Remote ischemic conditioning attenuates blood-brain barrier disruption after recombinant tissue plasminogen activator treatment via reducing PDGF-CC

• Published in: Pharmacological research Vol. 187; p. 106641
• Main Authors: He, Qianyan, Ma, Yinzhong, Fang, Cheng, Deng, Zijun, Wang, Fang, Qu, Yang, Yin, Meifang, Zhao, Ruoyu, Zhang, Dianhui, Guo, Fuyou, Yang, Yi, Chang, Junlei, Guo, Zhen-Ni
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2023
• Subjects: Acute ischemic stroke; Animals; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain Ischemia - metabolism; Cerebral Hemorrhage - drug therapy; Cerebral Hemorrhage - metabolism; Humans; Ischemic Stroke - metabolism; PDGF-CC; Platelet-Derived Growth Factor - metabolism; Receptor, Platelet-Derived Growth Factor alpha - metabolism; Receptor, Platelet-Derived Growth Factor alpha - therapeutic use; Remote ischemic conditioning; rtPA; Stroke - drug therapy; Stroke - metabolism; Thromboembolic stroke; Tissue Plasminogen Activator - metabolism; Tissue Plasminogen Activator - therapeutic use; RIPostC; Thromboembolic stroke; BBB; rtPA; Remote ischemic conditioning; RIPerC; HIF-1α; AIS; HT; RIC; RIPreC; GFAP; ZO-1; Blood-brain barrier; Acute ischemic stroke; PDGF; PDGF-CC

Treatment of acute ischemic stroke with the recombinant tissue plasminogen activator (rtPA) is associated with increased blood–brain barrier (BBB) disruption and hemorrhagic transformation. Remote ischemic conditioning (RIC) has demonstrated neuroprotective effects against acute ischemic stroke. How...