Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches

• Published in: Advanced drug delivery reviews Vol. 157; pp. 2 - 36
• Main Authors: Brayden, D.J., Hill, T.A., Fairlie, D.P., Maher, S., Mrsny, R.J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 2020
• Subjects: Drug-device combination products; Epithelial permeability; Nanoparticles; Oral bioavailability; Oral peptide delivery; Tight junctions; Nanoparticles; Oral bioavailability; Tight junctions; Oral peptide delivery; Drug-device combination products; Epithelial permeability

In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics especially peptides and proteins. In the intervening period, analysis of the preclinical and clinical trial failures of many purported platform technologies has led to reflection on the true status of the f...