Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance

• Published in: Cell metabolism Vol. 21; no. 3; pp. 403 - 416
• Main Authors: Kraakman, Michael J., Kammoun, Helene L., Allen, Tamara L., Deswaerte, Virginie, Henstridge, Darren C., Estevez, Emma, Matthews, Vance B., Neill, Bronwyn, White, David A., Murphy, Andrew J., Peijs, Lone, Yang, Christine, Risis, Steve, Bruce, Clinton R., Du, Xiao-Jun, Bobik, Alex, Lee-Young, Robert S., Kingwell, Bronwyn A., Vasanthakumar, Ajithkumar, Shi, Wei, Kallies, Axel, Lancaster, Graeme I., Rose-John, Stefan, Febbraio, Mark A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.03.2015
• Subjects: Adipose Tissue - metabolism; Adipose Tissue - physiology; Animals; Cytokine Receptor gp130 - metabolism; Diet, High-Fat - adverse effects; Insulin Resistance - physiology; Interleukin-6 - metabolism; Macrophages - metabolism; Macrophages - physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Interleukin-6 - metabolism; Signal Transduction - physiology

Interleukin-6 (IL-6) plays a paradoxical role in inflammation and metabolism. The pro-inflammatory effects of IL-6 are mediated via IL-6 “trans-signaling,” a process where the soluble form of the IL-6 receptor (sIL-6R) binds IL-6 and activates signaling in inflammatory cells that express the gp130 b...