Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms
Ginsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial...
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| Published in | Biomedicine & pharmacotherapy Vol. 166; p. 115340 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Masson SAS
01.10.2023
Elsevier |
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| Online Access | Get full text |
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| Abstract | Ginsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesenchymal transition (EMT) in endometrium-related cells, and activating the immune system to kill cells associated with endometrial diseases. We hope to provide a theoretical foundation for the treatment of endometrium-related diseases by ginsenosides. |
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| AbstractList | Ginsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesenchymal transition (EMT) in endometrium-related cells, and activating the immune system to kill cells associated with endometrial diseases. We hope to provide a theoretical foundation for the treatment of endometrium-related diseases by ginsenosides. |
| ArticleNumber | 115340 |
| Author | Xie, Feng Abudukeyoumu, Ayitila Zhang, Yang-Yang Xu, Feng-Yuan Sun, Jian-Song Shen, Hui-Hui Li, Ming-Qing Li, Mao-Zhi Ye, Jiang-Feng |
| Author_xml | – sequence: 1 givenname: Yang-Yang surname: Zhang fullname: Zhang, Yang-Yang organization: Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People’s Republic of China – sequence: 2 givenname: Mao-Zhi surname: Li fullname: Li, Mao-Zhi organization: Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People’s Republic of China – sequence: 3 givenname: Hui-Hui surname: Shen fullname: Shen, Hui-Hui organization: Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People’s Republic of China – sequence: 4 givenname: Ayitila surname: Abudukeyoumu fullname: Abudukeyoumu, Ayitila organization: Department of Gynecology, Shanghai Jiading Maternal Child Health Hospital, Shanghai 201800, People’s Republic of China – sequence: 5 givenname: Feng surname: Xie fullname: Xie, Feng organization: Medical Center of Diagnosis and Treatment for Cervical and Intrauterine Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, People’s Republic of China – sequence: 6 givenname: Jiang-Feng surname: Ye fullname: Ye, Jiang-Feng organization: Institute for Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138632, Singapore – sequence: 7 givenname: Feng-Yuan surname: Xu fullname: Xu, Feng-Yuan organization: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 8 givenname: Jian-Song surname: Sun fullname: Sun, Jian-Song organization: School of Life Science and Health Engineering, Jiangnan University, Wuxi 214122, People’s Republic of China – sequence: 9 givenname: Ming-Qing orcidid: 0000-0002-9276-0722 surname: Li fullname: Li, Ming-Qing email: mqli@fudan.edu.cn organization: Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People’s Republic of China |
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| Keywords | Autophagy EMT Endometrium Ginsenosides Apoptosis |
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