ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions - Zhang, Qianting; Xiao, Mu; Gu, Shuchen; Xu, Yongxian; Liu, Ting; Li, Hao; Yu, Yi; Qin, Lan; Zhu, Yezhang; Chen, Fenfang; Wang, Yulong; Ding, Chen; et al. (Nature cell biology, 2019)
Keywords: 631/67; 631/80/458/1733; 631/80/86; Anaplastic Lymphoma Kinase - genetics; Anaplastic Lymphoma Kinase - metabolism; Animals; Biomedical and Life Sciences; Blocking; Cancer; Cancer Research; Cell Biology; Cell Line; Cell Line, Tumor; Deoxyribonucleic acid; Developmental Biology; DNA; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic - drug effects; HEK293 Cells; Humans; Kinases; Life Sciences; Lung cancer; Lymphoma; Mice, Inbred BALB C; Mice, Nude; Mutation; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Neuroblastoma; Organic chemistry; Pancreatic cancer; Phosphorylation; Protein-tyrosine kinase; Signal transduction; Smad4 protein; Smad4 Protein - genetics; Smad4 Protein - metabolism; Stem Cells; Transduction; Transforming Growth Factor beta - pharmacology; Transplantation, Heterologous; Tumor suppressor genes; Tumorigenesis; Tumors; Tyrosine; Tyrosine - genetics; Tyrosine - metabolism