In vitro antimycobacterial activity and interaction profiles of diarylthiourea-copper (II) complexes with antitubercular drugs against Mycobacterium tuberculosis isolates

• Published in: Tuberculosis (Edinburgh, Scotland) Vol. 143; p. 102412
• Main Authors: Bielenica, Anna, Głogowska, Agnieszka, Augustynowicz- Kopeć, Ewa, Orzelska-Górka, Jolanta, Kurpios-Piec, Dagmara, Struga, Marta
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.12.2023
• Subjects: Antitubercular Agents - pharmacology; Copper; Drug-resistant; Ethambutol; Humans; Isoniazid - pharmacology; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Non-tuberculous mycobacteria; Synergism; Thiourea copper (II) complexes; Tuberculosis - microbiology; Tuberculosis, Multidrug-Resistant - microbiology; Two-drug combination; Non-tuberculous mycobacteria; Thiourea copper (II) complexes; Two-drug combination; Mycobacterium tuberculosis; Drug-resistant; Synergism

The activity of several halogenated copper (II) complexes of 4-chloro-3-nitrophenylthiourea derivatives has been tested against Mycobacterium tuberculosis strains and strains of non-tuberculous mycobacteria. The compounds were 2–16 times more potent than current TB-drugs against multidrug-resistant...