RNA methylation and cancer treatment

• Published in: Pharmacological research Vol. 174; p. 105937
• Main Authors: Yang, Baochen, Wang, Jing-Quan, Tan, Yao, Yuan, Runzhu, Chen, Zhe-Sheng, Zou, Chang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2021
• Subjects: Animals; Cancer therapy; FTO inhibitor; Humans; m6A methylation; Methylation; Neoplasms - drug therapy; Neoplasms - genetics; RNA; RNA methylase inhibitor; RNA methylation; IGF2BP; 5-methylcytosine (PubChem CID: 65040); RNA methylase inhibitor; CDK; ncRNA; F11R; MA; FTO inhibitor; N7-methylguanosine (PubChem CID: 6474236); RBM; AML; m6A methylation; tRNA; hTRM9L; Meclofenamic acid (PubChem CID: 4037); Decitabine (PubChem CID: 451668); SAH; 5'UTR; NXF; SAM; FTO; YTHDC; MRPP; YTHDF; lncRNA; N3-methylcytosine (PubChem CID: 140523); Rhein (PubChem CID: 10168); mRNA; snRNA; RNA methylation; Azacytidine (PubChem CID: 9444); SRSF; miRNA; ELAVL; WTAP; rRNA; METTL; snoRNA; YBX; ALKBH; N1-methyladenosine (PubChem CID: 27476); Cancer therapy; ZC3H; tmRNA; HDGF; Chemical compounds studied in this article N6-methyl-adenosine (PubChem CID: 90474015); Rhubarb (PubChem CID: 11980951); Daunorubicin (PubChem CID: 30323); ABPP

To this date, over 100 different types of RNA modification have been identified. Methylation of different RNA species has emerged as a critical regulator of transcript expression. RNA methylation and its related downstream signaling pathways are involved in plethora biological processes, including c...