Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis

• Published in: Oncogene Vol. 39; no. 12; pp. 2509 - 2522
• Main Authors: Chan, Yung-Chieh, Chang, Yu-Chan, Chuang, Hsiang-Hao, Yang, Yi-Chieh, Lin, Yuan-Feng, Huang, Ming-Shyan, Hsiao, Michael, Yang, Chih-Jen, Hua, Kuo-Tai
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2020; Nature Publishing Group
• Subjects: 13/105; 38/61; 631/67/1612; 631/67/322; 64/60; Adenocarcinoma; Adenocarcinoma of Lung - enzymology; Adenocarcinoma of Lung - genetics; Adenocarcinoma of Lung - metabolism; Adenocarcinoma of Lung - pathology; Animals; Apoptosis; Cell Biology; Cohort Studies; Disease Progression; DNA microarrays; Gene expression; Gene Knockdown Techniques; Glutamine; Human Genetics; Humans; Immunohistochemistry; Interferon regulatory factor; Interferon regulatory factor 1; Interferon Regulatory Factor-1 - antagonists & inhibitors; Interferon Regulatory Factor-1 - metabolism; Interferon-gamma - antagonists & inhibitors; Interferon-gamma - metabolism; Internal Medicine; Lung cancer; Lung Neoplasms - enzymology; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Male; Medicine; Medicine & Public Health; Metastases; Metastasis; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Oncology; Phosphoserine; Phosphoserine aminotransferase; RNA, Messenger - metabolism; RNA, Neoplasm - metabolism; Serine; Signal Transduction; Therapeutic applications; Therapeutic targets; Tissue Array Analysis; Transaminases; Transcription; Up-Regulation; γ-Interferon

An increasing number of enzymes involved in serine biosynthesis have been identified and correlated with malignant evolution in various types of cancer. Here we showed that the overexpression of phosphoserine aminotransferase 1 (PSAT1) is widely found in lung cancer tissues compared with nontumor ti...