Tetrahedral framework nucleic acids as an advanced drug delivery system for oligonucleotide drugs

• Published in: APL materials Vol. 8; no. 10; pp. 100701 - 100701-5
• Main Authors: Liu, Yuhao, Liu, Zhiqiang, Cui, Weitong, Li, Yanjing, Qin, Xin, Zhang, Mei, Lin, Yunfeng
• Format: Journal Article
• Language: English
• Published: AIP Publishing LLC 01.10.2020

Nucleic acid therapy has played a promising role in the treatment of many diseases, such as cancer, infections, immune diseases, and neurodegenerative diseases. However, its application is still limited mainly because of poor cell-entry performance and low resistance to in vivo degradation. Tetrahed...