Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury

• Published in: Pharmacological research Vol. 170; p. 105715
• Main Authors: D’Ascenzo, Fabrizio, Femminò, Saveria, Ravera, Francesco, Angelini, Filippo, Caccioppo, Andrea, Franchin, Luca, Grosso, Alberto, Comità, Stefano, Cavallari, Claudia, Penna, Claudia, De Ferrari, Gaetano Maria, Camussi, Giovanni, Pagliaro, Pasquale, Brizzi, Maria Felice
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2021
• Subjects: ACS; Acute Coronary Syndrome - blood; Acute Coronary Syndrome - diagnosis; Acute Coronary Syndrome - therapy; Aged; Animals; Arm - blood supply; Case-Control Studies; Cell Line; Disease Models, Animal; Double-Blind Method; Dual Specificity Phosphatase 6 - metabolism; Endothelial Cells - metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; Extracellular vesicles; Extracellular Vesicles - metabolism; Extracellular Vesicles - transplantation; Female; Humans; Ischemia/reperfusion injury; Ischemic Preconditioning, Myocardial - adverse effects; Male; Middle Aged; Myocardial Reperfusion Injury - diagnosis; Myocardial Reperfusion Injury - etiology; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - prevention & control; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Percutaneous Coronary Intervention - adverse effects; Phosphorylation; Rats; Rats, Wistar; Regional Blood Flow; Salvage pathways; STAT3 Transcription Factor - metabolism; Time Factors; Treatment Outcome; Salvage pathways; Extracellular vesicles; ACS; Ischemia/reperfusion injury

The relevance of extracellular vesicles (EV) as mediators of cardiac damage or recovery upon Ischemia Reperfusion Injury (IRI) and Remote Ischemic PreConditioning (RIPC) is controversial. This study aimed to investigate whether serum-derived EV, recovered from patients with Acute Coronary Syndrome (...