The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT

• Published in: Breast cancer research and treatment Vol. 167; no. 3; pp. 719 - 729
• Main Authors: Kirkham, Amy A., Eves, Neil D., Shave, Rob E., Bland, Kelcey A., Bovard, Joshua, Gelmon, Karen A., Virani, Sean A., McKenzie, Don C., Stöhr, Eric J., Waburton, Darren E. R., Campbell, Kristin L.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2018; Springer; Springer Nature B.V
• Subjects: Adult; Anthracyclines; Blood pressure; Body weight; Body weight gain; Breast cancer; Breast Neoplasms - complications; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Calcium-binding protein; Cancer research; Cancer therapies; Cardiotoxicity; Cardiotoxicity - physiopathology; Cardiotoxicity - prevention & control; Care and treatment; Chemotherapy; Clinical Trial; Doxorubicin; Doxorubicin - administration & dosage; Doxorubicin - adverse effects; Echocardiography; Exercise; Female; Heart diseases; Heart Diseases - chemically induced; Heart Diseases - physiopathology; Heart Diseases - prevention & control; Heart rate; Hemodynamics; Humans; Low back pain; Medicine; Medicine & Public Health; Middle Aged; Mood; Muscles; Oncology; Pain; Pain management; Physical Conditioning, Animal; Physical training; Troponin; Breast cancer; Exercise; Cardiotoxicity; Treatment symptoms; Doxorubicin

Purpose In rodents, a single exercise bout performed 24 h prior to a single doxorubicin treatment provides cardio-protection. This study investigated whether performing this intervention prior to every doxorubicin treatment for breast cancer reduced subclinical cardiotoxicity and treatment symptoms....