Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors

• Published in: Pharmacological research Vol. 163; p. 105336
• Main Authors: Pucci, Susanna, Fasoli, Francesca, Moretti, Milena, Benfante, Roberta, Di Lascio, Simona, Viani, Paola, Daga, Antonio, Gordon, Thomas J., McIntosh, Michael, Zoli, Michele, Clementi, Francesco, Gotti, Cecilia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2021
• Subjects: AKT1 and ERK1/2; Gene silencing; Glioblastoma cell lines; Neuronal nicotinic receptors; Proliferation; Gene silencing; AKT1 and ERK1/2; Glioblastoma cell lines; Proliferation; Neuronal nicotinic receptors

[Display omitted] •Choline compounds are highly increased in glioblastoma cells.•Choline is also an agonist of α7- and α9-containing nicotinic receptors.•Both choline and nicotine promote glioblastoma cell proliferation and survival.•These effects are blocked by specific nicotinic antagonists or α7-...