XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1

• Published in: Cell host & microbe Vol. 32; no. 3; pp. 315 - 321.e3
• Main Authors: Wang, Qian, Guo, Yicheng, Bowen, Anthony, Mellis, Ian A., Valdez, Riccardo, Gherasim, Carmen, Gordon, Aubree, Liu, Lihong, Ho, David D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.03.2024
• Subjects: Antibodies, Neutralizing; Antibodies, Viral; COVID-19; COVID-19 Vaccines; HK.3; Humans; HV.1; immunological imprinting; JD.1.1; JN.1; mRNA Vaccines; Omicron subvariants; SARS-CoV-2; serum neutralization; XBB.1.5 monovalent mRNA vaccine; COVID-19; XBB.1.5 monovalent mRNA vaccine; SARS-CoV-2; HV.1; JN.1; HK.3; JD.1.1; immunological imprinting; Omicron subvariants; serum neutralization

COVID-19 vaccines have recently been updated to specifically encode or contain the spike protein of the SARS-CoV-2 XBB.1.5 subvariant, but their immunogenicity in humans has yet to be fully evaluated and reported, particularly against emergent viruses that are rapidly expanding. We now report that a...