Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases

• Published in: Cell Vol. 186; no. 10; pp. 2144 - 2159.e22
• Main Authors: Ahn, Matae, Chen, Vivian Chih-Wei, Rozario, Pritisha, Ng, Wei Lun, Kong, Pui San, Sia, Wan Rong, Kang, Adrian Eng Zheng, Su, Qi, Nguyen, Lan Huong, Zhu, Feng, Chan, Wharton O.Y., Tan, Chee Wah, Cheong, Wan Shoo, Hey, Ying Ying, Foo, Randy, Guo, Fusheng, Lim, Yan Ting, Li, Xin, Chia, Wan Ni, Sobota, Radoslaw M., Fu, Nai Yang, Irving, Aaron T., Wang, Lin-Fa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.05.2023
• Subjects: Animals; Apoptosis Regulatory Proteins - metabolism; bats; Chiroptera - immunology; COVID-19; disease resistance; Humans; immune complex; inflammasome; Inflammasomes - immunology; inflammation; inflammatory diseases; longevity; Mice; Ribonucleoproteins - metabolism; SARS-CoV-2; viral reservoir; Virus Diseases - immunology; Virus Physiological Phenomena; bats; COVID-19; SARS-CoV-2; disease resistance; inflammation; inflammasome; immune complex; inflammatory diseases; longevity; viral reservoir

Bats are special in their ability to live long and host many emerging viruses. Our previous studies showed that bats have altered inflammasomes, which are central players in aging and infection. However, the role of inflammasome signaling in combating inflammatory diseases remains poorly understood....