The role of leptin and adiponectin as mediators in the relationship between adiposity and hand and knee osteoarthritis
To investigate associations of leptin and adiponectin levels with knee and hand osteoarthritis, and explore whether these mediate the association between adiposity and osteoarthritis. This is a cross-sectional analysis of baseline data from the population-based Netherlands Epidemiology of Obesity st...
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| Published in | Osteoarthritis and cartilage Vol. 27; no. 12; pp. 1761 - 1767 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.12.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | To investigate associations of leptin and adiponectin levels with knee and hand osteoarthritis, and explore whether these mediate the association between adiposity and osteoarthritis.
This is a cross-sectional analysis of baseline data from the population-based Netherlands Epidemiology of Obesity study. Adiposity was assessed with body mass index (BMI) and percentage total body fat (%TBF). Osteoarthritis, defined as hand or knee osteoarthritis, was determined using American College of Rheumatology criteria. Fasting serum adipokine levels were measured using immunoassays. Associations between adiposity and osteoarthritis were examined with logistic regression, adjusted for age, sex, ethnicity and education, and additionally for leptin and adiponectin as potential mediators.
In 6408 participants (56% women, median age 56 years), prevalence of osteoarthritis was 22% (10% isolated knee and 8% isolated hand osteoarthritis). Leptin levels were positively associated with osteoarthritis, while adiponectin levels were not. Leptin partially mediated the association of adiposity with osteoarthritis (OR 1.40 (95%CI 1.30; 1.52) attenuated to 1.38 (1.24; 1.54) per 5 units BMI and OR 1.25 (1.17; 1.35) to 1.20 (1.10; 1.32) per 5 units %TBF, representing 4% and 17% mediation, respectively). Larger proportion mediation by leptin was found in knee (13%/27%) than in hand osteoarthritis (9%/18%). Sex-stratified analyses generally showed stronger associations between adiposity, leptin and osteoarthritis in women than in men.
Serum leptin levels were associated with osteoarthritis, and partially mediated the association between adiposity and osteoarthritis, while adiponectin levels were not associated with osteoarthritis. These findings provide evidence for systemic effects of adipose tissue in osteoarthritis. |
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| AbstractList | To investigate associations of leptin and adiponectin levels with knee and hand osteoarthritis, and explore whether these mediate the association between adiposity and osteoarthritis.
This is a cross-sectional analysis of baseline data from the population-based Netherlands Epidemiology of Obesity study. Adiposity was assessed with body mass index (BMI) and percentage total body fat (%TBF). Osteoarthritis, defined as hand or knee osteoarthritis, was determined using American College of Rheumatology criteria. Fasting serum adipokine levels were measured using immunoassays. Associations between adiposity and osteoarthritis were examined with logistic regression, adjusted for age, sex, ethnicity and education, and additionally for leptin and adiponectin as potential mediators.
In 6408 participants (56% women, median age 56 years), prevalence of osteoarthritis was 22% (10% isolated knee and 8% isolated hand osteoarthritis). Leptin levels were positively associated with osteoarthritis, while adiponectin levels were not. Leptin partially mediated the association of adiposity with osteoarthritis (OR 1.40 (95%CI 1.30; 1.52) attenuated to 1.38 (1.24; 1.54) per 5 units BMI and OR 1.25 (1.17; 1.35) to 1.20 (1.10; 1.32) per 5 units %TBF, representing 4% and 17% mediation, respectively). Larger proportion mediation by leptin was found in knee (13%/27%) than in hand osteoarthritis (9%/18%). Sex-stratified analyses generally showed stronger associations between adiposity, leptin and osteoarthritis in women than in men.
Serum leptin levels were associated with osteoarthritis, and partially mediated the association between adiposity and osteoarthritis, while adiponectin levels were not associated with osteoarthritis. These findings provide evidence for systemic effects of adipose tissue in osteoarthritis. OBJECTIVESTo investigate associations of leptin and adiponectin levels with knee and hand osteoarthritis, and explore whether these mediate the association between adiposity and osteoarthritis. METHODSThis is a cross-sectional analysis of baseline data from the population-based Netherlands Epidemiology of Obesity study. Adiposity was assessed with body mass index (BMI) and percentage total body fat (%TBF). Osteoarthritis, defined as hand or knee osteoarthritis, was determined using American College of Rheumatology criteria. Fasting serum adipokine levels were measured using immunoassays. Associations between adiposity and osteoarthritis were examined with logistic regression, adjusted for age, sex, ethnicity and education, and additionally for leptin and adiponectin as potential mediators. RESULTSIn 6408 participants (56% women, median age 56 years), prevalence of osteoarthritis was 22% (10% isolated knee and 8% isolated hand osteoarthritis). Leptin levels were positively associated with osteoarthritis, while adiponectin levels were not. Leptin partially mediated the association of adiposity with osteoarthritis (OR 1.40 (95%CI 1.30; 1.52) attenuated to 1.38 (1.24; 1.54) per 5 units BMI and OR 1.25 (1.17; 1.35) to 1.20 (1.10; 1.32) per 5 units %TBF, representing 4% and 17% mediation, respectively). Larger proportion mediation by leptin was found in knee (13%/27%) than in hand osteoarthritis (9%/18%). Sex-stratified analyses generally showed stronger associations between adiposity, leptin and osteoarthritis in women than in men. CONCLUSIONSSerum leptin levels were associated with osteoarthritis, and partially mediated the association between adiposity and osteoarthritis, while adiponectin levels were not associated with osteoarthritis. These findings provide evidence for systemic effects of adipose tissue in osteoarthritis. |
| Author | de Mutsert, R. van Dijk, K.W. Kloppenburg, M. Visser, A.W. le Cessie, S. Veenbrink, A.I. Rosendaal, F.R. Kroon, F.P.B. |
| Author_xml | – sequence: 1 givenname: F.P.B. surname: Kroon fullname: Kroon, F.P.B. email: f.kroon.reum@lumc.nl organization: Department of Rheumatology, Leiden University Medical Centre (LUMC), Leiden, the Netherlands – sequence: 2 givenname: A.I. surname: Veenbrink fullname: Veenbrink, A.I. organization: Department of Internal Medicine, Medisch Spectrum Twente, the Netherlands – sequence: 3 givenname: R. surname: de Mutsert fullname: de Mutsert, R. organization: Department of Clinical Epidemiology, LUMC, Leiden, the Netherlands – sequence: 4 givenname: A.W. surname: Visser fullname: Visser, A.W. organization: Department of Rheumatology, Leiden University Medical Centre (LUMC), Leiden, the Netherlands – sequence: 5 givenname: K.W. surname: van Dijk fullname: van Dijk, K.W. organization: Department of Internal Medicine, LUMC, Leiden, the Netherlands – sequence: 6 givenname: S. surname: le Cessie fullname: le Cessie, S. organization: Department of Clinical Epidemiology, LUMC, Leiden, the Netherlands – sequence: 7 givenname: F.R. surname: Rosendaal fullname: Rosendaal, F.R. organization: Department of Clinical Epidemiology, LUMC, Leiden, the Netherlands – sequence: 8 givenname: M. surname: Kloppenburg fullname: Kloppenburg, M. organization: Department of Rheumatology, Leiden University Medical Centre (LUMC), Leiden, the Netherlands |
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| Keywords | Obesity Adipokines Osteoarthritis Mediation analysis |
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| SubjectTerms | Adipokines Mediation analysis Obesity Osteoarthritis |
| Title | The role of leptin and adiponectin as mediators in the relationship between adiposity and hand and knee osteoarthritis |
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