Early B-cell Factor1 (Ebf1) promotes early osteoblast differentiation but suppresses osteoblast function

• Published in: Bone (New York, N.Y.) Vol. 146; p. 115884
• Main Authors: Nieminen-Pihala, Vappu, Tarkkonen, Kati, Laine, Julius, Rummukainen, Petri, Saastamoinen, Lauri, Nagano, Kenichi, Baron, Roland, Kiviranta, Riku
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2021
• Subjects: Animals; B-Lymphocytes; Bone formation; Cell Differentiation; Conditional knockout mouse model; Ebf1; Mice; Osteoblast; Osteoblast differentiation; Osteoblasts; Osteocalcin; Osteogenesis; Osterix; Sp7 Transcription Factor - genetics; Trans-Activators - genetics; Transcriptional regulation; Bone formation; Osterix; Conditional knockout mouse model; Ebf1; Osteoblast; Transcriptional regulation; Osteoblast differentiation

Early B cell factor 1 (Ebf1) is a transcription factor that regulates B cell, neuronal cell and adipocyte differentiation. We and others have shown that Ebf1 is expressed in osteoblasts and that global deletion of Ebf1 results in increased bone formation in vivo. However, as Ebf1 is expressed in mul...