Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity

• Published in: Cell metabolism Vol. 35; no. 6; pp. 943 - 960.e9
• Main Authors: Zhang, Qingqing, Zhao, Qing, Li, Tao, Lu, Longya, Wang, Fei, Zhang, Hong, Liu, Zhi, Ma, Huihui, Zhu, Qihui, Wang, Jingjing, Zhang, Xuemei, Pei, Yang, Liu, Qisha, Xu, Yuyu, Qie, Jinlong, Luan, Xiaoting, Hu, Zhibin, Liu, Xingyin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.06.2023
• Subjects: Animals; Carcinogenesis; CD8-Positive T-Lymphocytes; colorectal cancer; Colorectal Neoplasms; Epigenesis, Genetic; epigenetic regulation; ILA; indole-3-lactic acid; Lactobacillus plantarum; Lactobacillus plantarum - physiology; Mice; Lactobacillus plantarum; colorectal cancer; indole-3-lactic acid; epigenetic regulation; ILA

Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-...