Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches

In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics especially peptides and proteins. In the intervening period, analysis of the preclinical and clinical trial failures of many purported platform technologies has led to reflection on the true status of the f...

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Published inAdvanced drug delivery reviews Vol. 157; pp. 2 - 36
Main Authors Brayden, D.J., Hill, T.A., Fairlie, D.P., Maher, S., Mrsny, R.J.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 2020
Subjects
Drug-device combination products
Epithelial permeability
Nanoparticles
Oral bioavailability
Oral peptide delivery
Tight junctions
Nanoparticles
Oral bioavailability
Tight junctions
Oral peptide delivery
Drug-device combination products
Epithelial permeability
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Abstract In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics especially peptides and proteins. In the intervening period, analysis of the preclinical and clinical trial failures of many purported platform technologies has led to reflection on the true status of the field and reigning in of expectations. Oral formulations of semaglutide, octreotide, and salmon calcitonin have completed Phase III trials, with oral semaglutide being approved by the FDA in 2019. The progress made with oral peptide formulations based on traditional permeation enhancers is against a background of low and variable oral bioavailability values of ~1%, leading to a current perception that only potent peptides with a viable cost of synthesis can be realistically considered. Desirable features of candidates should include a large therapeutic index, some stability in the GI tract, a long elimination half-life, and a relatively low clearance rate. Administration in nanoparticle formats have largely disappointed, with few prototypes reaching clinical trials: insufficient particle loading, lack of controlled release, low epithelial particle uptake, and lack of scalable synthesis being the main reasons for discontinuation. Disruptive technologies based on engineered devices promise improvements, but scale-up and toxicology aspects are issues to address. In parallel, medicinal chemists are synthesizing stable hydrophobic macrocyclic candidate peptides of lower molecular weight and with potential for greater oral bioavailability than linear peptides, but perhaps without the same requirement for elaborate drug delivery systems. In summary, while there have been advances in understanding the limitations of peptides for oral delivery, low membrane permeability, metabolism, and high clearance rates continue to hamper progress. Physiological barriers and variables to delivering oral peptides. [Display omitted]
AbstractList In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics especially peptides and proteins. In the intervening period, analysis of the preclinical and clinical trial failures of many purported platform technologies has led to reflection on the true status of the field and reigning in of expectations. Oral formulations of semaglutide, octreotide, and salmon calcitonin have completed Phase III trials, with oral semaglutide being approved by the FDA in 2019. The progress made with oral peptide formulations based on traditional permeation enhancers is against a background of low and variable oral bioavailability values of ~1%, leading to a current perception that only potent peptides with a viable cost of synthesis can be realistically considered. Desirable features of candidates should include a large therapeutic index, some stability in the GI tract, a long elimination half-life, and a relatively low clearance rate. Administration in nanoparticle formats have largely disappointed, with few prototypes reaching clinical trials: insufficient particle loading, lack of controlled release, low epithelial particle uptake, and lack of scalable synthesis being the main reasons for discontinuation. Disruptive technologies based on engineered devices promise improvements, but scale-up and toxicology aspects are issues to address. In parallel, medicinal chemists are synthesizing stable hydrophobic macrocyclic candidate peptides of lower molecular weight and with potential for greater oral bioavailability than linear peptides, but perhaps without the same requirement for elaborate drug delivery systems. In summary, while there have been advances in understanding the limitations of peptides for oral delivery, low membrane permeability, metabolism, and high clearance rates continue to hamper progress. Physiological barriers and variables to delivering oral peptides. [Display omitted]
In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics especially peptides and proteins. In the intervening period, analysis of the preclinical and clinical trial failures of many purported platform technologies has led to reflection on the true status of the field and reigning in of expectations. Oral formulations of semaglutide, octreotide, and salmon calcitonin have completed Phase III trials, with oral semaglutide being approved by the FDA in 2019. The progress made with oral peptide formulations based on traditional permeation enhancers is against a background of low and variable oral bioavailability values of ~1%, leading to a current perception that only potent peptides with a viable cost of synthesis can be realistically considered. Desirable features of candidates should include a large therapeutic index, some stability in the GI tract, a long elimination half-life, and a relatively low clearance rate. Administration in nanoparticle formats have largely disappointed, with few prototypes reaching clinical trials: insufficient particle loading, lack of controlled release, low epithelial particle uptake, and lack of scalable synthesis being the main reasons for discontinuation. Disruptive technologies based on engineered devices promise improvements, but scale-up and toxicology aspects are issues to address. In parallel, medicinal chemists are synthesizing stable hydrophobic macrocyclic candidate peptides of lower molecular weight and with potential for greater oral bioavailability than linear peptides, but perhaps without the same requirement for elaborate drug delivery systems. In summary, while there have been advances in understanding the limitations of peptides for oral delivery, low membrane permeability, metabolism, and high clearance rates continue to hamper progress.
Author Mrsny, R.J.
Maher, S.
Hill, T.A.
Fairlie, D.P.
Brayden, D.J.
Author_xml – sequence: 1
  givenname: D.J.
  surname: Brayden
  fullname: Brayden, D.J.
  email: david.brayden@ucd.ie
  organization: UCD School of Veterinary Medicine and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
– sequence: 2
  givenname: T.A.
  surname: Hill
  fullname: Hill, T.A.
  organization: Division of Chemistry and Structural Biology, Centre for Inflammation and Disease Research and ARC Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
– sequence: 3
  givenname: D.P.
  surname: Fairlie
  fullname: Fairlie, D.P.
  organization: Division of Chemistry and Structural Biology, Centre for Inflammation and Disease Research and ARC Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
– sequence: 4
  givenname: S.
  surname: Maher
  fullname: Maher, S.
  organization: School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland
– sequence: 5
  givenname: R.J.
  surname: Mrsny
  fullname: Mrsny, R.J.
  organization: Department of Pharmacy and Pharmacology, University of Bath, BA2 7AY, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32479930$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1021/acsami.8b20821
10.4155/tde.11.132
10.1002/jcph.166
10.1073/pnas.1417611111
10.1021/acs.jmedchem.7b01028
10.1007/s11095-014-1303-9
10.1007/s13318-016-0374-x
10.1007/s00280-002-0499-2
10.1021/acs.chemrev.9b00008
10.1038/d41573-020-00001-7
10.1016/S0924-8579(03)00219-X
10.1080/1061186X.2018.1455839
10.1038/nchem.1062
10.1016/j.jconrel.2016.01.056
10.1007/s11095-019-2682-8
10.1007/s00198-014-2796-0
10.2337/dc19-0883
10.3389/fendo.2019.00155
10.1038/nchembio.664
10.1016/j.regpep.2011.02.009
10.1002/jbmr.1602
10.1111/dom.13955
10.1016/j.nano.2013.07.011
10.1021/ml5002823
10.2337/dc19-0898
10.1007/s11095-013-1053-0
10.1016/j.addr.2017.12.006
10.1053/j.gastro.2017.01.002
10.1073/pnas.1722338115
10.1007/s13300-019-00706-y
10.1038/361091a0
10.1021/jm201685h
10.1001/jama.2019.2942
10.1002/anie.201405364
10.2147/IJN.S218944
10.3390/pharmaceutics11020078
10.1056/NEJMcibr1901766
10.1136/gutjnl-2019-319146
10.1371/journal.pone.0109939
10.1002/smll.201800462
10.1111/dom.13361
10.1021/acsnano.8b04315
10.1007/s13346-012-0069-z
10.1016/j.addr.2009.09.006
10.1002/jps.21184
10.1016/S0168-3659(99)00251-5
10.1006/jmbi.1993.1664
10.2337/diab.37.2.246
10.1016/j.ejpb.2014.10.008
10.1039/C2MD20203D
10.1021/acs.molpharmaceut.8b00809
10.4155/tde.10.5
10.2337/dc19-0749
10.1016/j.joca.2014.12.019
10.1016/j.nano.2019.102132
10.1111/dom.13847
10.1021/acs.jmedchem.7b00717
10.1021/mp300068j
10.1038/nrd.2018.183
10.1002/anie.201000620
10.1177/1932296814524871
10.1016/j.ijantimicag.2017.11.004
10.1208/s12248-014-9634-3
10.1016/j.jdiacomp.2019.107520
10.1021/ol3027347
10.1371/journal.pone.0059524
10.2337/dc19-0152
10.1016/j.jconrel.2017.02.024
10.1002/hlca.19850680319
10.7554/eLife.24665
10.1016/j.jconrel.2015.05.270
10.2174/1574884714666190328162637
10.1038/s41573-019-0053-0
10.1016/j.jconrel.2019.01.037
10.1016/j.cbpa.2017.02.006
10.1023/A:1018909210879
10.1038/ja.2014.111
10.1021/acsami.9b16104
10.1016/j.chembiol.2015.11.012
10.1021/acs.biochem.6b00226
10.1016/j.ijpharm.2017.02.019
10.1002/anie.201611914
10.1007/s13346-019-00678-3
10.1007/s11095-019-2618-3
10.1021/mp400685v
10.1016/j.bmc.2017.06.052
10.1016/0169-409X(89)90011-2
10.1016/j.xphs.2019.04.022
10.1126/scitranslmed.3007049
10.1208/s12248-019-0405-z
10.3390/pharmaceutics11110565
10.1021/acs.jmedchem.5b00919
10.1177/1756284818777945
10.1016/j.ijpharm.2019.02.014
10.1016/S0169-409X(00)00129-0
10.1016/S0264-410X(01)00258-4
10.1086/587654
10.1016/0169-409X(87)90066-4
10.1124/pr.110.003459
10.1007/s12325-019-01125-y
10.1016/j.apsb.2019.01.004
10.2147/DDDT.S30946
10.1016/j.ejpb.2010.03.010
10.1111/j.1365-2265.1993.tb00990.x
10.1016/j.jconrel.2018.03.004
10.3390/pharmaceutics12020099
10.1038/s41551-019-0513-1
10.1016/j.drudis.2014.10.003
10.1021/mp500809f
10.1016/j.bmc.2017.11.007
10.1016/0169-409X(89)90018-5
10.1007/s40262-018-0728-4
10.1016/j.jconrel.2018.01.012
10.1016/S2213-8587(18)30372-3
10.1016/j.jddst.2019.101394
10.1089/dia.2019.0185
10.1038/s41594-018-0067-z
10.4155/tde.12.79
10.1021/ja0563455
10.4155/tde-2015-0002
10.3390/pharmaceutics12010048
10.1016/j.jconrel.2018.03.013
10.1016/S0140-6736(19)31271-1
10.1186/1477-9560-4-6
10.1542/peds.24.4.544
10.2217/nnm-2018-0322
10.1016/j.bone.2016.07.019
10.1126/scitranslmed.aar7047
10.1016/j.ejps.2013.01.009
10.1080/21688370.2017.1361900
10.1016/j.biomaterials.2016.06.059
10.1016/j.jconrel.2018.10.022
10.1021/jm500223x
10.1210/jc.2012-1179
10.2174/138945006778019381
10.1021/jm500862r
10.1016/j.addr.2016.02.011
10.1023/A:1015999309353
10.1177/1091581809337737
10.3109/03639049309062992
10.1016/S2213-8587(19)30192-5
10.1016/j.biomaterials.2012.09.051
10.1016/S0169-409X(00)00120-4
10.1016/j.jconrel.2017.10.023
10.1016/j.jconrel.2014.10.026
10.1080/1061186X.2017.1300664
10.1016/j.jconrel.2007.05.019
10.1016/j.addr.2017.10.004
10.1016/j.ejpb.2019.08.011
10.1177/0091270010372625
10.1016/j.jconrel.2018.03.018
10.1038/s41551-019-0465-5
10.1007/978-3-642-10324-7_4
10.1016/j.addr.2016.02.004
10.1016/j.ejpb.2013.12.017
10.1016/j.autrev.2015.01.009
10.1016/j.addr.2008.09.008
10.1021/acs.jcim.8b00485
10.1073/pnas.1908929116
10.1248/bpb.29.1783
10.1016/j.addr.2018.07.017
10.1016/j.jconrel.2017.10.013
10.1021/acs.molpharmaceut.8b01053
10.1038/nrd.2018.18
10.1021/mp500776a
10.1111/dom.13498
10.1111/imr.12446
10.1586/era.10.88
10.1021/jm400887j
10.1002/prp2.522
10.1021/jm9806594
10.1071/CH19479
10.3390/ijms20164016
10.1002/anie.201609079
10.1016/j.biotechadv.2014.07.006
10.1016/j.addr.2016.10.005
10.1021/cr040669e
10.1016/j.addr.2011.07.004
10.1016/j.jconrel.2019.04.037
10.1021/acs.chemrev.8b00807
10.1016/j.biomaterials.2011.10.075
10.1210/jc.2014-4113
10.1248/bpb.20.812
10.1023/A:1007541423500
10.1016/S0169-409X(02)00091-1
10.1038/s41591-019-0598-9
10.1002/smll.201202623
10.1016/j.jconrel.2019.08.008
10.1016/j.pt.2012.06.005
10.1021/acs.langmuir.6b03944
10.1002/cbic.201500441
10.1021/acs.jmedchem.5b00128
10.1038/s41598-017-15108-y
10.1021/jm990315t
10.1016/j.clinthera.2011.03.003
10.1007/s11095-014-1350-2
10.1158/1078-0432.CCR-04-1534
10.1023/A:1005847703624
10.1038/sj.bjp.0707332
10.1080/1061186X.2019.1584200
10.1039/C9NA00308H
10.1016/0169-409X(93)90046-7
10.1080/10611860290022688
10.1093/rheumatology/kem222
10.1016/j.jconrel.2019.07.020
10.1016/j.clinthera.2012.11.004
10.1016/j.jconrel.2018.09.003
10.1021/acs.chemrev.6b00838
10.1016/0169-409X(91)90048-H
10.1016/j.peptides.2017.12.014
10.1016/j.jconrel.2018.07.045
10.1021/acs.molpharmaceut.9b00355
10.1002/jps.21084
10.1038/s41578-019-0156-6
10.1111/cts.12609
10.1038/nnano.2015.47
10.1002/cmdc.201600083
10.2165/00003495-199550050-00009
10.1002/cmdc.201600082
10.2478/s11658-008-0041-6
10.1038/srep24575
10.1016/j.biopha.2018.09.097
10.1021/acsnano.5b00028
10.1038/d41573-019-00014-x
10.1128/AAC.00693-12
10.1016/S2213-8587(19)30194-9
10.1021/ja063076p
10.1002/anie.200705797
10.1016/j.actbio.2015.12.017
10.1085/jgp.200810154
10.1021/acs.molpharmaceut.8b00466
10.7554/eLife.34469
10.1126/science.aaa4690
10.1126/sciimmunol.aba4219
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10.1002/anie.201401058
10.1016/j.jconrel.2018.03.033
10.1039/C9CC06234C
10.1016/j.ejpb.2014.12.024
10.1016/j.ejpb.2019.09.007
10.1007/s10989-017-9590-8
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Keywords Nanoparticles
Oral bioavailability
Tight junctions
Oral peptide delivery
Drug-device combination products
Epithelial permeability
Language English
License This is an open access article under the CC BY license.
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References Thwala, Delgado, Leone, Marigo, Benetti, Chenlo, Alvarez, Tovar, Dieguez, Csaba, Alonso (bb0600) 2018; 291
Qian, Martyna, Hard, Wang, Appiah-Kubi, Coss, Phelps, Rossman, Pei (bb1335) 2016; 55
Pappenheimer (bb0490) 1988; 571
Jin, Song, Zhu, Zhou, Chen, Zhang, Huang (bb0725) 2012; 33
Terlain, Thomas (bb1295) 1971
Brazil, Parkos (bb0485) 2016; 273
Shan, Zhu, Liu, Li, Zhong, Sun, Zhang, Huang (bb0780) 2015; 9
Hristov, McCartney, Beirne, Mahon, Reid, Bhattacharjee, Penarier, Werner, Bazile, Brayden (bb0625) 2020; 12
Danielsen, Hansen (bb0390) 2017; 5
Noble, Markham (bb1020) 1995; 50
Gruber, Longer, Robinson (bb0015) 1987; 1
Sugiyama, Yamamoto, Kawabe, Uchiyama, Quan, Muranishi (bb0400) 1997; 20
Gallay, Lin (bb1105) 2013; 7
Fjellestad-Paulsen, Hoeglund, Lundin, Paulsen (bb1050) 1993; 38
Lin (bb1120) 2011
Ke, Guo, Zhu, Jin, Huang (bb0670) 2015; 18
Bockus, Lexa, Pye, Kalgutkar, Gardner, Hund, Hewitt, Schwochert, Glassey, Price, Mathiowetz, Liras, Jacobson, Lokey (bb1245) 2015; 58
Tillman, Geary, Hardee (bb0360) 2008; 97
Krug, Amasheh, Dittmann, Christoffel, Fromm, Amasheh (bb0340) 2013; 34
Watari, Kodaka, Matsuhisa, Sakamoto, Hisaie, Kawashita, Takagi, Yamagishi, Suzuki, Tsujino, Yagi, Kondoh (bb0530) 2017; 7
Petersen, Nielsen, Rahbek, Guldbrandt, Brayden (bb0425) 2013; 48
Tuesca, Nakamura, Morishita, Joseph, Peppas, Lowman (bb0885) 2008; 97
Lohman, Nielsen, Kok, Hoang, Hill, Fairlie (bb1205) 2019; 55
Trier, Linderoth, Bjerregaard, Andresen, Rahbek (bb0115) 2014; 9
Geho, Rosenberg, Schwartz, Lau, Gana (bb0825) 2014; 8
Ristroph, Prud'homme (bb0570) 2019; 1
Husain, Bain, Jeppesen, Lingvay, Sørrig, Treppendahl, Vilsbøll (bb0275) 2020 Jan 5; 22
Witek, Wang, Schroeder, Lingwood, Dounas, Roth, Fouche, Blatter, Lemke, Keller, Riniker (bb1285) 2019; 59
Dumont, Jannin, Miolane, Lelong, Valour, Urbaniak, Fessi, Bourgeois (bb0565) 2019; 54
DeGoey, Chen, Cox, Wendt (bb1350) 2018; 61
Phan, Le-Vinh, Efiana, Bernkop-Schnürch (bb0540) 2019; 27
Hopkins, Bobardt, Chatterji, Garcia-Rivera, Lim, Gallay (bb1125) 2012; 56
Henriksen, Byrjalsen, Andersen, Bihlet, Russo, Alexandersen, Valter, Qvist, Lau, Riis, Christiansen, Karsdal, SMC021 Investigators (bb0150) 2016; 91
White, Renzelman, Rand, Rezai, McEwen, Gelev, Turner, Linington, Leung, Kalgutkar, Bauman, Zhang, Liras, Price, Mathiowetz, Jacobson, Lokey (bb1225) 2011; 7
Lakkireddy, Urmann, Besenius, Werner, Haack, Alié, Illel, Hortala, Vogel, Bazile (bb0690) 2016; 106
McCartney (bb0630) 2016
Jørgensen, Yu, Venkatasubramanian, Nielsen, Nielsen, Boisen, Rades, Müllertz (bb0880) 2020; 12
Guada, Beloqui, Kumar, Preat, Dios-Vieitez, Blanco-Prieto (bb1025) 2016; 225
Tomita, Shiga, Hayashi, Awazu (bb0320) 1988; 5
Anderson, Beutel, Trujillo (bb0035) 2020; 34
Fouche, Schaefer, Blatter, Berghausen, Desrayaud, Roth (bb1280) 2016; 11
Niu, Tedesco, Benetti, Mabondzo, Montagner, Marigo, Gonzalez-Touceda, Tovar, Diéguez, Santander-Ortega, Alonso (bb0615) 2017; 263
Zhang, Zhu, Jin, Shan, Huang (bb0730) 2014; 11
Mauger, Lackner (bb1080) 2005
Maggio, Pillion (bb0415) 2013; 3
Karsdal, Byrjalsen, Alexandersen, Bihlet, Andersen, Riis, Bay-Jensen, Christiansen, CSMC021C2301/2 Investigators (bb0155) 2015; 23
Vergunst, Gerlag, Dinant, Schulz, Vinkenoog, Smeets, Sanders, Reedquist, Tak (bb1170) 2007; 46
Simren, Tack (bb1010) 2018; 15
Huttunen, Raunio, Rautio (bb1340) 2011; 63
Burleigh, Maltbaek, Cambier, Green, Gale, James, Stetson (bb0475) 2020; 5
Ling, Huizinga, Mayo, Freitag, Aspeslet, Foster (bb1115) 2013; 53
Abramson, Caffarel-Salvador, Soares, Minahan, Tian, Lu, Dellal, Gao, Kim, Wainer, Collins, Tamang, Hayward, Yoshitake, Lee, Fujimoto, Fels, Frederiksen, Rahbek, Roxhed, Langer, Traverso (bb0845) 2019; 25
Binkley, Bone, Gilligan, Krause (bb0145) 2014; 25
Liu, Werner, Funke, Besenius, Saaby, Fanø, Mu, Müllertz (bb0450) 2019; 560
Presas, McCartney, Sultan, Hunger, Nellen, Alvarez, Werner, Bazile, Brayden, O'Driscoll (bb0620) 2018; 286
Granhall, Donsmark, Blicher, Golor, Søndergaard, Thomsen, Bækdal (bb0245) 2019; 58
Daugherty, McKee, FitzGerald, Mrsny (bb0110) 2000; 65
Mullard (bb0995) 2020; 19
Muranushi, Mack, Kim (bb0465) 1993; 19
Mullard (bb0985) 2018; 17
Hill, Lohman, Hoang, Nielsen, Scully, Kok, Liu, Lucke, Stoermer, Schroeder, Chaousis, Colless, Bernhardt, Edmonds, Griffith, Rotter, Ruggeri, Price, Liras, Craik, Fairlie (bb1200) 2014; 5
Biron, Chatterjee, Ovadia, Langenegger, Brueggen, Hoyer, Schmid, Jelnick, Gilon, Hoffman, Kessler (bb1315) 2008; 47
Bernkop-Schnürch (bb0765) 2018; 136-137
Eaimtrakarn, Rama Prasad, Ohno, Konishi, Yoshikawa, Shibata, Takada (bb0435) 2002; 10
Yoon, Jackman, Kim, Sut, Cho (bb0345) 2017; 33
Stern, Mehta, Carl (bb0140) 2013; 13
Sweeney, Fu, Wiedmann (bb1095) 2014; 57
Maher, Leonard, Jacobsen, Brayden (bb0330) 2009; 61
Melmed, Popovic, Bidlingmaier, Mercado, van der Lely, Biermasz, Bolanowski, Coculescu, Schopohl, Racz, Glaser, Goth, Greenman, Trainer, Mezosi, Shimon, Giustina, Korbonits, Bronstein, Kleinberg, Teichman, Gliko-Kabir, Mamluk, Haviv, Strasburger (bb0045) 2015; 100
Kondoh, Takahashi, Yagi (bb0090) 2012; 64
Bonengel, Jelkmann, Abdulkarim, Gumbleton, Reinstadler, Oberacher, Prüfert, Bernkop-Schnürch (bb0560) 2018; 273
Tyndall, Nall, Fairlie (bb0930) 2005; 105
Fernandez, Jannin, Chevrier, Chavant, Demarne, Carrière (bb0445) 2013; 30
Vorherr, Lewis, Berghausen, Huth, Schaefer, Wille, Gao, Wang (bb1250) 2019
Pfluegl, Kallen, Schirmer, Jansonius, Zurini, Walkinshaw (bb1040) 1993; 361
Vorherr, Lewis, Berghausen, Desrayaud, Schaefer (bb1220) 2018; 24
Yu, Cheng, Angelow, Gunzel, Kanzawa, Schneeberger, Fromm, Coalson (bb0495) 2009; 133
McCartney, Jannin, Chevrier, Boulghobra, Hristov, Ritter, Miolane, Chavant, Demarne, Brayden (bb0440) 2019; 310
Kidron (bb0405) 2011
Almansour, Taverner, Turner, Eggleston, Mrsny (bb0510) 2018; 288
Zhang, Qi, Lu, He, Li, Wu (bb0745) 2014; 10
Finch, Wong, Paczkowski, Wadi, Craik, Fairlie, Taylor (bb1155) 1999; 42
Quartara, Altamura (bb1150) 2006; 7
Samaridou, Kalamidas, Santalices, Crecente-Campo, Alonso (bb0610) 2020; 10
bb0590
Malde, Hill, Iyer, Fairlie (bb1300) 2019; 119
Valeur, Gueret, Adihou, Gopalakrishnan, Lemurell, Waldmann, Grossmann, Plowright (bb0955) 2017; 56
Boehm, Beaumont, Jones, Kalgutkar, Zhang, Atkinson, Bai, Brown, Eng, Goetz, Holder, Khunte, Lazzaro, Limberakis, Ryu, Shapiro, Tylaska, Yan, Turner, Leung, Ramaseshan, Price, Liras, Jacobson, Earp, Lokey, Mathiowetz, Menhaji-Klotz (bb1310) 2017; 60
Pearson, Chater, Wilcox (bb0650) 2016; 7
Walsh, Adamczyk, Chalasani, Maher, O'Toole, Fox, Leonard, Brayden (bb0355) 2011; 2
Song, Shi, Zhang, Hu, Zhang, Yin, Chu, Yan, Zhao, Zhang, Mu, Sun (bb0740) 2019; 16
Mosenzon, Blicher, Rosenlund, Eriksson, Heller, Hels, Pratley, Sathyapalan, Desouza (bb0270) 2019; 7
Jørgensen, Jepsen, Nielsen, Dufva, Nielsen, Rades, Boisen, Müllertz (bb0870) 2019; 143
Nielsen, Hoang, Lohman, Diness, Fairlie (bb1255) 2012; 14
Lecluyse, Sutton, Fix (bb0385) 1993; 265
Choonara, Choonara, Kumar, Bijukumar, du Toit, Pillay (bb0305) 2014; 32
Hunt, Hansen, Ericsson, Kallenbach, Ali, Dang-Tan, Malkin, W. J. Valentine WJ. (bb0210) 2019; 36
Leonard, Creed, Brayden, Baird (bb0860) 2000; 17
Nielsen, Lohman, Hoang, Hill, Jones, Lucke, Fairlie (bb1230) 2015; 16
Lalatsa, Garrett, Ferrarelli, Moger, Schätzlein, Uchegbu (bb0635) 2012; 9
Czogalla (bb1015) 2009; 14
Brown, Morrissey, Faircloth, Levine (bb1190) 2002; 50
Khedkar, Lebovitz, Fleming, Cherrington, Jose, Athalye, Vishweswaramurthy (bb0375) 2019; 12
Kling, Lukat, Almeida, Bauer, Fontaine, Sordello, Zaburannyi, Herrmann, Wenzel, Koenig, Ammerman, Barrio, Borchers, Bordon-Pallier, Broenstrup, Courtemanche, Gerlitz, Geslin, Hammann, Heinz, Hoffmann, Klieber, Kohlmann, Kurz, Lair, Matter, Nuermberger, Tyagi, Fraisse, Grosset, Lagrange, Mueller (bb1290) 2015; 348
Ortega, van der Donk (bb0940) 2016; 23
Fretzen (bb1000) 2018; 26
Grant, Rahman, Piekarz, Peer, Frye, Robey, Gardner, Figg, Bates (bb1070) 2010; 10
Mullard (bb0990) 2019; 18
Rezai, Bock, Zhou, Kalyanaraman, Lokey, Jacobson (bb1215) 2006; 128
Banerjee, Wong, Gogoi, Brown, Mitragotri (bb0855) 2017; 25
Binkhathlan, Hamdy, Brocks, Lavasanifar (bb1110) 2010; 75
Zhang, Shi, Song, Duan, Zhang, Sun, Li (bb0750) 2018; 26
Twarog, Fattah, Heade, Maher, Fattal, Brayden (bb0300) 2019; 11
Aroda, Rosenstock, Terauchi, Altuntas, Lalic, Morales Villegas, Jeppesen, Christiansen, Hertz, Haluzík, PIONEER 1 Investigators (bb0250) 2019; 42
Suessmuth, Mainz (bb0935) 2017; 56
Dougherty, Sahni, Pei (bb1330) 2019; 119
Brayden, Baird (bb0920) 2019; 380
Derakhshankhah, Jafari (bb1325) 2018; 108
Abramson, Halperin, Kim, Traverso (bb0205) 2019; 108
Brayden, Walsh (bb0720) 2014; 16
Clark, Blair, Liang, Brey, Brayden, Hirst (bb0025) 2001; 20
Takeuchi, Yamamoto, Kawashima (bb0080) 2001; 47
Chater, Wilcox, Pearson (bb0760) 2018; 124
Eldor, Arbit, Corcos, Kidron (bb0410) 2013; 8
bb0925
Martins, D'Auria, Liu, Fontana, Ferreira, Correia, Kemell, Moslova, Mäkilä, Salonen, Casettari, Hirvonen, Sarmento, Santos (bb0710) 2018; 14
Anderberg, Lindmark, Artursson (bb0325) 1993; 10
Nazir, Fürst, Lupo, Hupfauf, Gust, Bernkop-Schnürch (bb0770) 2019; 144
Mazzoni, Tentor, Strindberg, Nielsen, Keller, Alstrøm, Gundlach, Müllertz, Marizza, Boisen (bb0875) 2017; 268
bb1090
Durán-Lobato, Niu, Alonso (bb0055) 2019; 32
Kruecken, Harder, Jeschke, Holden-Dye, O'Connor, Welz, von Samson-Himmelstjerna (bb1130) 2012; 28
Almansour, Taverner, Eggleston, Mrsny (bb0515) 2018; 279
Hashim, Korupolu, Syed, Horlen, Beraki, Karamchedu, Dhalla, Ruffy, Imran (bb0850) 2019; 7
Dahlgren, Sjöblom, Hedeland, Lennernäs (bb0890) 2020; 12
Drucker (bb0195) 2020; 19
Montecalvo (bb1055) 2003; 51
Monk, Scola, Madala, Fairlie (bb1165) 2007; 152
Brayden, Alonso (bb0595) 2016; 106
Nielsen, Lohman, Hoang, Fairlie, Hill (bb1270) 2020; 73
LaMarche, Leeds, Amaral, Brewer, Bushell, Deng, Dewhurst, Ding, Dzink-Fox, Gamber, Jain, Lee, Lee, Lister, McKenney, Mullin, Osborne, Palestrant, Patane, Rann, Sachdeva, Shao, Tiamfook, Trzasko, Whitehead, Yifru, Yu, Yan, Zhu (bb1140) 2012; 55
Schumacher-Klinger, Fanous, Merzbach, Weinmuller, Reichart, Rader, Gitlin-Domagalska, Gilon, Kessler, Hoffman (bb1345) 2018; 15
White, Yudin (bb0945) 2011; 3
bb031
Dumont (10.1016/j.addr.2020.05.007_bb0565) 2019; 54
McCartney (10.1016/j.addr.2020.05.007_bb0440) 2019; 310
EFSA Panel of Food Additives and Nutrient Sources added to Food (ANS) (10.1016/j.addr.2020.05.007_bb0350) 2018; 16
Eldor (10.1016/j.addr.2020.05.007_bb0410) 2013; 8
Eaimtrakarn (10.1016/j.addr.2020.05.007_bb0435) 2002; 10
Boehm (10.1016/j.addr.2020.05.007_bb1310) 2017; 60
Brazil (10.1016/j.addr.2020.05.007_bb0485) 2016; 273
Smith (10.1016/j.addr.2020.05.007_bb0230) 2016; 6
Fretzen (10.1016/j.addr.2020.05.007_bb1000) 2018; 26
Arbit (10.1016/j.addr.2020.05.007_bb0220) 2006; 4
Rosenstock (10.1016/j.addr.2020.05.007_bb0260) 2019; 321
Nazir (10.1016/j.addr.2020.05.007_bb0770) 2019; 144
Fouche (10.1016/j.addr.2020.05.007_bb1275) 2016; 11
Tuesca (10.1016/j.addr.2020.05.007_bb0885) 2008; 97
Zinman (10.1016/j.addr.2020.05.007_bb0290) 2019; 42
Mantaj (10.1016/j.addr.2020.05.007_bb0120) 2018; 15
Hopkins (10.1016/j.addr.2020.05.007_bb1125) 2012; 56
Pridgen (10.1016/j.addr.2020.05.007_bb0705) 2013; 5
Mikol (10.1016/j.addr.2020.05.007_bb1045) 1993; 234
Suessmuth (10.1016/j.addr.2020.05.007_bb0935) 2017; 56
Martins (10.1016/j.addr.2020.05.007_bb0710) 2018; 14
Valeur (10.1016/j.addr.2020.05.007_bb0955) 2017; 56
Pereira de Sousa (10.1016/j.addr.2020.05.007_bb0645) 2015; 97
Khedkar (10.1016/j.addr.2020.05.007_bb0375) 2019; 12
Long (10.1016/j.addr.2020.05.007_bb0675) 2019; 14
Anselmo (10.1016/j.addr.2020.05.007_bb0060) 2019; 8
Geho (10.1016/j.addr.2020.05.007_bb0825) 2014; 8
Kim (10.1016/j.addr.2020.05.007_bb0700) 2018; 12
Pappenheimer (10.1016/j.addr.2020.05.007_bb0490) 1988; 571
Wang (10.1016/j.addr.2020.05.007_bb1240) 2014; 111
Brayden (10.1016/j.addr.2020.05.007_bb0460) 2014; 88
Pusztai (10.1016/j.addr.2020.05.007_bb0020) 1989; 3
Shan (10.1016/j.addr.2020.05.007_bb0780) 2015; 9
Liu (10.1016/j.addr.2020.05.007_bb0450) 2019; 560
Gradauer (10.1016/j.addr.2020.05.007_bb0095) 2015; 12
Bockus (10.1016/j.addr.2020.05.007_bb1245) 2015; 58
Twarog (10.1016/j.addr.2020.05.007_bb0300) 2019; 11
Simren (10.1016/j.addr.2020.05.007_bb1010) 2018; 15
White (10.1016/j.addr.2020.05.007_bb0945) 2011; 3
Tuvia (10.1016/j.addr.2020.05.007_bb0175) 2014; 31
Abramson (10.1016/j.addr.2020.05.007_bb0845) 2019; 25
Derakhshankhah (10.1016/j.addr.2020.05.007_bb1325) 2018; 108
Schoellhammer (10.1016/j.addr.2020.05.007_bb0900) 2017; 268
Banerjee (10.1016/j.addr.2020.05.007_bb0855) 2017; 25
Song (10.1016/j.addr.2020.05.007_bb0755) 2019; 14
Brayden (10.1016/j.addr.2020.05.007_bb0720) 2014; 16
Malde (10.1016/j.addr.2020.05.007_bb1300) 2019; 119
Fosgerau (10.1016/j.addr.2020.05.007_bb0010) 2015; 20
Almansour (10.1016/j.addr.2020.05.007_bb0515) 2018; 279
Hashim (10.1016/j.addr.2020.05.007_bb0850) 2019; 7
Niu (10.1016/j.addr.2020.05.007_bb0615) 2017; 263
Yu (10.1016/j.addr.2020.05.007_bb0495) 2009; 133
Rezai (10.1016/j.addr.2020.05.007_bb1215) 2006; 128
Krug (10.1016/j.addr.2020.05.007_bb0340) 2013; 34
Presas (10.1016/j.addr.2020.05.007_bb0620) 2018; 286
Leonard (10.1016/j.addr.2020.05.007_bb0860) 2000; 17
Fjellestad-Paulsen (10.1016/j.addr.2020.05.007_bb1050) 1993; 38
Monk (10.1016/j.addr.2020.05.007_bb1165) 2007; 152
Pieber (10.1016/j.addr.2020.05.007_bb0285) 2019; 7
Fairlie (10.1016/j.addr.2020.05.007_bb0950) 2000; 43
Lee (10.1016/j.addr.2020.05.007_bb0030) 1989; 4
Halberg (10.1016/j.addr.2020.05.007_bb0365) 2019; 7
Chen (10.1016/j.addr.2020.05.007_bb0735) 2018; 277
DeGoey (10.1016/j.addr.2020.05.007_bb1350) 2018; 61
Karsdal (10.1016/j.addr.2020.05.007_bb0160) 2011; 51
Almansour (10.1016/j.addr.2020.05.007_bb0510) 2018; 288
Mauger (10.1016/j.addr.2020.05.007_bb1080) 2005
Hill (10.1016/j.addr.2020.05.007_bb1200) 2014; 5
Anderberg (10.1016/j.addr.2020.05.007_bb0325) 1993; 10
Terlain (10.1016/j.addr.2020.05.007_bb1295) 1971
Muhammad (10.1016/j.addr.2020.05.007_bb1180) 2019; 14
Qian (10.1016/j.addr.2020.05.007_bb1335) 2016; 55
Damgé (10.1016/j.addr.2020.05.007_bb0050) 1988; 37
Bucheit (10.1016/j.addr.2020.05.007_bb0235) 2020; 22
Nielsen (10.1016/j.addr.2020.05.007_bb1230) 2015; 16
Banerjee (10.1016/j.addr.2020.05.007_bb0865) 2019; 297
Andreadis (10.1016/j.addr.2020.05.007_bb0185) 2018; 20
Durán-Lobato (10.1016/j.addr.2020.05.007_bb0055) 2019; 32
Vorherr (10.1016/j.addr.2020.05.007_bb1220) 2018; 24
McCartney (10.1016/j.addr.2020.05.007_bb0470) 2019; 11
Lamson (10.1016/j.addr.2020.05.007_bb0795) 2020; 4
Nielsen (10.1016/j.addr.2020.05.007_bb1260) 2014; 53
Fernandez (10.1016/j.addr.2020.05.007_bb0445) 2013; 30
Quartara (10.1016/j.addr.2020.05.007_bb1150) 2006; 7
Drucker (10.1016/j.addr.2020.05.007_bb0195) 2020; 19
Clark (10.1016/j.addr.2020.05.007_bb1305) 2010; 49
Binkhathlan (10.1016/j.addr.2020.05.007_bb1110) 2010; 75
Aroda (10.1016/j.addr.2020.05.007_bb0250) 2019; 42
Nielsen (10.1016/j.addr.2020.05.007_bb0965) 2017; 117
Lerner (10.1016/j.addr.2020.05.007_bb0310) 2015; 14
Tyndall (10.1016/j.addr.2020.05.007_bb0930) 2005; 105
Buckley (10.1016/j.addr.2020.05.007_bb0295) 2018; 10
Mayhew (10.1016/j.addr.2020.05.007_bb0480) 1999; 14
Wang (10.1016/j.addr.2020.05.007_bb0370) 2010; 1
Kelly (10.1016/j.addr.2020.05.007_bb0680) 2015; 10
Vergunst (10.1016/j.addr.2020.05.007_bb1170) 2007; 46
Menzel (10.1016/j.addr.2020.05.007_bb0545) 2018; 277
Bonengel (10.1016/j.addr.2020.05.007_bb0560) 2018; 273
Niu (10.1016/j.addr.2020.05.007_bb0605) 2018; 276
Zhang (10.1016/j.addr.2020.05.007_bb0745) 2014; 10
Brown (10.1016/j.addr.2020.05.007_bb0915) 2020; 5
Ristroph (10.1016/j.addr.2020.05.007_bb0570) 2019; 1
Schoellhammer (10.1016/j.addr.2020.05.007_bb0905) 2017; 152
Brayden (10.1016/j.addr.2020.05.007_bb0835) 2010; 199
Jørgensen (10.1016/j.addr.2020.05.007_bb0880) 2020; 12
Song (10.1016/j.addr.2020.05.007_bb0740) 2019; 16
White (10.1016/j.addr.2020.05.007_bb1225) 2011; 7
Thwala (10.1016/j.addr.2020.05.007_bb0600) 2018; 291
Mahmood (10.1016/j.addr.2020.05.007_bb0555) 2019; 142
Knudsen (10.1016/j.addr.2020.05.007_bb0190) 2019; 10
Fowler (10.1016/j.addr.2020.05.007_bb0685) 2013; 9
Watari (10.1016/j.addr.2020.05.007_bb0530) 2017; 7
Anderson (10.1016/j.addr.2020.05.007_bb0035) 2020; 34
Kling (10.1016/j.addr.2020.05.007_bb1290) 2015; 348
Liu (10.1016/j.addr.2020.05.007_bb1175) 2018; 25
Griesser (10.1016/j.addr.2020.05.007_bb0550) 2017; 520
Bockus (10.1016/j.addr.2020.05.007_bb1265) 2015; 58
Maggio (10.1016/j.addr.2020.05.007_bb0420) 2011; 167
Riley (10.1016/j.addr.2020.05.007_bb0225) 2009; 28
Loosli (10.1016/j.addr.2020.05.007_bb1035) 1985; 68
Lau (10.1016/j.addr.2020.05.007_bb0005) 2018; 26
Yoon (10.1016/j.addr.2020.05.007_bb0345) 2017; 33
Gallay (10.1016/j.addr.2020.05.007_bb1105) 2013; 7
Aguirre (10.1016/j.addr.2020.05.007_bb0100) 2016; 106
Husain (10.1016/j.addr.2020.05.007_bb0275) 2020; 22
Dittmann (10.1016/j.addr.2020.05.007_bb0335) 2014; 31
Hristov (10.1016/j.addr.2020.05.007_bb0625) 2020; 12
Zorzi (10.1016/j.addr.2020.05.007_bb0970) 2017; 38
Mullard (10.1016/j.addr.2020.05.007_bb0995) 2020; 19
Butler (10.1016/j.addr.2020.05.007_bb1060) 2014; 67
Huttunen (10.1016/j.addr.2020.05.007_bb1340) 2011; 63
LaMarche (10.1016/j.addr.2020.05.007_bb1140) 2012; 55
Tomita (10.1016/j.addr.2020.05.007_bb0320) 1988; 5
Bartlett (10.1016/j.addr.2020.05.007_bb1065) 2008; 46
Ohtsu (10.1016/j.addr.2020.05.007_bb0430) 2017; 42
Kondoh (10.1016/j.addr.2020.05.007_bb0090) 2012; 64
Loose (10.1016/j.addr.2020.05.007_bb0395) 2018; 51
Jørgensen (10.1016/j.addr.2020.05.007_bb0870) 2019; 143
Petersen (10.1016/j.addr.2020.05.007_bb0425) 2013; 48
Taverner (10.1016/j.addr.2020.05.007_bb0505) 2015; 210
Dougherty (10.1016/j.addr.2020.05.007_bb1330) 2019; 119
Zhang (10.1016/j.addr.2020.05.007_bb0750) 2018; 26
Hill (10.1016/j.addr.2020.05.007_bb0960) 2014; 53
Stern (10.1016/j.addr.2020.05.007_bb0140) 2013; 13
Mullard (10.1016/j.addr.2020.05.007_bb0985) 2018; 17
Filter (10.1016/j.addr.2020.05.007_bb0500) 2017; 6
McCartney (10.1016/j.addr.2020.05.007_bb0630) 2016
Samaridou (10.1016/j.addr.2020.05.007_bb0610) 2020; 10
Tillman (10.1016/j.addr.2020.05.007_bb0360) 2008; 97
Lohman (10.1016/j.addr.2020.05.007_bb1205) 2019; 55
Ling (10.1016/j.addr.2020.05.007_bb1115) 2013; 53
Binkley (10.1016/j.addr.2020.05.007_bb0145) 2014; 25
Rehmani (10.1016/j.addr.2020.05.007_bb0785) 2018; 100
Brown (10.1016/j.addr.2020.05.007_bb1190) 2002; 50
Grant (10.1016/j.addr.2020.05.007_bb0135) 2012; 3
Rodbard (10.1016/j.addr.2020.05.007_bb0255) 2019; 42
Melmed (10.1016/j.addr.2020.05.007_bb0045) 2015; 100
Wang (10.1016/j.addr.2020.05.007_bb0170) 2015; 12
Pratley (10.1016/j.addr.2020.05.007_bb0265) 2019; 394
Ke (10.1016/j.addr.2020.05.007_bb0670) 2015; 18
Kidron (10.1016/j.addr.2020.05.007_bb0405) 2011
Burleigh (10.1016/j.addr.2020.05.007_bb0475) 2020; 5
Witek (10.1016/j.addr.2020.05.007_bb1285) 2019; 59
Takeuchi (10.1016/j.addr.2020.05.007_bb0080) 2001; 47
Brayden (10.1016/j.addr.2020.05.007_bb0920) 2019; 380
Mosenzon (10.1016/j.addr.2020.05.007_bb0270) 2019; 7
Henriksen (10.1016/j.addr.2020.05.007_bb0150) 2016; 91
Nielsen (10.1016/j.addr.2020.05.007_bb1255) 2012; 14
Granhall (10.1016/j.addr.2020.05.007_bb0245) 2019; 58
Walsh (10.1016/j.addr.2020.05.007_bb0355) 2011; 2
Fu (10.1016/j.addr.2020.05.007_bb1100) 2014; 57
Clark (10.1016/j.addr.2020.05.007_bb0025) 2001; 20
Trier (10.1016/j.addr.2020.05.007_bb0115) 2014; 9
Lecluyse (10.1016/j.addr.2020.05.007_bb0385) 1993; 265
Rand (10.1016/j.addr.2020.05.007_bb1235) 2012; 3
Xu (10.1016/j.addr.2020.05.007_bb0805) 2020; 69
Artursson (10.1016/j.addr.2020.05.007_bb0800) 2020; 4
Brayden (10.1016/j.addr.2020.05.007_bb0595) 2016; 106
Menzel (10.1016/j.addr.2020.05.007_bb0075) 2018; 124
Karsdal (10.1016/j.addr.2020.05.007_bb0155) 2015; 23
Giordanetto (10.1016/j.addr.2020.05.007_bb0980) 2014; 57
Castelli (10.1016/j.addr.2020.05.007_bb0215) 2011; 33
Klonoff (10.1016/j.addr.2020.05.007_bb0830) 2019; 42
Mazzoni (10.1016/j.addr.2020.05.007_bb0875) 2017; 268
Schumacher-Klinger (10.1016/j.addr.2020.05.007_bb1345) 2018; 15
Wimalawansa (10.1016/j.addr.2020.05.007_bb0165) 2018; Vol. 4
Nuhoho (10.1016/j.addr.2020.05.007_bb0240) 2019; 10
Finch (10.1016/j.addr.2020.05.007_bb1155) 1999; 42
Mullard (10.1016/j.addr.2020.05.007_bb0990) 2019; 18
Rademaker-Lakhai (10.1016/j.addr.2020.05.007_bb1185) 2005; 11
Lo (10.1016/j.addr.2020.05.007_bb0585) 2002; 54
10.1016/j.addr.2020.05.007_bb0085
Chan (10.1016/j.addr.2020.05.007_
References_xml – volume: 10
  start-page: 472
  year: 2015
  end-page: 479
  ident: bb0680
  article-title: Mapping protein binding sites on the biomolecular corona of nanoparticles
  publication-title: Nat. Nanotechnol.
  contributor:
    fullname: Dawson
– volume: 152
  start-page: 1151
  year: 2017
  end-page: 1160
  ident: bb0905
  article-title: Ultrasound-mediated delivery of RNA to colonic mucosa of live mice
  publication-title: Gastroenterology
  contributor:
    fullname: Traverso
– volume: 14
  start-page: 166
  year: 2019
  end-page: 174
  ident: bb1180
  article-title: Surotomycin (a novel cyclic lipopeptide) vs. vancomycin for the treatment of
  publication-title: Curr. Clin. Pharmacol.
  contributor:
    fullname: Albert
– volume: 27
  start-page: 1017
  year: 2019
  end-page: 1024
  ident: bb0540
  article-title: Oral self-emulsifying delivery systems for systemic administration of therapeutic proteins: science fiction?
  publication-title: J. Drug Target.
  contributor:
    fullname: Bernkop-Schnürch
– volume: 49
  start-page: 6545
  year: 2010
  end-page: 6548
  ident: bb1305
  article-title: The engineering of an orally-active conotoxin for the treatment of neuropathic pain
  publication-title: Angew. Chem. Int. Ed.
  contributor:
    fullname: Craik
– volume: 33
  start-page: 358
  year: 2011
  end-page: 371
  ident: bb0215
  article-title: Comparing the efficacy and tolerability of a new daily oral vitamin B
  publication-title: Clin. Ther.
  contributor:
    fullname: Riley
– volume: 8
  year: 2013
  ident: bb0410
  article-title: Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study
  publication-title: PLoS One
  contributor:
    fullname: Kidron
– volume: 142
  start-page: 91
  year: 2019
  end-page: 101
  ident: bb0555
  article-title: SEDDS: a game changing approach for the oral administration of hydrophilic macromolecular drugs
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Bernkop-Schnürch
– volume: 4
  start-page: 171
  year: 1989
  end-page: 207
  ident: bb0030
  article-title: Penetration and enzymatic barriers to peptide and protein absorption
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Yamamoto
– volume: 116
  start-page: 17817
  year: 2019
  end-page: 17824
  ident: bb0520
  article-title: Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Stroud
– volume: 12
  start-page: 99
  year: 2020
  ident: bb0890
  article-title: The
  publication-title: Pharmaceutics
  contributor:
    fullname: Lennernäs
– volume: 56
  start-page: 10294
  year: 2017
  end-page: 10323
  ident: bb0955
  article-title: New modalities for challenging targets in drug discovery
  publication-title: Angew. Chem. Int. Ed.
  contributor:
    fullname: Plowright
– volume: 5
  year: 2013
  ident: bb0705
  article-title: Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery
  publication-title: Sci. Transl. Med.
  contributor:
    fullname: Farokhzad
– volume: 55
  start-page: 2376
  year: 2012
  end-page: 2387
  ident: bb1140
  article-title: Discovery of LFF571: an investigational agent for
  publication-title: J. Med. Chem.
  contributor:
    fullname: Zhu
– volume: 33
  start-page: 2750
  year: 2017
  end-page: 2759
  ident: bb0345
  article-title: Correlating membrane morphological responses with micellar aggregation behavior of capric acid and monocaprin
  publication-title: Langmuir
  contributor:
    fullname: Cho
– year: 2019
  ident: bb1250
  article-title: Pyridyl-Ala modified cyclic hexapeptides:
  publication-title: Int. J. Pept. Res. Ther.
  contributor:
    fullname: Wang
– volume: 7
  start-page: 105
  year: 2013
  end-page: 115
  ident: bb1105
  article-title: Profile of alisporivir and its potential in the treatment of hepatitis C
  publication-title: Drug Des. Dev. Ther.
  contributor:
    fullname: Lin
– volume: 234
  start-page: 1119
  year: 1993
  end-page: 1130
  ident: bb1045
  article-title: X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 Å resolution
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Walkinshaw
– volume: 55
  start-page: 2601
  year: 2016
  end-page: 2612
  ident: bb1335
  article-title: Discovery and mechanism of highly efficient cyclic cell-penetrating peptides
  publication-title: Biochemistry
  contributor:
    fullname: Pei
– volume: 22
  start-page: 10
  year: 2020
  end-page: 18
  ident: bb0235
  article-title: Oral semaglutide: a review of the first oral Glucagon-like peptide 1 receptor agonist
  publication-title: Diabetes Technol. Ther.
  contributor:
    fullname: Sisson
– volume: 7
  start-page: 71
  year: 1991
  end-page: 86
  ident: bb0575
  article-title: Peroral administration of nanoparticles
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Kreuter
– volume: 105
  start-page: 973
  year: 2005
  end-page: 999
  ident: bb0930
  article-title: Proteases universally recognize beta strands in their active sites
  publication-title: Chem. Rev.
  contributor:
    fullname: Fairlie
– volume: 24
  start-page: 102132
  year: 2019
  ident: bb0790
  article-title: Coating of PLA-nanoparticles with cyclic, arginine-rich cell penetrating peptides enables oral delivery of liraglutide
  publication-title: Nanomedicine
  contributor:
    fullname: Mier
– volume: 5
  start-page: 1148
  year: 2014
  end-page: 1151
  ident: bb1200
  article-title: Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed
  publication-title: ACS Med. Chem. Lett.
  contributor:
    fullname: Fairlie
– volume: 7
  start-page: 229
  year: 2016
  end-page: 244
  ident: bb0650
  article-title: The properties of the mucus barrier, a unique gel-how can nanoparticles cross it?
  publication-title: Ther. Deliv.
  contributor:
    fullname: Wilcox
– volume: 225
  start-page: 269
  year: 2016
  end-page: 282
  ident: bb1025
  article-title: Reformulating cyclosporine A (CsA): more than just a life cycle management strategy
  publication-title: J. Control. Release
  contributor:
    fullname: Blanco-Prieto
– start-page: 411
  year: 2017
  end-page: 499
  ident: bb0975
  article-title: Overview of Macrocycles in Clinical Development and Clinically Used
  contributor:
    fullname: Giordanetto
– volume: 2
  start-page: 1595
  year: 2011
  end-page: 1610
  ident: bb0355
  article-title: Oral delivery of macromolecules: rationale underpinning Gastrointestinal Permeation Enhancement Technology (GIPET)
  publication-title: Ther. Deliv.
  contributor:
    fullname: Brayden
– volume: 9
  start-page: 1764
  year: 2012
  end-page: 1774
  ident: bb0635
  article-title: Delivery of peptides to the blood and brain after oral uptake of quaternary ammonium palmitoyl glycol chitosan nanoparticles
  publication-title: Mol. Pharm.
  contributor:
    fullname: Uchegbu
– volume: 16
  year: 2018
  ident: bb0350
  article-title: Re-evaluation of sodium, potassium and calcium salts of fatty acids (E470a) and magnesium salts of fatty acids (E470b) as food additives
  publication-title: EFSA J.
  contributor:
    fullname: Younis
– volume: 291
  start-page: 157
  year: 2018
  end-page: 168
  ident: bb0600
  article-title: Protamine nanocapsules as carriers for oral peptide delivery
  publication-title: J. Control. Release
  contributor:
    fullname: Alonso
– volume: 11
  year: 2019
  ident: bb0300
  article-title: Intestinal permeation enhancers for oral delivery of macromolecules: a comparison between salcaprozate sodium (SNAC) and sodium caprate (C
  publication-title: Pharmaceutics
  contributor:
    fullname: Brayden
– volume: 7
  year: 2017
  ident: bb0530
  article-title: Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay
  publication-title: Sci. Rep.
  contributor:
    fullname: Kondoh
– volume: 12
  start-page: 1257
  year: 2020
  end-page: 1269
  ident: bb0625
  article-title: Silica-coated nanoparticles with a core of zinc, l-arginine, and a peptide designed for oral delivery
  publication-title: ACS Appl. Mater. Interfaces
  contributor:
    fullname: Brayden
– volume: 86
  start-page: 544
  year: 2014
  end-page: 551
  ident: bb0130
  article-title: The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition
  publication-title: Eur. J. Pharm. Biopharm.
  contributor:
    fullname: Buckley
– volume: 32
  start-page: 1269
  year: 2014
  end-page: 1282
  ident: bb0305
  article-title: A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules
  publication-title: Biotechnol. Adv.
  contributor:
    fullname: Pillay
– volume: 14
  start-page: 479
  year: 2015
  end-page: 489
  ident: bb0310
  article-title: Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease
  publication-title: Autoimmun. Rev.
  contributor:
    fullname: Matthias
– volume: 8
  start-page: 551
  year: 2014
  end-page: 559
  ident: bb0825
  article-title: A single-blind, placebo-controlled, dose-ranging trial of oral hepatic-directed vesicle insulin add-on to oral antidiabetic treatment in patients with type 2 diabetes mellitus
  publication-title: J. Diabetes Sci. Technol.
  contributor:
    fullname: Gana
– volume: 12
  start-page: 2245
  year: 2015
  end-page: 2253
  ident: bb0095
  article-title: Interaction with mixed micelles in the intestine attenuates the permeation-enhancing potential of alkyl-maltosides
  publication-title: Mol. Pharm.
  contributor:
    fullname: Yamashita
– volume: 273
  start-page: 94
  year: 2016
  end-page: 111
  ident: bb0485
  article-title: Pathobiology of neutrophil-epithelial interactions
  publication-title: Immunol. Rev.
  contributor:
    fullname: Parkos
– volume: 21
  start-page: 2576
  year: 2019
  end-page: 2580
  ident: bb0280
  article-title: GLP-1 receptor agonists for prevention of cardiorenal outcomes in type 2 diabetes: an updated meta-analysis including the REWIND and PIONEER 6 trials
  publication-title: Diabetes Obes. Metab.
  contributor:
    fullname: Esposito
– ident: bb0640
– volume: 15
  start-page: 5802
  year: 2018
  end-page: 5808
  ident: bb0120
  article-title: Role of the basement membrane as an intestinal barrier to absorption of macromolecules and nanoparticles
  publication-title: Mol. Pharm.
  contributor:
    fullname: Vllasaliu
– volume: 3
  start-page: 981
  year: 2012
  end-page: 996
  ident: bb0135
  article-title: Peptide therapeutics: it's all in the delivery
  publication-title: Ther. Deliv.
  contributor:
    fullname: Leone-Bay
– volume: 20
  start-page: 812
  year: 1997
  end-page: 814
  ident: bb0400
  article-title: Effects of various absorption enhancers on the intestinal absorption of water soluble drugs by in vitro Ussing chamber method: correlation with an in situ absorption experiment
  publication-title: Biol. Pharm. Bull.
  contributor:
    fullname: Muranishi
– volume: 25
  start-page: 1512
  year: 2019
  end-page: 1518
  ident: bb0845
  article-title: A luminal unfolding microneedle injector for oral delivery of macromolecules
  publication-title: Nat. Med.
  contributor:
    fullname: Traverso
– volume: 51
  year: 2003
  ident: bb1055
  article-title: Ramoplanin: a novel antimicrobial agent with the potential to prevent vancomycin-resistant enterococcal infection in high-risk patients
  publication-title: J. Antimicrob. Chemother.
  contributor:
    fullname: Montecalvo
– volume: 58
  start-page: 7409
  year: 2015
  end-page: 7418
  ident: bb1265
  article-title: Going out on a limb: delineating the rffects of β-branching, N-methylation, and side chain size on the passive permeability, solubility, and flexibility of sanguinamide A analogues
  publication-title: J. Med. Chem.
  contributor:
    fullname: Lokey
– volume: 11
  year: 2019
  ident: bb0470
  article-title: Evaluation of sucrose laurate as an intestinal permeation enhancer for macromolecules: ex vivo and in vivo studies
  publication-title: Pharmaceutics
  contributor:
    fullname: Brayden
– volume: 61
  start-page: 1427
  year: 2009
  end-page: 4149
  ident: bb0330
  article-title: Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Brayden
– volume: 22
  start-page: 442
  year: 2020 Jan 5
  end-page: 451
  ident: bb0275
  article-title: Semaglutide (SUSTAIN and PIONEER) reduces cardiovascular events in type 2 diabetes across varying cardiovascular risk
  publication-title: Diabetes Obes. Metab.
  contributor:
    fullname: Vilsbøll
– volume: 100
  start-page: 24
  year: 2018
  end-page: 35
  ident: bb0785
  article-title: Oral delivery of anti-diabetes therapeutics using cell penetrating and transcytosing peptide strategies
  publication-title: Peptides
  contributor:
    fullname: Dixon
– volume: 57
  start-page: 8503
  year: 2014
  end-page: 8516
  ident: bb1100
  article-title: Potent non-immunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition
  publication-title: J. Med. Chem.
  contributor:
    fullname: Sweeney
– volume: 560
  start-page: 377
  year: 2019
  end-page: 384
  ident: bb0450
  article-title: SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats
  publication-title: Int. J. Pharm.
  contributor:
    fullname: Müllertz
– volume: 33
  start-page: 1573
  year: 2012
  end-page: 1582
  ident: bb0725
  article-title: Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport
  publication-title: Biomaterials
  contributor:
    fullname: Huang
– ident: bb1090
– volume: 11
  start-page: 1520
  year: 2014
  end-page: 1532
  ident: bb0730
  article-title: Mechanism study of cellular uptake and tight junction opening mediated by goblet cell-specific trimethyl chitosan nanoparticles
  publication-title: Mol. Pharm.
  contributor:
    fullname: Huang
– volume: 363
  start-page: 611
  year: 2019
  end-page: 615
  ident: bb0840
  article-title: An ingestible self-orienting system for oral delivery of macromolecules
  publication-title: Science
  contributor:
    fullname: Traverso
– volume: 143
  start-page: 98
  year: 2019
  end-page: 105
  ident: bb0870
  article-title: Microcontainers for oral insulin delivery: in vitro studies of permeation enhancement
  publication-title: Eur. J. Pharm. Biopharm.
  contributor:
    fullname: Müllertz
– volume: 36
  start-page: 1
  year: 2019
  end-page: 15
  ident: bb0125
  article-title: Assessing the utility of in vitro screening tools for predicting bio-performance of oral peptide delivery
  publication-title: Pharm. Res.
  contributor:
    fullname: Buist
– volume: 20
  start-page: 2255
  year: 2018
  end-page: 2263
  ident: bb0185
  article-title: Semaglutide for type 2 diabetes mellitus: a systematic review and meta-analysis
  publication-title: Diabetes Obes. Metab.
  contributor:
    fullname: Tsapas
– volume: 24
  start-page: 35
  year: 2018
  end-page: 48
  ident: bb1220
  article-title: Modulation of oral bioavailability and metabolism for closely related cyclic hexapeptides
  publication-title: Int. J. Pept. Res. Ther.
  contributor:
    fullname: Schaefer
– volume: 15
  start-page: 589
  year: 2018
  end-page: 605
  ident: bb1010
  article-title: New treatments and therapeutic targets for IBS and other functional bowel disorders
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  contributor:
    fullname: Tack
– ident: bb0925
– volume: 7
  year: 2018
  ident: bb0105
  article-title: Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids
  publication-title: Elife
  contributor:
    fullname: Lencer
– volume: 3
  start-page: 215
  year: 1989
  end-page: 228
  ident: bb0020
  article-title: Transport of proteins through the membranes of the adult gastro-intestinal tract – a potential for drug delivery?
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Pusztai
– volume: 9
  start-page: 2345
  year: 2015
  end-page: 5236
  ident: bb0780
  article-title: Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-assembled nanoparticles for oral delivery of insulin
  publication-title: ACS Nano
  contributor:
    fullname: Huang
– volume: 18
  start-page: 155
  year: 2015
  end-page: 170
  ident: bb0670
  article-title: Efficient peroral delivery of insulin via vitamin B
  publication-title: J. Pharm. Sci.
  contributor:
    fullname: Huang
– volume: 58
  start-page: 4581
  year: 2015
  end-page: 4589
  ident: bb1245
  article-title: Probing the physicochemical boundaries of cell permeability and oral bioavailability in lipophilic macrocycles inspired by natural products
  publication-title: J. Med. Chem.
  contributor:
    fullname: Lokey
– volume: 28
  start-page: 385
  year: 2012
  end-page: 394
  ident: bb1130
  article-title: Anthelmintic cyclcooctadepsipeptides: complex in structure and mode of action
  publication-title: Trends Parasitol.
  contributor:
    fullname: von Samson-Himmelstjerna
– volume: 380
  start-page: 1671
  year: 2019
  end-page: 1673
  ident: bb0920
  article-title: Stomaching drug delivery
  publication-title: New Eng. Medical J.
  contributor:
    fullname: Baird
– volume: 309
  start-page: 106
  year: 2019
  end-page: 124
  ident: bb1320
  article-title: Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs
  publication-title: J. Control. Release
  contributor:
    fullname: Zhai
– volume: 10
  start-page: 255
  year: 2002
  end-page: 260
  ident: bb0435
  article-title: Absorption enhancing effect of labrasol on the intestinal absorption of insulin in rats
  publication-title: J. Drug Target.
  contributor:
    fullname: Takada
– volume: 11
  start-page: 1854
  year: 2005
  end-page: 1862
  ident: bb1185
  article-title: Phase I clinical and pharmacokinetic study of kahalalide F in patients with advanced androgen refractory prostate cancer
  publication-title: Clin. Cancer Res.
  contributor:
    fullname: Schellens
– volume: 51
  start-page: 422
  year: 2018
  end-page: 426
  ident: bb0395
  article-title: Urinary concentrations and antimicrobial activity of tobramycin in healthy volunteers receiving a single oral dose of a novel formulation for improved absorption
  publication-title: Int. J. Antimicrob. Agents
  contributor:
    fullname: Wagenlehner
– volume: 6
  year: 2017
  ident: bb0500
  article-title: Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1)
  publication-title: Elife
  contributor:
    fullname: Goldberg
– volume: 263
  start-page: 4
  year: 2017
  end-page: 17
  ident: bb0615
  article-title: Rational design of polyarginine nanocapsules intended to help peptides overcoming intestinal barriers
  publication-title: J. Control. Release
  contributor:
    fullname: Alonso
– volume: 14
  start-page: 989
  year: 2019
  end-page: 1009
  ident: bb0755
  article-title: Oral delivery system for low molecular weight protamine-dextran-poly(lactic-co-glycolic acid) carrying exenatide to overcome the mucus barrier and improve intestinal targeting efficiency
  publication-title: Nanomedicine
  contributor:
    fullname: Sun
– volume: 42
  start-page: 1724
  year: 2019
  end-page: 1732
  ident: bb0250
  article-title: PIONEER 1: randomized clinical trial of the efficacy and safety of oral semaglutide monotherapy in comparison with placebo in patients with Type 2 diabetes
  publication-title: Diabetes Care
  contributor:
    fullname: PIONEER 1 Investigators
– volume: 106
  start-page: 193
  year: 2016
  end-page: 195
  ident: bb0595
  article-title: Oral delivery of peptides: opportunities and issues for translation
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Alonso
– volume: 10
  start-page: 141
  year: 1993
  end-page: 162
  ident: bb0580
  article-title: Nano- and microparticles for the delivery of polypeptides and proteins
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Puisieux
– volume: 22
  start-page: 18
  year: 2020
  ident: bb0810
  article-title: Polymeric nanocarrier formulations of biologics using inverse flash nano-precipitation
  publication-title: AAPS J.
  contributor:
    fullname: Prud'homme
– volume: 57
  start-page: 7145
  year: 2014
  end-page: 7159
  ident: bb1095
  article-title: From chemical tools to clinical medicines: non-immunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds
  publication-title: J. Med. Chem.
  contributor:
    fullname: Wiedmann
– volume: 111
  start-page: 17504
  year: 2014
  end-page: 17509
  ident: bb1240
  article-title: Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Craik
– volume: 59
  start-page: 294
  year: 2019
  end-page: 308
  ident: bb1285
  article-title: Rationalization of the membrane permeability differences in a series of analogue cyclic decapeptides
  publication-title: J. Chem. Inf. Model.
  contributor:
    fullname: Riniker
– volume: 97
  start-page: 2607
  year: 2008
  end-page: 2618
  ident: bb0885
  article-title: Complexation hydrogels for oral insulin delivery: effects of polymer dosing on
  publication-title: J. Pharm. Sci.
  contributor:
    fullname: Lowman
– volume: 32
  year: 2019
  ident: bb0055
  article-title: Oral delivery of biologics for precision medicine
  publication-title: Adv. Mater.
  contributor:
    fullname: Alonso
– volume: 167
  start-page: 233
  year: 2011
  end-page: 238
  ident: bb0420
  article-title: Oral delivery of octreotide acetate in Intravail® improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss Webster mice
  publication-title: Regul. Pept.
  contributor:
    fullname: Grasso
– volume: 304
  start-page: 1
  year: 2019
  end-page: 6
  ident: bb0910
  article-title: Ultra-rapid drug delivery in the oral cavity using ultrasound
  publication-title: J. Control. Release
  contributor:
    fullname: Schoellhammer
– volume: 12
  start-page: 276
  year: 2019
  end-page: 282
  ident: bb0375
  article-title: Impact of insulin tregopil and is permeation enhancer on pharmacokinetics of metformin in healthy volunteers: randomized, open label, placebo-controlled, crossover study
  publication-title: Clin. Transl. Sci.
  contributor:
    fullname: Vishweswaramurthy
– volume: 31
  start-page: 288
  year: 2016
  end-page: 300
  ident: bb0665
  article-title: Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: a mucoadhesive and pH responsive carrier for improved oral delivery of insulin
  publication-title: Acta Biomater.
  contributor:
    fullname: Mishra
– volume: 11
  year: 2018
  ident: bb1005
  article-title: Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation
  publication-title: Ther. Adv. Gastroenterol.
  contributor:
    fullname: Rao
– volume: 3
  start-page: 16
  year: 2013
  end-page: 25
  ident: bb0415
  article-title: High efficiency intranasal drug delivery using Intravail® alkylsaccharide absorption enhancers
  publication-title: Drug Deliv. Transl. Res.
  contributor:
    fullname: Pillion
– volume: 11
  start-page: 1060
  year: 2016
  end-page: 1068
  ident: bb1280
  article-title: Pharmacokinetic studies around the mono- and difunctionalization of a bioavailable cyclic decapeptide scaffold
  publication-title: ChemMedChem
  contributor:
    fullname: Roth
– volume: 1
  start-page: 1
  year: 1987
  end-page: 18
  ident: bb0015
  article-title: Some biological issues in oral, controlled drug delivery
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Robinson
– start-page: 1783
  year: 2006
  end-page: 1789
  ident: bb0525
  article-title: A novel strategy for a drug delivery system using a claudin modulator
  publication-title: Biol. Pharm. Bull.
  contributor:
    fullname: Watanabe
– volume: 16
  start-page: 2289
  year: 2015
  end-page: 2293
  ident: bb1230
  article-title: Flexibility versus rigidity for orally bioavailable cyclic hexapeptides
  publication-title: ChemBioChem
  contributor:
    fullname: Fairlie
– volume: 6
  start-page: 42
  year: 2016
  end-page: 45
  ident: bb0230
  article-title: Cyanocobalamin/salcaprozate sodium: a novel way to treat vitamin B
  publication-title: Hematol. Oncol. Pharm.
  contributor:
    fullname: Courtney
– volume: 31
  start-page: 2010
  year: 2014
  end-page: 2021
  ident: bb0175
  article-title: A novel suspension formulation enhances intestinal absorption of macromolecules via transient and reversible transport mechanisms
  publication-title: Pharm. Res.
  contributor:
    fullname: Mamluk
– volume: 10
  start-page: 167
  year: 2014
  end-page: 176
  ident: bb0745
  article-title: Biotinylated liposomes as potential carriers for the oral delivery of insulin
  publication-title: Nanomedicine
  contributor:
    fullname: Wu
– volume: 23
  start-page: 532
  year: 2015
  end-page: 543
  ident: bb0155
  article-title: Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two Phase 3 trials
  publication-title: Osteoarthr. Cartil.
  contributor:
    fullname: CSMC021C2301/2 Investigators
– volume: 25
  start-page: 608
  year: 2017
  end-page: 615
  ident: bb0855
  article-title: Intestinal micropatches for oral insulin delivery
  publication-title: J. Drug Target.
  contributor:
    fullname: Mitragotri
– volume: 47
  start-page: 2595
  year: 2008
  end-page: 2599
  ident: bb1315
  article-title: Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues
  publication-title: Angew. Chem. Int. Ed.
  contributor:
    fullname: Kessler
– volume: 7
  start-page: 528
  year: 2019
  end-page: 539
  ident: bb0285
  article-title: PIONEER 7 investigators, Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, Phase 3a trial
  publication-title: Lancet Diabetes Endocrinol.
  contributor:
    fullname: Buse
– volume: 55
  start-page: 13362
  year: 2019
  end-page: 13365
  ident: bb1205
  article-title: Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities
  publication-title: Chem. Commun.
  contributor:
    fullname: Fairlie
– volume: 119
  start-page: 10241
  year: 2019
  end-page: 10287
  ident: bb1330
  article-title: Understanding cell penetration of cyclic peptides
  publication-title: Chem. Rev.
  contributor:
    fullname: Pei
– volume: 47
  start-page: 39
  year: 2001
  end-page: 54
  ident: bb0080
  article-title: Mucoadhesive nanoparticulate systems for peptide drug delivery
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Kawashima
– volume: 37
  start-page: 246
  year: 1988
  end-page: 251
  ident: bb0050
  article-title: New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carriers
  publication-title: Diabetes
  contributor:
    fullname: Couvreur
– volume: 10
  year: 2018
  ident: bb0295
  article-title: Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist
  publication-title: Sci. Transl. Med.
  contributor:
    fullname: Knudsen
– volume: 26
  start-page: 931
  year: 2018
  end-page: 940
  ident: bb0750
  article-title: Tf ligand-receptor-mediated exenatide-Zn
  publication-title: J. Drug Target.
  contributor:
    fullname: Li
– volume: 26
  start-page: 2863
  year: 2018
  end-page: 2872
  ident: bb1000
  article-title: Peptide therapeutics for the treatment of gastrointestinal disorders
  publication-title: Bioorg. Med. Chem.
  contributor:
    fullname: Fretzen
– volume: 65
  start-page: 297
  year: 2000
  end-page: 302
  ident: bb0110
  article-title: Epithelial application of
  publication-title: J. Control. Release
  contributor:
    fullname: Mrsny
– ident: bb0590
– volume: 117
  start-page: 8094
  year: 2017
  end-page: 8128
  ident: bb0965
  article-title: Orally absorbed cyclic peptides
  publication-title: Chem. Rev.
  contributor:
    fullname: Fairlie
– volume: 42
  start-page: 1965
  year: 1999
  end-page: 1974
  ident: bb1155
  article-title: Low molecular weight peptidic and cyclic antagonists of the receptor for the Complement Factor C5a
  publication-title: J. Med. Chem.
  contributor:
    fullname: Taylor
– volume: 13
  start-page: 1
  year: 2013
  end-page: 6
  ident: bb0140
  article-title: Oral delivery of peptides by Peptelligence™ technology
  publication-title: Drug Development & Delivery
  contributor:
    fullname: Carl
– volume: 88
  start-page: 830
  year: 2014
  end-page: 839
  ident: bb0460
  article-title: A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells
  publication-title: Eur. J. Pharm. Biopharm.
  contributor:
    fullname: Walsh
– volume: 31
  start-page: 2539
  year: 2014
  end-page: 2548
  ident: bb0335
  article-title: Laurate permeabilizes the paracellular pathway for small molecules in the intestinal epithelial cell model HT-29/B6 via opening the tight junctions by reversible relocation of claudin-5
  publication-title: Pharm. Res.
  contributor:
    fullname: Amasheh
– volume: 43
  start-page: 1271
  year: 2000
  end-page: 1281
  ident: bb0950
  article-title: Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing
  publication-title: J. Med. Chem.
  contributor:
    fullname: Burkett
– volume: 68
  start-page: 682
  year: 1985
  end-page: 704
  ident: bb1035
  article-title: Peptide conformations. Part 31. The conformation of cyclosporin A in the crystal and in solution
  publication-title: Helv. Chim. Acta
  contributor:
    fullname: Widmer
– volume: 3
  year: 2019
  ident: bb0815
  article-title: OR14-1 pharmacodynamics, safety, tolerability, and efficacy of oral insulin formulation (Oshadi Icp) among young adults with Type 1diabetes: a summary of clinical studies Phases I, Ib
  publication-title: J. Endocrine Soc.
  contributor:
    fullname: Koren
– volume: 10
  start-page: 241
  year: 2020
  end-page: 258
  ident: bb0610
  article-title: Tuning the PEG surface density of the PEG-PGA enveloped octaarginine-peptide nanocomplexes
  publication-title: Drug Deliv. Trans. Res.
  contributor:
    fullname: Alonso
– ident: bb0655
– volume: 53
  start-page: 13020
  year: 2014
  end-page: 13041
  ident: bb0960
  article-title: Constraining cyclic peptides To mimic protein structure motifs
  publication-title: Angew. Chem. Int. Ed.
  contributor:
    fullname: Fairlie
– volume: 97
  start-page: 2362
  year: 2012
  end-page: 2369
  ident: bb0180
  article-title: Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression
  publication-title: J. Clin. Endocrinol. Metab.
  contributor:
    fullname: Mamluk
– volume: 34
  start-page: 275
  year: 2013
  end-page: 282
  ident: bb0340
  article-title: Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells
  publication-title: Biomaterials
  contributor:
    fullname: Amasheh
– volume: 56
  start-page: 3888
  year: 2012
  end-page: 3897
  ident: bb1125
  article-title: The cyclophilin inhibitor SCY-635 disrupts hepatitis C virus NS5A-cyclophilin A complexes
  publication-title: Antimicrob. Agents Chemother.
  contributor:
    fullname: Gallay
– volume: 46
  start-page: 3
  year: 2001
  end-page: 26
  ident: bb1030
  article-title: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Feeney
– volume: 108
  start-page: 3138
  year: 2019
  end-page: 3145
  ident: bb0205
  article-title: Quantifying the value of orally delivered biologic therapies: a cost-effectiveness analysis of oral semaglutide
  publication-title: J. Pharm. Sci.
  contributor:
    fullname: Traverso
– volume: 100
  start-page: 1699
  year: 2015
  end-page: 1708
  ident: bb0045
  article-title: Safety and efficacy of oral octreotide in acromegaly: results of a multicenter Phase III trial
  publication-title: J. Clin. Endocrinol. Metab.
  contributor:
    fullname: Strasburger
– volume: 10
  year: 2019
  ident: bb0190
  article-title: The discovery and development of liraglutide and semaglutide
  publication-title: Front. Endocrinol.
  contributor:
    fullname: Lau
– volume: 20
  start-page: 208
  year: 2001
  end-page: 217
  ident: bb0025
  article-title: Targeting polymerised liposome vaccine carriers to intestinal M cells
  publication-title: Vaccine
  contributor:
    fullname: Hirst
– volume: 30
  start-page: 3077
  year: 2013
  end-page: 3087
  ident: bb0445
  article-title: In vitro digestion of the self-emulsifying lipid excipient Labrasol(®) by gastrointestinal lipases and influence of its colloidal structure on lipolysis rate
  publication-title: Pharm. Res.
  contributor:
    fullname: Carrière
– volume: 22
  start-page: 318
  year: 2003
  end-page: 331
  ident: bb1135
  article-title: Cyclo-octadepsipeptides: an anthelmintically-active class of compounds exhibiting a novel mode of action
  publication-title: Int. J. Antimicrob. Agents
  contributor:
    fullname: Walker
– volume: 54
  start-page: 1213
  year: 2002
  end-page: 1223
  ident: bb0585
  article-title: Catching target receptors for drug and vaccine delivery using TOGA gene expression profiling
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: O'Mahony
– volume: 27
  start-page: 1821
  year: 2012
  end-page: 1829
  ident: bb0040
  article-title: Oral calcitonin in postmenopausal osteoporosis (ORACAL) investigators, A Phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the oral calcitonin in postmenopausal osteoporosis (ORACAL) trial
  publication-title: J. Bone Miner. Res.
  contributor:
    fullname: Krause
– volume: 520
  start-page: 267
  year: 2017
  end-page: 274
  ident: bb0550
  article-title: Hydrophobic ion pairing: key to highly pay-loaded self-emulsifying peptide drug delivery systems
  publication-title: Int. J. Pharm.
  contributor:
    fullname: Bernkop-Schnürch
– volume: 20
  start-page: 122
  year: 2015
  end-page: 128
  ident: bb0010
  article-title: Peptide therapeutics: current status and future directions
  publication-title: Drug Discov. Today
  contributor:
    fullname: Hoffmann
– volume: 12
  start-page: 8893
  year: 2018
  end-page: 8900
  ident: bb0700
  article-title: Oral nanoparticles exhibit specific high-efficiency intestinal uptake and lymphatic transport
  publication-title: ACS Nano
  contributor:
    fullname: Bae
– volume: 19
  start-page: 277
  year: 2020
  end-page: 289
  ident: bb0195
  article-title: Advances in oral peptide therapeutics
  publication-title: Nat. Rev. Drug Discov.
  contributor:
    fullname: Drucker
– volume: 136-137
  start-page: 62
  year: 2018
  end-page: 72
  ident: bb0765
  article-title: Strategies to overcome the poly-cation dilemma in drug delivery
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Bernkop-Schnürch
– volume: 61
  start-page: 75
  year: 2009
  end-page: 85
  ident: bb0065
  article-title: Barrier properties of mucus
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Cone
– volume: 7
  start-page: 975
  year: 2006
  end-page: 992
  ident: bb1150
  article-title: Tachykinin receptors antagonists: from research to clinic
  publication-title: Curr. Drug Targets
  contributor:
    fullname: Altamura
– volume: 16
  start-page: 1064
  year: 2014
  end-page: 1076
  ident: bb0720
  article-title: Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative
  publication-title: AAPS J.
  contributor:
    fullname: Walsh
– volume: 46
  start-page: 1489
  year: 2008
  end-page: 1492
  ident: bb1065
  article-title: The case for vancomycin as the preferred drug for treatment of
  publication-title: Clin. Infect. Dis.
  contributor:
    fullname: Bartlett
– volume: 4
  start-page: 12
  year: 2020
  end-page: 13
  ident: bb0800
  article-title: A new opening for orally taken peptide drugs
  publication-title: Nat. Biomed. Eng.
  contributor:
    fullname: Lundquist
– volume: 1
  start-page: 4207
  year: 2019
  end-page: 4237
  ident: bb0570
  article-title: Hydrophobic ion pairing: encapsulating small molecules, peptides, and proteins into nanocarriers
  publication-title: Nanoscale
  contributor:
    fullname: Prud'homme
– volume: 17
  start-page: 150
  year: 2018
  ident: bb0985
  article-title: 2017 FDA drug approvals
  publication-title: Nat. Rev. Drug Discov.
  contributor:
    fullname: Mullard
– volume: 4
  start-page: 84
  year: 2020
  end-page: 96
  ident: bb0795
  article-title: Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
  publication-title: Nat. Biomed. Eng.
  contributor:
    fullname: Whitehead
– volume: 36
  start-page: 3483
  year: 2019
  end-page: 3493
  ident: bb0210
  article-title: Evaluation of the cost per patient achieving treatment targets with oral semaglutide: a short-term cost-effectiveness analysis in the United States
  publication-title: Adv. Ther.
  contributor:
    fullname: W. J. Valentine WJ.
– volume: 210
  start-page: 189
  year: 2015
  end-page: 197
  ident: bb0505
  article-title: Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation
  publication-title: J. Control. Release
  contributor:
    fullname: Mrsny
– volume: 50
  start-page: 924
  year: 1995
  end-page: 941
  ident: bb1020
  article-title: Cyclosporin: a review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral)
  publication-title: Drugs
  contributor:
    fullname: Markham
– start-page: 2349
  year: 1971
  end-page: 2356
  ident: bb1295
  article-title: Constitution of griselimycin, a polypeptide antibiotic extracted from Streptomyces cultures. I. Identification of the hydrolysis products
  publication-title: Bull. Soc. Chim. Fr.
  contributor:
    fullname: Thomas
– volume: 10
  start-page: 857
  year: 1993
  end-page: 864
  ident: bb0325
  article-title: Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route
  publication-title: Pharm. Res.
  contributor:
    fullname: Artursson
– volume: 38
  start-page: 177
  year: 1993
  end-page: 182
  ident: bb1050
  article-title: Pharmacokinetics of 1-deamino-8-D-arginine vasopressin after various routes of administration in healthy volunteers
  publication-title: Clin. Endocrinol.
  contributor:
    fullname: Paulsen
– volume: 60
  start-page: 9653
  year: 2017
  end-page: 9663
  ident: bb1310
  article-title: Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modulators
  publication-title: J. Med. Chem.
  contributor:
    fullname: Menhaji-Klotz
– volume: 288
  start-page: 111
  year: 2018
  end-page: 125
  ident: bb0510
  article-title: An intestinal paracellular pathway biased toward positively-charged macromolecules
  publication-title: J. Control. Release
  contributor:
    fullname: Mrsny
– volume: 115
  start-page: 7296
  year: 2018
  end-page: 7301
  ident: bb1355
  article-title: Ionic liquids for oral insulin delivery
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Mitragotri
– volume: 36
  start-page: 89
  year: 2019
  ident: bb0895
  article-title: Bottom-up fabrication of multilayer enteric devices for the oral delivery of peptides
  publication-title: Pharm. Res.
  contributor:
    fullname: Desai
– ident: bb0455
– volume: 152
  start-page: 429
  year: 2007
  end-page: 448
  ident: bb1165
  article-title: Function, structure and therapeutic potential of complement C5a receptors
  publication-title: Br. J. Pharmacol.
  contributor:
    fullname: Fairlie
– volume: 17
  start-page: 476
  year: 2000
  end-page: 478
  ident: bb0860
  article-title: Iontophoresis-enhanced absorptive flux of polar molecules across intestinal tissue in vitro
  publication-title: Pharm. Res.
  contributor:
    fullname: Baird
– volume: 25
  start-page: 2649
  year: 2014
  end-page: 2656
  ident: bb0145
  article-title: Efficacy and safety of oral recombinant calcitonin tablets in postmenopausal women with low bone mass and increased fracture risk: a randomized, placebo-controlled trial
  publication-title: Osteoporos. Int.
  contributor:
    fullname: Krause
– volume: Vol. 4
  start-page: 178
  year: 2018
  end-page: 191
  ident: bb0165
  article-title: Physiology of calcitonin and its therapeutic uses
  publication-title: Encyclopedia Endocrine Dis. 2nD Ed.
  contributor:
    fullname: Wimalawansa
– volume: 63
  start-page: 750
  year: 2011
  end-page: 771
  ident: bb1340
  article-title: Prodrugs – from serendipity to rational design
  publication-title: Pharmacol. Rev.
  contributor:
    fullname: Rautio
– volume: 42
  start-page: 611
  year: 2017
  end-page: 626
  ident: bb0430
  article-title: Absorption, distribution, metabolism, and excretion of the androgen receptor inhibitor enzalutamide in rats and dogs
  publication-title: Eur. J. Drug Metab. Pharmacokinet.
  contributor:
    fullname: Arai
– volume: 7
  year: 2019
  ident: bb0850
  article-title: Jejunal wall delivery of insulin via an ingestible capsule in anesthetized swine-A pharmacokinetic and pharmacodynamic study
  publication-title: Pharmacol. Res. Perspect.
  contributor:
    fullname: Imran
– volume: 53
  start-page: 12059
  year: 2014
  end-page: 12063
  ident: bb1260
  article-title: Improving on nature: making a cyclic heptapeptide orally bioavailable
  publication-title: Angew. Chem. Int. Ed.
  contributor:
    fullname: Fairlie
– volume: 268
  start-page: 343
  year: 2017
  end-page: 351
  ident: bb0875
  article-title: From concept to in vivo testing: microcontainers for oral drug delivery
  publication-title: J. Control. Release
  contributor:
    fullname: Boisen
– volume: 91
  start-page: 122
  year: 2016
  end-page: 129
  ident: bb0150
  article-title: A randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy and safety of oral salmon calcitonin in the treatment of osteoporosis in postmenopausal women taking calcium and vitamin D
  publication-title: Bone
  contributor:
    fullname: SMC021 Investigators
– volume: 97
  start-page: 225
  year: 2008
  end-page: 236
  ident: bb0360
  article-title: Oral delivery of antisense oligonucleotides in man
  publication-title: J. Pharm. Sci.
  contributor:
    fullname: Hardee
– volume: 67
  start-page: 631
  year: 2014
  end-page: 644
  ident: bb1060
  article-title: Glycopeptide antibiotics: Back to the future
  publication-title: J. Antibiot.
  contributor:
    fullname: Cooper
– volume: 46
  start-page: 1773
  year: 2007
  end-page: 1778
  ident: bb1170
  article-title: Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation
  publication-title: Rheumatology
  contributor:
    fullname: Tak
– volume: 128
  start-page: 14073
  year: 2006
  end-page: 14080
  ident: bb1215
  article-title: Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful
  publication-title: J. Am. Chem. Soc.
  contributor:
    fullname: Jacobson
– volume: 348
  start-page: 1106
  year: 2015
  end-page: 1112
  ident: bb1290
  article-title: Targeting DnaN for tuberculosis therapy using novel griselimycins
  publication-title: Science
  contributor:
    fullname: Mueller
– volume: 9
  year: 2014
  ident: bb0115
  article-title: Acylation of Glucagon-like peptide-2: interaction with lipid membranes and
  publication-title: PLoS One
  contributor:
    fullname: Rahbek
– volume: 128
  start-page: 2510
  year: 2006
  end-page: 2511
  ident: bb1210
  article-title: Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers
  publication-title: J. Am. Chem. Soc.
  contributor:
    fullname: Lokey
– volume: 64
  start-page: 515
  year: 2012
  end-page: 522
  ident: bb0090
  article-title: Spiral progression in the development of absorption enhancers based on the biology of tight junctions
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Yagi
– volume: 42
  start-page: 2262
  year: 2019
  end-page: 2271
  ident: bb0290
  article-title: PIONEER 8 Investigators. Efficacy, safety, and tolerability of oral semaglutide versus placebo added to insulin with or without metformin in patients with Type 2 diabetes: the PIONEER 8 Trial
  publication-title: Diabetes Care
  contributor:
    fullname: Araki
– volume: 361
  start-page: 91
  year: 1993
  end-page: 94
  ident: bb1040
  article-title: X-ray structure of a decameric cyclophilin-cyclosporin crystal complex
  publication-title: Nature
  contributor:
    fullname: Walkinshaw
– volume: 7
  start-page: 810
  year: 2011
  end-page: 817
  ident: bb1225
  article-title: On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
  publication-title: Nat. Chem. Biol.
  contributor:
    fullname: Lokey
– volume: 42
  start-page: 2272
  year: 2019
  end-page: 2281
  ident: bb0255
  article-title: PIONEER 2 investigators, oral semaglutide versus empagliflozin in patients with Type 2 diabetes uncontrolled on metformin: the PIONEER 2 trial
  publication-title: Diabetes Care
  contributor:
    fullname: Montanya
– volume: 133
  start-page: 111
  year: 2009
  end-page: 127
  ident: bb0495
  article-title: Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site
  publication-title: J. Gen. Physiol
  contributor:
    fullname: Coalson
– volume: 23
  start-page: 31
  year: 2016
  end-page: 44
  ident: bb0940
  article-title: New insights into the biosynthetic logic of ribosomally synthesized and post-translationally modified peptide natural products
  publication-title: Cell Chem. Biol.
  contributor:
    fullname: van der Donk
– volume: 119
  start-page: 9861
  year: 2019
  end-page: 9914
  ident: bb1300
  article-title: Crystal structures of protein-bound cyclic peptides
  publication-title: Chem. Rev.
  contributor:
    fullname: Fairlie
– volume: 5
  year: 2017
  ident: bb0390
  article-title: Intestinal surfactant permeation enhancers and their interaction with enterocyte cell membranes in a mucosal explant system
  publication-title: Tissue Barriers
  contributor:
    fullname: Hansen
– volume: 5
  start-page: 127
  year: 2020
  end-page: 148
  ident: bb0915
  article-title: Materials for oral delivery of proteins and peptides
  publication-title: Nat. Rev. Mater.
  contributor:
    fullname: Mitragotri
– volume: 3
  start-page: 1282
  year: 2012
  end-page: 1289
  ident: bb1235
  article-title: Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance
  publication-title: Medchemcomm
  contributor:
    fullname: Lokey
– volume: 11
  start-page: 1048
  year: 2016
  end-page: 1059
  ident: bb1275
  article-title: Design and development of a cyclic decapeptide scaffold with suitable properties for bioavailability and oral exposure
  publication-title: ChemMedChem
  contributor:
    fullname: Roth
– volume: 56
  start-page: 3770
  year: 2017
  end-page: 3821
  ident: bb0935
  article-title: Non-ribosomal peptide synthesis-principles and prospects
  publication-title: Angew. Chem. Int. Ed.
  contributor:
    fullname: Mainz
– volume: 14
  start-page: 139
  year: 2009
  end-page: 152
  ident: bb1015
  article-title: Oral cyclosporine a - the current picture of its liposomal and other delivery systems
  publication-title: Cell. Mol. Biol. Lett.
  contributor:
    fullname: Czogalla
– volume: 28
  start-page: 278
  year: 2009
  end-page: 293
  ident: bb0225
  article-title: Sub-chronic oral toxicity of salcaprozate sodium (SNAC) in Sprague–Dawley and Wistar rats
  publication-title: Int. J. Toxicol.
  contributor:
    fullname: Paehler
– volume: 394
  start-page: 39
  year: 2019
  end-page: 50
  ident: bb0265
  article-title: PIONEER 4 investigators, Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, Phase 3a trial
  publication-title: Lancet
  contributor:
    fullname: Meier
– volume: 38
  start-page: 24
  year: 2017
  end-page: 29
  ident: bb0970
  article-title: Cyclic peptide therapeutics: past, present and future
  publication-title: Curr. Opin. Chem. Biol.
  contributor:
    fullname: Heinis
– volume: 61
  start-page: 2636
  year: 2018
  end-page: 2651
  ident: bb1350
  article-title: Beyond the Rule of 5: Lessons learned from AbbVie's drugs and compound collection
  publication-title: J. Med. Chem.
  contributor:
    fullname: Wendt
– volume: 321
  start-page: 1466
  year: 2019
  end-page: 1480
  ident: bb0260
  article-title: Effect of additional oral semaglutide vs sitagliptin on glycated hemoglobin in adults with Type 2 diabetes uncontrolled with metformin alone or with wulfonylurea: the PIONEER 3 randomized clinical trial
  publication-title: JAMA
  contributor:
    fullname: PIONEER 3 Investigators
– volume: 106
  start-page: 223
  year: 2016
  end-page: 241
  ident: bb0100
  article-title: Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Brayden
– volume: 299
  start-page: 247
  year: 2001
  end-page: 254
  ident: bb1145
  article-title: Nepadutant pharmacokinetics and dose-effect relationships as tachykinin NK2 receptor antagonist are altered by intestinal inflammation in rodent models
  publication-title: J. Pharmacol. Exp. Ther.
  contributor:
    fullname: Maggi
– volume: 75
  start-page: 90
  year: 2010
  end-page: 95
  ident: bb1110
  article-title: Development of a polymeric micellar formulation for valspodar and assessment of its pharmacokinetics in rat
  publication-title: Eur. J. Pharm. Biopharm.
  contributor:
    fullname: Lavasanifar
– volume: 5
  year: 2020
  ident: bb0475
  article-title: Human DNA-PK activates a STING-independent DNA sensing pathway
  publication-title: Sci. Immunol.
  contributor:
    fullname: Stetson
– volume: 7
  start-page: 515
  year: 2019
  end-page: 527
  ident: bb0270
  article-title: PIONEER 5 Investigators, Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, Phase 3a trial
  publication-title: Lancet Diabetes Endocrinol.
  contributor:
    fullname: Desouza
– volume: 15
  start-page: 3468
  year: 2018
  end-page: 3477
  ident: bb1345
  article-title: Enhancing oral bioavailability of cyclic RGD hexa-peptides by the lipophilic prodrug charge masking approach: redirection of peptide intestinal permeability from a paracellular to transcellular pathway
  publication-title: Mol. Pharm.
  contributor:
    fullname: Hoffman
– volume: 265
  start-page: 955
  year: 1993
  end-page: 962
  ident: bb0385
  article-title: In vitro effects of long-chain acylcarnitines on the permeability, transepithelial electrical resistance and morphology of rat colonic mucosa
  publication-title: J. Pharmacol. Exp. Ther.
  contributor:
    fullname: Fix
– volume: 21
  start-page: 160
  year: 2019
  end-page: 169
  ident: bb0380
  article-title: Enterically delivered insulin tregopil exhibits rapid absorption characteristics and a pharmacodynamic effect similar to human insulin in conscious dogs
  publication-title: Diabetes Obes. Metab.
  contributor:
    fullname: Cherrington
– volume: 34
  start-page: 107520
  year: 2020
  ident: bb0035
  article-title: Oral semaglutide in type 2 diabetes
  publication-title: J. Diabetes Complicat.
  contributor:
    fullname: Trujillo
– volume: 1
  start-page: 75
  year: 2010
  end-page: 82
  ident: bb0370
  article-title: Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate
  publication-title: Ther. Deliv.
  contributor:
    fullname: Brayden
– volume: 8
  start-page: 19
  year: 2019
  end-page: 40
  ident: bb0060
  article-title: Non-invasive delivery of biologics
  publication-title: Nat. Rev. Drug Discov.
  contributor:
    fullname: Mitragotri
– volume: 18
  start-page: 85
  year: 2019
  end-page: 89
  ident: bb0990
  article-title: 2018 FDA drug approvals
  publication-title: Nat. Rev. Drug Discov.
  contributor:
    fullname: Mullard
– volume: 277
  start-page: 142
  year: 2018
  end-page: 153
  ident: bb0735
  article-title: N-trimethyl chitosan nanoparticles and CSKSSDYQC peptide: N-trimethyl chitosan conjugates enhance the oral bioavailability of gemcitabine to treat breast cancer
  publication-title: J. Control. Release
  contributor:
    fullname: Wen
– volume: 14
  year: 2018
  ident: bb0710
  article-title: Engineered multi-functional albumin-decorated porous silicon nanoparticles for FcRn translocation of insulin
  publication-title: Small
  contributor:
    fullname: Santos
– volume: 279
  start-page: 208
  year: 2018
  end-page: 219
  ident: bb0515
  article-title: Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation in polarized intestinal epithelia
  publication-title: J. Control. Release
  contributor:
    fullname: Mrsny
– volume: 24
  start-page: 544
  year: 1959
  end-page: 561
  ident: bb1085
  article-title: The effect of actinomycin D on cancer in childhood
  publication-title: Pediatrics
  contributor:
    fullname: Burchenal
– year: 2016
  ident: bb0630
  article-title: Use of Permeation Enhancers and Nanotechnology to Increase Intestinal Peptide Permeability
  contributor:
    fullname: McCartney
– volume: 12
  year: 2020
  ident: bb0880
  article-title: ,
  publication-title: Pharmaceutics
  contributor:
    fullname: Müllertz
– volume: 197
  start-page: 48
  year: 2015
  end-page: 57
  ident: bb0070
  article-title: Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse
  publication-title: J. Control. Release
  contributor:
    fullname: Hanes
– volume: 571
  start-page: 43
  year: 1988
  end-page: 51
  ident: bb0490
  article-title: Physiological regulation of epithelial junctions in intestinal epithelia
  publication-title: Acta Physiol. Scand. Suppl.
  contributor:
    fullname: Pappenheimer
– volume: 103
  start-page: 160
  year: 2016
  end-page: 169
  ident: bb0535
  article-title: ZOT-derived peptide and chitosan functionalized nanocarrier for oral delivery of protein drug
  publication-title: Biomaterials
  contributor:
    fullname: Tae
– volume: 10
  start-page: 44354
  year: 2018
  end-page: 44367
  ident: bb0715
  article-title: Microfluidic nanoassembly of bioengineered chitosan-modified FcRn-targeted porous silicon nanoparticles with hypromellose acetate succinate for oral delivery of antidiabetic peptides
  publication-title: ACS Appl. Mater. Interfaces
  contributor:
    fullname: Santos
– volume: 5
  start-page: 341
  year: 1988
  end-page: 346
  ident: bb0320
  article-title: Enhancement of colonic drug absorption by the paracellular permeation route
  publication-title: Pharm. Res.
  contributor:
    fullname: Awazu
– volume: 34
  start-page: 2333
  year: 2012
  end-page: 2338
  ident: bb0820
  article-title: Time-action profile of an oral enteric insulin formulation in healthy Chinese volunteers
  publication-title: Clin. Ther.
  contributor:
    fullname: Yu
– year: 2011
  ident: bb0405
  article-title: Methods and Compositions for Oral Administration of Proteins
  contributor:
    fullname: Kidron
– volume: 26
  start-page: 2700
  year: 2018
  end-page: 2707
  ident: bb0005
  article-title: Therapeutic peptides: historical perspectives, current development trends, and future directions
  publication-title: Bioorg. Med. Chem.
  contributor:
    fullname: Dunn
– volume: 144
  start-page: 40
  year: 2019
  end-page: 49
  ident: bb0770
  article-title: Zeta potential changing self-emulsifying drug delivery systems: a promising strategy to sequentially overcome mucus and epithelial barrier
  publication-title: Eur. J. Pharm. Biopharm.
  contributor:
    fullname: Bernkop-Schnürch
– volume: 14
  start-page: 5720
  year: 2012
  end-page: 5723
  ident: bb1255
  article-title: Total synthesis, structure, and oral absorption of a thiazole cyclic peptide, sanguinamide A
  publication-title: Org. Lett.
  contributor:
    fullname: Fairlie
– volume: 310
  start-page: 115
  year: 2019
  end-page: 126
  ident: bb0440
  article-title: Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: ex vivo and in vivo rat studies
  publication-title: J. Control. Release
  contributor:
    fullname: Brayden
– ident: bb1195
– start-page: 281
  year: 2005
  end-page: 297
  ident: bb1080
  article-title: The Actinomycins
  contributor:
    fullname: Lackner
– ident: bb0315
– volume: 14
  start-page: 257
  year: 1999
  end-page: 267
  ident: bb0480
  article-title: Epithelial integrity, cell death and cell loss in mammalian small intestine
  publication-title: Histol. Histopathol.
  contributor:
    fullname: Jenkins
– volume: 97
  start-page: 273
  year: 2015
  end-page: 279
  ident: bb0645
  article-title: Mucus permeating carriers: formulation and characterization of highly densely charged nanoparticles
  publication-title: Eur. J. Pharm. Biopharm.
  contributor:
    fullname: Bernkop-Schnürch
– volume: 50
  start-page: 333
  year: 2002
  end-page: 340
  ident: bb1190
  article-title: Preclinical toxicity studies of kahalalide F, a new anticancer agent: single and multiple dosing regimens in the rat
  publication-title: Cancer Chemother. Pharmacol.
  contributor:
    fullname: Levine
– volume: 19
  start-page: 929
  year: 1993
  end-page: 941
  ident: bb0465
  article-title: The effects of fatty acids and their derivatives on the intestinal absorption of insulin in rats
  publication-title: Drug Dev. Ind. Pharm.
  contributor:
    fullname: Kim
– volume: 42
  start-page: 2154
  year: 2019
  end-page: 2157
  ident: bb0830
  article-title: Divergent hypoglycemic effects of hepatic-directed prandial insulin: a six-month Phase 2b study in Type 1 diabetes
  publication-title: Diabetes Care
  contributor:
    fullname: Muchmore
– volume: 9
  start-page: 3282
  year: 2013
  end-page: 3394
  ident: bb0685
  article-title: Nanoparticle transport in epithelial cells: pathway switching through bioconjugation
  publication-title: Small
  contributor:
    fullname: Stolnik
– volume: 14
  start-page: 7743
  year: 2019
  end-page: 7758
  ident: bb0675
  article-title: Investigation of vitamin B
  publication-title: Int. J. Nanomedicine
  contributor:
    fullname: Deng
– volume: 19
  start-page: 79
  year: 2020
  end-page: 84
  ident: bb0995
  article-title: 2019 FDA drug approvals
  publication-title: Nat. Rev. Drug Discov.
  contributor:
    fullname: Mullard
– volume: 6
  start-page: 1
  year: 2016
  end-page: 12
  ident: bb1160
  article-title: Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists
  publication-title: Sci. Rep.
  contributor:
    fullname: Fairlie
– volume: 124
  start-page: 184
  year: 2018
  end-page: 192
  ident: bb0760
  article-title: Efficacy and safety concerns over the use of mucus modulating agents for drug delivery using nanoscale systems
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Pearson
– volume: 124
  start-page: 164
  year: 2018
  end-page: 174
  ident: bb0075
  article-title: Enzyme decorated drug carriers: targeted swords to cleave and overcome the mucus barrier
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Bernkop-Schnürch
– volume: 108
  start-page: 1090
  year: 2018
  end-page: 1096
  ident: bb1325
  article-title: Cell penetrating peptides: a concise review with emphasis on biomedical applications
  publication-title: Biomed. Pharmacother.
  contributor:
    fullname: Jafari
– volume: 10
  start-page: 2183
  year: 2019
  end-page: 2199
  ident: bb0240
  article-title: Orally administered semaglutide versus GLP-1 RAs in patients with Type 2 diabetes previously receiving 1-2 oral antidiabetics: systematic review and network meta-analysis
  publication-title: Diabetes Ther.
  contributor:
    fullname: Paine
– volume: 286
  start-page: 402
  year: 2018
  end-page: 414
  ident: bb0620
  article-title: Physicochemical, pharmacokinetic and pharmacodynamic analyses of amphiphilic cyclodextrin-based nanoparticles designed to enhance intestinal delivery of insulin
  publication-title: J. Control. Release
  contributor:
    fullname: O'Driscoll
– volume: 48
  start-page: 726
  year: 2013
  end-page: 734
  ident: bb0425
  article-title: Colonic absorption of salmon calcitonin using tetradecyl maltoside (TDM) as a permeation enhancer
  publication-title: Eur. J. Pharm. Sci.
  contributor:
    fullname: Brayden
– volume: 16
  start-page: 518
  year: 2019
  end-page: 532
  ident: bb0740
  article-title: Synthesis of CSK-DEX-PLGA nanoparticles for the oral delivery of exenatide to improve its mucus penetration and intestinal absorption
  publication-title: Mol. Pharm.
  contributor:
    fullname: Sun
– volume: 25
  start-page: 472
  year: 2018
  end-page: 481
  ident: bb1175
  article-title: Orthosteric and allosteric action of the C5a receptor antagonists
  publication-title: Nat. Struct. Mol. Biol.
  contributor:
    fullname: Zhang
– volume: 3
  start-page: 509
  year: 2011
  end-page: 524
  ident: bb0945
  article-title: Contemporary strategies for peptide macrocyclization
  publication-title: Nat. Chem.
  contributor:
    fullname: Yudin
– volume: 51
  start-page: 460
  year: 2011
  end-page: 471
  ident: bb0160
  article-title: Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in Phase III clinical trials
  publication-title: J. Clin. Pharmacol.
  contributor:
    fullname: Christiansen
– volume: 12
  start-page: 966
  year: 2015
  end-page: 973
  ident: bb0170
  article-title: Towards oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs
  publication-title: Mol. Pharm.
  contributor:
    fullname: Basit
– volume: 54
  start-page: 101394
  year: 2019
  ident: bb0565
  article-title: A proof-of-concept for developing oral lipidized peptide nanostructured lipid carrier formulations
  publication-title: J. Drug Deliv. Sci. Technol.
  contributor:
    fullname: Bourgeois
– volume: 268
  start-page: 113
  year: 2017
  end-page: 119
  ident: bb0900
  article-title: Defining optimal permeant characteristics for ultrasound-mediated gastrointestinal delivery
  publication-title: J. Control. Release
  contributor:
    fullname: Traverso
– volume: 58
  start-page: 781
  year: 2019
  end-page: 791
  ident: bb0245
  article-title: Safety and pharmacokinetics of single and multiple ascending doses of the novel oral human GLP-1 analogue, oral semaglutide, in healthy subjects and subjects with Type 2 diabetes
  publication-title: Clin. Pharmacokinet.
  contributor:
    fullname: Bækdal
– volume: 57
  start-page: 278
  year: 2014
  end-page: 295
  ident: bb0980
  article-title: Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties?
  publication-title: J. Med. Chem.
  contributor:
    fullname: Kihlberg
– volume: 16
  start-page: 2817
  year: 2019
  end-page: 2825
  ident: bb0775
  article-title: Zeta potential-changing polyphosphate nanoparticles: a promising approach to overcome the mucus and epithelial barrier
  publication-title: Mol. Pharm.
  contributor:
    fullname: Bernkop-Schnürch
– volume: 122
  start-page: 141
  year: 2007
  end-page: 150
  ident: bb0660
  article-title: Effective oral delivery of insulin in animal models using vitamin B
  publication-title: J. Control. Release
  contributor:
    fullname: Jain
– volume: 106
  start-page: 196
  year: 2016
  end-page: 222
  ident: bb0690
  article-title: Oral delivery of diabetes peptides - comparing standard formulations incorporating functional excipients and nanotechnologies in the translational context
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Bazile
– volume: 4
  start-page: 6
  year: 2006
  ident: bb0220
  article-title: Oral heparin: status review
  publication-title: Thromb. J.
  contributor:
    fullname: Majuru
– volume: 276
  start-page: 125
  year: 2018
  end-page: 139
  ident: bb0605
  article-title: PEG-PGA enveloped octaarginine-peptide nanocomplexes: an oral peptide delivery strategy
  publication-title: J. Control. Release
  contributor:
    fullname: Alonso
– volume: 277
  start-page: 165
  year: 2018
  end-page: 172
  ident: bb0545
  article-title: In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide
  publication-title: J. Control. Release
  contributor:
    fullname: Bernkop-Schnürch
– volume: 297
  start-page: 71
  year: 2019
  end-page: 78
  ident: bb0865
  article-title: Intestinal iontophoresis from mucoadhesive patches: a strategy for oral delivery
  publication-title: J. Control. Release
  contributor:
    fullname: Mitragotri
– volume: 10
  start-page: 997
  year: 2010
  end-page: 1008
  ident: bb1070
  article-title: Romidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors
  publication-title: Expert. Rev. Anticancer. Ther.
  contributor:
    fullname: Bates
– volume: 9
  start-page: 902
  year: 2019
  end-page: 922
  ident: bb0695
  article-title: Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
  publication-title: Acta Pharm. Sin. B
  contributor:
    fullname: Bae
– volume: 15
  start-page: 195
  year: 1997
  end-page: 206
  ident: bb1075
  article-title: Depsipeptide (FR901228, NSC-630176) pharmacokinetics in the rat by LC/MS/MS
  publication-title: Investig. New Drugs
  contributor:
    fullname: Jiang
– volume: 69
  start-page: 911
  year: 2020
  end-page: 919
  ident: bb0805
  article-title: Novel strategy for oral peptide delivery in incretin-based diabetes treatment
  publication-title: Gut
  contributor:
    fullname: Beloqui
– volume: 273
  start-page: 21
  year: 2018
  end-page: 29
  ident: bb0560
  article-title: Impact of different hydrophobic ion pairs of octreotide on its oral bioavailability in pigs
  publication-title: J. Control. Release
  contributor:
    fullname: Bernkop-Schnürch
– volume: 53
  start-page: 1303
  year: 2013
  end-page: 1312
  ident: bb1115
  article-title: Pharmacokinetics of voclosporin in renal impairment and hepatic impairment
  publication-title: J. Clin. Pharmacol.
  contributor:
    fullname: Foster
– start-page: 317
  year: 2011
  end-page: 328
  ident: bb1120
  article-title: Discovery of Cyclophilin Inhibitor NIM811 as a Novel Therapeutic Agent for HCV
  contributor:
    fullname: Lin
– ident: bb0200
– volume: 199
  start-page: 79
  year: 2010
  end-page: 112
  ident: bb0835
  article-title: Drug delivery systems in domestic animal species
  publication-title: Handb. Exp. Pharmacol.
  contributor:
    fullname: Baird
– volume: 73
  start-page: 344
  year: 2020
  end-page: 351
  ident: bb1270
  article-title: High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide Sanguinamide A
  publication-title: Aust. J. Chem.
  contributor:
    fullname: Hill
– volume: 7
  start-page: 179
  year: 2019
  end-page: 188
  ident: bb0365
  article-title: Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, Phase 2 trial
  publication-title: Lancet Diabetes Endocrinol.
  contributor:
    fullname: Plum-Mörschel
– volume: 10
  start-page: 44354
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0715
  article-title: Microfluidic nanoassembly of bioengineered chitosan-modified FcRn-targeted porous silicon nanoparticles with hypromellose acetate succinate for oral delivery of antidiabetic peptides
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.8b20821
  contributor:
    fullname: Martins
– volume: 2
  start-page: 1595
  year: 2011
  ident: 10.1016/j.addr.2020.05.007_bb0355
  article-title: Oral delivery of macromolecules: rationale underpinning Gastrointestinal Permeation Enhancement Technology (GIPET)
  publication-title: Ther. Deliv.
  doi: 10.4155/tde.11.132
  contributor:
    fullname: Walsh
– volume: 53
  start-page: 1303
  year: 2013
  ident: 10.1016/j.addr.2020.05.007_bb1115
  article-title: Pharmacokinetics of voclosporin in renal impairment and hepatic impairment
  publication-title: J. Clin. Pharmacol.
  doi: 10.1002/jcph.166
  contributor:
    fullname: Ling
– volume: 111
  start-page: 17504
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb1240
  article-title: Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1417611111
  contributor:
    fullname: Wang
– volume: 60
  start-page: 9653
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb1310
  article-title: Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modulators
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.7b01028
  contributor:
    fullname: Boehm
– volume: 31
  start-page: 2010
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0175
  article-title: A novel suspension formulation enhances intestinal absorption of macromolecules via transient and reversible transport mechanisms
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-014-1303-9
  contributor:
    fullname: Tuvia
– volume: 42
  start-page: 611
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0430
  article-title: Absorption, distribution, metabolism, and excretion of the androgen receptor inhibitor enzalutamide in rats and dogs
  publication-title: Eur. J. Drug Metab. Pharmacokinet.
  doi: 10.1007/s13318-016-0374-x
  contributor:
    fullname: Ohtsu
– volume: 50
  start-page: 333
  year: 2002
  ident: 10.1016/j.addr.2020.05.007_bb1190
  article-title: Preclinical toxicity studies of kahalalide F, a new anticancer agent: single and multiple dosing regimens in the rat
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/s00280-002-0499-2
  contributor:
    fullname: Brown
– volume: 119
  start-page: 10241
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb1330
  article-title: Understanding cell penetration of cyclic peptides
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.9b00008
  contributor:
    fullname: Dougherty
– volume: 19
  start-page: 79
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0995
  article-title: 2019 FDA drug approvals
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/d41573-020-00001-7
  contributor:
    fullname: Mullard
– volume: 22
  start-page: 318
  year: 2003
  ident: 10.1016/j.addr.2020.05.007_bb1135
  article-title: Cyclo-octadepsipeptides: an anthelmintically-active class of compounds exhibiting a novel mode of action
  publication-title: Int. J. Antimicrob. Agents
  doi: 10.1016/S0924-8579(03)00219-X
  contributor:
    fullname: Harder
– volume: 26
  start-page: 931
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0750
  article-title: Tf ligand-receptor-mediated exenatide-Zn2+ complex oral-delivery system for penetration enhancement of exenatide
  publication-title: J. Drug Target.
  doi: 10.1080/1061186X.2018.1455839
  contributor:
    fullname: Zhang
– volume: 3
  start-page: 509
  year: 2011
  ident: 10.1016/j.addr.2020.05.007_bb0945
  article-title: Contemporary strategies for peptide macrocyclization
  publication-title: Nat. Chem.
  doi: 10.1038/nchem.1062
  contributor:
    fullname: White
– volume: 225
  start-page: 269
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb1025
  article-title: Reformulating cyclosporine A (CsA): more than just a life cycle management strategy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2016.01.056
  contributor:
    fullname: Guada
– volume: 36
  start-page: 1
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0125
  article-title: Assessing the utility of in vitro screening tools for predicting bio-performance of oral peptide delivery
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-019-2682-8
  contributor:
    fullname: Gadgil
– volume: 25
  start-page: 2649
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0145
  article-title: Efficacy and safety of oral recombinant calcitonin tablets in postmenopausal women with low bone mass and increased fracture risk: a randomized, placebo-controlled trial
  publication-title: Osteoporos. Int.
  doi: 10.1007/s00198-014-2796-0
  contributor:
    fullname: Binkley
– volume: 42
  start-page: 2272
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0255
  article-title: PIONEER 2 investigators, oral semaglutide versus empagliflozin in patients with Type 2 diabetes uncontrolled on metformin: the PIONEER 2 trial
  publication-title: Diabetes Care
  doi: 10.2337/dc19-0883
  contributor:
    fullname: Rodbard
– volume: 10
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0190
  article-title: The discovery and development of liraglutide and semaglutide
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2019.00155
  contributor:
    fullname: Knudsen
– volume: 7
  start-page: 810
  year: 2011
  ident: 10.1016/j.addr.2020.05.007_bb1225
  article-title: On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.664
  contributor:
    fullname: White
– volume: 167
  start-page: 233
  year: 2011
  ident: 10.1016/j.addr.2020.05.007_bb0420
  article-title: Oral delivery of octreotide acetate in Intravail® improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss Webster mice
  publication-title: Regul. Pept.
  doi: 10.1016/j.regpep.2011.02.009
  contributor:
    fullname: Maggio
– volume: 27
  start-page: 1821
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb0040
  article-title: Oral calcitonin in postmenopausal osteoporosis (ORACAL) investigators, A Phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the oral calcitonin in postmenopausal osteoporosis (ORACAL) trial
  publication-title: J. Bone Miner. Res.
  doi: 10.1002/jbmr.1602
  contributor:
    fullname: Binkley
– volume: 22
  start-page: 442
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0275
  article-title: Semaglutide (SUSTAIN and PIONEER) reduces cardiovascular events in type 2 diabetes across varying cardiovascular risk
  publication-title: Diabetes Obes. Metab.
  doi: 10.1111/dom.13955
  contributor:
    fullname: Husain
– volume: 10
  start-page: 167
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0745
  article-title: Biotinylated liposomes as potential carriers for the oral delivery of insulin
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2013.07.011
  contributor:
    fullname: Zhang
– volume: 5
  start-page: 1148
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb1200
  article-title: Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed
  publication-title: ACS Med. Chem. Lett.
  doi: 10.1021/ml5002823
  contributor:
    fullname: Hill
– volume: 42
  start-page: 2262
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0290
  article-title: PIONEER 8 Investigators. Efficacy, safety, and tolerability of oral semaglutide versus placebo added to insulin with or without metformin in patients with Type 2 diabetes: the PIONEER 8 Trial
  publication-title: Diabetes Care
  doi: 10.2337/dc19-0898
  contributor:
    fullname: Zinman
– volume: 30
  start-page: 3077
  year: 2013
  ident: 10.1016/j.addr.2020.05.007_bb0445
  article-title: In vitro digestion of the self-emulsifying lipid excipient Labrasol(®) by gastrointestinal lipases and influence of its colloidal structure on lipolysis rate
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-013-1053-0
  contributor:
    fullname: Fernandez
– volume: 124
  start-page: 184
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0760
  article-title: Efficacy and safety concerns over the use of mucus modulating agents for drug delivery using nanoscale systems
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2017.12.006
  contributor:
    fullname: Chater
– volume: 152
  start-page: 1151
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0905
  article-title: Ultrasound-mediated delivery of RNA to colonic mucosa of live mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2017.01.002
  contributor:
    fullname: Schoellhammer
– volume: 115
  start-page: 7296
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb1355
  article-title: Ionic liquids for oral insulin delivery
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1722338115
  contributor:
    fullname: Banerjee
– volume: 13
  start-page: 1
  year: 2013
  ident: 10.1016/j.addr.2020.05.007_bb0140
  article-title: Oral delivery of peptides by Peptelligence™ technology
  publication-title: Drug Development & Delivery
  contributor:
    fullname: Stern
– volume: 10
  start-page: 2183
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0240
  article-title: Orally administered semaglutide versus GLP-1 RAs in patients with Type 2 diabetes previously receiving 1-2 oral antidiabetics: systematic review and network meta-analysis
  publication-title: Diabetes Ther.
  doi: 10.1007/s13300-019-00706-y
  contributor:
    fullname: Nuhoho
– volume: 361
  start-page: 91
  year: 1993
  ident: 10.1016/j.addr.2020.05.007_bb1040
  article-title: X-ray structure of a decameric cyclophilin-cyclosporin crystal complex
  publication-title: Nature
  doi: 10.1038/361091a0
  contributor:
    fullname: Pfluegl
– start-page: 281
  year: 2005
  ident: 10.1016/j.addr.2020.05.007_bb1080
  contributor:
    fullname: Mauger
– volume: 55
  start-page: 2376
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb1140
  article-title: Discovery of LFF571: an investigational agent for Clostridium Difficile infection
  publication-title: J. Med. Chem.
  doi: 10.1021/jm201685h
  contributor:
    fullname: LaMarche
– volume: 321
  start-page: 1466
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0260
  article-title: Effect of additional oral semaglutide vs sitagliptin on glycated hemoglobin in adults with Type 2 diabetes uncontrolled with metformin alone or with wulfonylurea: the PIONEER 3 randomized clinical trial
  publication-title: JAMA
  doi: 10.1001/jama.2019.2942
  contributor:
    fullname: Rosenstock
– volume: 53
  start-page: 12059
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb1260
  article-title: Improving on nature: making a cyclic heptapeptide orally bioavailable
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.201405364
  contributor:
    fullname: Nielsen
– volume: 14
  start-page: 7743
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0675
  article-title: Investigation of vitamin B12-modified amphiphilic sodium alginate derivatives for enhancing the oral delivery efficacy of peptide drugs
  publication-title: Int. J. Nanomedicine
  doi: 10.2147/IJN.S218944
  contributor:
    fullname: Long
– volume: 11
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0300
  article-title: Intestinal permeation enhancers for oral delivery of macromolecules: a comparison between salcaprozate sodium (SNAC) and sodium caprate (C10)
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics11020078
  contributor:
    fullname: Twarog
– volume: 380
  start-page: 1671
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0920
  article-title: Stomaching drug delivery
  publication-title: New Eng. Medical J.
  doi: 10.1056/NEJMcibr1901766
  contributor:
    fullname: Brayden
– volume: 69
  start-page: 911
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0805
  article-title: Novel strategy for oral peptide delivery in incretin-based diabetes treatment
  publication-title: Gut
  doi: 10.1136/gutjnl-2019-319146
  contributor:
    fullname: Xu
– volume: 9
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0115
  article-title: Acylation of Glucagon-like peptide-2: interaction with lipid membranes and in vitro intestinal permeability
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0109939
  contributor:
    fullname: Trier
– volume: 14
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0710
  article-title: Engineered multi-functional albumin-decorated porous silicon nanoparticles for FcRn translocation of insulin
  publication-title: Small
  doi: 10.1002/smll.201800462
  contributor:
    fullname: Martins
– volume: 20
  start-page: 2255
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0185
  article-title: Semaglutide for type 2 diabetes mellitus: a systematic review and meta-analysis
  publication-title: Diabetes Obes. Metab.
  doi: 10.1111/dom.13361
  contributor:
    fullname: Andreadis
– volume: 12
  start-page: 8893
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0700
  article-title: Oral nanoparticles exhibit specific high-efficiency intestinal uptake and lymphatic transport
  publication-title: ACS Nano
  doi: 10.1021/acsnano.8b04315
  contributor:
    fullname: Kim
– volume: 3
  start-page: 16
  year: 2013
  ident: 10.1016/j.addr.2020.05.007_bb0415
  article-title: High efficiency intranasal drug delivery using Intravail® alkylsaccharide absorption enhancers
  publication-title: Drug Deliv. Transl. Res.
  doi: 10.1007/s13346-012-0069-z
  contributor:
    fullname: Maggio
– volume: 61
  start-page: 1427
  year: 2009
  ident: 10.1016/j.addr.2020.05.007_bb0330
  article-title: Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2009.09.006
  contributor:
    fullname: Maher
– volume: 97
  start-page: 2607
  year: 2008
  ident: 10.1016/j.addr.2020.05.007_bb0885
  article-title: Complexation hydrogels for oral insulin delivery: effects of polymer dosing on in vivo efficacy
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.21184
  contributor:
    fullname: Tuesca
– volume: 65
  start-page: 297
  year: 2000
  ident: 10.1016/j.addr.2020.05.007_bb0110
  article-title: Epithelial application of Pseudomonas aeruginosa exotoxin a results in a selective targeting to cells in the liver, spleen and lymph node
  publication-title: J. Control. Release
  doi: 10.1016/S0168-3659(99)00251-5
  contributor:
    fullname: Daugherty
– volume: 234
  start-page: 1119
  year: 1993
  ident: 10.1016/j.addr.2020.05.007_bb1045
  article-title: X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 Å resolution
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.1993.1664
  contributor:
    fullname: Mikol
– volume: 37
  start-page: 246
  year: 1988
  ident: 10.1016/j.addr.2020.05.007_bb0050
  article-title: New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carriers
  publication-title: Diabetes
  doi: 10.2337/diab.37.2.246
  contributor:
    fullname: Damgé
– volume: 88
  start-page: 830
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0460
  article-title: A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2014.10.008
  contributor:
    fullname: Brayden
– volume: 3
  start-page: 1282
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb1235
  article-title: Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance
  publication-title: Medchemcomm
  doi: 10.1039/C2MD20203D
  contributor:
    fullname: Rand
– volume: 16
  start-page: 518
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0740
  article-title: Synthesis of CSK-DEX-PLGA nanoparticles for the oral delivery of exenatide to improve its mucus penetration and intestinal absorption
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.8b00809
  contributor:
    fullname: Song
– volume: 1
  start-page: 75
  year: 2010
  ident: 10.1016/j.addr.2020.05.007_bb0370
  article-title: Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate
  publication-title: Ther. Deliv.
  doi: 10.4155/tde.10.5
  contributor:
    fullname: Wang
– volume: 42
  start-page: 1724
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0250
  article-title: PIONEER 1: randomized clinical trial of the efficacy and safety of oral semaglutide monotherapy in comparison with placebo in patients with Type 2 diabetes
  publication-title: Diabetes Care
  doi: 10.2337/dc19-0749
  contributor:
    fullname: Aroda
– volume: 23
  start-page: 532
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0155
  article-title: Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two Phase 3 trials
  publication-title: Osteoarthr. Cartil.
  doi: 10.1016/j.joca.2014.12.019
  contributor:
    fullname: Karsdal
– volume: 24
  start-page: 102132
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0790
  article-title: Coating of PLA-nanoparticles with cyclic, arginine-rich cell penetrating peptides enables oral delivery of liraglutide
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2019.102132
  contributor:
    fullname: Uhl
– volume: 21
  start-page: 2576
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0280
  article-title: GLP-1 receptor agonists for prevention of cardiorenal outcomes in type 2 diabetes: an updated meta-analysis including the REWIND and PIONEER 6 trials
  publication-title: Diabetes Obes. Metab.
  doi: 10.1111/dom.13847
  contributor:
    fullname: Giugliano
– volume: 61
  start-page: 2636
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb1350
  article-title: Beyond the Rule of 5: Lessons learned from AbbVie's drugs and compound collection
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.7b00717
  contributor:
    fullname: DeGoey
– volume: 9
  start-page: 1764
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb0635
  article-title: Delivery of peptides to the blood and brain after oral uptake of quaternary ammonium palmitoyl glycol chitosan nanoparticles
  publication-title: Mol. Pharm.
  doi: 10.1021/mp300068j
  contributor:
    fullname: Lalatsa
– volume: 8
  start-page: 19
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0060
  article-title: Non-invasive delivery of biologics
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2018.183
  contributor:
    fullname: Anselmo
– volume: 49
  start-page: 6545
  year: 2010
  ident: 10.1016/j.addr.2020.05.007_bb1305
  article-title: The engineering of an orally-active conotoxin for the treatment of neuropathic pain
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.201000620
  contributor:
    fullname: Clark
– volume: 8
  start-page: 551
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0825
  article-title: A single-blind, placebo-controlled, dose-ranging trial of oral hepatic-directed vesicle insulin add-on to oral antidiabetic treatment in patients with type 2 diabetes mellitus
  publication-title: J. Diabetes Sci. Technol.
  doi: 10.1177/1932296814524871
  contributor:
    fullname: Geho
– volume: 51
  start-page: 422
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0395
  article-title: Urinary concentrations and antimicrobial activity of tobramycin in healthy volunteers receiving a single oral dose of a novel formulation for improved absorption
  publication-title: Int. J. Antimicrob. Agents
  doi: 10.1016/j.ijantimicag.2017.11.004
  contributor:
    fullname: Loose
– volume: 16
  start-page: 1064
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0720
  article-title: Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative
  publication-title: AAPS J.
  doi: 10.1208/s12248-014-9634-3
  contributor:
    fullname: Brayden
– volume: 34
  start-page: 107520
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0035
  article-title: Oral semaglutide in type 2 diabetes
  publication-title: J. Diabetes Complicat.
  doi: 10.1016/j.jdiacomp.2019.107520
  contributor:
    fullname: Anderson
– volume: 14
  start-page: 5720
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb1255
  article-title: Total synthesis, structure, and oral absorption of a thiazole cyclic peptide, sanguinamide A
  publication-title: Org. Lett.
  doi: 10.1021/ol3027347
  contributor:
    fullname: Nielsen
– volume: 8
  year: 2013
  ident: 10.1016/j.addr.2020.05.007_bb0410
  article-title: Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0059524
  contributor:
    fullname: Eldor
– volume: 42
  start-page: 2154
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0830
  article-title: Divergent hypoglycemic effects of hepatic-directed prandial insulin: a six-month Phase 2b study in Type 1 diabetes
  publication-title: Diabetes Care
  doi: 10.2337/dc19-0152
  contributor:
    fullname: Klonoff
– volume: 263
  start-page: 4
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0615
  article-title: Rational design of polyarginine nanocapsules intended to help peptides overcoming intestinal barriers
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2017.02.024
  contributor:
    fullname: Niu
– volume: 68
  start-page: 682
  year: 1985
  ident: 10.1016/j.addr.2020.05.007_bb1035
  article-title: Peptide conformations. Part 31. The conformation of cyclosporin A in the crystal and in solution
  publication-title: Helv. Chim. Acta
  doi: 10.1002/hlca.19850680319
  contributor:
    fullname: Loosli
– volume: 6
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0500
  article-title: Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1)
  publication-title: Elife
  doi: 10.7554/eLife.24665
  contributor:
    fullname: Filter
– volume: 210
  start-page: 189
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0505
  article-title: Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2015.05.270
  contributor:
    fullname: Taverner
– volume: 14
  start-page: 166
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb1180
  article-title: Surotomycin (a novel cyclic lipopeptide) vs. vancomycin for the treatment of Clostridioides Difficile infection: a systematic review and meta-analysis
  publication-title: Curr. Clin. Pharmacol.
  doi: 10.2174/1574884714666190328162637
  contributor:
    fullname: Muhammad
– volume: 19
  start-page: 277
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0195
  article-title: Advances in oral peptide therapeutics
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-019-0053-0
  contributor:
    fullname: Drucker
– volume: 297
  start-page: 71
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0865
  article-title: Intestinal iontophoresis from mucoadhesive patches: a strategy for oral delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2019.01.037
  contributor:
    fullname: Banerjee
– volume: 16
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0350
  article-title: Re-evaluation of sodium, potassium and calcium salts of fatty acids (E470a) and magnesium salts of fatty acids (E470b) as food additives
  publication-title: EFSA J.
  contributor:
    fullname: EFSA Panel of Food Additives and Nutrient Sources added to Food (ANS)
– volume: 38
  start-page: 24
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0970
  article-title: Cyclic peptide therapeutics: past, present and future
  publication-title: Curr. Opin. Chem. Biol.
  doi: 10.1016/j.cbpa.2017.02.006
  contributor:
    fullname: Zorzi
– volume: 10
  start-page: 857
  year: 1993
  ident: 10.1016/j.addr.2020.05.007_bb0325
  article-title: Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route
  publication-title: Pharm. Res.
  doi: 10.1023/A:1018909210879
  contributor:
    fullname: Anderberg
– volume: 67
  start-page: 631
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb1060
  article-title: Glycopeptide antibiotics: Back to the future
  publication-title: J. Antibiot.
  doi: 10.1038/ja.2014.111
  contributor:
    fullname: Butler
– volume: 6
  start-page: 42
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0230
  article-title: Cyanocobalamin/salcaprozate sodium: a novel way to treat vitamin B12 deficiency and anemia
  publication-title: Hematol. Oncol. Pharm.
  contributor:
    fullname: Smith
– volume: 12
  start-page: 1257
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0625
  article-title: Silica-coated nanoparticles with a core of zinc, l-arginine, and a peptide designed for oral delivery
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.9b16104
  contributor:
    fullname: Hristov
– volume: 23
  start-page: 31
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0940
  article-title: New insights into the biosynthetic logic of ribosomally synthesized and post-translationally modified peptide natural products
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2015.11.012
  contributor:
    fullname: Ortega
– volume: 55
  start-page: 2601
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb1335
  article-title: Discovery and mechanism of highly efficient cyclic cell-penetrating peptides
  publication-title: Biochemistry
  doi: 10.1021/acs.biochem.6b00226
  contributor:
    fullname: Qian
– volume: 520
  start-page: 267
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0550
  article-title: Hydrophobic ion pairing: key to highly pay-loaded self-emulsifying peptide drug delivery systems
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2017.02.019
  contributor:
    fullname: Griesser
– volume: 56
  start-page: 10294
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0955
  article-title: New modalities for challenging targets in drug discovery
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.201611914
  contributor:
    fullname: Valeur
– volume: 10
  start-page: 241
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0610
  article-title: Tuning the PEG surface density of the PEG-PGA enveloped octaarginine-peptide nanocomplexes
  publication-title: Drug Deliv. Trans. Res.
  doi: 10.1007/s13346-019-00678-3
  contributor:
    fullname: Samaridou
– volume: 36
  start-page: 89
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0895
  article-title: Bottom-up fabrication of multilayer enteric devices for the oral delivery of peptides
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-019-2618-3
  contributor:
    fullname: Nemeth
– volume: 11
  start-page: 1520
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0730
  article-title: Mechanism study of cellular uptake and tight junction opening mediated by goblet cell-specific trimethyl chitosan nanoparticles
  publication-title: Mol. Pharm.
  doi: 10.1021/mp400685v
  contributor:
    fullname: Zhang
– volume: 26
  start-page: 2700
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0005
  article-title: Therapeutic peptides: historical perspectives, current development trends, and future directions
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2017.06.052
  contributor:
    fullname: Lau
– volume: 3
  start-page: 215
  year: 1989
  ident: 10.1016/j.addr.2020.05.007_bb0020
  article-title: Transport of proteins through the membranes of the adult gastro-intestinal tract – a potential for drug delivery?
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/0169-409X(89)90011-2
  contributor:
    fullname: Pusztai
– volume: 108
  start-page: 3138
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0205
  article-title: Quantifying the value of orally delivered biologic therapies: a cost-effectiveness analysis of oral semaglutide
  publication-title: J. Pharm. Sci.
  doi: 10.1016/j.xphs.2019.04.022
  contributor:
    fullname: Abramson
– volume: 5
  year: 2013
  ident: 10.1016/j.addr.2020.05.007_bb0705
  article-title: Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3007049
  contributor:
    fullname: Pridgen
– volume: 14
  start-page: 257
  year: 1999
  ident: 10.1016/j.addr.2020.05.007_bb0480
  article-title: Epithelial integrity, cell death and cell loss in mammalian small intestine
  publication-title: Histol. Histopathol.
  contributor:
    fullname: Mayhew
– volume: 22
  start-page: 18
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0810
  article-title: Polymeric nanocarrier formulations of biologics using inverse flash nano-precipitation
  publication-title: AAPS J.
  doi: 10.1208/s12248-019-0405-z
  contributor:
    fullname: Markwalter
– volume: 11
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0470
  article-title: Evaluation of sucrose laurate as an intestinal permeation enhancer for macromolecules: ex vivo and in vivo studies
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics11110565
  contributor:
    fullname: McCartney
– volume: 58
  start-page: 7409
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb1265
  article-title: Going out on a limb: delineating the rffects of β-branching, N-methylation, and side chain size on the passive permeability, solubility, and flexibility of sanguinamide A analogues
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.5b00919
  contributor:
    fullname: Bockus
– volume: 11
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb1005
  article-title: Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation
  publication-title: Ther. Adv. Gastroenterol.
  doi: 10.1177/1756284818777945
  contributor:
    fullname: Rao
– volume: 560
  start-page: 377
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0450
  article-title: SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2019.02.014
  contributor:
    fullname: Liu
– volume: 46
  start-page: 3
  year: 2001
  ident: 10.1016/j.addr.2020.05.007_bb1030
  article-title: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(00)00129-0
  contributor:
    fullname: Lipinski
– start-page: 411
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0975
  contributor:
    fullname: Stotani
– volume: 20
  start-page: 208
  year: 2001
  ident: 10.1016/j.addr.2020.05.007_bb0025
  article-title: Targeting polymerised liposome vaccine carriers to intestinal M cells
  publication-title: Vaccine
  doi: 10.1016/S0264-410X(01)00258-4
  contributor:
    fullname: Clark
– volume: 46
  start-page: 1489
  year: 2008
  ident: 10.1016/j.addr.2020.05.007_bb1065
  article-title: The case for vancomycin as the preferred drug for treatment of Clostridium difficile infection
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/587654
  contributor:
    fullname: Bartlett
– volume: 1
  start-page: 1
  year: 1987
  ident: 10.1016/j.addr.2020.05.007_bb0015
  article-title: Some biological issues in oral, controlled drug delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/0169-409X(87)90066-4
  contributor:
    fullname: Gruber
– volume: 63
  start-page: 750
  year: 2011
  ident: 10.1016/j.addr.2020.05.007_bb1340
  article-title: Prodrugs – from serendipity to rational design
  publication-title: Pharmacol. Rev.
  doi: 10.1124/pr.110.003459
  contributor:
    fullname: Huttunen
– volume: 36
  start-page: 3483
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0210
  article-title: Evaluation of the cost per patient achieving treatment targets with oral semaglutide: a short-term cost-effectiveness analysis in the United States
  publication-title: Adv. Ther.
  doi: 10.1007/s12325-019-01125-y
  contributor:
    fullname: Hunt
– volume: 9
  start-page: 902
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0695
  article-title: Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
  publication-title: Acta Pharm. Sin. B
  doi: 10.1016/j.apsb.2019.01.004
  contributor:
    fullname: Han
– volume: 7
  start-page: 105
  year: 2013
  ident: 10.1016/j.addr.2020.05.007_bb1105
  article-title: Profile of alisporivir and its potential in the treatment of hepatitis C
  publication-title: Drug Des. Dev. Ther.
  doi: 10.2147/DDDT.S30946
  contributor:
    fullname: Gallay
– volume: 75
  start-page: 90
  year: 2010
  ident: 10.1016/j.addr.2020.05.007_bb1110
  article-title: Development of a polymeric micellar formulation for valspodar and assessment of its pharmacokinetics in rat
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2010.03.010
  contributor:
    fullname: Binkhathlan
– volume: 38
  start-page: 177
  year: 1993
  ident: 10.1016/j.addr.2020.05.007_bb1050
  article-title: Pharmacokinetics of 1-deamino-8-D-arginine vasopressin after various routes of administration in healthy volunteers
  publication-title: Clin. Endocrinol.
  doi: 10.1111/j.1365-2265.1993.tb00990.x
  contributor:
    fullname: Fjellestad-Paulsen
– volume: 276
  start-page: 125
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0605
  article-title: PEG-PGA enveloped octaarginine-peptide nanocomplexes: an oral peptide delivery strategy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2018.03.004
  contributor:
    fullname: Niu
– volume: 12
  start-page: 99
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0890
  article-title: The in vivo effect of transcellular permeation enhancers on the intestinal permeability of two peptide drugs, enalaprilat and hexarelin
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics12020099
  contributor:
    fullname: Dahlgren
– volume: 4
  start-page: 12
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0800
  article-title: A new opening for orally taken peptide drugs
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-019-0513-1
  contributor:
    fullname: Artursson
– volume: 20
  start-page: 122
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0010
  article-title: Peptide therapeutics: current status and future directions
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2014.10.003
  contributor:
    fullname: Fosgerau
– volume: 12
  start-page: 966
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0170
  article-title: Towards oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs
  publication-title: Mol. Pharm.
  doi: 10.1021/mp500809f
  contributor:
    fullname: Wang
– volume: 26
  start-page: 2863
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb1000
  article-title: Peptide therapeutics for the treatment of gastrointestinal disorders
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2017.11.007
  contributor:
    fullname: Fretzen
– volume: 4
  start-page: 171
  year: 1989
  ident: 10.1016/j.addr.2020.05.007_bb0030
  article-title: Penetration and enzymatic barriers to peptide and protein absorption
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/0169-409X(89)90018-5
  contributor:
    fullname: Lee
– volume: 58
  start-page: 781
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0245
  article-title: Safety and pharmacokinetics of single and multiple ascending doses of the novel oral human GLP-1 analogue, oral semaglutide, in healthy subjects and subjects with Type 2 diabetes
  publication-title: Clin. Pharmacokinet.
  doi: 10.1007/s40262-018-0728-4
  contributor:
    fullname: Granhall
– volume: 273
  start-page: 21
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0560
  article-title: Impact of different hydrophobic ion pairs of octreotide on its oral bioavailability in pigs
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2018.01.012
  contributor:
    fullname: Bonengel
– volume: 7
  start-page: 179
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0365
  article-title: Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, Phase 2 trial
  publication-title: Lancet Diabetes Endocrinol.
  doi: 10.1016/S2213-8587(18)30372-3
  contributor:
    fullname: Halberg
– volume: 54
  start-page: 101394
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0565
  article-title: A proof-of-concept for developing oral lipidized peptide nanostructured lipid carrier formulations
  publication-title: J. Drug Deliv. Sci. Technol.
  doi: 10.1016/j.jddst.2019.101394
  contributor:
    fullname: Dumont
– volume: 22
  start-page: 10
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0235
  article-title: Oral semaglutide: a review of the first oral Glucagon-like peptide 1 receptor agonist
  publication-title: Diabetes Technol. Ther.
  doi: 10.1089/dia.2019.0185
  contributor:
    fullname: Bucheit
– volume: 25
  start-page: 472
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb1175
  article-title: Orthosteric and allosteric action of the C5a receptor antagonists
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/s41594-018-0067-z
  contributor:
    fullname: Liu
– volume: 3
  start-page: 981
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb0135
  article-title: Peptide therapeutics: it's all in the delivery
  publication-title: Ther. Deliv.
  doi: 10.4155/tde.12.79
  contributor:
    fullname: Grant
– volume: 128
  start-page: 2510
  year: 2006
  ident: 10.1016/j.addr.2020.05.007_bb1210
  article-title: Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja0563455
  contributor:
    fullname: Rezai
– volume: 7
  start-page: 229
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0650
  article-title: The properties of the mucus barrier, a unique gel-how can nanoparticles cross it?
  publication-title: Ther. Deliv.
  doi: 10.4155/tde-2015-0002
  contributor:
    fullname: Pearson
– volume: 12
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0880
  article-title: In vitro, ex vivo and in vivo evaluation of microcontainers for oral delivery of insulin
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics12010048
  contributor:
    fullname: Jørgensen
– volume: 277
  start-page: 142
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0735
  article-title: N-trimethyl chitosan nanoparticles and CSKSSDYQC peptide: N-trimethyl chitosan conjugates enhance the oral bioavailability of gemcitabine to treat breast cancer
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2018.03.013
  contributor:
    fullname: Chen
– volume: 51
  issue: Suppl. 3
  year: 2003
  ident: 10.1016/j.addr.2020.05.007_bb1055
  article-title: Ramoplanin: a novel antimicrobial agent with the potential to prevent vancomycin-resistant enterococcal infection in high-risk patients
  publication-title: J. Antimicrob. Chemother.
  contributor:
    fullname: Montecalvo
– volume: 394
  start-page: 39
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0265
  article-title: PIONEER 4 investigators, Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, Phase 3a trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)31271-1
  contributor:
    fullname: Pratley
– volume: 4
  start-page: 6
  year: 2006
  ident: 10.1016/j.addr.2020.05.007_bb0220
  article-title: Oral heparin: status review
  publication-title: Thromb. J.
  doi: 10.1186/1477-9560-4-6
  contributor:
    fullname: Arbit
– volume: 24
  start-page: 544
  year: 1959
  ident: 10.1016/j.addr.2020.05.007_bb1085
  article-title: The effect of actinomycin D on cancer in childhood
  publication-title: Pediatrics
  doi: 10.1542/peds.24.4.544
  contributor:
    fullname: Tan
– volume: 14
  start-page: 989
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0755
  article-title: Oral delivery system for low molecular weight protamine-dextran-poly(lactic-co-glycolic acid) carrying exenatide to overcome the mucus barrier and improve intestinal targeting efficiency
  publication-title: Nanomedicine
  doi: 10.2217/nnm-2018-0322
  contributor:
    fullname: Song
– volume: 299
  start-page: 247
  year: 2001
  ident: 10.1016/j.addr.2020.05.007_bb1145
  article-title: Nepadutant pharmacokinetics and dose-effect relationships as tachykinin NK2 receptor antagonist are altered by intestinal inflammation in rodent models
  publication-title: J. Pharmacol. Exp. Ther.
  contributor:
    fullname: Lecci
– volume: 91
  start-page: 122
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0150
  article-title: A randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy and safety of oral salmon calcitonin in the treatment of osteoporosis in postmenopausal women taking calcium and vitamin D
  publication-title: Bone
  doi: 10.1016/j.bone.2016.07.019
  contributor:
    fullname: Henriksen
– volume: 18
  start-page: 155
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0670
  article-title: Efficient peroral delivery of insulin via vitamin B12 modified trimethyl chitosan nanoparticles
  publication-title: J. Pharm. Sci.
  contributor:
    fullname: Ke
– volume: 10
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0295
  article-title: Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aar7047
  contributor:
    fullname: Buckley
– volume: 48
  start-page: 726
  year: 2013
  ident: 10.1016/j.addr.2020.05.007_bb0425
  article-title: Colonic absorption of salmon calcitonin using tetradecyl maltoside (TDM) as a permeation enhancer
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2013.01.009
  contributor:
    fullname: Petersen
– volume: 5
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0390
  article-title: Intestinal surfactant permeation enhancers and their interaction with enterocyte cell membranes in a mucosal explant system
  publication-title: Tissue Barriers
  doi: 10.1080/21688370.2017.1361900
  contributor:
    fullname: Danielsen
– volume: 103
  start-page: 160
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0535
  article-title: ZOT-derived peptide and chitosan functionalized nanocarrier for oral delivery of protein drug
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2016.06.059
  contributor:
    fullname: Lee
– volume: 291
  start-page: 157
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0600
  article-title: Protamine nanocapsules as carriers for oral peptide delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2018.10.022
  contributor:
    fullname: Thwala
– volume: 57
  start-page: 7145
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb1095
  article-title: From chemical tools to clinical medicines: non-immunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds
  publication-title: J. Med. Chem.
  doi: 10.1021/jm500223x
  contributor:
    fullname: Sweeney
– volume: 97
  start-page: 2362
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb0180
  article-title: Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2012-1179
  contributor:
    fullname: Tuvia
– volume: 7
  start-page: 975
  year: 2006
  ident: 10.1016/j.addr.2020.05.007_bb1150
  article-title: Tachykinin receptors antagonists: from research to clinic
  publication-title: Curr. Drug Targets
  doi: 10.2174/138945006778019381
  contributor:
    fullname: Quartara
– volume: 57
  start-page: 8503
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb1100
  article-title: Potent non-immunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition
  publication-title: J. Med. Chem.
  doi: 10.1021/jm500862r
  contributor:
    fullname: Fu
– volume: 106
  start-page: 196
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0690
  article-title: Oral delivery of diabetes peptides - comparing standard formulations incorporating functional excipients and nanotechnologies in the translational context
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2016.02.011
  contributor:
    fullname: Lakkireddy
– volume: 5
  start-page: 341
  year: 1988
  ident: 10.1016/j.addr.2020.05.007_bb0320
  article-title: Enhancement of colonic drug absorption by the paracellular permeation route
  publication-title: Pharm. Res.
  doi: 10.1023/A:1015999309353
  contributor:
    fullname: Tomita
– year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0630
  contributor:
    fullname: McCartney
– volume: 28
  start-page: 278
  year: 2009
  ident: 10.1016/j.addr.2020.05.007_bb0225
  article-title: Sub-chronic oral toxicity of salcaprozate sodium (SNAC) in Sprague–Dawley and Wistar rats
  publication-title: Int. J. Toxicol.
  doi: 10.1177/1091581809337737
  contributor:
    fullname: Riley
– volume: 19
  start-page: 929
  year: 1993
  ident: 10.1016/j.addr.2020.05.007_bb0465
  article-title: The effects of fatty acids and their derivatives on the intestinal absorption of insulin in rats
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.3109/03639049309062992
  contributor:
    fullname: Muranushi
– volume: Vol. 4
  start-page: 178
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0165
  article-title: Physiology of calcitonin and its therapeutic uses
  contributor:
    fullname: Wimalawansa
– volume: 7
  start-page: 515
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0270
  article-title: PIONEER 5 Investigators, Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, Phase 3a trial
  publication-title: Lancet Diabetes Endocrinol.
  doi: 10.1016/S2213-8587(19)30192-5
  contributor:
    fullname: Mosenzon
– volume: 34
  start-page: 275
  year: 2013
  ident: 10.1016/j.addr.2020.05.007_bb0340
  article-title: Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2012.09.051
  contributor:
    fullname: Krug
– volume: 47
  start-page: 39
  year: 2001
  ident: 10.1016/j.addr.2020.05.007_bb0080
  article-title: Mucoadhesive nanoparticulate systems for peptide drug delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(00)00120-4
  contributor:
    fullname: Takeuchi
– year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb1250
  article-title: Pyridyl-Ala modified cyclic hexapeptides: in vitro and in vivo profiling for oral bioavailability
  publication-title: Int. J. Pept. Res. Ther.
  contributor:
    fullname: Vorherr
– volume: 268
  start-page: 113
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0900
  article-title: Defining optimal permeant characteristics for ultrasound-mediated gastrointestinal delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2017.10.023
  contributor:
    fullname: Schoellhammer
– volume: 197
  start-page: 48
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0070
  article-title: Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2014.10.026
  contributor:
    fullname: Maisel
– volume: 25
  start-page: 608
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0855
  article-title: Intestinal micropatches for oral insulin delivery
  publication-title: J. Drug Target.
  doi: 10.1080/1061186X.2017.1300664
  contributor:
    fullname: Banerjee
– volume: 122
  start-page: 141
  year: 2007
  ident: 10.1016/j.addr.2020.05.007_bb0660
  article-title: Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2007.05.019
  contributor:
    fullname: Chalasani
– volume: 124
  start-page: 164
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0075
  article-title: Enzyme decorated drug carriers: targeted swords to cleave and overcome the mucus barrier
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2017.10.004
  contributor:
    fullname: Menzel
– volume: 143
  start-page: 98
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0870
  article-title: Microcontainers for oral insulin delivery: in vitro studies of permeation enhancement
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2019.08.011
  contributor:
    fullname: Jørgensen
– volume: 51
  start-page: 460
  year: 2011
  ident: 10.1016/j.addr.2020.05.007_bb0160
  article-title: Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in Phase III clinical trials
  publication-title: J. Clin. Pharmacol.
  doi: 10.1177/0091270010372625
  contributor:
    fullname: Karsdal
– volume: 277
  start-page: 165
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0545
  article-title: In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2018.03.018
  contributor:
    fullname: Menzel
– volume: 4
  start-page: 84
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0795
  article-title: Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-019-0465-5
  contributor:
    fullname: Lamson
– volume: 199
  start-page: 79
  year: 2010
  ident: 10.1016/j.addr.2020.05.007_bb0835
  article-title: Drug delivery systems in domestic animal species
  publication-title: Handb. Exp. Pharmacol.
  doi: 10.1007/978-3-642-10324-7_4
  contributor:
    fullname: Brayden
– volume: 32
  issue: 13
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0055
  article-title: Oral delivery of biologics for precision medicine
  publication-title: Adv. Mater.
  contributor:
    fullname: Durán-Lobato
– volume: 106
  start-page: 223
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0100
  article-title: Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2016.02.004
  contributor:
    fullname: Aguirre
– volume: 86
  start-page: 544
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0130
  article-title: The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2013.12.017
  contributor:
    fullname: Welling
– volume: 14
  start-page: 479
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0310
  article-title: Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease
  publication-title: Autoimmun. Rev.
  doi: 10.1016/j.autrev.2015.01.009
  contributor:
    fullname: Lerner
– volume: 61
  start-page: 75
  year: 2009
  ident: 10.1016/j.addr.2020.05.007_bb0065
  article-title: Barrier properties of mucus
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2008.09.008
  contributor:
    fullname: Cone
– volume: 59
  start-page: 294
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb1285
  article-title: Rationalization of the membrane permeability differences in a series of analogue cyclic decapeptides
  publication-title: J. Chem. Inf. Model.
  doi: 10.1021/acs.jcim.8b00485
  contributor:
    fullname: Witek
– volume: 116
  start-page: 17817
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0520
  article-title: Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1908929116
  contributor:
    fullname: Vecchio
– start-page: 1783
  year: 2006
  ident: 10.1016/j.addr.2020.05.007_bb0525
  article-title: A novel strategy for a drug delivery system using a claudin modulator
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.29.1783
  contributor:
    fullname: Kondoh
– volume: 136-137
  start-page: 62
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0765
  article-title: Strategies to overcome the poly-cation dilemma in drug delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2018.07.017
  contributor:
    fullname: Bernkop-Schnürch
– volume: 268
  start-page: 343
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0875
  article-title: From concept to in vivo testing: microcontainers for oral drug delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2017.10.013
  contributor:
    fullname: Mazzoni
– volume: 15
  start-page: 5802
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0120
  article-title: Role of the basement membrane as an intestinal barrier to absorption of macromolecules and nanoparticles
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.8b01053
  contributor:
    fullname: Mantaj
– volume: 17
  start-page: 150
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0985
  article-title: 2017 FDA drug approvals
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2018.18
  contributor:
    fullname: Mullard
– volume: 12
  start-page: 2245
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0095
  article-title: Interaction with mixed micelles in the intestine attenuates the permeation-enhancing potential of alkyl-maltosides
  publication-title: Mol. Pharm.
  doi: 10.1021/mp500776a
  contributor:
    fullname: Gradauer
– volume: 21
  start-page: 160
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0380
  article-title: Enterically delivered insulin tregopil exhibits rapid absorption characteristics and a pharmacodynamic effect similar to human insulin in conscious dogs
  publication-title: Diabetes Obes. Metab.
  doi: 10.1111/dom.13498
  contributor:
    fullname: Gregory
– volume: 273
  start-page: 94
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0485
  article-title: Pathobiology of neutrophil-epithelial interactions
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12446
  contributor:
    fullname: Brazil
– volume: 10
  start-page: 997
  year: 2010
  ident: 10.1016/j.addr.2020.05.007_bb1070
  article-title: Romidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors
  publication-title: Expert. Rev. Anticancer. Ther.
  doi: 10.1586/era.10.88
  contributor:
    fullname: Grant
– volume: 57
  start-page: 278
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0980
  article-title: Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties?
  publication-title: J. Med. Chem.
  doi: 10.1021/jm400887j
  contributor:
    fullname: Giordanetto
– volume: 7
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0850
  article-title: Jejunal wall delivery of insulin via an ingestible capsule in anesthetized swine-A pharmacokinetic and pharmacodynamic study
  publication-title: Pharmacol. Res. Perspect.
  doi: 10.1002/prp2.522
  contributor:
    fullname: Hashim
– volume: 42
  start-page: 1965
  year: 1999
  ident: 10.1016/j.addr.2020.05.007_bb1155
  article-title: Low molecular weight peptidic and cyclic antagonists of the receptor for the Complement Factor C5a
  publication-title: J. Med. Chem.
  doi: 10.1021/jm9806594
  contributor:
    fullname: Finch
– volume: 73
  start-page: 344
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb1270
  article-title: High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide Sanguinamide A
  publication-title: Aust. J. Chem.
  doi: 10.1071/CH19479
  contributor:
    fullname: Nielsen
– ident: 10.1016/j.addr.2020.05.007_bb0085
  doi: 10.3390/ijms20164016
– volume: 56
  start-page: 3770
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0935
  article-title: Non-ribosomal peptide synthesis-principles and prospects
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.201609079
  contributor:
    fullname: Suessmuth
– volume: 32
  start-page: 1269
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0305
  article-title: A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2014.07.006
  contributor:
    fullname: Choonara
– volume: 106
  start-page: 193
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0595
  article-title: Oral delivery of peptides: opportunities and issues for translation
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2016.10.005
  contributor:
    fullname: Brayden
– volume: 105
  start-page: 973
  year: 2005
  ident: 10.1016/j.addr.2020.05.007_bb0930
  article-title: Proteases universally recognize beta strands in their active sites
  publication-title: Chem. Rev.
  doi: 10.1021/cr040669e
  contributor:
    fullname: Tyndall
– volume: 64
  start-page: 515
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb0090
  article-title: Spiral progression in the development of absorption enhancers based on the biology of tight junctions
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2011.07.004
  contributor:
    fullname: Kondoh
– volume: 304
  start-page: 1
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0910
  article-title: Ultra-rapid drug delivery in the oral cavity using ultrasound
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2019.04.037
  contributor:
    fullname: France
– volume: 119
  start-page: 9861
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb1300
  article-title: Crystal structures of protein-bound cyclic peptides
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.8b00807
  contributor:
    fullname: Malde
– volume: 33
  start-page: 1573
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb0725
  article-title: Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2011.10.075
  contributor:
    fullname: Jin
– volume: 100
  start-page: 1699
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0045
  article-title: Safety and efficacy of oral octreotide in acromegaly: results of a multicenter Phase III trial
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2014-4113
  contributor:
    fullname: Melmed
– volume: 20
  start-page: 812
  year: 1997
  ident: 10.1016/j.addr.2020.05.007_bb0400
  article-title: Effects of various absorption enhancers on the intestinal absorption of water soluble drugs by in vitro Ussing chamber method: correlation with an in situ absorption experiment
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.20.812
  contributor:
    fullname: Sugiyama
– volume: 265
  start-page: 955
  year: 1993
  ident: 10.1016/j.addr.2020.05.007_bb0385
  article-title: In vitro effects of long-chain acylcarnitines on the permeability, transepithelial electrical resistance and morphology of rat colonic mucosa
  publication-title: J. Pharmacol. Exp. Ther.
  contributor:
    fullname: Lecluyse
– volume: 17
  start-page: 476
  year: 2000
  ident: 10.1016/j.addr.2020.05.007_bb0860
  article-title: Iontophoresis-enhanced absorptive flux of polar molecules across intestinal tissue in vitro
  publication-title: Pharm. Res.
  doi: 10.1023/A:1007541423500
  contributor:
    fullname: Leonard
– volume: 54
  start-page: 1213
  year: 2002
  ident: 10.1016/j.addr.2020.05.007_bb0585
  article-title: Catching target receptors for drug and vaccine delivery using TOGA gene expression profiling
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(02)00091-1
  contributor:
    fullname: Lo
– volume: 3
  issue: Suppl. 1
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0815
  article-title: OR14-1 pharmacodynamics, safety, tolerability, and efficacy of oral insulin formulation (Oshadi Icp) among young adults with Type 1diabetes: a summary of clinical studies Phases I, Ib
  publication-title: J. Endocrine Soc.
  contributor:
    fullname: Rachmiel
– volume: 25
  start-page: 1512
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0845
  article-title: A luminal unfolding microneedle injector for oral delivery of macromolecules
  publication-title: Nat. Med.
  doi: 10.1038/s41591-019-0598-9
  contributor:
    fullname: Abramson
– volume: 9
  start-page: 3282
  year: 2013
  ident: 10.1016/j.addr.2020.05.007_bb0685
  article-title: Nanoparticle transport in epithelial cells: pathway switching through bioconjugation
  publication-title: Small
  doi: 10.1002/smll.201202623
  contributor:
    fullname: Fowler
– volume: 310
  start-page: 115
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0440
  article-title: Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: ex vivo and in vivo rat studies
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2019.08.008
  contributor:
    fullname: McCartney
– volume: 28
  start-page: 385
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb1130
  article-title: Anthelmintic cyclcooctadepsipeptides: complex in structure and mode of action
  publication-title: Trends Parasitol.
  doi: 10.1016/j.pt.2012.06.005
  contributor:
    fullname: Kruecken
– volume: 33
  start-page: 2750
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0345
  article-title: Correlating membrane morphological responses with micellar aggregation behavior of capric acid and monocaprin
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b03944
  contributor:
    fullname: Yoon
– volume: 16
  start-page: 2289
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb1230
  article-title: Flexibility versus rigidity for orally bioavailable cyclic hexapeptides
  publication-title: ChemBioChem
  doi: 10.1002/cbic.201500441
  contributor:
    fullname: Nielsen
– volume: 58
  start-page: 4581
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb1245
  article-title: Probing the physicochemical boundaries of cell permeability and oral bioavailability in lipophilic macrocycles inspired by natural products
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.5b00128
  contributor:
    fullname: Bockus
– volume: 7
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0530
  article-title: Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-15108-y
  contributor:
    fullname: Watari
– volume: 43
  start-page: 1271
  year: 2000
  ident: 10.1016/j.addr.2020.05.007_bb0950
  article-title: Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing
  publication-title: J. Med. Chem.
  doi: 10.1021/jm990315t
  contributor:
    fullname: Fairlie
– volume: 33
  start-page: 358
  year: 2011
  ident: 10.1016/j.addr.2020.05.007_bb0215
  article-title: Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study
  publication-title: Clin. Ther.
  doi: 10.1016/j.clinthera.2011.03.003
  contributor:
    fullname: Castelli
– volume: 31
  start-page: 2539
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0335
  article-title: Laurate permeabilizes the paracellular pathway for small molecules in the intestinal epithelial cell model HT-29/B6 via opening the tight junctions by reversible relocation of claudin-5
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-014-1350-2
  contributor:
    fullname: Dittmann
– volume: 11
  start-page: 1854
  year: 2005
  ident: 10.1016/j.addr.2020.05.007_bb1185
  article-title: Phase I clinical and pharmacokinetic study of kahalalide F in patients with advanced androgen refractory prostate cancer
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-04-1534
  contributor:
    fullname: Rademaker-Lakhai
– volume: 15
  start-page: 195
  year: 1997
  ident: 10.1016/j.addr.2020.05.007_bb1075
  article-title: Depsipeptide (FR901228, NSC-630176) pharmacokinetics in the rat by LC/MS/MS
  publication-title: Investig. New Drugs
  doi: 10.1023/A:1005847703624
  contributor:
    fullname: Chan
– volume: 152
  start-page: 429
  year: 2007
  ident: 10.1016/j.addr.2020.05.007_bb1165
  article-title: Function, structure and therapeutic potential of complement C5a receptors
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0707332
  contributor:
    fullname: Monk
– volume: 27
  start-page: 1017
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0540
  article-title: Oral self-emulsifying delivery systems for systemic administration of therapeutic proteins: science fiction?
  publication-title: J. Drug Target.
  doi: 10.1080/1061186X.2019.1584200
  contributor:
    fullname: Phan
– volume: 1
  start-page: 4207
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0570
  article-title: Hydrophobic ion pairing: encapsulating small molecules, peptides, and proteins into nanocarriers
  publication-title: Nanoscale
  doi: 10.1039/C9NA00308H
  contributor:
    fullname: Ristroph
– volume: 10
  start-page: 141
  year: 1993
  ident: 10.1016/j.addr.2020.05.007_bb0580
  article-title: Nano- and microparticles for the delivery of polypeptides and proteins
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/0169-409X(93)90046-7
  contributor:
    fullname: Couvreur
– volume: 10
  start-page: 255
  year: 2002
  ident: 10.1016/j.addr.2020.05.007_bb0435
  article-title: Absorption enhancing effect of labrasol on the intestinal absorption of insulin in rats
  publication-title: J. Drug Target.
  doi: 10.1080/10611860290022688
  contributor:
    fullname: Eaimtrakarn
– volume: 46
  start-page: 1773
  year: 2007
  ident: 10.1016/j.addr.2020.05.007_bb1170
  article-title: Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/kem222
  contributor:
    fullname: Vergunst
– volume: 309
  start-page: 106
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb1320
  article-title: Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2019.07.020
  contributor:
    fullname: Xu
– volume: 34
  start-page: 2333
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb0820
  article-title: Time-action profile of an oral enteric insulin formulation in healthy Chinese volunteers
  publication-title: Clin. Ther.
  doi: 10.1016/j.clinthera.2012.11.004
  contributor:
    fullname: Li
– volume: 288
  start-page: 111
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0510
  article-title: An intestinal paracellular pathway biased toward positively-charged macromolecules
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2018.09.003
  contributor:
    fullname: Almansour
– volume: 117
  start-page: 8094
  year: 2017
  ident: 10.1016/j.addr.2020.05.007_bb0965
  article-title: Orally absorbed cyclic peptides
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.6b00838
  contributor:
    fullname: Nielsen
– volume: 7
  start-page: 71
  year: 1991
  ident: 10.1016/j.addr.2020.05.007_bb0575
  article-title: Peroral administration of nanoparticles
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/0169-409X(91)90048-H
  contributor:
    fullname: Kreuter
– volume: 100
  start-page: 24
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0785
  article-title: Oral delivery of anti-diabetes therapeutics using cell penetrating and transcytosing peptide strategies
  publication-title: Peptides
  doi: 10.1016/j.peptides.2017.12.014
  contributor:
    fullname: Rehmani
– year: 2011
  ident: 10.1016/j.addr.2020.05.007_bb0405
  contributor:
    fullname: Kidron
– volume: 286
  start-page: 402
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0620
  article-title: Physicochemical, pharmacokinetic and pharmacodynamic analyses of amphiphilic cyclodextrin-based nanoparticles designed to enhance intestinal delivery of insulin
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2018.07.045
  contributor:
    fullname: Presas
– volume: 16
  start-page: 2817
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0775
  article-title: Zeta potential-changing polyphosphate nanoparticles: a promising approach to overcome the mucus and epithelial barrier
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.9b00355
  contributor:
    fullname: Akkus
– volume: 97
  start-page: 225
  year: 2008
  ident: 10.1016/j.addr.2020.05.007_bb0360
  article-title: Oral delivery of antisense oligonucleotides in man
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.21084
  contributor:
    fullname: Tillman
– volume: 571
  start-page: 43
  year: 1988
  ident: 10.1016/j.addr.2020.05.007_bb0490
  article-title: Physiological regulation of epithelial junctions in intestinal epithelia
  publication-title: Acta Physiol. Scand. Suppl.
  contributor:
    fullname: Pappenheimer
– volume: 5
  start-page: 127
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0915
  article-title: Materials for oral delivery of proteins and peptides
  publication-title: Nat. Rev. Mater.
  doi: 10.1038/s41578-019-0156-6
  contributor:
    fullname: Brown
– volume: 12
  start-page: 276
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0375
  article-title: Impact of insulin tregopil and is permeation enhancer on pharmacokinetics of metformin in healthy volunteers: randomized, open label, placebo-controlled, crossover study
  publication-title: Clin. Transl. Sci.
  doi: 10.1111/cts.12609
  contributor:
    fullname: Khedkar
– volume: 10
  start-page: 472
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0680
  article-title: Mapping protein binding sites on the biomolecular corona of nanoparticles
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/nnano.2015.47
  contributor:
    fullname: Kelly
– volume: 11
  start-page: 1060
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb1280
  article-title: Pharmacokinetic studies around the mono- and difunctionalization of a bioavailable cyclic decapeptide scaffold
  publication-title: ChemMedChem
  doi: 10.1002/cmdc.201600083
  contributor:
    fullname: Fouche
– volume: 50
  start-page: 924
  year: 1995
  ident: 10.1016/j.addr.2020.05.007_bb1020
  article-title: Cyclosporin: a review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral)
  publication-title: Drugs
  doi: 10.2165/00003495-199550050-00009
  contributor:
    fullname: Noble
– volume: 11
  start-page: 1048
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb1275
  article-title: Design and development of a cyclic decapeptide scaffold with suitable properties for bioavailability and oral exposure
  publication-title: ChemMedChem
  doi: 10.1002/cmdc.201600082
  contributor:
    fullname: Fouche
– volume: 14
  start-page: 139
  year: 2009
  ident: 10.1016/j.addr.2020.05.007_bb1015
  article-title: Oral cyclosporine a - the current picture of its liposomal and other delivery systems
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.2478/s11658-008-0041-6
  contributor:
    fullname: Czogalla
– volume: 6
  start-page: 1
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb1160
  article-title: Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists
  publication-title: Sci. Rep.
  doi: 10.1038/srep24575
  contributor:
    fullname: Seow
– volume: 108
  start-page: 1090
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb1325
  article-title: Cell penetrating peptides: a concise review with emphasis on biomedical applications
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2018.09.097
  contributor:
    fullname: Derakhshankhah
– volume: 9
  start-page: 2345
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0780
  article-title: Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-assembled nanoparticles for oral delivery of insulin
  publication-title: ACS Nano
  doi: 10.1021/acsnano.5b00028
  contributor:
    fullname: Shan
– volume: 18
  start-page: 85
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0990
  article-title: 2018 FDA drug approvals
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/d41573-019-00014-x
  contributor:
    fullname: Mullard
– volume: 56
  start-page: 3888
  year: 2012
  ident: 10.1016/j.addr.2020.05.007_bb1125
  article-title: The cyclophilin inhibitor SCY-635 disrupts hepatitis C virus NS5A-cyclophilin A complexes
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00693-12
  contributor:
    fullname: Hopkins
– volume: 7
  start-page: 528
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0285
  article-title: PIONEER 7 investigators, Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, Phase 3a trial
  publication-title: Lancet Diabetes Endocrinol.
  doi: 10.1016/S2213-8587(19)30194-9
  contributor:
    fullname: Pieber
– volume: 128
  start-page: 14073
  year: 2006
  ident: 10.1016/j.addr.2020.05.007_bb1215
  article-title: Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja063076p
  contributor:
    fullname: Rezai
– volume: 47
  start-page: 2595
  year: 2008
  ident: 10.1016/j.addr.2020.05.007_bb1315
  article-title: Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.200705797
  contributor:
    fullname: Biron
– start-page: 2349
  year: 1971
  ident: 10.1016/j.addr.2020.05.007_bb1295
  article-title: Constitution of griselimycin, a polypeptide antibiotic extracted from Streptomyces cultures. I. Identification of the hydrolysis products
  publication-title: Bull. Soc. Chim. Fr.
  contributor:
    fullname: Terlain
– volume: 31
  start-page: 288
  year: 2016
  ident: 10.1016/j.addr.2020.05.007_bb0665
  article-title: Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: a mucoadhesive and pH responsive carrier for improved oral delivery of insulin
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2015.12.017
  contributor:
    fullname: Verma
– volume: 133
  start-page: 111
  year: 2009
  ident: 10.1016/j.addr.2020.05.007_bb0495
  article-title: Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site
  publication-title: J. Gen. Physiol
  doi: 10.1085/jgp.200810154
  contributor:
    fullname: Yu
– volume: 15
  start-page: 3468
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb1345
  article-title: Enhancing oral bioavailability of cyclic RGD hexa-peptides by the lipophilic prodrug charge masking approach: redirection of peptide intestinal permeability from a paracellular to transcellular pathway
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.8b00466
  contributor:
    fullname: Schumacher-Klinger
– volume: 7
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0105
  article-title: Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids
  publication-title: Elife
  doi: 10.7554/eLife.34469
  contributor:
    fullname: Garcia-Castillo
– volume: 348
  start-page: 1106
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb1290
  article-title: Targeting DnaN for tuberculosis therapy using novel griselimycins
  publication-title: Science
  doi: 10.1126/science.aaa4690
  contributor:
    fullname: Kling
– volume: 5
  year: 2020
  ident: 10.1016/j.addr.2020.05.007_bb0475
  article-title: Human DNA-PK activates a STING-independent DNA sensing pathway
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.aba4219
  contributor:
    fullname: Burleigh
– volume: 142
  start-page: 91
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0555
  article-title: SEDDS: a game changing approach for the oral administration of hydrophilic macromolecular drugs
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2018.07.001
  contributor:
    fullname: Mahmood
– volume: 53
  start-page: 13020
  year: 2014
  ident: 10.1016/j.addr.2020.05.007_bb0960
  article-title: Constraining cyclic peptides To mimic protein structure motifs
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.201401058
  contributor:
    fullname: Hill
– volume: 279
  start-page: 208
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb0515
  article-title: Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation in polarized intestinal epithelia
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2018.03.033
  contributor:
    fullname: Almansour
– volume: 55
  start-page: 13362
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb1205
  article-title: Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities
  publication-title: Chem. Commun.
  doi: 10.1039/C9CC06234C
  contributor:
    fullname: Lohman
– volume: 97
  start-page: 273
  year: 2015
  ident: 10.1016/j.addr.2020.05.007_bb0645
  article-title: Mucus permeating carriers: formulation and characterization of highly densely charged nanoparticles
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2014.12.024
  contributor:
    fullname: Pereira de Sousa
– volume: 144
  start-page: 40
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0770
  article-title: Zeta potential changing self-emulsifying drug delivery systems: a promising strategy to sequentially overcome mucus and epithelial barrier
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2019.09.007
  contributor:
    fullname: Nazir
– start-page: 317
  year: 2011
  ident: 10.1016/j.addr.2020.05.007_bb1120
  contributor:
    fullname: Lin
– volume: 24
  start-page: 35
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb1220
  article-title: Modulation of oral bioavailability and metabolism for closely related cyclic hexapeptides
  publication-title: Int. J. Pept. Res. Ther.
  doi: 10.1007/s10989-017-9590-8
  contributor:
    fullname: Vorherr
– volume: 363
  start-page: 611
  year: 2019
  ident: 10.1016/j.addr.2020.05.007_bb0840
  article-title: An ingestible self-orienting system for oral delivery of macromolecules
  publication-title: Science
  doi: 10.1126/science.aau2277
  contributor:
    fullname: Abramson
– volume: 15
  start-page: 589
  year: 2018
  ident: 10.1016/j.addr.2020.05.007_bb1010
  article-title: New treatments and therapeutic targets for IBS and other functional bowel disorders
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-018-0034-5
  contributor:
    fullname: Simren
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Snippet In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics especially peptides and proteins. In the intervening period,...
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SubjectTerms Drug-device combination products
Epithelial permeability
Nanoparticles
Oral bioavailability
Oral peptide delivery
Tight junctions
Title Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches
URI https://dx.doi.org/10.1016/j.addr.2020.05.007
https://www.ncbi.nlm.nih.gov/pubmed/32479930
Volume 157
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