Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity
Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-...
Saved in:
| Published in | Cell metabolism Vol. 35; no. 6; pp. 943 - 960.e9 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
06.06.2023
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-lactic acid, ameliorated intestinal inflammation, tumor growth, and gut dysbiosis. Mechanistically, we indicated that indole-3-lactic acid accelerated IL12a production in dendritic cells by enhancing H3K27ac binding at the enhancer regions of IL12a that contributed to priming CD8+ T cell immunity against tumor growth. Furthermore, indole-3-lactic acid was found to transcriptionally inhibit Saa3 expression related to cholesterol metabolism of CD8+ T cells through changing chromatin accessibility and subsequent enhancing function of tumor-infiltrating CD8+ T cells. Together, our findings provide new insights into the epigenetic regulation of probiotics-mediated anti-tumor immunity and suggest the potential of L. plantarum L168 and indole-3-lactic acid to develop therapeutic strategies for patients with CRC.
[Display omitted]
•L. plantarum L168 and its derived ILA ameliorate colorectal tumorigenesis•ILA accelerates IL12a production in DCs to prime anti-tumor immunity of CD8+ T cells•ILA enhances function of CD8+ T cells through epigenetic mechanisms•ILA inhibits expression of Saa3 in CD8+ T cells to reduce tumor growth of CRC
The underlying anti-tumor immune mechanisms for probiotics preventing colorectal cancer remain largely unknown. Zhang et al. report that a strain of probiotics, L. plantarum L168 and its derived metabolite, indole-3-lactic acid, ameliorate colorectal tumorigenesis through contributing to anti-tumor immunity of CD8+ T cell via epigenetic regulation. |
|---|---|
| AbstractList | Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-lactic acid, ameliorated intestinal inflammation, tumor growth, and gut dysbiosis. Mechanistically, we indicated that indole-3-lactic acid accelerated IL12a production in dendritic cells by enhancing H3K27ac binding at the enhancer regions of IL12a that contributed to priming CD8
T cell immunity against tumor growth. Furthermore, indole-3-lactic acid was found to transcriptionally inhibit Saa3 expression related to cholesterol metabolism of CD8
T cells through changing chromatin accessibility and subsequent enhancing function of tumor-infiltrating CD8
T cells. Together, our findings provide new insights into the epigenetic regulation of probiotics-mediated anti-tumor immunity and suggest the potential of L. plantarum L168 and indole-3-lactic acid to develop therapeutic strategies for patients with CRC. Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-lactic acid, ameliorated intestinal inflammation, tumor growth, and gut dysbiosis. Mechanistically, we indicated that indole-3-lactic acid accelerated IL12a production in dendritic cells by enhancing H3K27ac binding at the enhancer regions of IL12a that contributed to priming CD8+ T cell immunity against tumor growth. Furthermore, indole-3-lactic acid was found to transcriptionally inhibit Saa3 expression related to cholesterol metabolism of CD8+ T cells through changing chromatin accessibility and subsequent enhancing function of tumor-infiltrating CD8+ T cells. Together, our findings provide new insights into the epigenetic regulation of probiotics-mediated anti-tumor immunity and suggest the potential of L. plantarum L168 and indole-3-lactic acid to develop therapeutic strategies for patients with CRC.Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-lactic acid, ameliorated intestinal inflammation, tumor growth, and gut dysbiosis. Mechanistically, we indicated that indole-3-lactic acid accelerated IL12a production in dendritic cells by enhancing H3K27ac binding at the enhancer regions of IL12a that contributed to priming CD8+ T cell immunity against tumor growth. Furthermore, indole-3-lactic acid was found to transcriptionally inhibit Saa3 expression related to cholesterol metabolism of CD8+ T cells through changing chromatin accessibility and subsequent enhancing function of tumor-infiltrating CD8+ T cells. Together, our findings provide new insights into the epigenetic regulation of probiotics-mediated anti-tumor immunity and suggest the potential of L. plantarum L168 and indole-3-lactic acid to develop therapeutic strategies for patients with CRC. Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-lactic acid, ameliorated intestinal inflammation, tumor growth, and gut dysbiosis. Mechanistically, we indicated that indole-3-lactic acid accelerated IL12a production in dendritic cells by enhancing H3K27ac binding at the enhancer regions of IL12a that contributed to priming CD8+ T cell immunity against tumor growth. Furthermore, indole-3-lactic acid was found to transcriptionally inhibit Saa3 expression related to cholesterol metabolism of CD8+ T cells through changing chromatin accessibility and subsequent enhancing function of tumor-infiltrating CD8+ T cells. Together, our findings provide new insights into the epigenetic regulation of probiotics-mediated anti-tumor immunity and suggest the potential of L. plantarum L168 and indole-3-lactic acid to develop therapeutic strategies for patients with CRC. [Display omitted] •L. plantarum L168 and its derived ILA ameliorate colorectal tumorigenesis•ILA accelerates IL12a production in DCs to prime anti-tumor immunity of CD8+ T cells•ILA enhances function of CD8+ T cells through epigenetic mechanisms•ILA inhibits expression of Saa3 in CD8+ T cells to reduce tumor growth of CRC The underlying anti-tumor immune mechanisms for probiotics preventing colorectal cancer remain largely unknown. Zhang et al. report that a strain of probiotics, L. plantarum L168 and its derived metabolite, indole-3-lactic acid, ameliorate colorectal tumorigenesis through contributing to anti-tumor immunity of CD8+ T cell via epigenetic regulation. |
| Author | Pei, Yang Zhao, Qing Liu, Zhi Wang, Jingjing Hu, Zhibin Zhang, Hong Zhang, Xuemei Xu, Yuyu Zhang, Qingqing Lu, Longya Li, Tao Wang, Fei Liu, Qisha Zhu, Qihui Qie, Jinlong Ma, Huihui Liu, Xingyin Luan, Xiaoting |
| Author_xml | – sequence: 1 givenname: Qingqing surname: Zhang fullname: Zhang, Qingqing organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 2 givenname: Qing surname: Zhao fullname: Zhao, Qing organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 3 givenname: Tao surname: Li fullname: Li, Tao organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 4 givenname: Longya surname: Lu fullname: Lu, Longya organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 5 givenname: Fei surname: Wang fullname: Wang, Fei organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 6 givenname: Hong surname: Zhang fullname: Zhang, Hong organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 7 givenname: Zhi surname: Liu fullname: Liu, Zhi organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 8 givenname: Huihui surname: Ma fullname: Ma, Huihui organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 9 givenname: Qihui surname: Zhu fullname: Zhu, Qihui organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 10 givenname: Jingjing surname: Wang fullname: Wang, Jingjing organization: State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China – sequence: 11 givenname: Xuemei surname: Zhang fullname: Zhang, Xuemei organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 12 givenname: Yang surname: Pei fullname: Pei, Yang organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 13 givenname: Qisha surname: Liu fullname: Liu, Qisha organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 14 givenname: Yuyu surname: Xu fullname: Xu, Yuyu organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 15 givenname: Jinlong surname: Qie fullname: Qie, Jinlong organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 16 givenname: Xiaoting surname: Luan fullname: Luan, Xiaoting organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China – sequence: 17 givenname: Zhibin surname: Hu fullname: Hu, Zhibin organization: State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China – sequence: 18 givenname: Xingyin orcidid: 0000-0001-8770-3494 surname: Liu fullname: Liu, Xingyin email: xingyinliu@njmu.edu.cn organization: Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37192617$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUtqHDEQhkVwiB_JBbIIWgZMd0ot9UOQTZg8YSAbZy1q1NVGg7o1kdQDvkMOkbPkZO722JssvFIJvq-oqv-SnU1hIsbeCigFiObDvrQj5bKCSpagShD1C3YhtKyKVlVwttR1DYUSUpyzy5T2ALKRWr5i57IVumpEe8H-bNHmsEPrvJ8TP3icMsZ5LHqK7kg9d1MfPBWy8AvoLF_InuNI3oWImRK3wYdINqPneR5DdLc0UXKJHx1yOjx8VzHS7ewxuzDxMPDN5-6a3_z7a8l77sZxnly-e81eDugTvXl8r9ivr19uNt-L7c9vPzaftoVVALnQHSoEKVG2rRCwg6ZB0CTU0ClLVUP10KCGurNDjzXKWmltAZWGHqpeV_KKvT_1PcTwe6aUzejSOglOFOZkqk6oTshWygV994jOu5F6c4huxHhnni64AN0JsDGkFGkw1uWHNXNE540As4Zl9mYNy6xhGVBmCWtRq__Up-7PSh9PEi0HOjqKJllHk6XerSmYPrjn9HucG7Ab |
| CitedBy_id | crossref_primary_10_1016_j_gendis_2025_101592 crossref_primary_10_2147_JIR_S458881 crossref_primary_10_1002_mef2_70006 crossref_primary_10_1016_j_ecoenv_2024_116912 crossref_primary_10_1016_j_micres_2024_127871 crossref_primary_10_1093_procel_pwad052 crossref_primary_10_1038_s41467_025_57071_7 crossref_primary_10_1016_j_foodchem_2024_139798 crossref_primary_10_1186_s13020_024_00991_1 crossref_primary_10_1039_D4FO04790G crossref_primary_10_1016_j_molcel_2023_10_019 crossref_primary_10_1016_j_tem_2024_06_016 crossref_primary_10_3390_nu16213587 crossref_primary_10_1128_msystems_00043_25 crossref_primary_10_1002_hed_27917 crossref_primary_10_3389_fimmu_2024_1449912 crossref_primary_10_1038_s41392_023_01693_0 crossref_primary_10_1021_acs_jafc_4c02868 crossref_primary_10_1039_D3CS00655G crossref_primary_10_1080_87559129_2024_2414908 crossref_primary_10_1080_19490976_2024_2447819 crossref_primary_10_3390_ijms25158250 crossref_primary_10_1016_j_eng_2024_08_005 crossref_primary_10_1182_blood_2024024219 crossref_primary_10_1021_acs_jafc_3c06183 crossref_primary_10_1016_j_lfs_2025_123557 crossref_primary_10_1016_j_isci_2023_108279 crossref_primary_10_1007_s11427_024_2831_x crossref_primary_10_1016_j_exger_2023_112319 crossref_primary_10_3390_microorganisms11092363 crossref_primary_10_3390_ijms25105083 crossref_primary_10_4240_wjgs_v16_i4_1008 crossref_primary_10_1080_20002297_2024_2411815 crossref_primary_10_1002_ctm2_70093 crossref_primary_10_3389_fimmu_2025_1542157 crossref_primary_10_1007_s12032_024_02480_9 crossref_primary_10_1186_s12951_024_02447_y crossref_primary_10_3389_fimmu_2024_1472772 crossref_primary_10_1007_s11427_023_2634_7 crossref_primary_10_1136_gutjnl_2024_333530 crossref_primary_10_1016_j_envint_2025_109258 crossref_primary_10_1038_s41392_024_02030_9 crossref_primary_10_1016_j_cofs_2024_101241 crossref_primary_10_1016_j_lwt_2025_117551 crossref_primary_10_1186_s40164_024_00575_7 crossref_primary_10_4252_wjsc_v16_i12_1110 crossref_primary_10_3892_ijo_2024_5661 crossref_primary_10_1016_j_celrep_2024_114798 crossref_primary_10_1016_j_fbio_2024_103758 crossref_primary_10_1016_j_ijfoodmicro_2024_110686 crossref_primary_10_1080_19490976_2024_2409209 crossref_primary_10_1080_19490976_2024_2427311 crossref_primary_10_1016_j_intimp_2024_112169 crossref_primary_10_3389_fgene_2024_1382502 crossref_primary_10_3390_biom14121646 crossref_primary_10_53469_jcmp_2024_06_09__27 crossref_primary_10_1016_j_coi_2025_102537 crossref_primary_10_1021_acs_jafc_4c01166 crossref_primary_10_1038_s41420_025_02366_3 crossref_primary_10_1007_s00203_024_04082_5 crossref_primary_10_1080_10408398_2024_2448562 crossref_primary_10_12677_HJFNS_2024_131018 crossref_primary_10_1002_adhm_202400856 crossref_primary_10_1016_j_identj_2024_02_007 crossref_primary_10_1134_S1990750824600766 crossref_primary_10_1038_s41522_024_00520_w crossref_primary_10_1080_10408398_2024_2387765 crossref_primary_10_1186_s12967_024_04955_9 crossref_primary_10_3390_nu15194159 crossref_primary_10_1002_cac2_12597 crossref_primary_10_1021_acsnano_4c15237 crossref_primary_10_1038_s41598_025_87105_5 crossref_primary_10_1038_s41467_025_57581_4 crossref_primary_10_1039_D3FO04806C crossref_primary_10_1080_19490976_2024_2347722 crossref_primary_10_1016_j_canlet_2024_216837 crossref_primary_10_1016_j_micres_2025_128136 crossref_primary_10_3389_fimmu_2025_1526967 crossref_primary_10_1097_CM9_0000000000002955 crossref_primary_10_4240_wjgs_v17_i2_97503 crossref_primary_10_1016_j_micres_2024_127668 crossref_primary_10_1038_s41598_024_68412_9 crossref_primary_10_1007_s10495_024_02052_2 crossref_primary_10_1016_j_cels_2024_11_010 crossref_primary_10_1186_s12967_025_06287_8 crossref_primary_10_1016_j_advnut_2025_100412 crossref_primary_10_1002_advs_202412865 crossref_primary_10_4251_wjgo_v16_i6_2697 crossref_primary_10_3389_fcimb_2024_1409464 crossref_primary_10_1016_j_celrep_2024_114891 crossref_primary_10_1016_j_ijbiomac_2025_139929 crossref_primary_10_1038_s41556_023_01314_6 crossref_primary_10_3390_biomedicines13020526 crossref_primary_10_1016_j_foodres_2024_115212 crossref_primary_10_1080_19490976_2024_2431643 crossref_primary_10_3389_fimmu_2024_1487242 crossref_primary_10_1016_j_placenta_2025_03_014 crossref_primary_10_1016_j_phrs_2024_107148 crossref_primary_10_3389_fmicb_2024_1301073 crossref_primary_10_1016_j_molmet_2024_102090 crossref_primary_10_1039_D3FO04807A crossref_primary_10_1016_j_mucimm_2025_01_011 crossref_primary_10_3389_fimmu_2023_1290414 crossref_primary_10_1016_j_tifs_2023_06_013 crossref_primary_10_1016_j_scitotenv_2024_174298 crossref_primary_10_3390_pr12020316 crossref_primary_10_1111_cas_16238 crossref_primary_10_1021_acs_jafc_4c03087 crossref_primary_10_1073_pnas_2309032120 crossref_primary_10_1111_jcmm_70358 crossref_primary_10_1016_j_canlet_2024_217117 crossref_primary_10_1016_j_phymed_2024_156122 crossref_primary_10_3390_ani14111640 crossref_primary_10_1080_29933935_2025_2454002 crossref_primary_10_1016_j_canlet_2024_217123 crossref_primary_10_34133_jbioxresearch_0028 crossref_primary_10_1002_smll_202302702 crossref_primary_10_1038_s41417_023_00715_x crossref_primary_10_1007_s00203_023_03737_z crossref_primary_10_1016_j_cytogfr_2024_10_007 crossref_primary_10_1021_acs_jafc_4c01622 crossref_primary_10_1186_s13071_024_06349_8 crossref_primary_10_1097_XCS_0000000000001299 crossref_primary_10_1007_s12602_025_10498_2 crossref_primary_10_1039_D3FO05452G crossref_primary_10_1038_s44321_024_00177_0 crossref_primary_10_1186_s13059_024_03373_w crossref_primary_10_3390_foods13172648 crossref_primary_10_3389_fimmu_2024_1456030 crossref_primary_10_1016_j_bonr_2024_101809 crossref_primary_10_1080_10408398_2023_2291188 crossref_primary_10_1016_j_canlet_2024_217113 crossref_primary_10_1038_s41467_024_51624_y crossref_primary_10_2217_epi_2023_0382 crossref_primary_10_1016_j_tips_2024_07_006 crossref_primary_10_3390_biomedicines12102360 crossref_primary_10_1016_j_ijbiomac_2025_140334 crossref_primary_10_1186_s12885_024_11982_8 crossref_primary_10_1002_cam4_70703 crossref_primary_10_1016_j_matt_2024_01_031 |
| Cites_doi | 10.1136/gut.52.5.713 10.1101/cshperspect.a000034 10.1038/s41467-021-24331-1 10.1016/j.celrep.2021.108706 10.1136/gutjnl-2019-318374 10.1146/annurev.immunol.26.021607.090400 10.7554/eLife.72171 10.1093/nar/gku864 10.1038/s41564-019-0541-3 10.1016/j.cell.2014.03.011 10.1038/s41586-020-2604-2 10.1016/j.chom.2019.02.003 10.1371/journal.pone.0108564 10.1016/j.jaut.2017.03.009 10.1016/j.cmet.2019.04.002 10.1016/j.smim.2017.08.009 10.1002/cti2.1213 10.1038/s41587-019-0209-9 10.1093/nar/gku365 10.1101/gad.399506 10.1016/j.cgh.2018.07.012 10.1093/bioinformatics/bts034 10.1136/gutjnl-2021-326789 10.1093/bioinformatics/btp616 10.1016/j.cell.2019.11.026 10.1038/jhg.2013.66 10.1038/s41591-019-0458-7 10.1093/bioinformatics/btp352 10.1093/nar/gkt214 10.1093/bioinformatics/btq033 10.1016/j.semcancer.2019.05.001 10.1038/nri.2016.42 10.1016/j.celrep.2020.01.035 10.1038/nmeth.1923 10.1093/bioinformatics/bts635 10.1126/science.1241165 10.1038/nrgastro.2014.66 10.1186/gb-2008-9-9-r137 10.1080/1040841X.2016.1179622 10.1038/s41577-019-0210-z 10.1093/bioinformatics/bty560 10.1016/j.cell.2017.06.016 10.1126/science.aac4255 10.1016/j.immuni.2022.07.016 10.1186/s13059-021-02466-0 10.1016/j.bone.2020.115471 10.1093/nsr/nwy160 10.3389/fnut.2021.693412 10.1136/gutjnl-2020-323951 10.1021/ac1003568 10.1080/19490976.2020.1785803 10.1093/mp/sst080 10.1093/bioinformatics/btu638 10.1038/s41598-021-87353-1 10.3389/fimmu.2021.670540 10.1016/j.cell.2015.06.001 10.1073/pnas.1813565116 10.1111/brv.12765 10.1093/nar/gkv007 10.1158/1940-6207.CAPR-16-0124 10.1093/nar/gkab520 10.1016/j.smim.2017.09.006 10.1038/ng.3510 10.1038/nmeth.3317 10.1042/BSR20211558 10.1093/annonc/mdr155 10.3390/ijms22136933 10.1038/nprot.2007.315 10.1080/10408398.2021.1944974 |
| ContentType | Journal Article |
| Copyright | 2023 Elsevier Inc. Copyright © 2023 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2023 Elsevier Inc. – notice: Copyright © 2023 Elsevier Inc. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.cmet.2023.04.015 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1932-7420 |
| EndPage | 960.e9 |
| ExternalDocumentID | 37192617 10_1016_j_cmet_2023_04_015 S1550413123001419 |
| Genre | Journal Article |
| GroupedDBID | --- --K 0R~ 1~5 29B 4.4 457 4G. 5GY 62- 6J9 7-5 AACTN AAEDW AAFTH AAIAV AAKRW AAKUH AALRI AAUCE AAVLU AAXUO ABJNI ABMAC ABMWF ABVKL ACGFO ACGFS ADBBV ADEZE ADJPV AEFWE AENEX AFTJW AGKMS AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL CS3 DIK DU5 E3Z EBS F5P FCP FDB FEDTE FIRID HVGLF IHE IXB J1W JIG M3Z M41 O-L O9- OK1 P2P RCE ROL RPZ SES TR2 UNMZH ZA5 2WC 53G AAEDT AAIKJ AAMRU AAYWO AAYXX ABDGV ACVFH ADCNI ADVLN AEUPX AEXQZ AFPUW AGCQF AGHFR AIGII AKAPO AKBMS AKRWK AKYEP APXCP CITATION EJD HZ~ OZT RIG SSZ CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c400t-98a4a033a377110b066a09e14f84ce26e5f6a9058cfda5a35499c0a490d02d923 |
| IEDL.DBID | IXB |
| ISSN | 1550-4131 1932-7420 |
| IngestDate | Fri Jul 11 03:06:57 EDT 2025 Thu Apr 03 07:03:09 EDT 2025 Tue Jul 01 03:58:21 EDT 2025 Thu Apr 24 23:02:30 EDT 2025 Fri Feb 23 02:37:19 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Lactobacillus plantarum colorectal cancer indole-3-lactic acid epigenetic regulation ILA |
| Language | English |
| License | Copyright © 2023 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c400t-98a4a033a377110b066a09e14f84ce26e5f6a9058cfda5a35499c0a490d02d923 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-8770-3494 |
| OpenAccessLink | http://www.cell.com/article/S1550413123001419/pdf |
| PMID | 37192617 |
| PQID | 2814813733 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2814813733 pubmed_primary_37192617 crossref_citationtrail_10_1016_j_cmet_2023_04_015 crossref_primary_10_1016_j_cmet_2023_04_015 elsevier_sciencedirect_doi_10_1016_j_cmet_2023_04_015 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-06-06 |
| PublicationDateYYYYMMDD | 2023-06-06 |
| PublicationDate_xml | – month: 06 year: 2023 text: 2023-06-06 day: 06 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cell metabolism |
| PublicationTitleAlternate | Cell Metab |
| PublicationYear | 2023 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Langmead, Salzberg (bib56) 2012; 9 Kimura (bib29) 2013; 58 Ritchie, Phipson, Wu, Hu, Law, Shi, Smyth (bib50) 2015; 43 Arkan (bib7) 2017; 32 Guo, Akan, Luo, Lin (bib25) 2023; 63 Thomas, Denu (bib27) 2021; 10 Den Hartigh, Wang, Goodspeed, Ding, Averill, Subramanian, Wietecha, O'Brien, Chait (bib37) 2014; 9 Bolyen, Rideout, Dillon, Bokulich, Abnet, Al-Ghalith, Alexander, Alm, Arumugam, Asnicar (bib47) 2019; 37 Tamura, Yanai, Savitsky, Taniguchi (bib32) 2008; 26 Boettger, Salem, Handsaker, Peloso, Kathiresan, Hirschhorn, McCarroll (bib45) 2016; 48 Du, Tang, Yuan (bib30) 2020; 45 Gapa, Alfardus, Fischle (bib42) 2022; 42 Zheng, Wu, Song, Ogino, Fuchs, Chan, Giovannucci, Cao, Zhang (bib14) 2020; 69 Dulai, Sandborn, Gupta (bib18) 2016; 9 Leek, Johnson, Parker, Jaffe, Storey (bib62) 2012; 28 Ma, Bi, Lu, Su, Huang, Liu, Wang, Yang, Kalady, Qian (bib36) 2019; 30 Chen, Gong, Guo, Wang, Zhang, Liu, Yu, Xiong, Luo (bib70) 2013; 6 Hill, Guarner, Reid, Gibson, Merenstein, Pot, Morelli, Canani, Flint, Salminen (bib5) 2014; 11 Yang, Jin, Yang, Sun, Wu, Shen, Hong, Li, Lu, Cao (bib65) 2022; 55 Li, Elmén, Segota, Xian, Tinoco, Feng, Fujita, Segura Muñoz, Schmaltz, Bradley (bib8) 2020; 30 Liao, Smyth, Shi (bib49) 2013; 41 Leek (bib61) 2014; 42 Luu, Riester, Baldrich, Reichardt, Yuille, Busetti, Klein, Wempe, Leister, Raifer (bib15) 2021; 12 Rooks, Garrett (bib20) 2016; 16 Yachida, Mizutani, Shiroma, Shiba, Nakajima, Sakamoto, Watanabe, Masuda, Nishimoto, Kubo (bib4) 2019; 25 Wu, Hashimoto-Hill, Woo, Eshleman, Whitt, Engleman, Karns, Denson, Haslam, Alenghat (bib16) 2020; 586 Jia, Wu, Han, Fu, Luo, Guo, Su, Du, Liu (bib12) 2020; 9 Wculek, Cueto, Mujal, Melero, Krummel, Sancho (bib24) 2020; 20 Nadeem, Kumar, Al-Abbasi, Kamal, Anwar (bib3) 2020; 64 Lee, Hall, Kroehling, Wu, Najar, Nguyen, Lin, Yeung, Silva, Li (bib69) 2020; 180 Song, Chan (bib2) 2019; 17 Oh, Lee, Kim, Kim, Lee (bib10) 2020; 12 Li, Handsaker, Wysoker, Fennell, Ruan, Homer, Marth, Abecasis, Durbin (bib51) 2009; 25 Robinson, McCarthy, Smyth (bib60) 2010; 26 Belkaid, Hand (bib23) 2014; 157 Alharbi, Schmitz, Bailey, Rasko (bib43) 2021; 49 Long, Wong, Tong, Chu, Ho Szeto, Go, Coker, Chan, Chan, Sung, Yu (bib68) 2019; 4 Sivan, Corrales, Hubert, Williams, Aquino-Michaels, Earley, Benyamin, Lei, Jabri, Alegre (bib11) 2015; 350 Kurotaki, Yoshida, Tamura (bib33) 2020; 138 Quinlan, Hall (bib57) 2010; 26 Dobin, Davis, Schlesinger, Drenkow, Zaleski, Jha, Batut, Chaisson, Gingeras (bib48) 2013; 29 Nirschl, Suárez-Fariñas, Izar, Prakadan, Dannenfelser, Tirosh, Liu, Zhu, Devi, Carroll (bib64) 2017; 170 Wu, Wang, Wan, Yao, Yuan (bib39) 2021; 22 Kumar, Lee, Lee (bib22) 2021; 96 Smith, Howitt, Panikov, Michaud, Gallini, Bohlooly-Y, Glickman, Garrett (bib41) 2013; 341 Ramírez, Dündar, Diehl, Grüning, Manke (bib53) 2014; 42 Chen, Sun, Zhang (bib40) 2017; 83 Zhang, Liu, Meyer, Eeckhoute, Johnson, Bernstein, Nusbaum, Myers, Brown, Li, Liu (bib52) 2008; 9 Jacobs, Gebel, Heger, Grèze, Schild, Dudziak, Ullrich (bib46) 2021; 12 Zhao, Zhong, Liu, Wang, Gao (bib34) 2021; 8 Chen, Luan, Liu, Wang, Chang, Snijders, Mao, Secombe, Dan, Chen (bib17) 2019; 25 Kim, Langmead, Salzberg (bib58) 2015; 12 Fraga, Clowers, Moore, Zink (bib55) 2010; 82 Ngo, Chen, Zhang, Whitaker, Wang, Wang (bib28) 2019; 116 Hu, La Vecchia, de Groh, Negri, Morrison, Mery (bib35) 2012; 23 Xu, Wang, Wright, Hyle, Zhang, Shao, Niu, Fan, Rosikiewicz, Djekidel (bib38) 2021; 22 de Vos, Tilg, Van Hul, Cani (bib19) 2022; 71 Weigmann, Tubbe, Seidel, Nicolaev, Becker, Neurath (bib63) 2007; 2 Sun, Chen, Fang (bib26) 2019; 6 Anders, Pyl, Huber (bib59) 2015; 31 Saber, Alipour, Faghfoori, Yari Khosroushahi (bib6) 2017; 43 Chen, Zhou, Chen, Gu (bib54) 2018; 34 Huang, Cho, Meng, Walker (bib21) 2021; 11 Kihara, de la Fuente, Fujino, Takahashi, Pappas, Mantyh (bib66) 2003; 52 Oeckinghaus, Ghosh (bib31) 2009; 1 Chen, Pitmon, Wang (bib1) 2017; 32 Han, Song, Hu, Fu, Feng, Mu, Xing, Wang, Wang, Zhang (bib9) 2021; 34 Man, Zhu, Zhu, Liu, Karki, Malik, Sharma, Li, Malireddi, Gurung (bib67) 2015; 162 Sugimura, Li, Chu, Lau, Fong, Liu, Liang, Nakatsu, Su, Coker (bib13) 2021; 71 Splinter, Heath, Kooren, Palstra, Klous, Grosveld, Galjart, de Laat (bib44) 2006; 20 Xu (10.1016/j.cmet.2023.04.015_bib38) 2021; 22 Splinter (10.1016/j.cmet.2023.04.015_bib44) 2006; 20 Guo (10.1016/j.cmet.2023.04.015_bib25) 2023; 63 Zhao (10.1016/j.cmet.2023.04.015_bib34) 2021; 8 Liao (10.1016/j.cmet.2023.04.015_bib49) 2013; 41 Zhang (10.1016/j.cmet.2023.04.015_bib52) 2008; 9 Kim (10.1016/j.cmet.2023.04.015_bib58) 2015; 12 Man (10.1016/j.cmet.2023.04.015_bib67) 2015; 162 Thomas (10.1016/j.cmet.2023.04.015_bib27) 2021; 10 Hu (10.1016/j.cmet.2023.04.015_bib35) 2012; 23 Fraga (10.1016/j.cmet.2023.04.015_bib55) 2010; 82 Huang (10.1016/j.cmet.2023.04.015_bib21) 2021; 11 Lee (10.1016/j.cmet.2023.04.015_bib69) 2020; 180 Anders (10.1016/j.cmet.2023.04.015_bib59) 2015; 31 Tamura (10.1016/j.cmet.2023.04.015_bib32) 2008; 26 Chen (10.1016/j.cmet.2023.04.015_bib17) 2019; 25 Kimura (10.1016/j.cmet.2023.04.015_bib29) 2013; 58 Long (10.1016/j.cmet.2023.04.015_bib68) 2019; 4 Wculek (10.1016/j.cmet.2023.04.015_bib24) 2020; 20 Weigmann (10.1016/j.cmet.2023.04.015_bib63) 2007; 2 Ramírez (10.1016/j.cmet.2023.04.015_bib53) 2014; 42 Chen (10.1016/j.cmet.2023.04.015_bib1) 2017; 32 Yachida (10.1016/j.cmet.2023.04.015_bib4) 2019; 25 Sugimura (10.1016/j.cmet.2023.04.015_bib13) 2021; 71 Gapa (10.1016/j.cmet.2023.04.015_bib42) 2022; 42 Arkan (10.1016/j.cmet.2023.04.015_bib7) 2017; 32 Kurotaki (10.1016/j.cmet.2023.04.015_bib33) 2020; 138 de Vos (10.1016/j.cmet.2023.04.015_bib19) 2022; 71 Langmead (10.1016/j.cmet.2023.04.015_bib56) 2012; 9 Jacobs (10.1016/j.cmet.2023.04.015_bib46) 2021; 12 Luu (10.1016/j.cmet.2023.04.015_bib15) 2021; 12 Quinlan (10.1016/j.cmet.2023.04.015_bib57) 2010; 26 Oh (10.1016/j.cmet.2023.04.015_bib10) 2020; 12 Dobin (10.1016/j.cmet.2023.04.015_bib48) 2013; 29 Smith (10.1016/j.cmet.2023.04.015_bib41) 2013; 341 Nirschl (10.1016/j.cmet.2023.04.015_bib64) 2017; 170 Chen (10.1016/j.cmet.2023.04.015_bib54) 2018; 34 Sun (10.1016/j.cmet.2023.04.015_bib26) 2019; 6 Nadeem (10.1016/j.cmet.2023.04.015_bib3) 2020; 64 Kumar (10.1016/j.cmet.2023.04.015_bib22) 2021; 96 Han (10.1016/j.cmet.2023.04.015_bib9) 2021; 34 Chen (10.1016/j.cmet.2023.04.015_bib40) 2017; 83 Li (10.1016/j.cmet.2023.04.015_bib51) 2009; 25 Saber (10.1016/j.cmet.2023.04.015_bib6) 2017; 43 Li (10.1016/j.cmet.2023.04.015_bib8) 2020; 30 Wu (10.1016/j.cmet.2023.04.015_bib39) 2021; 22 Boettger (10.1016/j.cmet.2023.04.015_bib45) 2016; 48 Kihara (10.1016/j.cmet.2023.04.015_bib66) 2003; 52 Hill (10.1016/j.cmet.2023.04.015_bib5) 2014; 11 Ma (10.1016/j.cmet.2023.04.015_bib36) 2019; 30 Ritchie (10.1016/j.cmet.2023.04.015_bib50) 2015; 43 Leek (10.1016/j.cmet.2023.04.015_bib62) 2012; 28 Song (10.1016/j.cmet.2023.04.015_bib2) 2019; 17 Wu (10.1016/j.cmet.2023.04.015_bib16) 2020; 586 Den Hartigh (10.1016/j.cmet.2023.04.015_bib37) 2014; 9 Rooks (10.1016/j.cmet.2023.04.015_bib20) 2016; 16 Robinson (10.1016/j.cmet.2023.04.015_bib60) 2010; 26 Zheng (10.1016/j.cmet.2023.04.015_bib14) 2020; 69 Bolyen (10.1016/j.cmet.2023.04.015_bib47) 2019; 37 Yang (10.1016/j.cmet.2023.04.015_bib65) 2022; 55 Alharbi (10.1016/j.cmet.2023.04.015_bib43) 2021; 49 Leek (10.1016/j.cmet.2023.04.015_bib61) 2014; 42 Sivan (10.1016/j.cmet.2023.04.015_bib11) 2015; 350 Ngo (10.1016/j.cmet.2023.04.015_bib28) 2019; 116 Jia (10.1016/j.cmet.2023.04.015_bib12) 2020; 9 Du (10.1016/j.cmet.2023.04.015_bib30) 2020; 45 Belkaid (10.1016/j.cmet.2023.04.015_bib23) 2014; 157 Dulai (10.1016/j.cmet.2023.04.015_bib18) 2016; 9 Oeckinghaus (10.1016/j.cmet.2023.04.015_bib31) 2009; 1 Chen (10.1016/j.cmet.2023.04.015_bib70) 2013; 6 |
| References_xml | – volume: 12 start-page: 4077 year: 2021 ident: bib15 article-title: Microbial short-chain fatty acids modulate CD8(+) T cell responses and improve adoptive immunotherapy for cancer publication-title: Nat. Commun. – volume: 49 start-page: 7825 year: 2021 end-page: 7838 ident: bib43 article-title: CTCF as a regulator of alternative splicing: new tricks for an old player publication-title: Nucleic Acids Res. – volume: 58 start-page: 439 year: 2013 end-page: 445 ident: bib29 article-title: Histone modifications for human epigenome analysis publication-title: J. Hum. Genet. – volume: 32 start-page: 43 year: 2017 end-page: 53 ident: bib1 article-title: Microbiome, inflammation and colorectal cancer publication-title: Semin. Immunol. – volume: 64 start-page: 51 year: 2020 end-page: 60 ident: bib3 article-title: Risk of colorectal cancer in inflammatory bowel diseases publication-title: Semin. Cancer Biol. – volume: 37 start-page: 852 year: 2019 end-page: 857 ident: bib47 article-title: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 publication-title: Nat. Biotechnol. – volume: 48 start-page: 359 year: 2016 end-page: 366 ident: bib45 article-title: Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels publication-title: Nat. Genet. – volume: 11 start-page: 506 year: 2014 end-page: 514 ident: bib5 article-title: Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 10 start-page: e72171 year: 2021 ident: bib27 article-title: Short-chain fatty acids activate acetyltransferase p300 publication-title: Elife – volume: 28 start-page: 882 year: 2012 end-page: 883 ident: bib62 article-title: The sva package for removing batch effects and other unwanted variation in high-throughput experiments publication-title: Bioinformatics – volume: 22 start-page: 244 year: 2021 ident: bib38 article-title: Acute depletion of CTCF rewires genome-wide chromatin accessibility publication-title: Genome Biol. – volume: 43 start-page: e47 year: 2015 ident: bib50 article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies publication-title: Nucleic Acids Res. – volume: 52 start-page: 713 year: 2003 end-page: 719 ident: bib66 article-title: Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats publication-title: Gut – volume: 41 start-page: e108 year: 2013 ident: bib49 article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote publication-title: Nucleic Acids Res. – volume: 9 start-page: 357 year: 2012 end-page: 359 ident: bib56 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods – volume: 12 start-page: 357 year: 2015 end-page: 360 ident: bib58 article-title: HISAT: a fast spliced aligner with low memory requirements publication-title: Nat. Methods – volume: 1 start-page: a000034 year: 2009 ident: bib31 article-title: The NF-kappaB family of transcription factors and its regulation publication-title: Cold Spring Harb. Perspect. Biol. – volume: 11 start-page: 8088 year: 2021 ident: bib21 article-title: The impact of indole-3-lactic acid on immature intestinal innate immunity and development: a transcriptomic analysis publication-title: Sci. Rep. – volume: 586 start-page: 108 year: 2020 end-page: 112 ident: bib16 article-title: Microbiota-derived metabolite promotes HDAC3 activity in the gut publication-title: Nature – volume: 180 start-page: 79 year: 2020 end-page: 91.e16 ident: bib69 article-title: Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease publication-title: Cell – volume: 17 start-page: 275 year: 2019 end-page: 289 ident: bib2 article-title: Environmental factors, gut microbiota, and colorectal cancer prevention publication-title: Clin. Gastroenterol. Hepatol. – volume: 9 start-page: 887 year: 2016 end-page: 894 ident: bib18 article-title: Colorectal cancer and dysplasia in inflammatory bowel disease: a review of disease epidemiology, pathophysiology, and management publication-title: Cancer Prev. Res. – volume: 350 start-page: 1084 year: 2015 end-page: 1089 ident: bib11 article-title: Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy publication-title: Science – volume: 45 start-page: 210 year: 2020 end-page: 222 ident: bib30 article-title: Suppression of HDAC2 by sodium butyrate alleviates apoptosis of kidney cells in db/db mice and HG-induced NRK-52E cells publication-title: Int. J. Mol. Med. – volume: 96 start-page: 2522 year: 2021 end-page: 2545 ident: bib22 article-title: Diverse roles of microbial indole compounds in eukaryotic systems publication-title: Biol. Rev. Camb. Philos. Soc. – volume: 9 start-page: e108564 year: 2014 ident: bib37 article-title: Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice publication-title: PLoS One – volume: 42 start-page: e161 year: 2014 ident: bib61 article-title: svaseq: removing batch effects and other unwanted noise from sequencing data publication-title: Nucleic Acids Res. – volume: 30 start-page: 1753 year: 2020 end-page: 1766.e6 ident: bib8 article-title: Prebiotic-induced anti-tumor immunity attenuates tumor growth publication-title: Cell Rep. – volume: 6 start-page: 1769 year: 2013 end-page: 1780 ident: bib70 article-title: A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: application in the study of rice metabolomics publication-title: Mol. Plant – volume: 16 start-page: 341 year: 2016 end-page: 352 ident: bib20 article-title: Gut microbiota, metabolites and host immunity publication-title: Nat. Rev. Immunol. – volume: 8 start-page: 693412 year: 2021 ident: bib34 article-title: Therapeutic and improving function of lactobacilli in the prevention and treatment of cardiovascular-related diseases: a novel perspective from gut microbiota publication-title: Front. Nutr. – volume: 42 start-page: W187 year: 2014 end-page: W191 ident: bib53 article-title: deepTools: a flexible platform for exploring deep-sequencing data publication-title: Nucleic Acids Res. – volume: 25 start-page: 968 year: 2019 end-page: 976 ident: bib4 article-title: Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer publication-title: Nat.Med. – volume: 30 start-page: 143 year: 2019 end-page: 156.e5 ident: bib36 article-title: Cholesterol induces CD8(+) T cell exhaustion in the tumor microenvironment publication-title: Cell Metab. – volume: 12 start-page: 670540 year: 2021 ident: bib46 article-title: Characterization and manipulation of the crosstalk between dendritic and natural killer cells within the tumor microenvironment publication-title: Front. Immunol. – volume: 116 start-page: 3668 year: 2019 end-page: 3677 ident: bib28 article-title: Epigenomic analysis reveals DNA motifs regulating histone modifications in human and mouse publication-title: Proc. Natl. Acad. Sci. USA – volume: 23 start-page: 491 year: 2012 end-page: 500 ident: bib35 article-title: Dietary cholesterol intake and cancer publication-title: Ann. Oncol. – volume: 341 start-page: 569 year: 2013 end-page: 573 ident: bib41 article-title: The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis publication-title: Science – volume: 12 start-page: 1785803 year: 2020 ident: bib10 article-title: Cancer-protective effect of a synbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer publication-title: Gut Microb. – volume: 55 start-page: 1747 year: 2022 ident: bib65 article-title: Androgen receptor-mediated CD8(+) T cell stemness programs drive sex differences in antitumor immunity publication-title: Immunity – volume: 63 start-page: 114 year: 2023 end-page: 124 ident: bib25 article-title: Dietary polysaccharides exert biological functions via epigenetic regulations: Advance and prospectives publication-title: Crit. Rev. Food Sci. Nutr. – volume: 9 start-page: e1213 year: 2020 ident: bib12 article-title: Porphyromonas gingivalis and Lactobacillus rhamnosus GG regulate the Th17/Treg balance in colitis via TLR4 and TLR2 publication-title: Clin.Transl.Immunology – volume: 29 start-page: 15 year: 2013 end-page: 21 ident: bib48 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics – volume: 162 start-page: 45 year: 2015 end-page: 58 ident: bib67 article-title: Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer publication-title: Cell – volume: 20 start-page: 7 year: 2020 end-page: 24 ident: bib24 article-title: Dendritic cells in cancer immunology and immunotherapy publication-title: Nat. Rev. Immunol. – volume: 170 start-page: 127 year: 2017 end-page: 141.e15 ident: bib64 article-title: IFNgamma-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment publication-title: Cell – volume: 71 start-page: 1020 year: 2022 end-page: 1032 ident: bib19 article-title: Gut microbiome and health: mechanistic insights publication-title: Gut – volume: 26 start-page: 535 year: 2008 end-page: 584 ident: bib32 article-title: The IRF family transcription factors in immunity and oncogenesis publication-title: Annu. Rev. Immunol. – volume: 32 start-page: 35 year: 2017 end-page: 42 ident: bib7 article-title: The intricate connection between diet, microbiota, and cancer: A jigsaw puzzle publication-title: Semin. Immunol. – volume: 9 start-page: R137 year: 2008 ident: bib52 article-title: Model-based analysis of ChIP-Seq (MACS) publication-title: Genome Biol. – volume: 34 start-page: i884 year: 2018 end-page: i890 ident: bib54 article-title: fastp: an ultra-fast all-in-one FASTQ preprocessor publication-title: Bioinformatics – volume: 69 start-page: 970 year: 2020 end-page: 972 ident: bib14 article-title: Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer publication-title: Gut – volume: 42 year: 2022 ident: bib42 article-title: Unconventional metabolites in chromatin regulation publication-title: Biosci. Rep. – volume: 25 start-page: 2078 year: 2009 end-page: 2079 ident: bib51 article-title: The Sequence Alignment/Map format and SAMtools publication-title: Bioinformatics – volume: 71 start-page: 2011 year: 2021 end-page: 2021 ident: bib13 article-title: Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis publication-title: Gut – volume: 43 start-page: 96 year: 2017 end-page: 115 ident: bib6 article-title: Cellular and molecular effects of yeast probiotics on cancer publication-title: Crit. Rev. Microbiol. – volume: 82 start-page: 4165 year: 2010 end-page: 4173 ident: bib55 article-title: Signature-discovery Approach for Sample Matching of a Nerve-Agent Precursor Using Liquid Chromatography-Mass Spectrometry, XCMS, and chemometrics publication-title: Anal. Chem. – volume: 2 start-page: 2307 year: 2007 end-page: 2311 ident: bib63 article-title: Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue publication-title: Nat. Protoc. – volume: 157 start-page: 121 year: 2014 end-page: 141 ident: bib23 article-title: Role of the microbiota in immunity and inflammation publication-title: Cell – volume: 26 start-page: 841 year: 2010 end-page: 842 ident: bib57 article-title: BEDTools: a flexible suite of utilities for comparing genomic features publication-title: Bioinformatics – volume: 22 start-page: 6933 year: 2021 ident: bib39 article-title: Dissecting the interplay mechanism between epigenetics and gut microbiota: health maintenance and disease prevention publication-title: Int. J. Mol. Sci. – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: bib60 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics – volume: 138 start-page: 115471 year: 2020 ident: bib33 article-title: Epigenetic and transcriptional regulation of osteoclast differentiation publication-title: Bone – volume: 34 start-page: 108706 year: 2021 ident: bib9 article-title: Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy publication-title: Cell Rep. – volume: 6 start-page: 1138 year: 2019 end-page: 1148 ident: bib26 article-title: Influence of the microbiota on epigenetics in colorectal cancer publication-title: Natl. Sci. Rev. – volume: 25 start-page: 537 year: 2019 end-page: 552.e8 ident: bib17 article-title: Drosophila histone demethylase KDM5 regulates social behavior through immune control and gut microbiota maintenance publication-title: Cell Host Microbe – volume: 20 start-page: 2349 year: 2006 end-page: 2354 ident: bib44 article-title: CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus publication-title: Genes Dev. – volume: 31 start-page: 166 year: 2015 end-page: 169 ident: bib59 article-title: HTSeq--a Python framework to work with high-throughput sequencing data publication-title: Bioinformatics – volume: 4 start-page: 2319 year: 2019 end-page: 2330 ident: bib68 article-title: Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity publication-title: Nat. Microbiol. – volume: 83 start-page: 31 year: 2017 end-page: 42 ident: bib40 article-title: Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases publication-title: J. Autoimmun. – volume: 52 start-page: 713 year: 2003 ident: 10.1016/j.cmet.2023.04.015_bib66 article-title: Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats publication-title: Gut doi: 10.1136/gut.52.5.713 – volume: 1 start-page: a000034 year: 2009 ident: 10.1016/j.cmet.2023.04.015_bib31 article-title: The NF-kappaB family of transcription factors and its regulation publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a000034 – volume: 12 start-page: 4077 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib15 article-title: Microbial short-chain fatty acids modulate CD8(+) T cell responses and improve adoptive immunotherapy for cancer publication-title: Nat. Commun. doi: 10.1038/s41467-021-24331-1 – volume: 34 start-page: 108706 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib9 article-title: Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy publication-title: Cell Rep. doi: 10.1016/j.celrep.2021.108706 – volume: 69 start-page: 970 year: 2020 ident: 10.1016/j.cmet.2023.04.015_bib14 article-title: Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer publication-title: Gut doi: 10.1136/gutjnl-2019-318374 – volume: 26 start-page: 535 year: 2008 ident: 10.1016/j.cmet.2023.04.015_bib32 article-title: The IRF family transcription factors in immunity and oncogenesis publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.26.021607.090400 – volume: 10 start-page: e72171 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib27 article-title: Short-chain fatty acids activate acetyltransferase p300 publication-title: Elife doi: 10.7554/eLife.72171 – volume: 42 start-page: e161 year: 2014 ident: 10.1016/j.cmet.2023.04.015_bib61 article-title: svaseq: removing batch effects and other unwanted noise from sequencing data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku864 – volume: 4 start-page: 2319 year: 2019 ident: 10.1016/j.cmet.2023.04.015_bib68 article-title: Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity publication-title: Nat. Microbiol. doi: 10.1038/s41564-019-0541-3 – volume: 157 start-page: 121 year: 2014 ident: 10.1016/j.cmet.2023.04.015_bib23 article-title: Role of the microbiota in immunity and inflammation publication-title: Cell doi: 10.1016/j.cell.2014.03.011 – volume: 586 start-page: 108 year: 2020 ident: 10.1016/j.cmet.2023.04.015_bib16 article-title: Microbiota-derived metabolite promotes HDAC3 activity in the gut publication-title: Nature doi: 10.1038/s41586-020-2604-2 – volume: 25 start-page: 537 year: 2019 ident: 10.1016/j.cmet.2023.04.015_bib17 article-title: Drosophila histone demethylase KDM5 regulates social behavior through immune control and gut microbiota maintenance publication-title: Cell Host Microbe doi: 10.1016/j.chom.2019.02.003 – volume: 9 start-page: e108564 year: 2014 ident: 10.1016/j.cmet.2023.04.015_bib37 article-title: Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice publication-title: PLoS One doi: 10.1371/journal.pone.0108564 – volume: 83 start-page: 31 year: 2017 ident: 10.1016/j.cmet.2023.04.015_bib40 article-title: Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases publication-title: J. Autoimmun. doi: 10.1016/j.jaut.2017.03.009 – volume: 30 start-page: 143 year: 2019 ident: 10.1016/j.cmet.2023.04.015_bib36 article-title: Cholesterol induces CD8(+) T cell exhaustion in the tumor microenvironment publication-title: Cell Metab. doi: 10.1016/j.cmet.2019.04.002 – volume: 32 start-page: 35 year: 2017 ident: 10.1016/j.cmet.2023.04.015_bib7 article-title: The intricate connection between diet, microbiota, and cancer: A jigsaw puzzle publication-title: Semin. Immunol. doi: 10.1016/j.smim.2017.08.009 – volume: 9 start-page: e1213 year: 2020 ident: 10.1016/j.cmet.2023.04.015_bib12 article-title: Porphyromonas gingivalis and Lactobacillus rhamnosus GG regulate the Th17/Treg balance in colitis via TLR4 and TLR2 publication-title: Clin.Transl.Immunology doi: 10.1002/cti2.1213 – volume: 37 start-page: 852 year: 2019 ident: 10.1016/j.cmet.2023.04.015_bib47 article-title: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-019-0209-9 – volume: 42 start-page: W187 year: 2014 ident: 10.1016/j.cmet.2023.04.015_bib53 article-title: deepTools: a flexible platform for exploring deep-sequencing data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku365 – volume: 20 start-page: 2349 year: 2006 ident: 10.1016/j.cmet.2023.04.015_bib44 article-title: CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus publication-title: Genes Dev. doi: 10.1101/gad.399506 – volume: 17 start-page: 275 year: 2019 ident: 10.1016/j.cmet.2023.04.015_bib2 article-title: Environmental factors, gut microbiota, and colorectal cancer prevention publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/j.cgh.2018.07.012 – volume: 28 start-page: 882 year: 2012 ident: 10.1016/j.cmet.2023.04.015_bib62 article-title: The sva package for removing batch effects and other unwanted variation in high-throughput experiments publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts034 – volume: 71 start-page: 1020 year: 2022 ident: 10.1016/j.cmet.2023.04.015_bib19 article-title: Gut microbiome and health: mechanistic insights publication-title: Gut doi: 10.1136/gutjnl-2021-326789 – volume: 26 start-page: 139 year: 2010 ident: 10.1016/j.cmet.2023.04.015_bib60 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 180 start-page: 79 year: 2020 ident: 10.1016/j.cmet.2023.04.015_bib69 article-title: Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease publication-title: Cell doi: 10.1016/j.cell.2019.11.026 – volume: 58 start-page: 439 year: 2013 ident: 10.1016/j.cmet.2023.04.015_bib29 article-title: Histone modifications for human epigenome analysis publication-title: J. Hum. Genet. doi: 10.1038/jhg.2013.66 – volume: 25 start-page: 968 year: 2019 ident: 10.1016/j.cmet.2023.04.015_bib4 article-title: Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer publication-title: Nat.Med. doi: 10.1038/s41591-019-0458-7 – volume: 25 start-page: 2078 year: 2009 ident: 10.1016/j.cmet.2023.04.015_bib51 article-title: The Sequence Alignment/Map format and SAMtools publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 41 start-page: e108 year: 2013 ident: 10.1016/j.cmet.2023.04.015_bib49 article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt214 – volume: 26 start-page: 841 year: 2010 ident: 10.1016/j.cmet.2023.04.015_bib57 article-title: BEDTools: a flexible suite of utilities for comparing genomic features publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq033 – volume: 64 start-page: 51 year: 2020 ident: 10.1016/j.cmet.2023.04.015_bib3 article-title: Risk of colorectal cancer in inflammatory bowel diseases publication-title: Semin. Cancer Biol. doi: 10.1016/j.semcancer.2019.05.001 – volume: 16 start-page: 341 year: 2016 ident: 10.1016/j.cmet.2023.04.015_bib20 article-title: Gut microbiota, metabolites and host immunity publication-title: Nat. Rev. Immunol. doi: 10.1038/nri.2016.42 – volume: 30 start-page: 1753 year: 2020 ident: 10.1016/j.cmet.2023.04.015_bib8 article-title: Prebiotic-induced anti-tumor immunity attenuates tumor growth publication-title: Cell Rep. doi: 10.1016/j.celrep.2020.01.035 – volume: 9 start-page: 357 year: 2012 ident: 10.1016/j.cmet.2023.04.015_bib56 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 – volume: 29 start-page: 15 issue: 1 year: 2013 ident: 10.1016/j.cmet.2023.04.015_bib48 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 341 start-page: 569 year: 2013 ident: 10.1016/j.cmet.2023.04.015_bib41 article-title: The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis publication-title: Science doi: 10.1126/science.1241165 – volume: 11 start-page: 506 year: 2014 ident: 10.1016/j.cmet.2023.04.015_bib5 article-title: Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2014.66 – volume: 45 start-page: 210 year: 2020 ident: 10.1016/j.cmet.2023.04.015_bib30 article-title: Suppression of HDAC2 by sodium butyrate alleviates apoptosis of kidney cells in db/db mice and HG-induced NRK-52E cells publication-title: Int. J. Mol. Med. – volume: 9 start-page: R137 year: 2008 ident: 10.1016/j.cmet.2023.04.015_bib52 article-title: Model-based analysis of ChIP-Seq (MACS) publication-title: Genome Biol. doi: 10.1186/gb-2008-9-9-r137 – volume: 43 start-page: 96 year: 2017 ident: 10.1016/j.cmet.2023.04.015_bib6 article-title: Cellular and molecular effects of yeast probiotics on cancer publication-title: Crit. Rev. Microbiol. doi: 10.1080/1040841X.2016.1179622 – volume: 20 start-page: 7 year: 2020 ident: 10.1016/j.cmet.2023.04.015_bib24 article-title: Dendritic cells in cancer immunology and immunotherapy publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-019-0210-z – volume: 34 start-page: i884 year: 2018 ident: 10.1016/j.cmet.2023.04.015_bib54 article-title: fastp: an ultra-fast all-in-one FASTQ preprocessor publication-title: Bioinformatics doi: 10.1093/bioinformatics/bty560 – volume: 170 start-page: 127 year: 2017 ident: 10.1016/j.cmet.2023.04.015_bib64 article-title: IFNgamma-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment publication-title: Cell doi: 10.1016/j.cell.2017.06.016 – volume: 350 start-page: 1084 year: 2015 ident: 10.1016/j.cmet.2023.04.015_bib11 article-title: Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy publication-title: Science doi: 10.1126/science.aac4255 – volume: 55 start-page: 1747 year: 2022 ident: 10.1016/j.cmet.2023.04.015_bib65 article-title: Androgen receptor-mediated CD8(+) T cell stemness programs drive sex differences in antitumor immunity publication-title: Immunity doi: 10.1016/j.immuni.2022.07.016 – volume: 22 start-page: 244 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib38 article-title: Acute depletion of CTCF rewires genome-wide chromatin accessibility publication-title: Genome Biol. doi: 10.1186/s13059-021-02466-0 – volume: 138 start-page: 115471 year: 2020 ident: 10.1016/j.cmet.2023.04.015_bib33 article-title: Epigenetic and transcriptional regulation of osteoclast differentiation publication-title: Bone doi: 10.1016/j.bone.2020.115471 – volume: 6 start-page: 1138 year: 2019 ident: 10.1016/j.cmet.2023.04.015_bib26 article-title: Influence of the microbiota on epigenetics in colorectal cancer publication-title: Natl. Sci. Rev. doi: 10.1093/nsr/nwy160 – volume: 8 start-page: 693412 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib34 article-title: Therapeutic and improving function of lactobacilli in the prevention and treatment of cardiovascular-related diseases: a novel perspective from gut microbiota publication-title: Front. Nutr. doi: 10.3389/fnut.2021.693412 – volume: 71 start-page: 2011 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib13 article-title: Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis publication-title: Gut doi: 10.1136/gutjnl-2020-323951 – volume: 82 start-page: 4165 year: 2010 ident: 10.1016/j.cmet.2023.04.015_bib55 article-title: Signature-discovery Approach for Sample Matching of a Nerve-Agent Precursor Using Liquid Chromatography-Mass Spectrometry, XCMS, and chemometrics publication-title: Anal. Chem. doi: 10.1021/ac1003568 – volume: 12 start-page: 1785803 year: 2020 ident: 10.1016/j.cmet.2023.04.015_bib10 article-title: Cancer-protective effect of a synbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer publication-title: Gut Microb. doi: 10.1080/19490976.2020.1785803 – volume: 6 start-page: 1769 year: 2013 ident: 10.1016/j.cmet.2023.04.015_bib70 article-title: A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: application in the study of rice metabolomics publication-title: Mol. Plant doi: 10.1093/mp/sst080 – volume: 31 start-page: 166 year: 2015 ident: 10.1016/j.cmet.2023.04.015_bib59 article-title: HTSeq--a Python framework to work with high-throughput sequencing data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu638 – volume: 11 start-page: 8088 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib21 article-title: The impact of indole-3-lactic acid on immature intestinal innate immunity and development: a transcriptomic analysis publication-title: Sci. Rep. doi: 10.1038/s41598-021-87353-1 – volume: 12 start-page: 670540 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib46 article-title: Characterization and manipulation of the crosstalk between dendritic and natural killer cells within the tumor microenvironment publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.670540 – volume: 162 start-page: 45 year: 2015 ident: 10.1016/j.cmet.2023.04.015_bib67 article-title: Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer publication-title: Cell doi: 10.1016/j.cell.2015.06.001 – volume: 116 start-page: 3668 year: 2019 ident: 10.1016/j.cmet.2023.04.015_bib28 article-title: Epigenomic analysis reveals DNA motifs regulating histone modifications in human and mouse publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1813565116 – volume: 96 start-page: 2522 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib22 article-title: Diverse roles of microbial indole compounds in eukaryotic systems publication-title: Biol. Rev. Camb. Philos. Soc. doi: 10.1111/brv.12765 – volume: 43 start-page: e47 year: 2015 ident: 10.1016/j.cmet.2023.04.015_bib50 article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv007 – volume: 9 start-page: 887 year: 2016 ident: 10.1016/j.cmet.2023.04.015_bib18 article-title: Colorectal cancer and dysplasia in inflammatory bowel disease: a review of disease epidemiology, pathophysiology, and management publication-title: Cancer Prev. Res. doi: 10.1158/1940-6207.CAPR-16-0124 – volume: 49 start-page: 7825 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib43 article-title: CTCF as a regulator of alternative splicing: new tricks for an old player publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkab520 – volume: 32 start-page: 43 year: 2017 ident: 10.1016/j.cmet.2023.04.015_bib1 article-title: Microbiome, inflammation and colorectal cancer publication-title: Semin. Immunol. doi: 10.1016/j.smim.2017.09.006 – volume: 48 start-page: 359 year: 2016 ident: 10.1016/j.cmet.2023.04.015_bib45 article-title: Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels publication-title: Nat. Genet. doi: 10.1038/ng.3510 – volume: 12 start-page: 357 year: 2015 ident: 10.1016/j.cmet.2023.04.015_bib58 article-title: HISAT: a fast spliced aligner with low memory requirements publication-title: Nat. Methods doi: 10.1038/nmeth.3317 – volume: 42 year: 2022 ident: 10.1016/j.cmet.2023.04.015_bib42 article-title: Unconventional metabolites in chromatin regulation publication-title: Biosci. Rep. doi: 10.1042/BSR20211558 – volume: 23 start-page: 491 year: 2012 ident: 10.1016/j.cmet.2023.04.015_bib35 article-title: Dietary cholesterol intake and cancer publication-title: Ann. Oncol. doi: 10.1093/annonc/mdr155 – volume: 22 start-page: 6933 year: 2021 ident: 10.1016/j.cmet.2023.04.015_bib39 article-title: Dissecting the interplay mechanism between epigenetics and gut microbiota: health maintenance and disease prevention publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22136933 – volume: 2 start-page: 2307 year: 2007 ident: 10.1016/j.cmet.2023.04.015_bib63 article-title: Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue publication-title: Nat. Protoc. doi: 10.1038/nprot.2007.315 – volume: 63 start-page: 114 year: 2023 ident: 10.1016/j.cmet.2023.04.015_bib25 article-title: Dietary polysaccharides exert biological functions via epigenetic regulations: Advance and prospectives publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408398.2021.1944974 |
| SSID | ssj0036393 |
| Score | 2.7022123 |
| Snippet | Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms... Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 943 |
| SubjectTerms | Animals Carcinogenesis CD8-Positive T-Lymphocytes colorectal cancer Colorectal Neoplasms Epigenesis, Genetic epigenetic regulation ILA indole-3-lactic acid Lactobacillus plantarum Lactobacillus plantarum - physiology Mice |
| Title | Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity |
| URI | https://dx.doi.org/10.1016/j.cmet.2023.04.015 https://www.ncbi.nlm.nih.gov/pubmed/37192617 https://www.proquest.com/docview/2814813733 |
| Volume | 35 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NatwwEBZhIdBLadIk3bQJKuS2iNVa8t-x2SSEUnpJFvYm9Gdw8f6wawfyDn2IPEueLDOyHQg0e-hRRkJiZjTzCc83Q8hFlCItz2RY3y5lMp9Ipl3iQCHGQsCFoGRCtc_fye1M_pzH8z0y7bkwmFbZ-f7Wpwdv3X0Zd9Icr8tyfIfgGlwwuN6QrYgkPiGzQOKbX_beWEAEDkn2MJnh7I440-Z42YXHfMpIhHKn2Br338HpPfAZgtDNJ_KxQ4_0R3vAA7Lnl4dkv-0n-fiZ_P2F3XOMtmVVNVu6rkBsetMsmAM7e_COwgN8VXkmWBW4URRmOqoXvkKiPoBOijWsUR6wSd0ssGsW-sJySx9KTf06DHHhpm1hD0qlq4JOr7IRvX9-wr8AtAyMk_rxiMxuru-nt6xrt8AsXOSa5ZmWmguhRZoCKDAARjTP_UQWmbQ-SnxcJDrncWYLp2Mt8GVpuZY5dzxyABSPyWC5WvovhJpIW517jp2RpOTGFNa5LJLCx1gY3Q7JpJezsl0tcmyJUak-6eyPQt0o1I3iUoFuhmT0umbdVuLYOTvu1afe2JOCULFz3fde1wouGspNL_2q2aoog5fjRKRCDMlJawSv5xApAGXAgqf_uetX8gFHIQUt-UYG9abxZwB2anMerPkFTv39oQ |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKKwQXRHm020IxErfKWm_svI50odqWpRe20t4svyKlyj60m1Tqf-BH9Lfwy5hxkkpI0APHJGPZmrFnPisz8xHyKUqxLM9k2N8uZTIfSaZd4sAgxkLAhaBkQrfPq2RyLS_n8XyHjPtaGEyr7Hx_69ODt-7eDDttDtdlOfyB4BpcMLjekK2YPyF7gAZS5G-4mJ_17lhACA5Z9iDNULyrnGmTvOzCY0JlJEK_U-TG_Xt0-hf6DFHo_CV50cFH-rld4T7Z8ctX5GlLKHn3mvycIn2O0basqmZL1xXoTW-aBXOw0W69o3ADX1WeCVaF4igKko7qha-wUh9QJ8Um1qgQmKRuFkibhc6w3NLbUlO_Do84cNNy2INV6aqg4y_ZKZ39usffALQMJSf13Rtyff51Np6wjm-BWTjJNcszLTUXQos0BVRgAI1onvuRLDJpfZT4uEh0zuPMFk7HWuDV0nItc-545AApviW7y9XSHxJqIm117jlSI0nJjSmsc1kkhY-xM7odkFGvZ2W7ZuTIiVGpPuvsRqFtFNpGcanANgNy-jBm3bbieFQ67s2n_thQCmLFo-M-9rZWcNJQb3rpV81WRRlcHUciFWJADtpN8LAOkQJSBjB49J-zfiDPJrPvUzW9uPp2TJ7jl5CPlrwju_Wm8e8B-dTmJOzs3w9DAM8 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lactobacillus+plantarum-derived+indole-3-lactic+acid+ameliorates+colorectal+tumorigenesis+via+epigenetic+regulation+of+CD8%2B+T%C2%A0cell+immunity&rft.jtitle=Cell+metabolism&rft.au=Zhang%2C+Qingqing&rft.au=Zhao%2C+Qing&rft.au=Li%2C+Tao&rft.au=Lu%2C+Longya&rft.date=2023-06-06&rft.pub=Elsevier+Inc&rft.issn=1550-4131&rft.eissn=1932-7420&rft.volume=35&rft.issue=6&rft.spage=943&rft.epage=960.e9&rft_id=info:doi/10.1016%2Fj.cmet.2023.04.015&rft.externalDocID=S1550413123001419 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1550-4131&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1550-4131&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1550-4131&client=summon |