Yeasts collectively extend the limits of habitable temperatures by secreting glutathione
The conventional view is that high temperatures cause microorganisms to replicate slowly or die. In this view, microorganisms autonomously combat heat-induced damages. However, microorganisms co-exist with each other, which raises the underexplored and timely question of whether microorganisms can c...
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Published in | Nature microbiology Vol. 5; no. 7; pp. 943 - 954 |
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Format | Journal Article |
Language | English |
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Nature Publishing Group
01.07.2020
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Abstract | The conventional view is that high temperatures cause microorganisms to replicate slowly or die. In this view, microorganisms autonomously combat heat-induced damages. However, microorganisms co-exist with each other, which raises the underexplored and timely question of whether microorganisms can cooperatively combat heat-induced damages at high temperatures. Here, we use the budding yeast Saccharomyces cerevisiae to show that cells can help each other and their future generations to survive and replicate at high temperatures. As a consequence, even at the same temperature, a yeast population can exponentially grow, never grow or grow after unpredictable durations (hours to days) of stasis, depending on its population density. Through the same mechanism, yeasts collectively delay and can eventually stop their approach to extinction, with higher population densities stopping faster. These features arise from yeasts secreting and extracellularly accumulating glutathione-a ubiquitous heat-damage-preventing antioxidant. We show that the secretion of glutathione, which eliminates harmful extracellular chemicals, is both necessary and sufficient for yeasts to collectively survive at high temperatures. A mathematical model, which is generally applicable to any cells that cooperatively replicate by secreting molecules, recapitulates all of these features. Our study demonstrates how organisms can cooperatively define and extend the boundaries of life-permitting temperatures. |
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AbstractList | The conventional view is that high temperatures cause microorganisms to replicate slowly or die. In this view, microorganisms autonomously combat heat-induced damages. However, microorganisms co-exist with each other, which raises the underexplored and timely question of whether microorganisms can cooperatively combat heat-induced damages at high temperatures. Here, we use the budding yeast Saccharomyces cerevisiae to show that cells can help each other and their future generations to survive and replicate at high temperatures. As a consequence, even at the same temperature, a yeast population can exponentially grow, never grow or grow after unpredictable durations (hours to days) of stasis, depending on its population density. Through the same mechanism, yeasts collectively delay and can eventually stop their approach to extinction, with higher population densities stopping faster. These features arise from yeasts secreting and extracellularly accumulating glutathione—a ubiquitous heat-damage-preventing antioxidant. We show that the secretion of glutathione, which eliminates harmful extracellular chemicals, is both necessary and sufficient for yeasts to collectively survive at high temperatures. A mathematical model, which is generally applicable to any cells that cooperatively replicate by secreting molecules, recapitulates all of these features. Our study demonstrates how organisms can cooperatively define and extend the boundaries of life-permitting temperatures.Saccharomyces cerevisiae cells work collectively to survive and replicate at high temperatures by secreting glutathione, an antioxidant that mitigates heat-mediated damage to yeast cells. The conventional view is that high temperatures cause microorganisms to replicate slowly or die. In this view, microorganisms autonomously combat heat-induced damages. However, microorganisms co-exist with each other, which raises the underexplored and timely question of whether microorganisms can cooperatively combat heat-induced damages at high temperatures. Here, we use the budding yeast Saccharomyces cerevisiae to show that cells can help each other and their future generations to survive and replicate at high temperatures. As a consequence, even at the same temperature, a yeast population can exponentially grow, never grow or grow after unpredictable durations (hours to days) of stasis, depending on its population density. Through the same mechanism, yeasts collectively delay and can eventually stop their approach to extinction, with higher population densities stopping faster. These features arise from yeasts secreting and extracellularly accumulating glutathione-a ubiquitous heat-damage-preventing antioxidant. We show that the secretion of glutathione, which eliminates harmful extracellular chemicals, is both necessary and sufficient for yeasts to collectively survive at high temperatures. A mathematical model, which is generally applicable to any cells that cooperatively replicate by secreting molecules, recapitulates all of these features. Our study demonstrates how organisms can cooperatively define and extend the boundaries of life-permitting temperatures. |
Author | Youk, Hyun Laman Trip, Diederik S |
Author_xml | – sequence: 1 givenname: Diederik S orcidid: 0000-0001-6635-0626 surname: Laman Trip fullname: Laman Trip, Diederik S organization: Department of Bionanoscience, Delft University of Technology, Delft, the Netherlands – sequence: 2 givenname: Hyun orcidid: 0000-0003-1687-5760 surname: Youk fullname: Youk, Hyun email: h.youk@tudelft.nl, h.youk@tudelft.nl, h.youk@tudelft.nl organization: CIFAR, CIFAR Azrieli Global Scholars Program, Toronto, Ontario, Canada. h.youk@tudelft.nl |
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Cites_doi | 10.1201/9780429258770 10.1038/s41559-018-0535-1 10.1126/science.1242782 10.1073/pnas.94.2.514 10.1002/yea.3209 10.1007/s00253-012-4075-3 10.1038/nature07921 10.1111/j.1365-2958.2012.08085.x 10.1074/jbc.275.18.13259 10.1063/1.4823332 10.1002/j.2050-0416.1977.tb06813.x 10.1016/j.copbio.2011.04.014 10.1042/bj3520071 10.1111/j.1567-1364.2011.00753.x 10.1126/science.aai7825 10.1126/science.1219805 10.1016/0375-9601(92)90325-G 10.1016/j.jchromb.2016.02.015 10.1099/00221287-143-6-1885 10.1128/MMBR.05018-11 10.1073/pnas.1810858115 10.1146/annurev.micro.55.1.165 10.1016/j.febslet.2007.07.002 10.1016/S0021-9258(19)61523-1 10.1038/nprot.2012.016 10.1371/journal.pbio.2000640 10.1016/j.molcel.2010.10.006 10.1016/j.bpj.2010.10.036 10.1091/mbc.12.2.323 10.1091/mbc.e10-11-0906 10.1091/mbc.e04-07-0560 10.1038/nature03842 10.1074/jbc.275.20.15535 10.1007/BF02426954 10.1099/00221287-137-3-637 10.1016/j.talanta.2007.09.028 10.1128/JB.154.3.1222-1226.1983 10.1016/j.gde.2011.10.001 10.1074/jbc.M802908200 10.1073/pnas.93.10.5116 10.1038/emboj.2011.105 10.1091/mbc.11.12.4241 10.7554/eLife.00367 10.1016/0005-2760(89)90312-3 10.1002/(SICI)1097-0061(199812)14:16<1511::AID-YEA356>3.0.CO;2-S 10.1371/journal.pbio.1001122 10.1038/nprot.2006.238 |
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References | 32587374 - Nat Microbiol. 2020 Jul;5(7):883-884 M Dhaoui (704_CR42) 2011; 22 M Mojtahedi (704_CR46) 2016; 14 J Garcia-Ojalvo (704_CR47) 1992; 168 NQ Balaban (704_CR21) 2011; 21 FM Yakes (704_CR27) 1997; 94 704_CR3 704_CR4 K Ghosh (704_CR5) 2010; 99 JH Koschwanez (704_CR11) 2011; 9 L Dai (704_CR44) 2012; 336 C Kumar (704_CR32) 2011; 30 K Sugiyama (704_CR24) 2000; 352 M Thorsen (704_CR36) 2012; 84 CM Grant (704_CR40) 1996; 29 K Richter (704_CR8) 2010; 40 K Sugiyama (704_CR25) 2000; 275 V Bharathi (704_CR19) 2016; 33 P Leuenberger (704_CR6) 2017; 355 C Riccardi (704_CR50) 2006; 1 DJ Jamieson (704_CR30) 1998; 14 DA Charlebois (704_CR20) 2018; 115 T Bilinski (704_CR29) 1989; 1001 704_CR1 RM Walsh (704_CR15) 1977; 83 704_CR2 M Scott (704_CR18) 2011; 22 J Postmus (704_CR14) 2008; 283 MB Toledano (704_CR33) 2007; 581 K Mehdi (704_CR35) 1997; 143 J Gore (704_CR10) 2009; 459 E Dekel (704_CR17) 2005; 436 J Verghese (704_CR7) 2012; 76 AP Gasch (704_CR23) 2000; 11 E Cabiscol (704_CR28) 2000; 275 MT Elskens (704_CR34) 1991; 137 HC Causton (704_CR22) 2001; 12 D Giustarini (704_CR38) 2016; 1019 704_CR45 GG Perrone (704_CR37) 2005; 16 K Kiriyama (704_CR43) 2012; 96 C Trapnell (704_CR49) 2012; 7 H Youk (704_CR48) 2014; 343 B Zechmann (704_CR31) 2011; 11 DA Ratkowsky (704_CR16) 1983; 154 JH Koschwanez (704_CR12) 2013; 2 A Bourbouloux (704_CR41) 2000; 275 MB Miller (704_CR9) 2001; 55 C Ratzke (704_CR13) 2018; 2 AR Araujo (704_CR39) 2008; 74 JF Davidson (704_CR26) 1996; 93 |
References_xml | – ident: 704_CR2 doi: 10.1201/9780429258770 – volume: 2 start-page: 867 year: 2018 ident: 704_CR13 publication-title: Nat. Ecol. Evol. doi: 10.1038/s41559-018-0535-1 contributor: fullname: C Ratzke – volume: 343 start-page: 1242782 year: 2014 ident: 704_CR48 publication-title: Science doi: 10.1126/science.1242782 contributor: fullname: H Youk – volume: 94 start-page: 514 year: 1997 ident: 704_CR27 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.94.2.514 contributor: fullname: FM Yakes – ident: 704_CR3 – volume: 33 start-page: 607 year: 2016 ident: 704_CR19 publication-title: Yeast doi: 10.1002/yea.3209 contributor: fullname: V Bharathi – volume: 96 start-page: 1021 year: 2012 ident: 704_CR43 publication-title: Appl. Microbiol. Biotechnol. doi: 10.1007/s00253-012-4075-3 contributor: fullname: K Kiriyama – volume: 459 start-page: 253 year: 2009 ident: 704_CR10 publication-title: Nature doi: 10.1038/nature07921 contributor: fullname: J Gore – volume: 84 start-page: 1177 year: 2012 ident: 704_CR36 publication-title: Mol. Microbiol. doi: 10.1111/j.1365-2958.2012.08085.x contributor: fullname: M Thorsen – volume: 275 start-page: 13259 year: 2000 ident: 704_CR41 publication-title: J. Biol. Chem. doi: 10.1074/jbc.275.18.13259 contributor: fullname: A Bourbouloux – ident: 704_CR45 doi: 10.1063/1.4823332 – volume: 83 start-page: 169 year: 1977 ident: 704_CR15 publication-title: J. Inst. Brew. doi: 10.1002/j.2050-0416.1977.tb06813.x contributor: fullname: RM Walsh – volume: 22 start-page: 559 year: 2011 ident: 704_CR18 publication-title: Curr. Opin. Biotechnol. doi: 10.1016/j.copbio.2011.04.014 contributor: fullname: M Scott – volume: 352 start-page: 71 year: 2000 ident: 704_CR24 publication-title: Biochem. J. doi: 10.1042/bj3520071 contributor: fullname: K Sugiyama – volume: 11 start-page: 631 year: 2011 ident: 704_CR31 publication-title: FEMS Yeast Res. doi: 10.1111/j.1567-1364.2011.00753.x contributor: fullname: B Zechmann – volume: 355 start-page: eaai7825 year: 2017 ident: 704_CR6 publication-title: Science doi: 10.1126/science.aai7825 contributor: fullname: P Leuenberger – volume: 336 start-page: 1175 year: 2012 ident: 704_CR44 publication-title: Science doi: 10.1126/science.1219805 contributor: fullname: L Dai – volume: 168 start-page: 35 year: 1992 ident: 704_CR47 publication-title: Phys. Lett. A doi: 10.1016/0375-9601(92)90325-G contributor: fullname: J Garcia-Ojalvo – volume: 1019 start-page: 21 year: 2016 ident: 704_CR38 publication-title: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2016.02.015 contributor: fullname: D Giustarini – volume: 143 start-page: 1885 year: 1997 ident: 704_CR35 publication-title: Microbiology doi: 10.1099/00221287-143-6-1885 contributor: fullname: K Mehdi – volume: 76 start-page: 115 year: 2012 ident: 704_CR7 publication-title: Microbiol. Mol. Biol. Rev. doi: 10.1128/MMBR.05018-11 contributor: fullname: J Verghese – volume: 115 start-page: E10797 year: 2018 ident: 704_CR20 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1810858115 contributor: fullname: DA Charlebois – volume: 55 start-page: 165 year: 2001 ident: 704_CR9 publication-title: Annu. Rev. Microbiol doi: 10.1146/annurev.micro.55.1.165 contributor: fullname: MB Miller – volume: 581 start-page: 3598 year: 2007 ident: 704_CR33 publication-title: FEBS Lett. doi: 10.1016/j.febslet.2007.07.002 contributor: fullname: MB Toledano – ident: 704_CR1 – volume: 275 start-page: 27393 year: 2000 ident: 704_CR28 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)61523-1 contributor: fullname: E Cabiscol – volume: 7 start-page: 562 year: 2012 ident: 704_CR49 publication-title: Nat. Protoc. doi: 10.1038/nprot.2012.016 contributor: fullname: C Trapnell – volume: 14 start-page: e2000640 year: 2016 ident: 704_CR46 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.2000640 contributor: fullname: M Mojtahedi – volume: 40 start-page: 253 year: 2010 ident: 704_CR8 publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.10.006 contributor: fullname: K Richter – volume: 99 start-page: 3996 year: 2010 ident: 704_CR5 publication-title: Biophys. J. doi: 10.1016/j.bpj.2010.10.036 contributor: fullname: K Ghosh – volume: 12 start-page: 323 year: 2001 ident: 704_CR22 publication-title: Mol. Biol. Cell doi: 10.1091/mbc.12.2.323 contributor: fullname: HC Causton – volume: 22 start-page: 2054 year: 2011 ident: 704_CR42 publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e10-11-0906 contributor: fullname: M Dhaoui – volume: 16 start-page: 218 year: 2005 ident: 704_CR37 publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e04-07-0560 contributor: fullname: GG Perrone – volume: 436 start-page: 588 year: 2005 ident: 704_CR17 publication-title: Nature doi: 10.1038/nature03842 contributor: fullname: E Dekel – volume: 275 start-page: 15535 year: 2000 ident: 704_CR25 publication-title: J. Biol. Chem. doi: 10.1074/jbc.275.20.15535 contributor: fullname: K Sugiyama – volume: 29 start-page: 511 year: 1996 ident: 704_CR40 publication-title: Curr. Genet. doi: 10.1007/BF02426954 contributor: fullname: CM Grant – volume: 137 start-page: 637 year: 1991 ident: 704_CR34 publication-title: J. Gen. Microbiol. doi: 10.1099/00221287-137-3-637 contributor: fullname: MT Elskens – volume: 74 start-page: 1511 year: 2008 ident: 704_CR39 publication-title: Talanta doi: 10.1016/j.talanta.2007.09.028 contributor: fullname: AR Araujo – ident: 704_CR4 – volume: 154 start-page: 1222 year: 1983 ident: 704_CR16 publication-title: J. Bacteriol. doi: 10.1128/JB.154.3.1222-1226.1983 contributor: fullname: DA Ratkowsky – volume: 21 start-page: 768 year: 2011 ident: 704_CR21 publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2011.10.001 contributor: fullname: NQ Balaban – volume: 283 start-page: 23524 year: 2008 ident: 704_CR14 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M802908200 contributor: fullname: J Postmus – volume: 93 start-page: 5116 year: 1996 ident: 704_CR26 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.93.10.5116 contributor: fullname: JF Davidson – volume: 30 start-page: 2044 year: 2011 ident: 704_CR32 publication-title: EMBO J. doi: 10.1038/emboj.2011.105 contributor: fullname: C Kumar – volume: 11 start-page: 4241 year: 2000 ident: 704_CR23 publication-title: Mol. Biol. Cell doi: 10.1091/mbc.11.12.4241 contributor: fullname: AP Gasch – volume: 2 start-page: e00367 year: 2013 ident: 704_CR12 publication-title: eLife doi: 10.7554/eLife.00367 contributor: fullname: JH Koschwanez – volume: 1001 start-page: 102 year: 1989 ident: 704_CR29 publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2760(89)90312-3 contributor: fullname: T Bilinski – volume: 14 start-page: 1511 year: 1998 ident: 704_CR30 publication-title: Yeast doi: 10.1002/(SICI)1097-0061(199812)14:16<1511::AID-YEA356>3.0.CO;2-S contributor: fullname: DJ Jamieson – volume: 9 start-page: e1001122 year: 2011 ident: 704_CR11 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1001122 contributor: fullname: JH Koschwanez – volume: 1 start-page: 1458 year: 2006 ident: 704_CR50 publication-title: Nat. Protoc. doi: 10.1038/nprot.2006.238 contributor: fullname: C Riccardi |
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SubjectTerms | Antioxidants Biological Transport Cell Proliferation Ecosystem Gene Expression Regulation, Fungal Genes, Fungal Glutathione Glutathione - biosynthesis Heat High temperature Mathematical models Microorganisms Models, Theoretical Population density Saccharomyces cerevisiae Species extinction Temperature Yeast Yeasts - metabolism |
Title | Yeasts collectively extend the limits of habitable temperatures by secreting glutathione |
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