Molecular-Genetic PET Imaging Using an HSV1-tk Mutant Reporter Gene with Enhanced Specificity to Acycloguanosine Nucleoside Analogs - Najjar, Amer M; Nishii, Ryuichi; Maxwell, David S; Volgin, Andrei; Mukhopadhyay, Uday; Bornmann, William G; Tong, William; Alauddin, Mian; Gelovani, Juri G (Journal of Nuclear Medicine, 2009)
Keywords: Animals; Arabinofuranosyluracil - analogs & derivatives; Arabinofuranosyluracil - chemistry; Cell Line, Tumor; Enzymes; Feasibility Studies; Fluorine Radioisotopes; Fluorouracil - analogs & derivatives; Fluorouracil - chemistry; Genes, Reporter; Guanine - analogs & derivatives; Guanine - chemistry; Herpesvirus 1, Human - enzymology; Humans; Kinases; Mice; Mice, Nude; Models, Molecular; Mutation; Neoplasm Transplantation; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals - chemistry; Signal transduction; Stem cells; Structure-Activity Relationship; Thymidine Kinase - chemistry; Thymidine Kinase - genetics; Thymidine Kinase - metabolism; Transplantation, Heterologous; Tumors