Single-domain antibody C7b for address delivery of nanoparticles to HER2-positive cancers

• Published in: Nanoscale Vol. 12; no. 42; pp. 21885 - 21894
• Main Authors: Vorotnikov, Yuri A, Novikova, Evgeniya D, Solovieva, Anastasiya O, Shanshin, Daniil V, Tsygankova, Alphiya R, Shcherbakov, Dmitrii N, Efremova, Olga A, Shestopalov, Michael A
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 05.11.2020
• Subjects: Allergic reactions; Breast Neoplasms - diagnosis; Breast Neoplasms - drug therapy; Cancer; Cell Line, Tumor; Diagnostic systems; Domains; Humans; Monoclonal antibodies; Nanoparticles; Phosphorescence; Production methods; Receptor, ErbB-2; Silicon dioxide; Single-Domain Antibodies; Targeted cancer therapy; Trastuzumab; Xenotransplantation

Monoclonal antibodies (mAb) demonstrate great potential as immunotherapy agents for the treatment of diseases such as cancer as well as tagging for the targeted delivery of multicomponent therapeutic or diagnostic systems. Nevertheless, the large physical size, poor stability of mAbs and abnormal al...