The LncRNA ZBED3-AS1 induces chondrogenesis of human synovial fluid mesenchymal stem cells

• Published in: Biochemical and biophysical research communications Vol. 487; no. 2; pp. 457 - 463
• Main Authors: Ou, Farong, Su, Kai, Sun, Jiadong, Liao, Wenting, Yao, Yu, Zheng, Youhua, Zhang, Zhiguang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.05.2017
• Subjects: Cell Differentiation - physiology; Cells, Cultured; Chondrocytes - cytology; Chondrocytes - metabolism; Chondrogenesis - physiology; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Human synovial fluid-derived mesenchymal stem cell; Humans; lncRNA; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Synovial Fluid - cytology; Synovial Fluid - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; ZBED3-AS1; Human synovial fluid-derived mesenchymal stem cell; ZBED3-AS1; lncRNA

Human synovial fluid-derived mesenchymal stem cells (SFMSCs) have great potential for cartilage induction and are promising for cell-based strategies for articular cartilage repair. Many long non-coding RNAs (lncRNAs) regulate chondrogenesis of MSCs. We hypothesized that the divergent lncRNA ZBED3-A...