Mitochondrial activator BGP-15 protects sperm quality against oxidative damage and improves embryo developmental competence

• Published in: F&S Science (Online) Vol. 6; no. 1; p. 42
• Main Authors: Gonzalez, Macarena B, McPherson, Nicole O, Connaughton, Haley S, Winstanley, Yasmyn E, Kennedy, David T, Campugan, Carl A, Febbraio, Mark A, Barry, Michael, Rose, Ryan D, Robker, Rebecca L
• Format: Journal Article
• Language: English
• Published: United States 01.02.2025
• Subjects: Animals; Embryonic Development - drug effects; Female; Fertilization in Vitro; Humans; Male; Membrane Potential, Mitochondrial - drug effects; Mice; Mice, Inbred C57BL; Mitochondria - drug effects; Mitochondria - metabolism; Oxidative Stress - drug effects; Sperm Motility - drug effects; Spermatozoa - drug effects; Spermatozoa - metabolism; Aging; spermatozoa; DNA damage; embryonic development; fertility

To study the efficacy of mitochondrial activator BGP-15 to preserve sperm quality and competence against cellular damage. Spermatozoa from mice or humans were treated in vitro with BGP-15, and sperm quality markers were assessed. Spermatozoa from young (8-12 weeks old) or reproductively old (>14...