Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles

• Published in: Osteoarthritis and cartilage Vol. 27; no. 12; pp. 1768 - 1777
• Main Authors: Akhbari, P., Jaggard, M.K., Boulangé, C.L., Vaghela, U., Graça, G., Bhattacharya, R., Lindon, J.C., Williams, H.R.T., Gupte, C.M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2019
• Subjects: Metabolic profiling; Metabonomics; NMR; Osteoarthritis; Synovial fluid; Metabolic profiling; Synovial fluid; NMR; Osteoarthritis; Metabonomics

The hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected in the synovial fluid (SF) composition of the two joints, but the nature of these differences remains unknown. The objective was to identify difference...