An artificial redox coenzyme based on a triazine dye template

• Published in: Enzyme and microbial technology Vol. 18; no. 8; pp. 570 - 580
• Main Authors: Burton, Steven J., Vivian Stead, C., Ansell, Richard J., Lowe, Christopher R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 1996; Elsevier Science
• Subjects: Biological and medical sciences; Biomimetic coenzyme; Biotechnology; coenzyme analog; Enzyme engineering; Fundamental and applied biological sciences. Psychology; horse liver alcohol dehydrogenase; Methods. Procedures. Technologies; Miscellaneous; triazine dyes; triazine dyes; Biomimetic coenzyme; horse liver alcohol dehydrogenase; coenzyme analog; Dyes; Purification; Enzyme; Liver; Alcohol dehydrogenase; Coenzyme; Vertebrata; Mammalia; Analog; Horse; Triazine derivatives; Nicotinamide; Oxidoreductases; Perissodactyla; Chemical synthesis; Ungulata; Physicochemical properties; Enzymatic reaction

A series of nicotinamide-containing compounds based on the structure of a triazine dye, C.I. Reactive Blue 2, which is known to interact at the coenzyme-binding sites of several NAD(P)(H)-dependent dehydrogenases, 1,2 were designed, synthesized, and characterized. The preparation of these compounds...