Tetrahedral framework nucleic acids as an advanced drug delivery system for oligonucleotide drugs

Nucleic acid therapy has played a promising role in the treatment of many diseases, such as cancer, infections, immune diseases, and neurodegenerative diseases. However, its application is still limited mainly because of poor cell-entry performance and low resistance to in vivo degradation. Tetrahed...

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Published inAPL materials Vol. 8; no. 10; pp. 100701 - 100701-5
Main Authors Liu, Yuhao, Liu, Zhiqiang, Cui, Weitong, Li, Yanjing, Qin, Xin, Zhang, Mei, Lin, Yunfeng
Format Journal Article
LanguageEnglish
Published AIP Publishing LLC 01.10.2020
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Abstract Nucleic acid therapy has played a promising role in the treatment of many diseases, such as cancer, infections, immune diseases, and neurodegenerative diseases. However, its application is still limited mainly because of poor cell-entry performance and low resistance to in vivo degradation. Tetrahedral framework nucleic acids (tFNAs) have shown potential in delivering low-molecular-weight drugs owing to their stability, biocompatibility, cell-entry performance, and flexible drug-loading ability. In particular, tFNAs can successfully deliver oligonucleotide drugs with improved effects and co-deliver oligonucleotide drugs with other drugs for synergistic effects. In this review, the recent progress on tFNA-based delivery of oligonucleotide drugs is outlined by single delivery systems—through sequence extension and complementation, and co-delivery systems—through multiple sequence extension, drug–DNA interactions, and specific binding. Furthermore, the current limitations and future developments of tFNA-based delivery of oligonucleotide drugs are discussed.
AbstractList Nucleic acid therapy has played a promising role in the treatment of many diseases, such as cancer, infections, immune diseases, and neurodegenerative diseases. However, its application is still limited mainly because of poor cell-entry performance and low resistance to in vivo degradation. Tetrahedral framework nucleic acids (tFNAs) have shown potential in delivering low-molecular-weight drugs owing to their stability, biocompatibility, cell-entry performance, and flexible drug-loading ability. In particular, tFNAs can successfully deliver oligonucleotide drugs with improved effects and co-deliver oligonucleotide drugs with other drugs for synergistic effects. In this review, the recent progress on tFNA-based delivery of oligonucleotide drugs is outlined by single delivery systems—through sequence extension and complementation, and co-delivery systems—through multiple sequence extension, drug–DNA interactions, and specific binding. Furthermore, the current limitations and future developments of tFNA-based delivery of oligonucleotide drugs are discussed.
Author Li, Yanjing
Lin, Yunfeng
Cui, Weitong
Liu, Yuhao
Zhang, Mei
Liu, Zhiqiang
Qin, Xin
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crossref_primary_10_1016_j_biomaterials_2023_122283
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SSID ssj0001033896
Score 2.2334712
Snippet Nucleic acid therapy has played a promising role in the treatment of many diseases, such as cancer, infections, immune diseases, and neurodegenerative...
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Title Tetrahedral framework nucleic acids as an advanced drug delivery system for oligonucleotide drugs
URI http://dx.doi.org/10.1063/5.0025211
https://doaj.org/article/8add9922985e4f278f4fa4caf4d5df36
Volume 8
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