IL-17A–producing sinonasal MAIT cells in patients with chronic rhinosinusitis with nasal polyps

• Published in: Journal of allergy and clinical immunology Vol. 149; no. 2; pp. 599 - 609.e7
• Main Authors: Rha, Min-Seok, Yoon, Young Hoon, Koh, June-Young, Jung, Jae Hyung, Lee, Ha Seok, Park, Soo Kyoung, Park, Su-Hyung, Kim, Yong Min, Rha, Ki-Sang, Shin, Eui-Cheol
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2022
• Subjects: Adult; Chronic Disease; Chronic rhinosinusitis; Female; Humans; IL-17A; Interleukin-17 - biosynthesis; MAIT cells; Male; Middle Aged; mucosal-associated invariant T cells; Mucosal-Associated Invariant T Cells - immunology; nasal polyp; Nasal Polyps - immunology; Paranasal Sinuses - immunology; Rhinitis - immunology; Sinusitis - immunology; NP; TCR; Chronic rhinosinusitis; IL-17A; 5-OP-RU; CRS; PMA; MAIT cells; NSAID; CRSwNP; E-NP; nasal polyp; MR1; CRSsNP; ILC2; CT; PB; NE-NP; mucosal-associated invariant T cells; UP; MAIT

Diverse immune cells contribute to the pathogenesis of chronic rhinosinusitis (CRS), an inflammatory disease of the nasal cavity and paranasal sinuses. However, whether mucosal-associated invariant T (MAIT) cells are present in human sinonasal tissues remains unclear. Furthermore, the characteristic...