Quantitative Detection of Promoter Hypermethylation of Multiple Genes in the Tumor, Urine, and Serum DNA of Patients with Renal Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 64; no. 15; pp. 5511 - 5517
• Main Authors: Hoque, Mohammad Obaidul, Begum, Shahnaz, Topaloglu, Ozlem, Jeronimo, Carmen, Mambo, Elizabeth, Westra, William H., Califano, J. A., Sidransky, David
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.08.2004
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic agents; Biological and medical sciences; DNA Methylation; DNA, Neoplasm - blood; DNA, Neoplasm - urine; Female; Genes, Tumor Suppressor - physiology; Humans; Kidney - metabolism; Kidney - pathology; Kidney Neoplasms - diagnosis; Kidney Neoplasms - genetics; Male; Medical sciences; Middle Aged; Neoplasm Proteins - blood; Neoplasm Proteins - genetics; Neoplasm Proteins - urine; Pharmacology. Drug treatments; Polymerase Chain Reaction; Promoter Regions, Genetic - genetics; Sensitivity and Specificity; Tumors; Kidney disease; Human; Urine; Biological fluid; Urinary system disease; Transcription promoter; Malignant tumor; Gene; DNA; Kidney cancer; Genetics; Serum; Methylation; Quantitative analysis

Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of human cancers and is a promising marker for cancer detection. We investigated the feasibility of detecting aberrant DNA methylation in the urine and serum samples of re...