Inter- and Intraspecies Metabolite Exchange Promotes Virulence of Antibiotic-Resistant Staphylococcus aureus

• Published in: Cell host & microbe Vol. 16; no. 4; pp. 531 - 537
• Main Authors: Hammer, Neal D., Cassat, James E., Noto, Michael J., Lojek, Lisa J., Chadha, Ashley D., Schmitz, Jonathan E., Creech, C. Buddy, Skaar, Eric P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.10.2014
• Subjects: Animals; Coinfection - microbiology; Coinfection - pathology; Disease Models, Animal; Drug Resistance, Bacterial; Humans; Mice, Inbred C57BL; Microbial Interactions; Mutation; Osteomyelitis - microbiology; Osteomyelitis - pathology; Staphylococcal Infections - microbiology; Staphylococcal Infections - pathology; Staphylococcus aureus - growth & development; Staphylococcus aureus - metabolism; Staphylococcus aureus - physiology; Virulence

Adaptations that enable antimicrobial resistance often pose a fitness cost to the microorganism. Resistant pathogens must therefore overcome such fitness decreases to persist within their hosts. Here we demonstrate that the reduced fitness associated with one resistance-conferring mutation can be of...