the protective effect of SEDDS for incorporated peptide drugs towards intestinal peptidases publication-title: Int. J. Pharm. – volume: 17 start-page: 3202 year: 2020 end-page: 3213 ident: b0660 article-title: Exploring the impact of surfactant type and digestion: Highly digestible surfactants improve oral bioavailability of nilotinib publication-title: Mol. Pharm. – volume: 93 start-page: 2476 year: 2004 end-page: 2487 ident: b1385 article-title: In vitro characterization of PEGylated phospholipid micelles for improved drug solubilization: effects of PEG chain length and PC incorporation publication-title: J. Pharm. Sci. – year: 2021 ident: b1435 article-title: Oral delivery of proteins and peptides: Challenges, status quo and future perspectives publication-title: Acta Pharmaceut. Sin. B – volume: 11 start-page: 61 year: 1994 end-page: 95 ident: b0230 article-title: Enzymatic barriers for GI peptide and protein delivery publication-title: Crit. Rev. Ther. Drug Carrier Syst. – volume: 101 start-page: 108 year: 2016 end-page: 121 ident: b0025 article-title: Oral delivery of macromolecular drugs: Where we are after almost100 years of attempts publication-title: Adv. Drug Deliv. Rev. – volume: 10 start-page: 1865 year: 2013 end-page: 1873 ident: b0820 article-title: Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles publication-title: Mol. Pharm. – volume: 21 start-page: 6097 year: 1982 end-page: 6103 ident: b0985 article-title: Transbilayer redistribution of phosphatidylethanolamine during fusion of phospholipid vesicles. Dependence on fusion rate, lipid phase separation, and formation of nonbilayer structures publication-title: Biochemistry – volume: 59 start-page: 478 year: 2007 end-page: 490 ident: b1245 article-title: Solid lipid nanoparticles as a drug delivery system for peptides and proteins publication-title: Adv. Drug Deliv. Rev. – volume: 53 start-page: 73 year: 2021 end-page: 88 ident: b0920 article-title: Oral self-nanoemulsifying formulation of GLP-1 agonist peptide exendin-4: development, characterization and permeability assesment on Caco-2 cell monolayer publication-title: Amino Acids – volume: 18 start-page: 19 year: 2019 end-page: 40 ident: b0125 article-title: Non-invasive delivery strategies for biologics publication-title: Nat. Rev. Drug Discovery – volume: 81 start-page: 1930 year: 2001 end-page: 1937 ident: b0790 article-title: Diffusion of macromolecules and virus-like particles in human cervical mucus publication-title: Biophy. J. – volume: 93 start-page: 95 year: 2003 end-page: 103 ident: b0215 article-title: Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems publication-title: J. Control. Release – volume: 593 year: 2021 ident: b1310 article-title: Oral mucus-penetrating PEGylated liposomes to improve drug absorption: Differences in the interaction mechanisms of a mucoadhesive liposome publication-title: Int. J. Pharm. – volume: 2 start-page: 82 year: 2012 end-page: 95 ident: b1375 article-title: Novel nanomicellar formulation approaches for anterior and posterior segment ocular drug delivery publication-title: Rec. Pat. Nanomed. – volume: 552 start-page: 287 year: 2019 end-page: 294 ident: b0305 article-title: Arginine-based cationic surfactants: Biodegradable auxiliary agents for the formation of hydrophobic ion pairs with hydrophilic macromolecular drugs publication-title: J. Colloid Interface Sci. – volume: 317 start-page: 82 year: 2006 end-page: 89 ident: b1275 article-title: Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN®) versus drug nanocrystals publication-title: Int. J. Pharm. – volume: 159 year: 2021 ident: b0400 article-title: Sodium glycodeoxycholate and sodium deoxycholate as epithelial permeation enhancers: in vitro and ex vivo intestinal and buccal bioassays publication-title: Eur. J. Pharm. Sci. – reference: C. Dumont, V. Jannin, A. Beloqui, V. Préat, H. Fessi, S. Bourgeois, In vitro evaluation of leuprolide-containing solid lipid-based nanosuspensions: ability to encapsulate, release, protect and permeate in the gastrointestinal tract, ratio, 1 2. – volume: 13 year: 2021 ident: b0735 article-title: Nanostructured Lipid Carriers (NLCs) for Oral Peptide Drug Delivery: About the Impact of Surface Decoration publication-title: Pharmaceutics – reference: S. Faulkner, EnterisBioPharma touts more Phase II data for oral endometriosis therapy, Drug Delivery Business, 201/8. – volume: 142 start-page: 258 year: 2019 end-page: 264 ident: b0750 article-title: Fenofibrate oral absorption from SNEDDS and super-SNEDDS is not significantly affected by lipase inhibition in rats publication-title: Eur. J. Pharm. Biopharm. – volume: 6 start-page: 3049 year: 2011 ident: b0490 article-title: Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin publication-title: Int. J. Nanomed. – volume: 150 start-page: 77 year: 2020 end-page: 86 ident: b1505 article-title: Phosphorylated PEG-emulsifier: Powerful tool for development of zeta potential changing self-emulsifying drug delivery systems (SEDDS) publication-title: Eur. J. Pharm. Biopharm. – volume: 52 start-page: 929 year: 2000 end-page: 940 ident: b0555 article-title: Effect of ion pairing with alkylamines on the in-vitro dermal penetration and local tissue disposition of salicylates publication-title: J. Pharm. Pharmacol. – volume: 32 start-page: 2662 year: 2011 end-page: 2672 ident: b0630 article-title: Tailoring nanostructured solid-lipid carriers for time-controlled intracellular siRNA kinetics to sustain RNAi-mediated chemosensitization publication-title: Biomaterials – volume: 38 start-page: 1262 year: 2012 end-page: 1269 ident: b0655 article-title: In vitro digestion kinetics of excipients for lipid-based drug delivery and introduction of a relative lipolysis half life publication-title: Drug Dev. Ind. Pharm. – volume: 406 year: 2021 ident: b1465 article-title: Multifunctional drug-loaded micelles encapsulated in thermo-sensitive hydrogel for in vivo local cancer treatment: Synergistic effects of anti-vascular and immuno-chemotherapy publication-title: Chem. Eng. J. – volume: 68 start-page: 535 year: 2008 end-page: 544 ident: b1270 article-title: Cyclosporine-loaded solid lipid nanoparticles (SLN®): Drug–lipid physicochemical interactions and characterization of drug incorporation publication-title: Eur. J. Pharm. Biopharm. – volume: 6 start-page: 5032 year: 2020 end-page: 5039 ident: b1230 article-title: The Effect of Counterions in Hydrophobic Ion Pairs on Oral Bioavailability of Exenatide publication-title: ACS Biomater. Sci. Eng. – volume: 11 start-page: 865 year: 2015 end-page: 876 ident: b0925 article-title: Exendin-4 loaded nanoparticles with a lipid shell and aqueous core containing micelles for enhanced intestinal absorption publication-title: J. Biomed. Nanotechnol. – volume: 51 start-page: 1241 year: 1999 end-page: 1250 ident: b0405 article-title: Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: Their intestinal mucosal toxicity and absorption-enhancing mechanism of n-lauryl-β-d-maltopyranoside publication-title: J. Pharm. Pharmacol. – volume: 56 start-page: 1283 year: 2019 end-page: 1292 ident: b0045 article-title: Lipid nanoparticles as vehicles for oral delivery of insulin and insulin analogs: preliminary ex vivo and in vivo studies publication-title: Acta Diabetol. – volume: 20 start-page: 187 year: 2010 end-page: 191 ident: b1120 article-title: Amphotericin B loaded SLN prepared with the coacervation technique JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2010) 20 publication-title: J. Drug Delivery Sci. Technol. – volume: 38 start-page: 173 year: 2002 end-page: 182 ident: b1020 article-title: Uptake of liposomes by Peyeŕ s patches following per os administration in mice publication-title: Revista Brasileira de Ciências Farmacêuticas – volume: 415 start-page: 150 year: 2011 end-page: 157 ident: b1300 article-title: Oral peptide delivery by tetraether lipid liposomes publication-title: Int. J. Pharm. – volume: 7 start-page: 113 year: 2019 end-page: 128 ident: b0205 article-title: Nanotechnology in insulin delivery for management of diabetes publication-title: Pharmaceut. Nanotechnol. – volume: 472 start-page: 20 year: 2014 end-page: 26 ident: b0345 article-title: In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin publication-title: Int. J. Pharm. – reference: M. Kidron, I.M. Raz, M. Wolfensberger, H. Schwob, C. Schruefer, Pharmacokinetics (PK) and pharmacodynamics (PD) of oral insulin in healthy subjects, in: American Diabetes Association 68th Annual MeetingSan Francisco, CA. – volume: 32 start-page: 1901935 year: 2020 ident: b0180 article-title: Oral delivery of biologics for precision medicine publication-title: Adv. Mater. – volume: 2011 year: 2011 ident: b0495 article-title: Encapsulation of protein-polysaccharide HIP complex in polymeric nanoparticles publication-title: J. Drug Deliv. – volume: 22 start-page: 871 year: 2014 end-page: 882 ident: b0895 article-title: Recent approaches of lipid-based delivery system for lymphatic targeting via oral route publication-title: J. Drug Target. – volume: 10 start-page: 603 year: 2018 end-page: 613 ident: b0970 article-title: The stimulation of GLP-1 secretion and delivery of GLP-1 agonists via nanostructured lipid carriers publication-title: Nanoscale – volume: 536 start-page: 283 year: 2018 end-page: 291 ident: b0680 article-title: Development of rectal self-emulsifying suspension of a moisture-labile water-soluble drug publication-title: Int. J. Pharm. – volume: 70 start-page: 248 year: 2009 end-page: 253 ident: b0600 article-title: Strategic approaches for improving entrapment of hydrophilic peptide drugs by lipid nanoparticles publication-title: Colloids Surf., B – volume: 133 start-page: 13481 year: 2011 end-page: 13488 ident: b1390 article-title: Structure and dynamics of highly PEG-ylated sterically stabilized micelles in aqueous media publication-title: J. Am. Chem. Soc. – volume: 362 start-page: 16 year: 2008 end-page: 19 ident: b0965 article-title: Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs: III. In vivo oral absorption study publication-title: Int. J. Pharmaceut. – volume: 34 start-page: 143 year: 2016 end-page: 150 ident: b0200 article-title: Engineered knottin peptides as diagnostics, therapeutics, and drug delivery vehicles publication-title: Curr. Opin. Chem. Biol. – volume: 561 start-page: 289 year: 2019 end-page: 295 ident: b0995 article-title: Cytotoxicity and permeability enhancement of Capmul® MCM in nanoemulsion formulation publication-title: Int. J. Pharm. – volume: 166 start-page: 115 year: 2013 end-page: 123 ident: b0880 article-title: Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier publication-title: J. Control. Release – volume: 54 start-page: 128 year: 2020 end-page: 138 ident: b0285 article-title: Review of drugs approved via the 505 (b)(2) pathway: Uncovering drug development trends and regulatory requirements publication-title: Therap. Innov. Regul. Sci. – start-page: 1 year: 2020 end-page: 23 ident: b1480 article-title: Advanced trends in protein and peptide drug delivery: a special emphasis on aquasomes and microneedles techniques publication-title: Drug Deliv. Transl. Res. – volume: 114 start-page: 74 year: 2018 end-page: 83 ident: b0725 article-title: Preparation and comparison of tacrolimus-loaded solid dispersion and self-microemulsifying drug delivery system by in vitro/in vivo evaluation publication-title: Eur. J. Pharm. Sci. – volume: 21 start-page: 1499 year: 2000 end-page: 1507 ident: b0225 article-title: Oral peptide drug delivery: polymer–inhibitor conjugates protecting insulin from enzymatic degradation in vitro publication-title: Biomaterials – volume: 51 start-page: 285 year: 2011 end-page: 330 ident: b1055 article-title: Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity publication-title: Crit. Rev. Food Sci. Nutr. – volume: 106 start-page: 298 year: 2005 end-page: 308 ident: b0455 article-title: Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts publication-title: J. Control. Release – volume: 10 start-page: 1228 year: 1993 end-page: 1231 ident: b1015 article-title: Stability of liposomes in vitro and their uptake by rat Peyer's patches following oral administration publication-title: Pharm Res – volume: 17 start-page: 3236 year: 2020 end-page: 3245 ident: b0770 article-title: Cosolvents in Self-Emulsifying Drug Delivery Systems (SEDDS): Do They Really Solve Our Solubility Problems? publication-title: Mol. Pharm. – volume: 28 start-page: 7436 year: 2012 end-page: 7441 ident: b0830 article-title: Investigation of the Hydration of Nonfouling Material Poly(sulfobetaine methacrylate) by Low-Field Nuclear Magnetic Resonance publication-title: Langmuir – volume: 19 start-page: 129 year: 2011 end-page: 141 ident: b1130 article-title: Nanoparticles: emerging carriers for drug delivery publication-title: Saudi Pharmaceut. J. – volume: 23 start-page: 768 year: 2015 end-page: 774 ident: b0795 article-title: Size selectivity of intestinal mucus to diffusing particulates is dependent on surface chemistry and exposure to lipids publication-title: J. Drug Target. – volume: 172 start-page: 872 year: 2013 end-page: 878 ident: b1325 article-title: Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats publication-title: J. Control. Release – volume: 67 start-page: 383 year: 2018 end-page: 400 ident: b1070 article-title: Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: A comprehensive review, International Journal of Polymeric Materials and Polymeric publication-title: Biomaterials – volume: 147 year: 2020 ident: b0570 article-title: Evaluation of self-emulsifying drug delivery systems for oral insulin delivery using an in vitro model simulating the intestinal proteolysis publication-title: Eur. J. Pharm. Sci. – volume: 73 start-page: 1 year: 2009 end-page: 15 ident: b0240 article-title: Lipid–an emerging platform for oral delivery of drugs with poor bioavailability publication-title: Eur. J. Pharm. Biopharm. – volume: 8 start-page: 97 year: 2018 end-page: 105 ident: b1355 article-title: Biomimetic thiamine-and niacin-decorated liposomes for enhanced oral delivery of insulin publication-title: Acta Pharmaceut. Sin. B – volume: 255 start-page: 242 year: 2017 end-page: 257 ident: b0275 article-title: Lipophilic peptide character – What oral barriers fear the most publication-title: J. Control. Release – volume: 5 start-page: 337 year: 2014 end-page: 365 ident: b1380 article-title: Recent developments in protein and peptide parenteral delivery approaches publication-title: Therap. Deliv. – volume: 26 start-page: 1097 year: 2021 end-page: 1105 ident: b0095 article-title: New perspectives in oral peptide delivery publication-title: Drug Discov. Today – volume: 4 year: 2016 ident: b1490 article-title: Chemically modified peptides and proteins-critical considerations for oral delivery publication-title: Tiss. Barr. – volume: 152 start-page: 10 year: 2020 end-page: 17 ident: b0330 article-title: Hydrophobic ion pairing of a GLP-1 analogue for incorporating into lipid nanocarriers designed for oral delivery publication-title: Eur. J. Pharm. Biopharm. – year: 2021 ident: b1160 article-title: Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos publication-title: J. Control. Release – volume: 13 start-page: 5173 year: 2018 ident: b0445 article-title: Facilitated permeation of insulin across TR146 cells by cholic acid derivatives-modified elastic bilosomes publication-title: Int. J. Nanomed. – volume: 582 start-page: 815 year: 2021 end-page: 824 ident: b0360 article-title: Internal liquid crystal structures in nanocarriers containing drug hydrophobic ion pairs dictate drug release publication-title: J. Colloid Interface Sci. – volume: 37 year: 2020 ident: b0690 article-title: Self-Emulsifying Drug Delivery System (SEDDS): An Emerging Dosage Form to Improve the Bioavailability of Poorly Absorbed Drugs publication-title: Crit. Rev.™ Therap. Drug Carr. Syst. – volume: 106 start-page: 277 year: 2016 end-page: 319 ident: b0130 article-title: Intestinal permeation enhancers for oral peptide delivery publication-title: Adv. Drug Deliv. Rev. – volume: 36 start-page: 22 year: 2017 end-page: 28 ident: b0165 article-title: Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles publication-title: Curr. Opin. Pharmacol. – volume: 11 start-page: 1337 year: 2016 end-page: 1343 ident: b0810 article-title: Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo publication-title: Nanomedicine – volume: 6 start-page: 2462 year: 2005 end-page: 2467 ident: b0975 article-title: Exploiting the vitamin B12 pathway to enhance oral drug delivery via polymeric micelles publication-title: Biomacromolecules – volume: 489 start-page: 237 year: 2015 end-page: 245 ident: b0440 article-title: Reversible hydrophobic ion-paring complex strategy to minimize acylation of octreotide during long-term delivery from PLGA microparticles publication-title: Int. J. Pharm. – volume: 32 start-page: 401 year: 2015 end-page: 407 ident: b0625 article-title: Oral self-nanoemulsifying peptide drug delivery systems: impact of lipase on drug release publication-title: J. Microencapsul. – volume: 96 start-page: 447 year: 2015 end-page: 453 ident: b0815 article-title: Nano-carrier systems: strategies to overcome the mucus gel barrier publication-title: Eur. J. Pharm. Biopharm. – volume: 590 year: 2020 ident: b1205 article-title: Storage stability of proteins in a liquid-based formulation: Liquid vs. solid self-emulsifying drug delivery publication-title: Int. J. Pharm. – volume: 10 start-page: 135 year: 2020 ident: b1095 article-title: An overview of micro-and nanoemulsions as vehicles for essential oils: Formulation, preparation and stability publication-title: Nanomaterials – volume: 106 start-page: 3120 year: 2017 end-page: 3130 ident: b0870 article-title: Self-assembled core-shell-type lipid-polymer hybrid nanoparticles: intracellular trafficking and relevance for oral absorption publication-title: J. Pharm. Sci. – volume: 3 start-page: 361 year: 2013 end-page: 372 ident: b0900 article-title: Oral lipid-based drug delivery systems–an overview publication-title: Acta Pharmaceut. Sin. B – volume: 10 start-page: 386 year: 2015 end-page: 395 ident: b0665 article-title: Preparation and evaluation of nattokinase-loaded self-double-emulsifying drug delivery system publication-title: Asian J. Pharm. Sci. – volume: 61 start-page: 363 year: 2013 end-page: 372 ident: b1190 article-title: Combining two technologies: Multifunctional polymers and self-nanoemulsifying drug delivery system (SNEDDS) for oral insulin administration publication-title: Int. J. Biol. Macromol. – volume: 561 start-page: 197 year: 2019 end-page: 205 ident: b0540 article-title: Self-emulsifying drug delivery systems: Impact of stability of hydrophobic ion pairs on drug release publication-title: Int. J. Pharm. – volume: 45 start-page: 89 year: 2000 end-page: 121 ident: b1065 article-title: Microemulsion-based media as novel drug delivery systems publication-title: Adv. Drug Deliv. Rev. – volume: 370 start-page: 26 year: 2009 end-page: 32 ident: b1305 article-title: Chitosan–aprotinin coated liposomes for oral peptide delivery: development, characterisation and in vivo evaluation publication-title: Int. J. Pharm. – volume: 9 start-page: e113 year: 2012 end-page: e119 ident: b0155 article-title: Overcoming poor permeability: translating permeation enhancers for oral peptide delivery publication-title: Drug Discov. Today: Technol. – volume: 56 year: 2007 ident: b0065 article-title: Comparison of an Oral Insulin (Capsulin) and Aetrapid During an Isoglycaemic Clamp Study in Persons with Type 2 Diabetes publication-title: Diabetes – volume: 41 start-page: 376 year: 2010 end-page: 382 ident: b0740 article-title: Effects of non-ionic surfactants on in vitro triglyceride digestion and their susceptibility to digestion by pancreatic enzymes publication-title: Eur. J. Pharm. Sci. – volume: 50 start-page: 924 year: 1995 end-page: 941 ident: b0150 article-title: Cyclosporin publication-title: Drugs – volume: 54 year: 2019 ident: b1255 article-title: A proof-of-concept for developing oral lipidized peptide Nanostructured Lipid Carrier formulations publication-title: J. Drug Delivery Sci. Technol. – volume: 13 start-page: 35 year: 2018 end-page: 38 ident: b1040 article-title: Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach publication-title: Int. J. Nanomed. – volume: 11 start-page: 1323 year: 2014 end-page: 1335 ident: b0265 article-title: Oral peptide and protein delivery: intestinal obstacles and commercial prospects publication-title: Exp. Opin. Drug Deliv. – volume: 29 start-page: 54 year: 1994 end-page: 58 ident: b0460 article-title: Alteration of colonic absorption by long-chain unsaturated fatty acids: influence of hydroxylation and degree of unsaturation publication-title: Scand. J. Gastroenterol. – volume: 19 start-page: 1531 year: 2004 end-page: 1538 ident: b0105 article-title: Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover publication-title: J. Bone Miner. Res. – volume: 137 start-page: 31 year: 2009 end-page: 37 ident: b0550 article-title: Quasi-equilibrium analysis of the ion-pair mediated membrane transport of low-permeability drugs publication-title: J. Control. Release – volume: 5 start-page: 205 year: 2015 ident: b0720 article-title: Formulation, optimization, and evaluation of self-emulsifying drug delivery systems of nevirapine publication-title: Int. J. Pharmaceut. Invest. – volume: 15 start-page: 745 year: 1998 end-page: 750 ident: b1025 article-title: Solid lipid nanoparticles in lymph and plasma after duodenal administration to rats publication-title: Pharm. Res. – start-page: 1 year: 2021 end-page: 6 ident: b0135 article-title: Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery publication-title: Drug Deliv. Transl. Res. – volume: 15 start-page: 684 year: 2013 end-page: 695 ident: b0860 article-title: Nonlinear absorption kinetics of self-emulsifying drug delivery systems (SEDDS) containing tocotrienols as lipophilic molecules: in vivo and in vitro studies publication-title: The AAPS journal – volume: 151 start-page: 1 year: 2020 end-page: 8 ident: b0475 article-title: About the impact of superassociation of hydrophobic ion pairs on membrane permeability publication-title: Eur. J. Pharm. Biopharm. – volume: 26 start-page: 216 year: 2019 end-page: 225 ident: b1335 article-title: Design of novel proliposome formulation for antioxidant peptide, glutathione with enhanced oral bioavailability and stability publication-title: Drug Deliv. – volume: 16 start-page: 5013 year: 2019 end-page: 5024 ident: b0850 article-title: Effect of surface charges on oral absorption of intact solid lipid nanoparticles publication-title: Mol. Pharm. – volume: 340 start-page: 153 year: 2007 end-page: 162 ident: b0390 article-title: Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: preparation and characterization publication-title: Int. J. Pharm. – volume: 113 start-page: 211 year: 2017 end-page: 228 ident: b1140 article-title: Polymeric mixed micelles as nanomedicines: Achievements and perspectives publication-title: Eur. J. Pharm. Biopharm. – volume: 14 start-page: 87 year: 2004 end-page: 109 ident: b1155 article-title: Novel camptothecin analogue (gimatecan)-containing liposomes prepared by the ethanol injection method publication-title: J. Liposome Res. – volume: 5 start-page: 127 year: 2020 end-page: 148 ident: b0120 article-title: Materials for oral delivery of proteins and peptides publication-title: Nat. Rev. Mater. – volume: 12 start-page: 1703 year: 2015 end-page: 1716 ident: b1180 article-title: Self-emulsifying drug delivery systems in oral (poly) peptide drug delivery publication-title: Exp. Opin. Drug Deliv. – volume: 106 start-page: 597 year: 2021 end-page: 602 ident: b0190 article-title: Desmopressin oral lyophilisate in young children: new insights in pharmacokinetics and pharmacodynamics publication-title: Arch. Dis. Child. – volume: 4 start-page: 133 year: 2009 ident: 10.1016/j.addr.2021.114097_b1165 article-title: A model-based methodology for spray-drying process development publication-title: J. Pharmaceut. Innov. doi: 10.1007/s12247-009-9064-4 – volume: 5 start-page: 1501 year: 2021 ident: 10.1016/j.addr.2021.114097_b0175 article-title: Transient Permeation Enhancer®(TPE®) technology for oral delivery of octreotide: a technological evaluation publication-title: Exp. Opin. Drug Deliv. doi: 10.1080/17425247.2021.1942838 – volume: 102 start-page: 11173 year: 2005 ident: 10.1016/j.addr.2021.114097_b0320 article-title: Polymorphism of DNA–anionic liposome complexes reveals hierarchy of ion-mediated interactions publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.0502416102 – volume: 51 start-page: 1241 year: 1999 ident: 10.1016/j.addr.2021.114097_b0405 article-title: Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: Their intestinal mucosal toxicity and absorption-enhancing mechanism of n-lauryl-β-d-maltopyranoside publication-title: J. Pharm. Pharmacol. doi: 10.1211/0022357991776976 – start-page: 237 year: 2015 ident: 10.1016/j.addr.2021.114097_b0670 article-title: Solid lipid excipients as matrix agents for sustained drug delivery publication-title: Excip. Appl. Formul. Des. Drug Deliv. – volume: 21 start-page: 6097 year: 1982 ident: 10.1016/j.addr.2021.114097_b0985 article-title: Transbilayer redistribution of phosphatidylethanolamine during fusion of phospholipid vesicles. Dependence on fusion rate, lipid phase separation, and formation of nonbilayer structures publication-title: Biochemistry doi: 10.1021/bi00267a011 – volume: 9 start-page: 2345 year: 2015 ident: 10.1016/j.addr.2021.114097_b0775 article-title: Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-assembled nanoparticles for oral delivery of insulin publication-title: ACS Nano doi: 10.1021/acsnano.5b00028 – volume: 1 start-page: 147 year: 2012 ident: 10.1016/j.addr.2021.114097_b1135 article-title: Preparation, characterization and applications of liposomes: state of the art publication-title: J. Coll. Sci. Biotechnol. doi: 10.1166/jcsb.2012.1020 – volume: 110 start-page: 124 year: 2021 ident: 10.1016/j.addr.2021.114097_b0310 article-title: Lysine-Based Biodegradable Surfactants: Increasing the Lipophilicity of Insulin by Hydrophobic Ion Paring publication-title: J. Pharm. Sci. doi: 10.1016/j.xphs.2020.07.024 – volume: 117 start-page: 303 year: 2014 ident: 10.1016/j.addr.2021.114097_b0465 article-title: Ion pairing with linoleic acid simultaneously enhances encapsulation efficiency and antibacterial activity of vancomycin in solid lipid nanoparticles publication-title: Colloids Surf., B doi: 10.1016/j.colsurfb.2014.02.045 – volume: 52 start-page: 1 year: 1998 ident: 10.1016/j.addr.2021.114097_b0235 article-title: The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins publication-title: J. Control. Release doi: 10.1016/S0168-3659(97)00204-6 – volume: 54 year: 2019 ident: 10.1016/j.addr.2021.114097_b1255 article-title: A proof-of-concept for developing oral lipidized peptide Nanostructured Lipid Carrier formulations publication-title: J. Drug Delivery Sci. Technol. doi: 10.1016/j.jddst.2019.101394 – volume: 10 start-page: 9916 year: 2018 ident: 10.1016/j.addr.2021.114097_b0910 article-title: Biomimetic viruslike and charge reversible nanoparticles to sequentially overcome mucus and epithelial barriers for oral insulin delivery publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.7b16524 – volume: 27 start-page: 78 year: 2010 ident: 10.1016/j.addr.2021.114097_b1110 article-title: Solid lipid nanoparticles produced through a coacervation method publication-title: J. Microencapsul. doi: 10.3109/02652040903031279 – volume: 21 start-page: 561 year: 2011 ident: 10.1016/j.addr.2021.114097_b0700 article-title: The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review publication-title: Expert Opin. Ther. Pat. doi: 10.1517/13543776.2011.561784 – volume: 159 year: 2021 ident: 10.1016/j.addr.2021.114097_b0400 article-title: Sodium glycodeoxycholate and sodium deoxycholate as epithelial permeation enhancers: in vitro and ex vivo intestinal and buccal bioassays publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2021.105737 – volume: 67 start-page: 383 year: 2018 ident: 10.1016/j.addr.2021.114097_b1070 article-title: Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: A comprehensive review, International Journal of Polymeric Materials and Polymeric publication-title: Biomaterials – volume: 11 start-page: 865 year: 2015 ident: 10.1016/j.addr.2021.114097_b0925 article-title: Exendin-4 loaded nanoparticles with a lipid shell and aqueous core containing micelles for enhanced intestinal absorption publication-title: J. Biomed. Nanotechnol. doi: 10.1166/jbn.2015.1971 – ident: 10.1016/j.addr.2021.114097_b0035 – volume: 137 start-page: 31 year: 2009 ident: 10.1016/j.addr.2021.114097_b0550 article-title: Quasi-equilibrium analysis of the ion-pair mediated membrane transport of low-permeability drugs publication-title: J. Control. Release doi: 10.1016/j.jconrel.2009.02.018 – volume: 536 start-page: 353 year: 2018 ident: 10.1016/j.addr.2021.114097_b0525 article-title: Impact of digestion on the transport of dextran-loaded self-emulsified nanoemulsion through MDCK epithelial cell monolayer and rat intestines publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.12.009 – volume: 18 start-page: 19 year: 2019 ident: 10.1016/j.addr.2021.114097_b0125 article-title: Non-invasive delivery strategies for biologics publication-title: Nat. Rev. Drug Discovery doi: 10.1038/nrd.2018.183 – volume: 114 start-page: 74 year: 2018 ident: 10.1016/j.addr.2021.114097_b0725 article-title: Preparation and comparison of tacrolimus-loaded solid dispersion and self-microemulsifying drug delivery system by in vitro/in vivo evaluation publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2017.12.002 – volume: 143 start-page: 98 year: 2019 ident: 10.1016/j.addr.2021.114097_b1455 article-title: Microcontainers for oral insulin delivery–in vitro studies of permeation enhancement publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2019.08.011 – volume: 81 start-page: 265 year: 2012 ident: 10.1016/j.addr.2021.114097_b1345 article-title: Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2012.02.009 – volume: 106 start-page: 277 year: 2016 ident: 10.1016/j.addr.2021.114097_b0130 article-title: Intestinal permeation enhancers for oral peptide delivery publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2016.06.005 – volume: 2 start-page: 621 year: 2016 ident: 10.1016/j.addr.2021.114097_b0990 article-title: Drug delivery via cell membrane fusion using lipopeptide modified liposomes publication-title: ACS Cent. Sci. doi: 10.1021/acscentsci.6b00172 – volume: 50 start-page: 2 year: 2013 ident: 10.1016/j.addr.2021.114097_b1430 article-title: Reprint of: Nanocarrier systems for oral drug delivery: Do we really need them? publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2013.06.011 – volume: 12 start-page: 1026 year: 2020 ident: 10.1016/j.addr.2021.114097_b0940 article-title: Oral Insulin Delivery Using Poly (Styrene Co-Maleic Acid) Micelles in a Diabetic Mouse Model publication-title: Pharmaceutics doi: 10.3390/pharmaceutics12111026 – volume: 271 start-page: 55 year: 2018 ident: 10.1016/j.addr.2021.114097_b0765 article-title: Do drug release studies from SEDDS make any sense? publication-title: J. Control. Release doi: 10.1016/j.jconrel.2017.12.027 – volume: 496 start-page: 993 year: 2015 ident: 10.1016/j.addr.2021.114097_b1410 article-title: Goblet cell targeting nanoparticle containing drug-loaded micelle cores for oral delivery of insulin publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2015.10.078 – volume: 472 start-page: 20 year: 2014 ident: 10.1016/j.addr.2021.114097_b0345 article-title: In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2014.05.047 – volume: 8 start-page: 2733 year: 2013 ident: 10.1016/j.addr.2021.114097_b1005 article-title: Advanced drug delivery to the lymphatic system: lipid-based nanoformulations publication-title: Int. J. Nanomed. – ident: 10.1016/j.addr.2021.114097_b1445 doi: 10.5958/0975-4377.2020.00035.X – volume: 560 start-page: 377 year: 2019 ident: 10.1016/j.addr.2021.114097_b1240 article-title: SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2019.02.014 – volume: 124 start-page: 150 year: 2018 ident: 10.1016/j.addr.2021.114097_b0805 article-title: Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2017.10.001 – volume: 83 start-page: 382 year: 2011 ident: 10.1016/j.addr.2021.114097_b0595 article-title: Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: influences of fatty acids publication-title: Colloids Surf., B doi: 10.1016/j.colsurfb.2010.12.014 – volume: 16 start-page: 5013 year: 2019 ident: 10.1016/j.addr.2021.114097_b0850 article-title: Effect of surface charges on oral absorption of intact solid lipid nanoparticles publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.9b00861 – volume: 362 start-page: 2 year: 2008 ident: 10.1016/j.addr.2021.114097_b0325 article-title: Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs: I. Formulation development publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2008.05.018 – volume: 561 start-page: 197 year: 2019 ident: 10.1016/j.addr.2021.114097_b0540 article-title: Self-emulsifying drug delivery systems: Impact of stability of hydrophobic ion pairs on drug release publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2019.03.001 – volume: 39 start-page: 373 year: 2010 ident: 10.1016/j.addr.2021.114097_b0520 article-title: Lyophilization of water-in-oil emulsions to prepare phospholipid-based anhydrous reverse micelles for oral peptide delivery publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2010.01.006 – volume: 8 start-page: 1085 year: 2013 ident: 10.1016/j.addr.2021.114097_b1290 article-title: Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle–double emulsion method via the combined use of different solid lipids publication-title: Nanomedicine doi: 10.2217/nnm.12.141 – volume: 53 start-page: 73 year: 2021 ident: 10.1016/j.addr.2021.114097_b0920 article-title: Oral self-nanoemulsifying formulation of GLP-1 agonist peptide exendin-4: development, characterization and permeability assesment on Caco-2 cell monolayer publication-title: Amino Acids doi: 10.1007/s00726-020-02926-0 – volume: 11 start-page: 11048 year: 2019 ident: 10.1016/j.addr.2021.114097_b0875 article-title: Biological fate of ingested lipid-based nanoparticles: current understanding and future directions publication-title: Nanoscale doi: 10.1039/C9NR03025E – volume: 5 start-page: 337 year: 2014 ident: 10.1016/j.addr.2021.114097_b1380 article-title: Recent developments in protein and peptide parenteral delivery approaches publication-title: Therap. Deliv. doi: 10.4155/tde.14.5 – volume: 338 start-page: 644 year: 2021 ident: 10.1016/j.addr.2021.114097_b0415 article-title: Bile acid transporter-mediated oral absorption of insulin via hydrophobic ion-pairing approach publication-title: J. Control. Release doi: 10.1016/j.jconrel.2021.08.060 – volume: 6 start-page: 213 year: 2015 ident: 10.1016/j.addr.2021.114097_b0185 article-title: Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis publication-title: World J. Gastroint. Pharmacol. Therap. doi: 10.4292/wjgpt.v6.i4.213 – ident: 10.1016/j.addr.2021.114097_b0075 – start-page: 1 year: 2021 ident: 10.1016/j.addr.2021.114097_b0135 article-title: Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery publication-title: Drug Deliv. Transl. Res. – volume: 8 start-page: 25444 year: 2016 ident: 10.1016/j.addr.2021.114097_b0845 article-title: Enhanced Oral Delivery of Protein Drugs Using Zwitterion-Functionalized Nanoparticles to Overcome both the Diffusion and Absorption Barriers publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.6b08183 – volume: 11 start-page: 1939 year: 2015 ident: 10.1016/j.addr.2021.114097_b0620 article-title: Environment-responsive aza-BODIPY dyes quenching in water as potential probes to visualize the in vivo fate of lipid-based nanocarriers publication-title: Nanomedicine doi: 10.1016/j.nano.2015.06.013 – start-page: 1 year: 2020 ident: 10.1016/j.addr.2021.114097_b1480 article-title: Advanced trends in protein and peptide drug delivery: a special emphasis on aquasomes and microneedles techniques publication-title: Drug Deliv. Transl. Res. – start-page: 1 year: 2021 ident: 10.1016/j.addr.2021.114097_b0510 article-title: Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide publication-title: Pharm. Res. doi: 10.1007/s11095-021-03004-0 – volume: 10 start-page: 9315 year: 2018 ident: 10.1016/j.addr.2021.114097_b0935 article-title: Novel solid lipid nanoparticle with endosomal escape function for oral delivery of insulin publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.8b00507 – volume: 13 start-page: 923 year: 2016 ident: 10.1016/j.addr.2021.114097_b0250 article-title: Development of oral self nano-emulsifying delivery system (s) of lanreotide with improved stability against presystemic thiol-disulfide exchange reactions publication-title: Exp. Opin. Drug Deliv. doi: 10.1517/17425247.2016.1167034 – volume: 3 start-page: 361 year: 2013 ident: 10.1016/j.addr.2021.114097_b0900 article-title: Oral lipid-based drug delivery systems–an overview publication-title: Acta Pharmaceut. Sin. B doi: 10.1016/j.apsb.2013.10.001 – volume: 46 start-page: 221 year: 2006 ident: 10.1016/j.addr.2021.114097_b1100 article-title: Microemulsions: a potential delivery system for bioactives in food publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408690590956710 – volume: 9 start-page: 9217 year: 2015 ident: 10.1016/j.addr.2021.114097_b0785 article-title: Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo publication-title: ACS Nano doi: 10.1021/acsnano.5b03876 – volume: 6 start-page: 3049 year: 2011 ident: 10.1016/j.addr.2021.114097_b0490 article-title: Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin publication-title: Int. J. Nanomed. – volume: 197 start-page: 48 year: 2015 ident: 10.1016/j.addr.2021.114097_b0800 article-title: Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse publication-title: J. Control. Release doi: 10.1016/j.jconrel.2014.10.026 – volume: 40 start-page: 623 year: 1995 ident: 10.1016/j.addr.2021.114097_b0760 article-title: Correlation of octanol/water solubility ratios and partition coefficients publication-title: J. Chem. Eng. Data doi: 10.1021/je00019a019 – volume: 160 year: 2020 ident: 10.1016/j.addr.2021.114097_b1090 article-title: Rapid production of liposomes using high pressure carbon dioxide and direct ultrasonication publication-title: J. Supercrit. Fluids doi: 10.1016/j.supflu.2020.104782 – volume: 61 start-page: 375 year: 2006 ident: 10.1016/j.addr.2021.114097_b1265 article-title: Preparation, characterization and physico-chemical properties of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC): their benefits as colloidal drug carrier systems publication-title: Die Pharmazie-Int. J. Pharmaceut. Sci. – volume: 75 start-page: 2819 year: 2004 ident: 10.1016/j.addr.2021.114097_b0450 article-title: The effect of various liposome formulations on insulin penetration across Caco-2 cell monolayer publication-title: Life Sci. doi: 10.1016/j.lfs.2004.05.027 – volume: 543 start-page: 508 year: 1978 ident: 10.1016/j.addr.2021.114097_b0605 article-title: Effects of bile salts on the structural integrity of liposomes publication-title: Biochim. Biophys. Acta (BBA)-Gen. Sub. doi: 10.1016/0304-4165(78)90305-7 – volume: 15 start-page: 216 year: 2018 ident: 10.1016/j.addr.2021.114097_b0355 article-title: Hydrophobic ion pairing of peptide antibiotics for processing into controlled release nanocarrier formulations publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.7b00824 – start-page: 43 year: 2019 ident: 10.1016/j.addr.2021.114097_b1400 – volume: 81 start-page: 136 year: 2013 ident: 10.1016/j.addr.2021.114097_b0015 article-title: The future of peptide-based drugs publication-title: Chem. Biol. Drug Des. doi: 10.1111/cbdd.12055 – volume: 590 year: 2020 ident: 10.1016/j.addr.2021.114097_b1205 article-title: Storage stability of proteins in a liquid-based formulation: Liquid vs. solid self-emulsifying drug delivery publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2020.119918 – volume: 14 start-page: 87 year: 2004 ident: 10.1016/j.addr.2021.114097_b1155 article-title: Novel camptothecin analogue (gimatecan)-containing liposomes prepared by the ethanol injection method publication-title: J. Liposome Res. doi: 10.1081/LPR-120039794 – volume: 22 start-page: 10 year: 2020 ident: 10.1016/j.addr.2021.114097_b0140 article-title: Oral semaglutide: a review of the first oral glucagon-like peptide 1 receptor agonist publication-title: Diab. Technol. Ther. doi: 10.1089/dia.2019.0185 – volume: 13 start-page: 35 year: 2018 ident: 10.1016/j.addr.2021.114097_b1040 article-title: Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S124703 – volume: 7 start-page: eabe2620 year: 2021 ident: 10.1016/j.addr.2021.114097_b1485 article-title: A microneedle platform for buccal macromolecule delivery publication-title: Sci. Adv. doi: 10.1126/sciadv.abe2620 – volume: 7 start-page: 113 year: 2019 ident: 10.1016/j.addr.2021.114097_b0205 article-title: Nanotechnology in insulin delivery for management of diabetes publication-title: Pharmaceut. Nanotechnol. doi: 10.2174/2211738507666190321110721 – volume: 51 start-page: 460 year: 2011 ident: 10.1016/j.addr.2021.114097_b0110 article-title: Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials publication-title: J. Clin. Pharmacol. doi: 10.1177/0091270010372625 – volume: 3 start-page: 568 year: 2009 ident: 10.1016/j.addr.2021.114097_b0160 article-title: Oral insulin and buccal insulin: a critical reappraisal publication-title: J. Diabetes Sci. Technol. doi: 10.1177/193229680900300323 – volume: 107 start-page: 2136 year: 2018 ident: 10.1016/j.addr.2021.114097_b1360 article-title: Bioadhesive chitosan-coated cationic nanoliposomes with improved insulin encapsulation and prolonged oral hypoglycemic effect in diabetic mice publication-title: J. Pharm. Sci. doi: 10.1016/j.xphs.2018.04.011 – volume: 149 start-page: 255 year: 1997 ident: 10.1016/j.addr.2021.114097_b1250 article-title: Peptide-loaded solid lipid nanoparticles (SLN): influence of production parameters publication-title: Int. J. Pharm. doi: 10.1016/S0378-5173(97)04885-0 – volume: 23 start-page: 2074 year: 2016 ident: 10.1016/j.addr.2021.114097_b0380 article-title: Development and in vitro evaluation of an oral SEDDS for desmopressin publication-title: Drug Deliv. doi: 10.3109/10717544.2016.1143056 – volume: 559 start-page: 228 year: 2019 ident: 10.1016/j.addr.2021.114097_b0755 article-title: Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2019.01.039 – volume: 296 start-page: 162 year: 2019 ident: 10.1016/j.addr.2021.114097_b0210 article-title: Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals publication-title: J. Control. Release doi: 10.1016/j.jconrel.2019.01.023 – volume: 93 start-page: 488 year: 2004 ident: 10.1016/j.addr.2021.114097_b0350 article-title: Biodegradable nanoparticles containing protein-fatty acid complexes for oral delivery of salmon calcitonin publication-title: J. Pharm. Sci. doi: 10.1002/jps.10573 – volume: 166 start-page: 115 year: 2013 ident: 10.1016/j.addr.2021.114097_b0880 article-title: Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier publication-title: J. Control. Release doi: 10.1016/j.jconrel.2012.12.021 – volume: 38 start-page: 173 year: 2002 ident: 10.1016/j.addr.2021.114097_b1020 article-title: Uptake of liposomes by Peyeŕ s patches following per os administration in mice publication-title: Revista Brasileira de Ciências Farmacêuticas – volume: 2011 year: 2011 ident: 10.1016/j.addr.2021.114097_b0495 article-title: Encapsulation of protein-polysaccharide HIP complex in polymeric nanoparticles publication-title: J. Drug Deliv. doi: 10.1155/2011/458128 – volume: 15 start-page: 405 year: 2002 ident: 10.1016/j.addr.2021.114097_b0890 article-title: Lipid-based formulations for intestinal lymphatic delivery publication-title: Eur. J. Pharm. Sci. doi: 10.1016/S0928-0987(02)00051-9 – volume: 10 start-page: 167 year: 2014 ident: 10.1016/j.addr.2021.114097_b1350 article-title: Biotinylated liposomes as potential carriers for the oral delivery of insulin publication-title: Nanomedicine doi: 10.1016/j.nano.2013.07.011 – volume: 460 start-page: 119 year: 2014 ident: 10.1016/j.addr.2021.114097_b1315 article-title: Enhanced oral absorption of insulin-loaded liposomes containing bile salts: a mechanistic study publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2013.11.028 – volume: 370 start-page: 26 year: 2009 ident: 10.1016/j.addr.2021.114097_b1305 article-title: Chitosan–aprotinin coated liposomes for oral peptide delivery: development, characterisation and in vivo evaluation publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2008.11.013 – volume: 113 start-page: 211 year: 2017 ident: 10.1016/j.addr.2021.114097_b1140 article-title: Polymeric mixed micelles as nanomedicines: Achievements and perspectives publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2016.12.019 – volume: 15 start-page: 605 year: 2020 ident: 10.1016/j.addr.2021.114097_b1415 article-title: Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions publication-title: Nat. Nanotechnol. doi: 10.1038/s41565-020-0693-6 – volume: 36 start-page: 192 year: 2016 ident: 10.1016/j.addr.2021.114097_b0945 article-title: Development and evaluation of insulin-loaded cationic solid lipid nanoparticles for oral delivery publication-title: J. Drug Delivery Sci. Technol. doi: 10.1016/j.jddst.2016.10.012 – volume: 21 start-page: 1499 year: 2000 ident: 10.1016/j.addr.2021.114097_b0225 article-title: Oral peptide drug delivery: polymer–inhibitor conjugates protecting insulin from enzymatic degradation in vitro publication-title: Biomaterials doi: 10.1016/S0142-9612(00)00039-9 – year: 2021 ident: 10.1016/j.addr.2021.114097_b1160 article-title: Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos publication-title: J. Control. Release doi: 10.1016/j.jconrel.2021.08.013 – volume: 10 year: 2018 ident: 10.1016/j.addr.2021.114097_b0220 article-title: Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aar7047 – volume: 133 start-page: 13481 year: 2011 ident: 10.1016/j.addr.2021.114097_b1390 article-title: Structure and dynamics of highly PEG-ylated sterically stabilized micelles in aqueous media publication-title: J. Am. Chem. Soc. doi: 10.1021/ja204043b – volume: 90 start-page: 141 year: 1993 ident: 10.1016/j.addr.2021.114097_b0295 article-title: Effect of ion-pairing on 1-octanol-water partitioning of peptide drugs. I: the nonapeptide leuprolide acetate publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(93)90150-E – volume: 4 start-page: 18 year: 2012 ident: 10.1016/j.addr.2021.114097_b0710 article-title: Self emulsifying drug delivery system: A Novel approach publication-title: Int. J. Curr. Pharmaceut. Res. – volume: 452 start-page: 374 year: 2013 ident: 10.1016/j.addr.2021.114097_b0615 article-title: Bile salts enhance the intestinal absorption of lipophilic drug loaded lipid nanocarriers: mechanism and effect in rats publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2013.05.021 – volume: 583 year: 2020 ident: 10.1016/j.addr.2021.114097_b0715 article-title: Synthesis and in vitro characterization of a preactivated thiolated acrylic acid/acrylamide-methylpropane sulfonic acid copolymer as a mucoadhesive sprayable polymer publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2020.119371 – volume: 142 start-page: 258 year: 2019 ident: 10.1016/j.addr.2021.114097_b0750 article-title: Fenofibrate oral absorption from SNEDDS and super-SNEDDS is not significantly affected by lipase inhibition in rats publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2019.07.002 – volume: 31 start-page: 691 year: 2021 ident: 10.1016/j.addr.2021.114097_b0435 article-title: Glargine insulin loaded lipid nanoparticles: Oral delivery of liquid and solid oral dosage forms publication-title: Nutrit. Metabol. Cardiovasc. Dis. doi: 10.1016/j.numecd.2020.09.020 – volume: 96 start-page: 447 year: 2015 ident: 10.1016/j.addr.2021.114097_b0815 article-title: Nano-carrier systems: strategies to overcome the mucus gel barrier publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2015.01.022 – volume: 172 start-page: 872 year: 2013 ident: 10.1016/j.addr.2021.114097_b1325 article-title: Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats publication-title: J. Control. Release doi: 10.1016/j.jconrel.2013.10.011 – volume: 51 start-page: 285 year: 2011 ident: 10.1016/j.addr.2021.114097_b1055 article-title: Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408398.2011.559558 – volume: 33 start-page: 8881 year: 2012 ident: 10.1016/j.addr.2021.114097_b0960 article-title: The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier publication-title: Biomaterials doi: 10.1016/j.biomaterials.2012.08.047 – volume: 593 year: 2021 ident: 10.1016/j.addr.2021.114097_b1310 article-title: Oral mucus-penetrating PEGylated liposomes to improve drug absorption: Differences in the interaction mechanisms of a mucoadhesive liposome publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2020.120148 – volume: 520 start-page: 267 year: 2017 ident: 10.1016/j.addr.2021.114097_b0040 article-title: Hydrophobic ion pairing: key to highly payloaded self-emulsifying peptide drug delivery systems publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.02.019 – volume: 69 start-page: 911 year: 2020 ident: 10.1016/j.addr.2021.114097_b0515 article-title: Novel strategy for oral peptide delivery in incretin-based diabetes treatment publication-title: Gut doi: 10.1136/gutjnl-2019-319146 – volume: 1 start-page: 4207 year: 2019 ident: 10.1016/j.addr.2021.114097_b0290 article-title: Hydrophobic ion pairing: encapsulating small molecules, peptides, and proteins into nanocarriers publication-title: Nanosc. Adv. doi: 10.1039/C9NA00308H – volume: 142 start-page: 102 year: 2019 ident: 10.1016/j.addr.2021.114097_b1200 article-title: Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2018.11.006 – volume: 327 start-page: 153 year: 2006 ident: 10.1016/j.addr.2021.114097_b1280 article-title: Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2006.07.026 – volume: 12 start-page: 8893 year: 2018 ident: 10.1016/j.addr.2021.114097_b0885 article-title: Oral Nanoparticles Exhibit Specific High-Efficiency Intestinal Uptake and Lymphatic Transport publication-title: ACS Nano doi: 10.1021/acsnano.8b04315 – volume: 19 start-page: 129 year: 2011 ident: 10.1016/j.addr.2021.114097_b1130 article-title: Nanoparticles: emerging carriers for drug delivery publication-title: Saudi Pharmaceut. J. doi: 10.1016/j.jsps.2011.04.001 – volume: 10 start-page: 1865 year: 2013 ident: 10.1016/j.addr.2021.114097_b0820 article-title: Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles publication-title: Mol. Pharm. doi: 10.1021/mp300649z – volume: 106 start-page: 3120 year: 2017 ident: 10.1016/j.addr.2021.114097_b0870 article-title: Self-assembled core-shell-type lipid-polymer hybrid nanoparticles: intracellular trafficking and relevance for oral absorption publication-title: J. Pharm. Sci. doi: 10.1016/j.xphs.2017.05.029 – volume: 103 start-page: 3985 year: 2014 ident: 10.1016/j.addr.2021.114097_b1340 article-title: Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole publication-title: J. Pharm. Sci. doi: 10.1002/jps.24215 – volume: 222 start-page: 79 year: 2015 ident: 10.1016/j.addr.2021.114097_b0315 article-title: Amino acid-based surfactants–do they deserve more attention? publication-title: Adv. Colloid Interface Sci. doi: 10.1016/j.cis.2014.10.013 – volume: 538 start-page: 159 year: 2018 ident: 10.1016/j.addr.2021.114097_b0375 article-title: Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2018.01.018 – volume: 32 start-page: 2662 year: 2011 ident: 10.1016/j.addr.2021.114097_b0630 article-title: Tailoring nanostructured solid-lipid carriers for time-controlled intracellular siRNA kinetics to sustain RNAi-mediated chemosensitization publication-title: Biomaterials doi: 10.1016/j.biomaterials.2010.12.029 – volume: 27 start-page: 1382 year: 2006 ident: 10.1016/j.addr.2021.114097_b1235 article-title: In vitro and in vivo evaluation of a novel oral insulin formulation publication-title: Acta Pharmacol. Sin. doi: 10.1111/j.1745-7254.2006.00424.x – volume: 434 start-page: 40 year: 2014 ident: 10.1016/j.addr.2021.114097_b1145 article-title: Preparation, optimization, characterization and cytotoxicity in vitro of Baicalin-loaded mixed micelles publication-title: J. Colloid Interface Sci. doi: 10.1016/j.jcis.2014.07.045 – volume: 508 start-page: 102 year: 2016 ident: 10.1016/j.addr.2021.114097_b0650 article-title: Impact of lipases on the protective effect of SEDDS for incorporated peptide drugs towards intestinal peptidases publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2016.04.044 – volume: 294 start-page: 259 year: 2019 ident: 10.1016/j.addr.2021.114097_b1330 article-title: Long-term oral administration of Exendin-4 to control type 2 diabetes in a rat model publication-title: J. Control. Release doi: 10.1016/j.jconrel.2018.12.028 – volume: 19 start-page: 743 year: 2014 ident: 10.1016/j.addr.2021.114097_b0915 article-title: Lymphatic transport of puerarin occurs after oral administration of different lipid-based formulations to unconscious lymph duct-cannulated rats publication-title: Pharm. Dev. Technol. doi: 10.3109/10837450.2013.829093 – volume: 19 start-page: 277 year: 2020 ident: 10.1016/j.addr.2021.114097_b1450 article-title: Advances in oral peptide therapeutics publication-title: Nat. Rev. Drug Discovery doi: 10.1038/s41573-019-0053-0 – volume: 252 start-page: 28 year: 2017 ident: 10.1016/j.addr.2021.114097_b1105 article-title: Nanoemulsion: Concepts, development and applications in drug delivery publication-title: J. Control Release doi: 10.1016/j.jconrel.2017.03.008 – volume: 34 start-page: 143 year: 2016 ident: 10.1016/j.addr.2021.114097_b0200 article-title: Engineered knottin peptides as diagnostics, therapeutics, and drug delivery vehicles publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2016.08.022 – ident: 10.1016/j.addr.2021.114097_b0280 – volume: 28 start-page: 7436 year: 2012 ident: 10.1016/j.addr.2021.114097_b0830 article-title: Investigation of the Hydration of Nonfouling Material Poly(sulfobetaine methacrylate) by Low-Field Nuclear Magnetic Resonance publication-title: Langmuir doi: 10.1021/la300394c – volume: 65 start-page: S95 year: 2001 ident: 10.1016/j.addr.2021.114097_b1045 article-title: Absorption and distribution of dietary fatty acids from different sources publication-title: Early Human Dev. doi: 10.1016/S0378-3782(01)00211-0 – volume: 19 start-page: 929 year: 1993 ident: 10.1016/j.addr.2021.114097_b0340 article-title: The effects of fatty acids and their derivatives on the intestinal absorption of insulin in rat publication-title: Drug Dev. Ind. Pharm. doi: 10.3109/03639049309062992 – volume: 8 start-page: 97 year: 2018 ident: 10.1016/j.addr.2021.114097_b1355 article-title: Biomimetic thiamine-and niacin-decorated liposomes for enhanced oral delivery of insulin publication-title: Acta Pharmaceut. Sin. B doi: 10.1016/j.apsb.2017.11.007 – volume: 207 start-page: 21 year: 2000 ident: 10.1016/j.addr.2021.114097_b0050 article-title: A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt: fatty acid micellar systems using the CaCo-2 cell culture model publication-title: Int. J. Pharm. doi: 10.1016/S0378-5173(00)00526-3 – volume: 587 start-page: 279 year: 2021 ident: 10.1016/j.addr.2021.114097_b1510 article-title: Polyphosphate coatings: A promising strategy to overcome the polycation dilemma publication-title: J. Colloid Interface Sci. doi: 10.1016/j.jcis.2020.12.019 – volume: 37 year: 2020 ident: 10.1016/j.addr.2021.114097_b0690 article-title: Self-Emulsifying Drug Delivery System (SEDDS): An Emerging Dosage Form to Improve the Bioavailability of Poorly Absorbed Drugs publication-title: Crit. Rev.™ Therap. Drug Carr. Syst. – volume: 277 start-page: 165 year: 2018 ident: 10.1016/j.addr.2021.114097_b1225 article-title: In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide publication-title: J. Control. Release doi: 10.1016/j.jconrel.2018.03.018 – volume: 13 start-page: 5173 year: 2018 ident: 10.1016/j.addr.2021.114097_b0445 article-title: Facilitated permeation of insulin across TR146 cells by cholic acid derivatives-modified elastic bilosomes publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S168310 – start-page: 2326 year: 2021 ident: 10.1016/j.addr.2021.114097_b1475 article-title: Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs publication-title: Acta Pharmaceut. Sin. B doi: 10.1016/j.apsb.2021.03.003 – volume: 20 start-page: 187 year: 2010 ident: 10.1016/j.addr.2021.114097_b1120 article-title: Amphotericin B loaded SLN prepared with the coacervation technique JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2010) 20 publication-title: J. Drug Delivery Sci. Technol. doi: 10.1016/S1773-2247(10)50028-5 – volume: 477 start-page: 390 year: 2014 ident: 10.1016/j.addr.2021.114097_b0930 article-title: Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2014.10.039 – volume: 167 start-page: 82 year: 2018 ident: 10.1016/j.addr.2021.114097_b1220 article-title: Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability publication-title: Colloids Surf., B doi: 10.1016/j.colsurfb.2018.03.034 – volume: 50 start-page: 924 year: 1995 ident: 10.1016/j.addr.2021.114097_b0150 article-title: Cyclosporin publication-title: Drugs doi: 10.2165/00003495-199550050-00009 – volume: 8 start-page: 8 year: 2020 ident: 10.1016/j.addr.2021.114097_b1370 article-title: Liposomal lactoferrin as potential preventative and cure for COVID-19 publication-title: Int. J. Res. Health Sci. – volume: 12 start-page: 99 year: 2020 ident: 10.1016/j.addr.2021.114097_b0420 article-title: The in vivo effect of transcellular permeation enhancers on the intestinal permeability of two peptide drugs enalaprilat and hexarelin publication-title: Pharmaceutics doi: 10.3390/pharmaceutics12020099 – volume: 6 start-page: 1155 year: 2011 ident: 10.1016/j.addr.2021.114097_b0580 article-title: Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation publication-title: Int. J. Nanomed. – volume: 30 start-page: 35 year: 2006 ident: 10.1016/j.addr.2021.114097_b0245 article-title: Characterisation of the thiol-disulphide chemistry of desmopressin by LC, mu-LC, LC-ESI-MS and Maldi-Tof publication-title: Amino Acids doi: 10.1007/s00726-005-0241-6 – volume: 81 start-page: 129 year: 2016 ident: 10.1016/j.addr.2021.114097_b0300 article-title: Development and in vitro characterisation of an oral self-emulsifying delivery system for daptomycin publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2015.10.005 – volume: 38 start-page: 1262 year: 2012 ident: 10.1016/j.addr.2021.114097_b0655 article-title: In vitro digestion kinetics of excipients for lipid-based drug delivery and introduction of a relative lipolysis half life publication-title: Drug Dev. Ind. Pharm. doi: 10.3109/03639045.2011.645834 – volume: 21 start-page: 1570 year: 2013 ident: 10.1016/j.addr.2021.114097_b0635 article-title: Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics publication-title: Mol. Ther. doi: 10.1038/mt.2013.124 – volume: 102 start-page: 4406 year: 2013 ident: 10.1016/j.addr.2021.114097_b0825 article-title: Development and evaluation of a novel mucus diffusion test system approved by self-nanoemulsifying drug delivery systems publication-title: J. Pharm. Sci. doi: 10.1002/jps.23757 – volume: 23 start-page: 768 year: 2015 ident: 10.1016/j.addr.2021.114097_b0795 article-title: Size selectivity of intestinal mucus to diffusing particulates is dependent on surface chemistry and exposure to lipids publication-title: J. Drug Target. doi: 10.3109/1061186X.2015.1086359 – volume: 12 start-page: 1703 year: 2015 ident: 10.1016/j.addr.2021.114097_b1180 article-title: Self-emulsifying drug delivery systems in oral (poly) peptide drug delivery publication-title: Exp. Opin. Drug Deliv. doi: 10.1517/17425247.2015.1068287 – volume: 27 start-page: 1017 year: 2019 ident: 10.1016/j.addr.2021.114097_b0470 article-title: Oral self-emulsifying delivery systems for systemic administration of therapeutic proteins: science fiction? publication-title: J. Drug Target. doi: 10.1080/1061186X.2019.1584200 – volume: 527 start-page: 184 year: 2017 ident: 10.1016/j.addr.2021.114097_b0545 article-title: An investigation into the ability of alendronate ion pairs to increase oral absorption publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.05.042 – volume: 47 start-page: 22 year: 2021 ident: 10.1016/j.addr.2021.114097_b0585 article-title: Impact of bile salts and a medium chain fatty acid on the physical properties of self-emulsifying drug delivery systems publication-title: Drug Dev. Ind. Pharm. doi: 10.1080/03639045.2020.1851241 – volume: 11 start-page: 61 year: 1994 ident: 10.1016/j.addr.2021.114097_b0230 article-title: Enzymatic barriers for GI peptide and protein delivery publication-title: Crit. Rev. Ther. Drug Carrier Syst. – volume: 70 start-page: 1096 year: 1976 ident: 10.1016/j.addr.2021.114097_b0335 article-title: Effect of bile salts and fatty acids on the colonic absorption of oxalate publication-title: Gastroenterology doi: 10.1016/S0016-5085(76)80318-6 – ident: 10.1016/j.addr.2021.114097_b0010 – volume: 6 start-page: 5032 year: 2020 ident: 10.1016/j.addr.2021.114097_b1230 article-title: The Effect of Counterions in Hydrophobic Ion Pairs on Oral Bioavailability of Exenatide publication-title: ACS Biomater. Sci. Eng. doi: 10.1021/acsbiomaterials.0c00637 – volume: 56 start-page: 1283 year: 2019 ident: 10.1016/j.addr.2021.114097_b0045 article-title: Lipid nanoparticles as vehicles for oral delivery of insulin and insulin analogs: preliminary ex vivo and in vivo studies publication-title: Acta Diabetol. doi: 10.1007/s00592-019-01403-9 – volume: 13 start-page: 408 year: 2020 ident: 10.1016/j.addr.2021.114097_b0395 article-title: In vitro and ex vivo evaluation of penetratin as a non-invasive permeation enhancer in the penetration of salmon calcitonin through TR146 buccal cells and porcine buccal tissues publication-title: Pharmaceuticals doi: 10.3390/ph13110408 – volume: 17 start-page: 3236 year: 2020 ident: 10.1016/j.addr.2021.114097_b0770 article-title: Cosolvents in Self-Emulsifying Drug Delivery Systems (SEDDS): Do They Really Solve Our Solubility Problems? publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.0c00343 – volume: 81 start-page: 1930 year: 2001 ident: 10.1016/j.addr.2021.114097_b0790 article-title: Diffusion of macromolecules and virus-like particles in human cervical mucus publication-title: Biophy. J. doi: 10.1016/S0006-3495(01)75844-4 – volume: 10 start-page: 549 year: 1993 ident: 10.1016/j.addr.2021.114097_b1030 article-title: Uptake of phosphatidylserine liposomes by rat Peyer's patches following intraluminal administration publication-title: Pharm. Res. doi: 10.1023/A:1018945902276 – volume: 4 year: 2016 ident: 10.1016/j.addr.2021.114097_b1490 article-title: Chemically modified peptides and proteins-critical considerations for oral delivery publication-title: Tiss. Barr. – volume: 15 start-page: 1829 year: 2020 ident: 10.1016/j.addr.2021.114097_b0610 article-title: Cellular uptake of self-emulsifying drug-delivery systems: polyethylene glycol versus polyglycerol surface publication-title: Nanomedicine (Lond) doi: 10.2217/nnm-2020-0127 – volume: 5 start-page: 205 year: 2015 ident: 10.1016/j.addr.2021.114097_b0720 article-title: Formulation, optimization, and evaluation of self-emulsifying drug delivery systems of nevirapine publication-title: Int. J. Pharmaceut. Invest. doi: 10.4103/2230-973X.167676 – volume: 8 start-page: 1407 year: 2011 ident: 10.1016/j.addr.2021.114097_b1035 article-title: Solid lipid nanoparticles: an oral bioavailability enhancer vehicle publication-title: Exp. Opin. Drug Deliv. doi: 10.1517/17425247.2011.604311 – volume: 56 year: 2007 ident: 10.1016/j.addr.2021.114097_b0065 article-title: Comparison of an Oral Insulin (Capsulin) and Aetrapid During an Isoglycaemic Clamp Study in Persons with Type 2 Diabetes publication-title: Diabetes – volume: 573 year: 2020 ident: 10.1016/j.addr.2021.114097_b0530 article-title: Hydrophobic H-bond pairing: a novel approach to improve membrane permeability publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2019.118863 – volume: 22 start-page: 871 year: 2014 ident: 10.1016/j.addr.2021.114097_b0895 article-title: Recent approaches of lipid-based delivery system for lymphatic targeting via oral route publication-title: J. Drug Target. doi: 10.3109/1061186X.2014.950664 – volume: 97 start-page: 223 year: 2015 ident: 10.1016/j.addr.2021.114097_b0565 article-title: Effective incorporation of insulin in mucus permeating self-nanoemulsifying drug delivery systems publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2015.04.013 – volume: 192 start-page: 219 year: 2014 ident: 10.1016/j.addr.2021.114097_b0730 article-title: ‘Stealth’lipid-based formulations: Poly (ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug publication-title: J. Control. Release doi: 10.1016/j.jconrel.2014.07.037 – volume: 41 start-page: 376 year: 2010 ident: 10.1016/j.addr.2021.114097_b0740 article-title: Effects of non-ionic surfactants on in vitro triglyceride digestion and their susceptibility to digestion by pancreatic enzymes publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2010.07.005 – volume: 10 start-page: 135 year: 2020 ident: 10.1016/j.addr.2021.114097_b1095 article-title: An overview of micro-and nanoemulsions as vehicles for essential oils: Formulation, preparation and stability publication-title: Nanomaterials doi: 10.3390/nano10010135 – volume: 8 start-page: 7024 year: 2016 ident: 10.1016/j.addr.2021.114097_b0855 article-title: Evidence does not support absorption of intact solid lipid nanoparticles via oral delivery publication-title: Nanoscale doi: 10.1039/C5NR07474F – volume: 415 start-page: 150 year: 2011 ident: 10.1016/j.addr.2021.114097_b1300 article-title: Oral peptide delivery by tetraether lipid liposomes publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2011.05.066 – volume: 10 start-page: 16 year: 2018 ident: 10.1016/j.addr.2021.114097_b1195 article-title: Microemulsion as drug delivery system for Peptides and Proteins publication-title: J. Pharmaceut. Sci. Res. – volume: 152 start-page: 10 year: 2020 ident: 10.1016/j.addr.2021.114097_b0330 article-title: Hydrophobic ion pairing of a GLP-1 analogue for incorporating into lipid nanocarriers designed for oral delivery publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2020.04.025 – volume: 150 start-page: 77 year: 2020 ident: 10.1016/j.addr.2021.114097_b1505 article-title: Phosphorylated PEG-emulsifier: Powerful tool for development of zeta potential changing self-emulsifying drug delivery systems (SEDDS) publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2020.03.004 – volume: 561 start-page: 289 year: 2019 ident: 10.1016/j.addr.2021.114097_b0995 article-title: Cytotoxicity and permeability enhancement of Capmul® MCM in nanoemulsion formulation publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2019.03.010 – volume: 17 start-page: 3129 year: 2020 ident: 10.1016/j.addr.2021.114097_b1420 article-title: Lipophilic arginine esters: The gateway to preservatives without side effects publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.0c00610 – volume: 10 start-page: 1228 year: 1993 ident: 10.1016/j.addr.2021.114097_b1015 article-title: Stability of liposomes in vitro and their uptake by rat Peyer's patches following oral administration publication-title: Pharm Res doi: 10.1023/A:1018936806278 – volume: 124 year: 1971 ident: 10.1016/j.addr.2021.114097_b0835 article-title: Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases publication-title: Biochem. J doi: 10.1042/bj1240058P – volume: 52 start-page: 838 year: 2019 ident: 10.1016/j.addr.2021.114097_b1285 article-title: Preparation and characterization of solid lipid nanoparticles loaded with salmon calcitonin phospholipid complex publication-title: J. Drug Delivery Sci. Technol. doi: 10.1016/j.jddst.2019.05.045 – volume: 6 start-page: 37 year: 2017 ident: 10.1016/j.addr.2021.114097_b1050 article-title: Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery publication-title: Sustain. Chem. Pharm. doi: 10.1016/j.scp.2017.07.002 – volume: 43 start-page: 1694 year: 2017 ident: 10.1016/j.addr.2021.114097_b0425 article-title: Development and in vitro characterization of self-emulsifying drug delivery system (SEDDS) for oral opioid peptide delivery publication-title: Drug Dev. Ind. Pharm. doi: 10.1080/03639045.2017.1338722 – volume: 7 start-page: 520 year: 2013 ident: 10.1016/j.addr.2021.114097_b0030 article-title: Oral insulin delivery: how far are we? publication-title: J. Diabetes Sci. Technol. doi: 10.1177/193229681300700228 – volume: 15 start-page: 745 year: 1998 ident: 10.1016/j.addr.2021.114097_b1025 article-title: Solid lipid nanoparticles in lymph and plasma after duodenal administration to rats publication-title: Pharm. Res. doi: 10.1023/A:1011975120776 – volume: 14 start-page: 14 year: 2021 ident: 10.1016/j.addr.2021.114097_b1460 article-title: Multifunctional Delivery Systems for Peptide Nucleic Acids publication-title: Pharmaceuticals doi: 10.3390/ph14010014 – volume: 173 start-page: 112 year: 2021 ident: 10.1016/j.addr.2021.114097_b0115 article-title: Oral delivery of peptide therapeutics in infants: Challenges and opportunities publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2021.03.011 – volume: 9 start-page: 613 year: 2018 ident: 10.1016/j.addr.2021.114097_b0005 article-title: The discovery of insulin: an important milestone in the history of medicine publication-title: Front. Endocrinol. doi: 10.3389/fendo.2018.00613 – volume: 68 start-page: 535 year: 2008 ident: 10.1016/j.addr.2021.114097_b1270 article-title: Cyclosporine-loaded solid lipid nanoparticles (SLN®): Drug–lipid physicochemical interactions and characterization of drug incorporation publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2007.07.006 – volume: 10 start-page: 203 year: 2018 ident: 10.1016/j.addr.2021.114097_b1170 article-title: Advanced pharmaceutical applications of hot-melt extrusion coupled with fused deposition modelling (FDM) 3D printing for personalised drug delivery publication-title: Pharmaceutics doi: 10.3390/pharmaceutics10040203 – volume: 32 start-page: 1901935 year: 2020 ident: 10.1016/j.addr.2021.114097_b0180 article-title: Oral delivery of biologics for precision medicine publication-title: Adv. Mater. doi: 10.1002/adma.201901935 – volume: 13 year: 2021 ident: 10.1016/j.addr.2021.114097_b0950 article-title: Oral Insulin Delivery by Chitosan Coated Solid Lipid Nanoparticles: Ex vivo and in vivo Studies publication-title: J. Young Pharm. doi: 10.5530/jyp.2021.13.10 – volume: 61 start-page: 6505 year: 2013 ident: 10.1016/j.addr.2021.114097_b0745 article-title: Influence of emulsifier structure on lipid bioaccessibility in oil–water nanoemulsions publication-title: J. Agric. Food. Chem. doi: 10.1021/jf401548r – volume: 15 start-page: 684 year: 2013 ident: 10.1016/j.addr.2021.114097_b0860 article-title: Nonlinear absorption kinetics of self-emulsifying drug delivery systems (SEDDS) containing tocotrienols as lipophilic molecules: in vivo and in vitro studies publication-title: The AAPS journal doi: 10.1208/s12248-013-9481-7 – volume: 26 start-page: 216 year: 2019 ident: 10.1016/j.addr.2021.114097_b1335 article-title: Design of novel proliposome formulation for antioxidant peptide, glutathione with enhanced oral bioavailability and stability publication-title: Drug Deliv. doi: 10.1080/10717544.2018.1551441 – volume: 59 start-page: 478 year: 2007 ident: 10.1016/j.addr.2021.114097_b1245 article-title: Solid lipid nanoparticles as a drug delivery system for peptides and proteins publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2007.04.007 – volume: 157 start-page: 2 year: 2020 ident: 10.1016/j.addr.2021.114097_b0270 article-title: Systemic delivery of peptides by the oral route: formulation and medicinal chemistry approaches publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2020.05.007 – volume: 6 start-page: 1031 year: 2001 ident: 10.1016/j.addr.2021.114097_b0590 article-title: Bilosomes: the answer to oral vaccine delivery? publication-title: Drug Discov. Today doi: 10.1016/S1359-6446(01)02010-4 – volume: 52 start-page: 409 year: 2013 ident: 10.1016/j.addr.2021.114097_b0645 article-title: Edible lipid nanoparticles: digestion, absorption, and potential toxicity publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2013.04.008 – volume: 101 start-page: 108 year: 2016 ident: 10.1016/j.addr.2021.114097_b0025 article-title: Oral delivery of macromolecular drugs: Where we are after almost100 years of attempts publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2016.01.010 – volume: 151 start-page: 1 year: 2020 ident: 10.1016/j.addr.2021.114097_b0475 article-title: About the impact of superassociation of hydrophobic ion pairs on membrane permeability publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2020.03.016 – volume: 104 start-page: 379 year: 2005 ident: 10.1016/j.addr.2021.114097_b1080 article-title: Preparation of plasmid DNA-containing liposomes using a high-pressure homogenization–extrusion technique publication-title: J. Control. Release doi: 10.1016/j.jconrel.2005.02.001 – volume: 9 start-page: 1005 year: 2003 ident: 10.1016/j.addr.2021.114097_b1395 article-title: Interactions of VIP, secretin and PACAP1-38 with phospholipids: a biological paradox revisited publication-title: Curr. Pharm. Des. doi: 10.2174/1381612033455206 – volume: 26 start-page: 1097 year: 2021 ident: 10.1016/j.addr.2021.114097_b0095 article-title: New perspectives in oral peptide delivery publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2021.01.020 – volume: 5 start-page: A515 year: 2021 ident: 10.1016/j.addr.2021.114097_b0170 article-title: One-Year Outcomes of the Open-Label Extension of CHIASMA OPTIMAL, a Phase 3 Study of Oral Octreotide Capsules in Acromegaly publication-title: J. Endocr. Soc. doi: 10.1210/jendso/bvab048.1054 – year: 2021 ident: 10.1016/j.addr.2021.114097_b1435 article-title: Oral delivery of proteins and peptides: Challenges, status quo and future perspectives publication-title: Acta Pharmaceut. Sin. B – volume: 523 start-page: 357 year: 2017 ident: 10.1016/j.addr.2021.114097_b0560 article-title: Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.03.027 – volume: 147 year: 2020 ident: 10.1016/j.addr.2021.114097_b0570 article-title: Evaluation of self-emulsifying drug delivery systems for oral insulin delivery using an in vitro model simulating the intestinal proteolysis publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2020.105272 – volume: 17 start-page: 3202 year: 2020 ident: 10.1016/j.addr.2021.114097_b0660 article-title: Exploring the impact of surfactant type and digestion: Highly digestible surfactants improve oral bioavailability of nilotinib publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.0c00305 – volume: 6 start-page: 2462 year: 2005 ident: 10.1016/j.addr.2021.114097_b0975 article-title: Exploiting the vitamin B12 pathway to enhance oral drug delivery via polymeric micelles publication-title: Biomacromolecules doi: 10.1021/bm0503165 – volume: 97 start-page: 1569 year: 2009 ident: 10.1016/j.addr.2021.114097_b0840 article-title: Selective filtering of particles by the extracellular matrix: an electrostatic bandpass publication-title: Biophys. J. doi: 10.1016/j.bpj.2009.07.009 – volume: 10 start-page: 603 year: 2018 ident: 10.1016/j.addr.2021.114097_b0970 article-title: The stimulation of GLP-1 secretion and delivery of GLP-1 agonists via nanostructured lipid carriers publication-title: Nanoscale doi: 10.1039/C7NR07736J – volume: 271 start-page: 4 year: 1984 ident: 10.1016/j.addr.2021.114097_b0410 article-title: Structural restriction in bile acids and non-ionic detergents for promotion of heparin absorption from rat gastro-intestinal tract publication-title: Archives Internationales de Pharmacodynamie et de Thérapie – volume: 93 start-page: 2476 year: 2004 ident: 10.1016/j.addr.2021.114097_b1385 article-title: In vitro characterization of PEGylated phospholipid micelles for improved drug solubilization: effects of PEG chain length and PC incorporation publication-title: J. Pharm. Sci. doi: 10.1002/jps.20150 – start-page: 113899 year: 2021 ident: 10.1016/j.addr.2021.114097_b0085 article-title: Nanotechnologies for the delivery of biologicals: historical perspective and current landscape publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2021.113899 – volume: 273 start-page: 29 year: 2004 ident: 10.1016/j.addr.2021.114097_b1260 article-title: Preparation and characterization of solid lipid nanoparticles containing peptide publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2003.12.016 – volume: 5 start-page: 127 year: 2020 ident: 10.1016/j.addr.2021.114097_b0120 article-title: Materials for oral delivery of proteins and peptides publication-title: Nat. Rev. Mater. doi: 10.1038/s41578-019-0156-6 – volume: 23 start-page: 1972 year: 2016 ident: 10.1016/j.addr.2021.114097_b0575 article-title: Enhanced oral bioavailability of insulin-loaded solid lipid nanoparticles: pharmacokinetic bioavailability of insulin-loaded solid lipid nanoparticles in diabetic rats publication-title: Drug Delivery – volume: 4 start-page: 141 year: 2007 ident: 10.1016/j.addr.2021.114097_b1440 article-title: Recent advances in protein and peptide drug delivery systems publication-title: Curr. Drug Deliv. doi: 10.2174/156720107780362339 – volume: 106 start-page: 597 year: 2021 ident: 10.1016/j.addr.2021.114097_b0190 article-title: Desmopressin oral lyophilisate in young children: new insights in pharmacokinetics and pharmacodynamics publication-title: Arch. Dis. Child. doi: 10.1136/archdischild-2019-318225 – volume: 37 start-page: 911 year: 1959 ident: 10.1016/j.addr.2021.114097_b0500 article-title: A rapid method of total lipid extraction and purification publication-title: Can. J. Biochem. Physiol. doi: 10.1139/y59-099 – volume: 57 start-page: 169 year: 2005 ident: 10.1016/j.addr.2021.114097_b0055 article-title: Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model publication-title: J. Pharm. Pharmacol. doi: 10.1211/0022357055434 – volume: 490 start-page: 146 year: 2015 ident: 10.1016/j.addr.2021.114097_b0905 article-title: Novel self-nanoemulsifying self-nanosuspension (SNESNS) for enhancing oral bioavailability of diacerein: simultaneous portal blood absorption and lymphatic delivery publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2015.05.039 – volume: 362 start-page: 16 year: 2008 ident: 10.1016/j.addr.2021.114097_b0965 article-title: Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs: III. In vivo oral absorption study publication-title: Int. J. Pharmaceut. doi: 10.1016/j.ijpharm.2008.05.015 – volume: 54 start-page: 128 year: 2020 ident: 10.1016/j.addr.2021.114097_b0285 article-title: Review of drugs approved via the 505 (b)(2) pathway: Uncovering drug development trends and regulatory requirements publication-title: Therap. Innov. Regul. Sci. doi: 10.1007/s43441-019-00036-y – volume: 19 start-page: 1531 year: 2004 ident: 10.1016/j.addr.2021.114097_b0105 article-title: Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover publication-title: J. Bone Miner. Res. doi: 10.1359/JBMR.040715 – volume: 31 start-page: 2420 year: 2014 ident: 10.1016/j.addr.2021.114097_b0640 article-title: Solid lipid particles for oral delivery of peptide and protein drugs II–the digestion of trilaurin protects desmopressin from proteolytic degradation publication-title: Pharm. Res. doi: 10.1007/s11095-014-1337-z – volume: 61 start-page: 363 year: 2013 ident: 10.1016/j.addr.2021.114097_b1190 article-title: Combining two technologies: Multifunctional polymers and self-nanoemulsifying drug delivery system (SNEDDS) for oral insulin administration publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2013.08.002 – volume: 11 start-page: 825 year: 2017 ident: 10.1016/j.addr.2021.114097_b0080 article-title: Oral insulin delivery in a physiologic context publication-title: J. Diabetes Sci. Technol. doi: 10.1177/1932296817691303 – start-page: 155 year: 2019 ident: 10.1016/j.addr.2021.114097_b0705 article-title: The role of excipients in the microstructure of Topical semisolid drug products, The Role of Microstructure in Topical Drug Product Development publication-title: Springer – volume: 582 start-page: 815 year: 2021 ident: 10.1016/j.addr.2021.114097_b0360 article-title: Internal liquid crystal structures in nanocarriers containing drug hydrophobic ion pairs dictate drug release publication-title: J. Colloid Interface Sci. doi: 10.1016/j.jcis.2020.08.045 – volume: 33 start-page: 211 year: 2007 ident: 10.1016/j.addr.2021.114097_b0145 article-title: Cyclosporine A: a review of current oral and intravenous delivery systems publication-title: Drug Dev. Ind. Pharm. doi: 10.1080/03639040601155665 – volume: 132 start-page: 259 year: 1996 ident: 10.1016/j.addr.2021.114097_b1295 article-title: Thymopentin in solid lipid nanoparticles publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(95)04388-8 – volume: 107 start-page: 203 year: 2018 ident: 10.1016/j.addr.2021.114097_b0505 article-title: Transformation of biopharmaceutical classification system class I and III drugs into ionic liquids and lipophilic salts for enhanced developability using lipid formulations publication-title: J. Pharm. Sci. doi: 10.1016/j.xphs.2017.05.019 – volume: 4 start-page: 516 year: 2015 ident: 10.1016/j.addr.2021.114097_b1175 article-title: Lyophilization/freeze drying–a review publication-title: World J. Pharm. Res. – year: 2020 ident: 10.1016/j.addr.2021.114097_b1365 article-title: Pleiotropic effect of Lactoferrin in the prevention and treatment of COVID-19 infection: randomized clinical trial, in vitro and in silico preliminary evidences publication-title: BioRxiv – volume: 93 start-page: 95 year: 2003 ident: 10.1016/j.addr.2021.114097_b0215 article-title: Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems publication-title: J. Control. Release doi: 10.1016/j.jconrel.2003.05.001 – volume: 13 year: 2021 ident: 10.1016/j.addr.2021.114097_b0735 article-title: Nanostructured Lipid Carriers (NLCs) for Oral Peptide Drug Delivery: About the Impact of Surface Decoration publication-title: Pharmaceutics doi: 10.3390/pharmaceutics13081312 – volume: 142 start-page: 91 year: 2019 ident: 10.1016/j.addr.2021.114097_b0020 article-title: SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2018.07.001 – volume: 273 start-page: 21 year: 2018 ident: 10.1016/j.addr.2021.114097_b0370 article-title: Impact of different hydrophobic ion pairs of octreotide on its oral bioavailability in pigs publication-title: J. Control. Release doi: 10.1016/j.jconrel.2018.01.012 – volume: 8 start-page: 207 year: 2011 ident: 10.1016/j.addr.2021.114097_b1075 article-title: Lipid-based oral multiparticulate formulations–advantages, technological advances and industrial applications publication-title: Exp. Opin. Drug Deliv. doi: 10.1517/17425247.2011.547469 – volume: 2 start-page: 82 year: 2012 ident: 10.1016/j.addr.2021.114097_b1375 article-title: Novel nanomicellar formulation approaches for anterior and posterior segment ocular drug delivery publication-title: Rec. Pat. Nanomed. – ident: 10.1016/j.addr.2021.114097_b0430 – volume: 32 start-page: 401 year: 2015 ident: 10.1016/j.addr.2021.114097_b0625 article-title: Oral self-nanoemulsifying peptide drug delivery systems: impact of lipase on drug release publication-title: J. Microencapsul. doi: 10.3109/02652048.2015.1035685 – volume: 340 start-page: 153 year: 2007 ident: 10.1016/j.addr.2021.114097_b0390 article-title: Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: preparation and characterization publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2007.03.009 – volume: 13 start-page: 565 year: 2021 ident: 10.1016/j.addr.2021.114097_b0385 article-title: Development, Characterization, and Ex Vivo Assessment of Elastic Liposomes for Enhancing the Buccal Delivery of Insulin publication-title: Pharmaceutics doi: 10.3390/pharmaceutics13040565 – volume: 73 start-page: 1 year: 2009 ident: 10.1016/j.addr.2021.114097_b0240 article-title: Lipid–an emerging platform for oral delivery of drugs with poor bioavailability publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2009.06.001 – volume: 45 start-page: 89 year: 2000 ident: 10.1016/j.addr.2021.114097_b1065 article-title: Microemulsion-based media as novel drug delivery systems publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/S0169-409X(00)00103-4 – volume: 489 start-page: 237 year: 2015 ident: 10.1016/j.addr.2021.114097_b0440 article-title: Reversible hydrophobic ion-paring complex strategy to minimize acylation of octreotide during long-term delivery from PLGA microparticles publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2015.04.075 – volume: 430 start-page: 216 year: 2012 ident: 10.1016/j.addr.2021.114097_b0865 article-title: Solid lipid nanoparticles as intracellular drug transporters: an investigation of the uptake mechanism and pathway publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2012.03.032 – volume: 70 start-page: 248 year: 2009 ident: 10.1016/j.addr.2021.114097_b0600 article-title: Strategic approaches for improving entrapment of hydrophilic peptide drugs by lipid nanoparticles publication-title: Colloids Surf., B doi: 10.1016/j.colsurfb.2008.12.031 – volume: 14 start-page: 1325 year: 2017 ident: 10.1016/j.addr.2021.114097_b0675 article-title: Lipid-Drug Conjugate for Enhancing Drug Delivery publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.6b01027 – volume: 20 start-page: 813 year: 2012 ident: 10.1016/j.addr.2021.114097_b1085 article-title: Nanostructured lipid carriers system: recent advances in drug delivery publication-title: J. Drug Target. doi: 10.3109/1061186X.2012.716845 – volume: 95 start-page: 667 year: 2006 ident: 10.1016/j.addr.2021.114097_b1125 article-title: Drug encapsulation using supercritical fluid extraction of emulsions publication-title: J. Pharm. Sci. doi: 10.1002/jps.20555 – volume: 99 start-page: 2320 year: 2010 ident: 10.1016/j.addr.2021.114097_b0685 article-title: Self-emulsifying O/W formulations of paclitaxel prepared from mixed nonionic surfactants publication-title: J. Pharm. Sci. doi: 10.1002/jps.21993 – volume: 50 start-page: 965 year: 2012 ident: 10.1016/j.addr.2021.114097_b0100 article-title: The single dose pharmacokinetic profile of a novel oral human parathyroid hormone formulation in healthy postmenopausal women publication-title: Bone doi: 10.1016/j.bone.2012.01.009 – volume: 10 start-page: 386 year: 2015 ident: 10.1016/j.addr.2021.114097_b0665 article-title: Preparation and evaluation of nattokinase-loaded self-double-emulsifying drug delivery system publication-title: Asian J. Pharm. Sci. doi: 10.1016/j.ajps.2015.04.005 – ident: 10.1016/j.addr.2021.114097_b1425 – volume: 115 start-page: 7296 year: 2018 ident: 10.1016/j.addr.2021.114097_b1470 article-title: Ionic liquids for oral insulin delivery publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.1722338115 – volume: 11 start-page: 1337 year: 2016 ident: 10.1016/j.addr.2021.114097_b0810 article-title: Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo publication-title: Nanomedicine doi: 10.2217/nnm-2016-0047 – volume: 12 start-page: 179 year: 2010 ident: 10.1016/j.addr.2021.114097_b0195 article-title: Oral insulin–a review of current status publication-title: Diabetes Obes. Metab. doi: 10.1111/j.1463-1326.2009.01150.x – volume: 536 start-page: 283 year: 2018 ident: 10.1016/j.addr.2021.114097_b0680 article-title: Development of rectal self-emulsifying suspension of a moisture-labile water-soluble drug publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.11.067 – volume: 24 start-page: 440 year: 2019 ident: 10.1016/j.addr.2021.114097_b0070 article-title: A review of non-invasive insulin delivery systems for diabetes therapy in clinical trials over the past decade publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2018.11.010 – volume: 106 start-page: 298 year: 2005 ident: 10.1016/j.addr.2021.114097_b0455 article-title: Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts publication-title: J. Control. Release doi: 10.1016/j.jconrel.2005.05.016 – volume: 12 start-page: 1673 year: 2017 ident: 10.1016/j.addr.2021.114097_b1495 article-title: Mechanism of hepatic targeting via oral administration of DSPE–PEG–cholic acid-modified nanoliposomes publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S125047 – volume: 16 start-page: 4677 year: 2021 ident: 10.1016/j.addr.2021.114097_b0480 article-title: Facilitated Buccal Insulin Delivery via Hydrophobic Ion-Pairing Approach: In vitro and ex vivo Evaluation publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S318092 – volume: 62 start-page: 88 year: 2012 ident: 10.1016/j.addr.2021.114097_b1000 article-title: Contribution of formulation and excipients towards enhanced permeation of curcumin publication-title: Arzneimittelforschung doi: 10.1055/s-0031-1295487 – volume: 29 start-page: 54 year: 1994 ident: 10.1016/j.addr.2021.114097_b0460 article-title: Alteration of colonic absorption by long-chain unsaturated fatty acids: influence of hydroxylation and degree of unsaturation publication-title: Scand. J. Gastroenterol. doi: 10.3109/00365529409090437 – ident: 10.1016/j.addr.2021.114097_b0090 – volume: 105 start-page: 152 year: 2013 ident: 10.1016/j.addr.2021.114097_b1060 article-title: Antibacterial microemulsion prevents sepsis and triggers healing of wound in wistar rats publication-title: Colloids Surf., B doi: 10.1016/j.colsurfb.2013.01.009 – volume: 13 start-page: 459 year: 2021 ident: 10.1016/j.addr.2021.114097_b1185 article-title: Oligonucleotide Delivery across the Caco-2 Monolayer: The Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS) publication-title: Pharmaceutics doi: 10.3390/pharmaceutics13040459 – volume: 61 start-page: 1427 year: 2009 ident: 10.1016/j.addr.2021.114097_b0060 article-title: Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2009.09.006 – volume: 317 start-page: 82 year: 2006 ident: 10.1016/j.addr.2021.114097_b1275 article-title: Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN®) versus drug nanocrystals publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2006.02.045 – volume: 6 start-page: 666 year: 2013 ident: 10.1016/j.addr.2021.114097_b1010 article-title: Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium publication-title: Mucosal Immunol. doi: 10.1038/mi.2013.30 – volume: 10 start-page: 117 year: 2016 ident: 10.1016/j.addr.2021.114097_b0695 article-title: Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol publication-title: Drug Des. Devel. Therapy doi: 10.2147/DDDT.S95905 – volume: 26 year: 2009 ident: 10.1016/j.addr.2021.114097_b1215 article-title: Self-emulsifying drug delivery systems (SEDDS): formulation development, characterization, and applications publication-title: Crit. Rev.™ Therap. Drug Carr. Syst. – volume: 308 start-page: 250 year: 1978 ident: 10.1016/j.addr.2021.114097_b1150 article-title: Preparation and properties of ether-injection liposomes publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.1978.tb22027.x – volume: 36 start-page: 22 year: 2017 ident: 10.1016/j.addr.2021.114097_b0165 article-title: Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles publication-title: Curr. Opin. Pharmacol. doi: 10.1016/j.coph.2017.07.011 – volume: 7 start-page: 863 year: 1990 ident: 10.1016/j.addr.2021.114097_b0260 article-title: Absorption of polyethylene glycols 600 through 2000: the molecular weight dependence of gastrointestinal and nasal absorption publication-title: Pharm. Res. doi: 10.1023/A:1015921101465 – start-page: 1 year: 2021 ident: 10.1016/j.addr.2021.114097_b1320 article-title: A study on chitosan-coated liposomes as a carrier of bovine serum albumin as oral protein drug publication-title: J. Dispersion Sci. Technol. doi: 10.1080/01932691.2020.1773849 – volume: 4 year: 2012 ident: 10.1016/j.addr.2021.114097_b0780 article-title: Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3003453 – volume: 9 start-page: 601 year: 2013 ident: 10.1016/j.addr.2021.114097_b0955 article-title: N-octyl-N-arginine chitosan micelles as an oral delivery system of insulin publication-title: J. Biomed. Nanotechnol. doi: 10.1166/jbn.2013.1572 – volume: 2011 year: 2011 ident: 10.1016/j.addr.2021.114097_b1115 article-title: Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique publication-title: Int. J. Chem. Eng. doi: 10.1155/2011/132435 – volume: 552 start-page: 287 year: 2019 ident: 10.1016/j.addr.2021.114097_b0305 article-title: Arginine-based cationic surfactants: Biodegradable auxiliary agents for the formation of hydrophobic ion pairs with hydrophilic macromolecular drugs publication-title: J. Colloid Interface Sci. doi: 10.1016/j.jcis.2019.05.057 – volume: 9 start-page: e113 year: 2012 ident: 10.1016/j.addr.2021.114097_b0155 article-title: Overcoming poor permeability: translating permeation enhancers for oral peptide delivery publication-title: Drug Discov. Today: Technol. doi: 10.1016/j.ddtec.2011.11.006 – volume: 406 year: 2021 ident: 10.1016/j.addr.2021.114097_b1465 article-title: Multifunctional drug-loaded micelles encapsulated in thermo-sensitive hydrogel for in vivo local cancer treatment: Synergistic effects of anti-vascular and immuno-chemotherapy publication-title: Chem. Eng. J. – volume: 35 start-page: 1 year: 2004 ident: 10.1016/j.addr.2021.114097_b0535 article-title: Separation of amino acids by polymeric reversed micelle extraction publication-title: Sep. Purif. Technol. doi: 10.1016/S1383-5866(03)00092-3 – ident: 10.1016/j.addr.2021.114097_b0365 – volume: 584 start-page: 684 year: 2021 ident: 10.1016/j.addr.2021.114097_b1210 article-title: Solidification of self-emulsifying drug delivery systems (SEDDS): Impact on storage stability of a therapeutic protein publication-title: J. Colloid Interface Sci. doi: 10.1016/j.jcis.2020.11.051 – volume: 2 start-page: 361 year: 1996 ident: 10.1016/j.addr.2021.114097_b0255 article-title: Investigations into the diffusion behaviour of polypeptides in native intestinal mucus with regard to their peroral administration publication-title: Pharm. Pharmacol. Commun. – volume: 52 start-page: 929 year: 2000 ident: 10.1016/j.addr.2021.114097_b0555 article-title: Effect of ion pairing with alkylamines on the in-vitro dermal penetration and local tissue disposition of salicylates publication-title: J. Pharm. Pharmacol. doi: 10.1211/0022357001774813 – volume: 13 start-page: 1503 year: 2016 ident: 10.1016/j.addr.2021.114097_b1500 article-title: Cell-penetrating self-nanoemulsifying drug delivery systems (SNEDDS) for oral gene delivery publication-title: Exp. Opin. Drug Deliv. doi: 10.1080/17425247.2016.1213236 – volume: 255 start-page: 242 year: 2017 ident: 10.1016/j.addr.2021.114097_b0275 article-title: Lipophilic peptide character – What oral barriers fear the most publication-title: J. Control. Release doi: 10.1016/j.jconrel.2017.04.038 – volume: 11 start-page: 1323 year: 2014 ident: 10.1016/j.addr.2021.114097_b0265 article-title: Oral peptide and protein delivery: intestinal obstacles and commercial prospects publication-title: Exp. Opin. Drug Deliv. doi: 10.1517/17425247.2014.917077 – volume: 1798 start-page: 2090 year: 2010 ident: 10.1016/j.addr.2021.114097_b1405 article-title: Specific formation of trypsin-resistant micelles on a hydrophobic peptide observed with Triton X-100 but not with octylglucoside publication-title: Biochim. Biophys. Acta (BBA)-Biomembr. doi: 10.1016/j.bbamem.2010.07.013 – volume: 151 start-page: 73 year: 2020 ident: 10.1016/j.addr.2021.114097_b0485 article-title: Hydrophobic ion pairing (HIP) of (poly) peptide drugs: Benefits and drawbacks of different preparation methods publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2020.04.004 – volume: 8 start-page: 3024 year: 2012 ident: 10.1016/j.addr.2021.114097_b0980 article-title: Simulation of fusion-mediated nanoemulsion interactions with model lipid bilayers publication-title: Soft Matter doi: 10.1039/c2sm25847a |
| SSID | ssj0012760 |
| Score | 2.7036273 |
| SecondaryResourceType | review_article |
| Snippet | [Display omitted]
The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the... The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 114097 |
| SubjectTerms | Administration, Oral Drug Carriers - chemistry Drug Liberation Drug Stability Humans Hydrophobic and Hydrophilic Interactions Intestinal Mucosa - metabolism Lipid-based nanocarriers Liposomes Liposomes - chemistry Micelles Mucus - metabolism Nanoparticle Drug Delivery System - chemistry Nanoparticles - chemistry NLC Oral drug delivery Peptide Hydrolases - metabolism Peptides - administration & dosage Peptides - pharmacokinetics Proteins - administration & dosage Proteins - pharmacokinetics SEDDS Self-emulsifying drug delivery systems SLN Therapeutic peptides |
| Title | Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers |
| URI | https://dx.doi.org/10.1016/j.addr.2021.114097 https://www.ncbi.nlm.nih.gov/pubmed/34999121 https://www.proquest.com/docview/2618520811 |
| Volume | 182 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fSyMxEA6iHPgi6nla75QIhy8a283-jG8iSlVOBRX6FmaTFFbKtnTrQ1_ub7-Z7G57B6cPvi6T3bAzycwk833D2E_p0O84CwKMikWUwFAoZ5QwPZsZ5WTPAJ1D_rpP-i_R7SAerLDLFgtDZZXN3l_v6X63bp50m7_ZnRRF94l4RDA7GcjAX18RojyKUrLys9-LMo9Aph4pTMKCpBvgTF3jhYubOEFlQJS5nvjp_87pveDTO6HrTbbRRI_8op7gFltx5Tb7UveTnG-z48eaiHp-yp-XuKrqlB_zxyVF9fwrsw9TfI11I6rKmPPxkP-Fw-ITqnSxruJQWu6JHIqyOufLU3juAcJUOkVDR8WksILcoeUllOgcp9QGr9phL9dXz5d90fRbEAZX8kyoocyTEFSsDKgIEwlrcxUqo1Igypg0NxD28ggSaa0dYqYhUwkOpVDhFEmG39hqOS7dHuMUhToZugQAorSXQaokSirIsjzLk6DDgvZHa9OQkVNPjJFuq85eNSlHk3J0rZwOO1mMmdRUHB9Kx63-9D8GpdFXfDjuqFW2xpVG1ydQuvFbpTHXzGKJIRTOfre2gsU8QkocAxnsf_Kr39m6JFyFL277wVZn0zd3gNHOLD_05nzI1i5u7vr3fwCs_v7x |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxEB6VIgSXCsqr5WUk1At1k_U-zQ1VVAHaUolUys2atR1pUbSJsukhF347M97dBCTogetqvGvteDwz9jffALxTnvyOdyjR6lQmGU6l9lZLO3SF1V4NLfI55MVlNrpOvkzSyQ6c9rUwDKvs9v52Tw-7dfdk0P3NwaKqBt-ZR4Syk4mKwvVVfgfuJmS-3Mbg5OcG5xGpPJQKs7Rk8a5ypgV5kXUzKaiKmDM3MD_93Tv9K_oMXujsIex14aP42M7wEez4eh_utQ0l1_twdNUyUa-PxXhbWNUciyNxteWoXj8G921Jr3F-xrCMtZhPxW-FWGLBUBfnG4G1E4HJoaqbD2J7DC9ChTBjp3jorFpUTrI_dKLGmrzjkvvgNU_g-uzT-HQku4YL0pIpr6SeqjKLUafaok4ok3Cu1LG2OkfmjMlLi_GwTDBTzrkppRoqV-hJijTOoWT8FHbree2fg-Aw1KvYZ4iY5MMCc61IUmNRlEWZRQcQ9T_a2I6NnJtizEwPO_thWDmGlWNa5RzA-82YRcvFcat02uvP_LGiDDmLW8e97ZVtyNT4_gRrP79pDCWbRaoohqLZP2tXwWYeMWeOkYoO__Orb-D-aHxxbs4_X359AQ8UF1kEpNtL2F0tb_wrCn1W5euwtH8Bc7sAjg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Oral+delivery+of+therapeutic+peptides+and+proteins%3A+Technology+landscape+of+lipid-based+nanocarriers&rft.jtitle=Advanced+drug+delivery+reviews&rft.au=Haddadzadegan%2C+Soheil&rft.au=Dorkoosh%2C+Farid&rft.au=Bernkop-Schn%C3%BCrch%2C+Andreas&rft.date=2022-03-01&rft.pub=Elsevier+B.V&rft.issn=0169-409X&rft.eissn=1872-8294&rft.volume=182&rft_id=info:doi/10.1016%2Fj.addr.2021.114097&rft.externalDocID=S0169409X21004907 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0169-409X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0169-409X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0169-409X&client=summon |