CYP2C19 polymorphism influences Helicobacter pylori eradication

• Published in: World journal of gastroenterology : WJG Vol. 20; no. 43; pp. 16029 - 16036
• Main Authors: Kuo, Chao-Hung, Lu, Chien-Yu, Shih, Hsiang-Yao, Liu, Chung-Jung, Wu, Meng-Chieh, Hu, Huang-Ming, Hsu, Wen-Hung, Yu, Fang-Jung, Wu, Deng-Chyang, Kuo, Fu-Chen
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 21.11.2014
• Subjects: Anti-Bacterial Agents - therapeutic use; CYP2C19; Cytochrome P-450 CYP2C19 - genetics; Cytochrome P-450 CYP2C19 - metabolism; Drug Therapy, Combination; Eradicati; Genotype; Helicobacter; Helicobacter Infections - diagnosis; Helicobacter Infections - drug therapy; Helicobacter Infections - epidemiology; Helicobacter Infections - microbiology; Helicobacter pylori - drug effects; Humans; Pharmacogenetics; Phenotype; Polymorphism; Polymorphism, Genetic; Proton Pump Inhibitors - pharmacokinetics; Proton Pump Inhibitors - therapeutic use; pylori; Topic Highlight; Treatment Outcome; Omeprazole; Helicobacter pylori; Pantoprazole; Esomeprazole; Rabeprazole; CYP2C19; Eradication; Lansoprazole; Polymorphism

The known factors that have contributed to the decline of Helicobacter pylori(H.pylori)eradication rate include antibiotic resistance,poor compliance,high gastric acidity,high bacterial load,and cytochrome P450 2C19(CYP2C19)polymorphism.Proton pump inhibitor(PPI)is important in the eradication regim...