Immune index: A gene and cell prognostic signature for immunotherapy response prediction in hepatocellular carcinoma

• Published in: Pharmacological research Vol. 187; p. 106583
• Main Authors: Cui, Xiuliang, Han, Lu, Cui, Longjiu, Fu, Gongbo, Liu, Erdong, Wang, Duowei, Song, Bin, Zhang, Yongxiang, Zhou, Wenxia, Wang, Hongyang, Fu, Jing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2023
• Subjects: Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - genetics; CD8-Positive T-Lymphocytes; Hepatocellular carcinoma; Humans; Immune microenvironment; Immune therapy; Immunotherapy; Liver Neoplasms - drug therapy; Liver Neoplasms - genetics; Prognosis; Single cell; Tumor Microenvironment; Immune microenvironment; Prognosis; Immune therapy; Single cell; Hepatocellular carcinoma; HCC; ICB; TIME

The heterogeneity of tumor immune microenvironment (TIME) plays important roles in the development and immunotherapy response of hepatocellular carcinoma (HCC). Using machine learning algorithms, we introduced the immune index (IMI), a prognostic model based on the HCC immune landscape. We found tha...