Metabonomic Characterization of the 3-Nitropropionic Acid Rat Model of Huntington’s Disease

• Published in: Neurochemical research Vol. 34; no. 7; pp. 1261 - 1271
• Main Authors: Tsang, T. M., Haselden, J. N., Holmes, E.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.07.2009; Springer Nature B.V
• Subjects: Animals; Behavior, Animal - drug effects; Biochemistry; Biomedical and Life Sciences; Biomedicine; Brain - metabolism; Brain Stem - metabolism; Cell Biology; Cerebellum - metabolism; Cerebral Cortex - metabolism; Choline - metabolism; Corpus Striatum - metabolism; Disease Models, Animal; gamma-Aminobutyric Acid - metabolism; Hippocampus - metabolism; Huntington Disease - chemically induced; Huntington Disease - metabolism; Lactic Acid - metabolism; Male; Metabolomics; Neurochemistry; Neurology; Neurosciences; Nitro Compounds; Nuclear Magnetic Resonance, Biomolecular - methods; Original Paper; Phosphorylcholine - metabolism; Propionates; Rats; Rats, Sprague-Dawley; Succinic Acid - metabolism; Taurine - physiology; Mitochondria; Choline; Huntington’s disease (HD); Metabonomics; Succinate; Magic-angle-spinning (MAS); Acetylaspartate (NAA); 3-Nitropropionic acid (3-NP); Acetylaspartylglutamate (NAAG); NMR spectroscopy; γ-Amino-butyric acid (GABA)

3-Nitropropionic acid (3-NP)-induced neurotoxicity can be used as a model for the genetic neurodegenerative disorder Huntington’s disease (HD). A metabolic profiling strategy was adopted to explore the biochemical consequences of 3-NP administered to rats in specific brain regions. 1 H NMR spectrosc...