Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles
The hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected in the synovial fluid (SF) composition of the two joints, but the nature of these differences remains unknown. The objective was to identify difference...
Saved in:
Published in | Osteoarthritis and cartilage Vol. 27; no. 12; pp. 1768 - 1777 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.12.2019
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected in the synovial fluid (SF) composition of the two joints, but the nature of these differences remains unknown. The objective was to identify differences in osteoarthritic hip and knee SF metabolites using metabolic profiling with Nuclear Magnetic Resonance (NMR) spectroscopy.
Twenty-four SF samples (12 hip, 12 knee) were collected from patients with end-stage osteoarthritis (ESOA) undergoing hip/knee arthroplasty. Samples were matched for age, gender, ethnicity and had similar medical comorbidities. NMR spectroscopy was used to analyse the metabolites present in each sample. Principal Component Analysis and Orthogonal Partial Least Squares Discriminant Analysis were undertaken to investigate metabolic differences between the groups. Metabolites were identified using 2D NMR spectra, statistical spectroscopy and by comparison to entries in published databases.
There were significant differences in the metabolic profile between the groups. Four metabolites were found in significantly greater quantities in the knee group compared to the hip group (N-acetylated molecules, glycosaminoglycans, citrate and glutamine).
This is the first study to indicate differences in the metabolic profile of hip and knee SF in ESOA. The identified metabolites can broadly be grouped into those involved in collagen degradation, the tricarboxylic acid cycle and oxidative metabolism in diseased joints. These findings may represent a combination of intra and extra-articular factors. |
---|---|
AbstractList | The hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected in the synovial fluid (SF) composition of the two joints, but the nature of these differences remains unknown. The objective was to identify differences in osteoarthritic hip and knee SF metabolites using metabolic profiling with Nuclear Magnetic Resonance (NMR) spectroscopy.
Twenty-four SF samples (12 hip, 12 knee) were collected from patients with end-stage osteoarthritis (ESOA) undergoing hip/knee arthroplasty. Samples were matched for age, gender, ethnicity and had similar medical comorbidities. NMR spectroscopy was used to analyse the metabolites present in each sample. Principal Component Analysis and Orthogonal Partial Least Squares Discriminant Analysis were undertaken to investigate metabolic differences between the groups. Metabolites were identified using 2D NMR spectra, statistical spectroscopy and by comparison to entries in published databases.
There were significant differences in the metabolic profile between the groups. Four metabolites were found in significantly greater quantities in the knee group compared to the hip group (N-acetylated molecules, glycosaminoglycans, citrate and glutamine).
This is the first study to indicate differences in the metabolic profile of hip and knee SF in ESOA. The identified metabolites can broadly be grouped into those involved in collagen degradation, the tricarboxylic acid cycle and oxidative metabolism in diseased joints. These findings may represent a combination of intra and extra-articular factors. OBJECTIVEThe hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected in the synovial fluid (SF) composition of the two joints, but the nature of these differences remains unknown. The objective was to identify differences in osteoarthritic hip and knee SF metabolites using metabolic profiling with Nuclear Magnetic Resonance (NMR) spectroscopy. DESIGNTwenty-four SF samples (12 hip, 12 knee) were collected from patients with end-stage osteoarthritis (ESOA) undergoing hip/knee arthroplasty. Samples were matched for age, gender, ethnicity and had similar medical comorbidities. NMR spectroscopy was used to analyse the metabolites present in each sample. Principal Component Analysis and Orthogonal Partial Least Squares Discriminant Analysis were undertaken to investigate metabolic differences between the groups. Metabolites were identified using 2D NMR spectra, statistical spectroscopy and by comparison to entries in published databases. RESULTSThere were significant differences in the metabolic profile between the groups. Four metabolites were found in significantly greater quantities in the knee group compared to the hip group (N-acetylated molecules, glycosaminoglycans, citrate and glutamine). CONCLUSIONSThis is the first study to indicate differences in the metabolic profile of hip and knee SF in ESOA. The identified metabolites can broadly be grouped into those involved in collagen degradation, the tricarboxylic acid cycle and oxidative metabolism in diseased joints. These findings may represent a combination of intra and extra-articular factors. |
Author | Gupte, C.M. Akhbari, P. Graça, G. Boulangé, C.L. Williams, H.R.T. Jaggard, M.K. Bhattacharya, R. Lindon, J.C. Vaghela, U. |
Author_xml | – sequence: 1 givenname: P. surname: Akhbari fullname: Akhbari, P. email: pakhbari@nhs.net organization: Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, London, United Kingdom – sequence: 2 givenname: M.K. surname: Jaggard fullname: Jaggard, M.K. email: m.jaggard@nhs.net organization: Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, London, United Kingdom – sequence: 3 givenname: C.L. surname: Boulangé fullname: Boulangé, C.L. email: c.boulange09@imperial.ac.uk organization: Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom – sequence: 4 givenname: U. surname: Vaghela fullname: Vaghela, U. email: uddhav.vaghela14@imperial.ac.uk organization: School of Medicine, Imperial College London, London, United Kingdom – sequence: 5 givenname: G. surname: Graça fullname: Graça, G. email: g.gomes-da-graca@imperial.ac.uk organization: Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom – sequence: 6 givenname: R. surname: Bhattacharya fullname: Bhattacharya, R. email: rajarshi.bhattacharya@imperial.ac.uk organization: Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, London, United Kingdom – sequence: 7 givenname: J.C. surname: Lindon fullname: Lindon, J.C. email: j.lindon@imperial.ac.uk organization: Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom – sequence: 8 givenname: H.R.T. surname: Williams fullname: Williams, H.R.T. email: h.williams@imperial.ac.uk organization: Department of Digestive Diseases, Imperial College Healthcare NHS Trust, London, United Kingdom – sequence: 9 givenname: C.M. surname: Gupte fullname: Gupte, C.M. email: c.gupte00@imperial.ac.uk organization: Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, London, United Kingdom |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31491490$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kcmKFTEUhoN0Yw_6Ai4ky3ZRZaaaxI20I_QAouuQSk68uVYlZZJquO_iw5riti6FA8niH5LzXaATHzwg9IKSmhLavt7X-6BVzQgdatLVhHZP0DltGKuGtuEn5U5aXommF2foIqU9IYRTSp6iM07FUIaco9_vnbUQwWtI2Hmcd4B1mJeQXHbB42Dxzi1YeYN_egCcDj48ODVhO63ObI6QMgQV8y4WR3qDFfarnkBFPKsfHrLTOEIKXpUKfHV3-_UVTgvoHEPSYTnglFdz2HpmyGoMU9EvMVg3QXqGTq2aEjx_PC_R948fvl1_rm7uP325fndTaUFIrtjYG66U6ttRD4IDVTCMAkTDteh6IUY9WsYN61szmLIZ3UAZ1lnBtRV65Jfo6phbin-tkLKcXdIwTcpDWJNkxToIwfqhSNlRqsv7UwQrl-hmFQ-SErlRkXu5UZEbFUk6WagU08vH_HWcwfyz_MVQBG-PAii_fHAQZdJuY2JcLKuSJrj_5f8BYjejxg |
CitedBy_id | crossref_primary_10_1093_bmb_ldaa037 crossref_primary_10_3390_metabo12100963 crossref_primary_10_1016_j_ocarto_2022_100295 crossref_primary_10_1007_s00402_024_05371_w crossref_primary_10_1016_j_biotri_2022_100227 crossref_primary_10_1302_2046_3758_101_BJR_2020_0285_R1 crossref_primary_10_1088_2057_1976_ad43ef crossref_primary_10_1016_j_arr_2020_101249 crossref_primary_10_1038_s41467_024_46663_4 crossref_primary_10_1016_j_ocarto_2022_100237 crossref_primary_10_1007_s00276_022_03068_6 crossref_primary_10_1016_j_ocarto_2021_100170 |
Cites_doi | 10.1136/ard.2009.120857 10.1002/jbm.b.33663 10.5435/JAAOS-21-01-63 10.3109/00365513.2014.992946 10.1136/bmjopen-2014-006286 10.3109/00365548.2015.1006674 10.1016/j.joca.2015.12.004 10.1016/j.jbspin.2016.05.018 10.12659/MSM.892160 10.2106/00004623-197961030-00017 10.1021/ac048630x 10.1155/2012/698709 10.1016/j.jbiomech.2005.06.026 10.1002/jor.1100170211 10.1016/j.mito.2004.07.022 10.1007/s11306-015-0937-x 10.1021/ac051632c 10.1093/nar/gks1065 10.1021/ac8011544 10.5936/csbj.201301009 10.1016/j.joca.2005.04.005 10.1111/j.2517-6161.1995.tb02031.x 10.2106/00004623-200509000-00003 10.2106/JBJS.H.01408 10.1038/nature06882 10.1096/fasebj.6.3.1740236 10.1021/acs.jproteome.6b00676 10.3415/VCOT-06-12-0101 10.1371/journal.pone.0175109 10.1002/art.39707 10.1002/jcp.10030 10.2106/JBJS.J.01413 10.2215/CJN.11971113 10.1155/2015/684794 10.1146/annurev.anchem.1.031207.113026 10.1186/1471-2164-7-142 10.1016/0304-4165(80)90463-8 10.1016/0079-6565(89)80008-1 10.1016/j.joca.2008.06.025 10.1093/nar/gkm957 10.1371/journal.pmed.1001606 10.1021/ac5025039 10.1093/bioinformatics/btt612 10.1016/j.joca.2015.09.003 10.1016/j.jmr.2015.07.014 |
ContentType | Journal Article |
Copyright | 2019 Osteoarthritis Research Society International Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
Copyright_xml | – notice: 2019 Osteoarthritis Research Society International – notice: Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
DBID | NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.joca.2019.07.017 |
DatabaseName | PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1522-9653 |
EndPage | 1777 |
ExternalDocumentID | 10_1016_j_joca_2019_07_017 31491490 S1063458419311756 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K --M .1- .FO .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAWTL AAXUO ABBQC ABFNM ABJNI ABLVK ABMAC ABMZM ABVKL ABXDB ABYKQ ACDAQ ACGFS ACRLP ADBBV ADEZE ADMUD AEBSH AEKER AENEX AEVXI AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG COF CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEE HMK HMO HVGLF HZ~ IHE IXB J1W KOM LCYCR M27 M31 M41 MO0 N9A NCXOZ O-L O9- OAUVE OI0 OK1 OV- OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SEL SES SEW SPCBC SSH SSZ T5K WUQ Z5R ~G- 0SF AAXKI ADVLN AFCTW AFJKZ AKRWK NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c400t-2b8d3aaa86bc943e1ae9b4e453c47844bcbf23d286d9d653c5ec5e27f43cf4cb3 |
IEDL.DBID | IXB |
ISSN | 1063-4584 |
IngestDate | Fri Aug 16 10:39:26 EDT 2024 Thu Sep 26 21:46:37 EDT 2024 Sat Sep 28 08:34:43 EDT 2024 Fri Feb 23 02:24:40 EST 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 12 |
Keywords | Metabolic profiling Synovial fluid NMR Osteoarthritis Metabonomics |
Language | English |
License | Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c400t-2b8d3aaa86bc943e1ae9b4e453c47844bcbf23d286d9d653c5ec5e27f43cf4cb3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | http://www.oarsijournal.com/article/S1063458419311756/pdf |
PMID | 31491490 |
PQID | 2286944289 |
PQPubID | 23479 |
PageCount | 10 |
ParticipantIDs | proquest_miscellaneous_2286944289 crossref_primary_10_1016_j_joca_2019_07_017 pubmed_primary_31491490 elsevier_sciencedirect_doi_10_1016_j_joca_2019_07_017 |
PublicationCentury | 2000 |
PublicationDate | December 2019 2019-12-00 20191201 |
PublicationDateYYYYMMDD | 2019-12-01 |
PublicationDate_xml | – month: 12 year: 2019 text: December 2019 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Osteoarthritis and cartilage |
PublicationTitleAlternate | Osteoarthritis Cartilage |
PublicationYear | 2019 |
Publisher | Elsevier Ltd |
Publisher_xml | – name: Elsevier Ltd |
References | Xu, Chen, Luo, Ding, Gao, Zhang (bib16) 2017; 16 Parvizi, Jacovides, Antoci, Ghanem (bib48) 2011; 93 Kim, Hwang, Kim, Ahn, Cha, Kim (bib15) 2017 October; 84 Zhai, Wang-Sattler, Hart, Arden, Hakim, Illig (bib12) 2010; 69 Thompson, Oegema (bib36) 1979; 61 Liu, Hou, Yin, Yin (bib42) 2015; 21 Ulrich, Akutsu, Doreleijers, Harano, Ioannidis, Lin (bib29) 2008; 36 Lamers, van Nesselrooij, Kraus, Jordan, Renner, Dragomir (bib11) 2005; 13 Chen, Gupte, Akhtar, Smith, Cobb (bib1) 2012; 2012 Hardingham, Fosang (bib35) 1992; 6 Lacitignola, Fanizzi, Francioso (bib22) 2008; 21 Snelling, Bas, Puskas, Dakin, Suva, Finckh (bib7) 2017; 12 Zhang, Li, Zhang, Yang, Chen (bib17) 2015; 2015 Posma, Robinette, Holmes, Nicholson (bib33) 2014; 30 Schiller, Naji, Huster, Kaufmann, Arnold (bib37) 2001; 13 Qiu, Cai, Zhou, Li, Zhao, Xie (bib13) 2014 Adams, Setton, Nettles (bib47) 2013; 21 Kresse, Schonherr (bib34) 2001; 189 Holmes, Loo, Stamler, Bictash, Yap, Chan (bib9) 2008; 453 Lindon JC, Nicholson JK. Spectroscopic and Statistical Techniques for Information Recovery in Metabonomics and Metabolomics, doi:10.1146/annurev.anchem.1.031207.113026. Annual Review of Analytical Chemistry 2008; 1: 45-69. Fischer, Kettunen, Wurtz, Haller, Havulinna, Kangas (bib8) 2014; 11 Wishart, Jewison, Guo, Wilson, Knox, Liu (bib28) 2013; 41 Lenski, Scherer (bib50) 2015; 47 Damyanovich, Staples, Chan, Marshall (bib21) 1999; 17 Di Cesare, Chang, Preston, Liu (bib49) 2005; 87 Olszewska-Slonina, Jung, Matewski, Olszewski, Krzyzynska-Malinowska, Braszkiewicz (bib6) 2015; 75 Zhang, Likhodii, Zhang, Aref-Eshghi, Harper, Randell (bib18) 2014; 4 Veselkov, Lindon, Ebbels, Crockford, Volynkin, Holmes (bib25) 2009; 81 Krasnokutsky, Attur, Palmer, Samuels, Abramson (bib2) 2008; 16 Dona, Jiménez, Schäfer, Humpfer, Spraul, Lewis (bib24) 2014; 86 Cloarec, Dumas, Craig, Barton, Trygg, Hudson (bib30) 2005; 77 Yoshida, Faust, Wilckens, Kitagawa, Fetto, Chao (bib3) 2006; 39 Dieterle, Ross, Schlotterbeck, Senn (bib26) 2006; 78 de Sousa, Dos Santos Junior, Aguiar, da Costa Sartore, de Oliveira, Almeida (bib41) 2019; 2019 Nicholson, Wilson (bib45) 1989; 21 Catterall, Zura, Bolognesi, Kraus (bib43) 2016; 24 Berg, Stryer (bib38) 2002 Yu, Zheng, Nettleton, Alexander, Coresh, Boerwinkle (bib10) 2014; 9 van den Berg, Hoefsloot, Westerhuis, Smilde, van der Werf (bib27) 2006; 7 Blanco, Lopez-Armada, Maneiro (bib40) 2004; 4 Andriacchi, Koo, Scanlan (bib4) 2009; 91 Nagana Gowda, Raftery (bib46) 2015; 260 Benjamini, Hochberg (bib32) 1995; 57 Hoppenfeld, De Boer, Buckley (bib23) 2009 Handley, Speight, Leyden, Lowther (bib39) 1980; 627 Galandakova, Ulrichova, Langova, Hanakova, Vrbka, Hartl (bib5) 2017; 105 Zhang, Sun, Likhodii, Liu, Aref-Eshghi, Harper (bib19) 2016; 24 Reyes, Leyland, Peat, Cooper, Arden, Prieto-Alhambra (bib44) 2016; 68 Zhang, Sun, Likhodii, Aref-Eshghi, Harper, Randell (bib14) 2016; 12 Bartel, Krumsiek, Theis (bib31) 2013; 4 de Sousa (10.1016/j.joca.2019.07.017_bib41) 2019; 2019 Nagana Gowda (10.1016/j.joca.2019.07.017_bib46) 2015; 260 Snelling (10.1016/j.joca.2019.07.017_bib7) 2017; 12 Yu (10.1016/j.joca.2019.07.017_bib10) 2014; 9 Krasnokutsky (10.1016/j.joca.2019.07.017_bib2) 2008; 16 Galandakova (10.1016/j.joca.2019.07.017_bib5) 2017; 105 Parvizi (10.1016/j.joca.2019.07.017_bib48) 2011; 93 Blanco (10.1016/j.joca.2019.07.017_bib40) 2004; 4 van den Berg (10.1016/j.joca.2019.07.017_bib27) 2006; 7 Damyanovich (10.1016/j.joca.2019.07.017_bib21) 1999; 17 Adams (10.1016/j.joca.2019.07.017_bib47) 2013; 21 Schiller (10.1016/j.joca.2019.07.017_bib37) 2001; 13 Handley (10.1016/j.joca.2019.07.017_bib39) 1980; 627 Zhang (10.1016/j.joca.2019.07.017_bib17) 2015; 2015 Benjamini (10.1016/j.joca.2019.07.017_bib32) 1995; 57 Cloarec (10.1016/j.joca.2019.07.017_bib30) 2005; 77 Hoppenfeld (10.1016/j.joca.2019.07.017_bib23) 2009 Ulrich (10.1016/j.joca.2019.07.017_bib29) 2008; 36 Reyes (10.1016/j.joca.2019.07.017_bib44) 2016; 68 Catterall (10.1016/j.joca.2019.07.017_bib43) 2016; 24 Liu (10.1016/j.joca.2019.07.017_bib42) 2015; 21 Dona (10.1016/j.joca.2019.07.017_bib24) 2014; 86 Nicholson (10.1016/j.joca.2019.07.017_bib45) 1989; 21 Zhang (10.1016/j.joca.2019.07.017_bib19) 2016; 24 Zhang (10.1016/j.joca.2019.07.017_bib18) 2014; 4 Lenski (10.1016/j.joca.2019.07.017_bib50) 2015; 47 Thompson (10.1016/j.joca.2019.07.017_bib36) 1979; 61 Berg (10.1016/j.joca.2019.07.017_bib38) 2002 Dieterle (10.1016/j.joca.2019.07.017_bib26) 2006; 78 Di Cesare (10.1016/j.joca.2019.07.017_bib49) 2005; 87 Zhang (10.1016/j.joca.2019.07.017_bib14) 2016; 12 Chen (10.1016/j.joca.2019.07.017_bib1) 2012; 2012 Veselkov (10.1016/j.joca.2019.07.017_bib25) 2009; 81 Holmes (10.1016/j.joca.2019.07.017_bib9) 2008; 453 Xu (10.1016/j.joca.2019.07.017_bib16) 2017; 16 Zhai (10.1016/j.joca.2019.07.017_bib12) 2010; 69 Kresse (10.1016/j.joca.2019.07.017_bib34) 2001; 189 Lamers (10.1016/j.joca.2019.07.017_bib11) 2005; 13 Bartel (10.1016/j.joca.2019.07.017_bib31) 2013; 4 Hardingham (10.1016/j.joca.2019.07.017_bib35) 1992; 6 Kim (10.1016/j.joca.2019.07.017_bib15) 2017; 84 Andriacchi (10.1016/j.joca.2019.07.017_bib4) 2009; 91 10.1016/j.joca.2019.07.017_bib20 Qiu (10.1016/j.joca.2019.07.017_bib13) 2014 Lacitignola (10.1016/j.joca.2019.07.017_bib22) 2008; 21 Fischer (10.1016/j.joca.2019.07.017_bib8) 2014; 11 Yoshida (10.1016/j.joca.2019.07.017_bib3) 2006; 39 Wishart (10.1016/j.joca.2019.07.017_bib28) 2013; 41 Posma (10.1016/j.joca.2019.07.017_bib33) 2014; 30 Olszewska-Slonina (10.1016/j.joca.2019.07.017_bib6) 2015; 75 |
References_xml | – volume: 68 start-page: 1869 year: 2016 end-page: 1875 ident: bib44 article-title: Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort study publication-title: Arthritis & rheumatology (Hoboken, N.J.) contributor: fullname: Prieto-Alhambra – volume: 12 year: 2017 ident: bib7 article-title: Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype publication-title: PLoS One contributor: fullname: Finckh – year: 2002 ident: bib38 article-title: Amino acids are made from intermediates of the citric acid cycle and other major pathways publication-title: Biochemistry contributor: fullname: Stryer – volume: 6 start-page: 861 year: 1992 end-page: 870 ident: bib35 article-title: Proteoglycans: many forms and many functions publication-title: FASEB J contributor: fullname: Fosang – volume: 30 start-page: 893 year: 2014 end-page: 895 ident: bib33 article-title: MetaboNetworks, an interactive Matlab-based toolbox for creating, customizing and exploring sub-networks from KEGG publication-title: Bioinformatics contributor: fullname: Nicholson – volume: 78 start-page: 4281 year: 2006 end-page: 4290 ident: bib26 article-title: Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics publication-title: Anal Chem contributor: fullname: Senn – volume: 84 start-page: 605 year: 2017 October end-page: 610 ident: bib15 article-title: Metabolite profiles of synovial fluid change with the radiographic severity of knee osteoarthritis publication-title: Jt Bone Spine contributor: fullname: Kim – volume: 21 start-page: 63 year: 2013 end-page: 64 ident: bib47 article-title: The role of metabolomics in osteoarthritis research publication-title: J Am Acad Orthop Surg contributor: fullname: Nettles – volume: 4 year: 2013 ident: bib31 article-title: Statistical methods for the analysis of high-throughput metabolomics data publication-title: Comput Struct Biotechnol J contributor: fullname: Theis – volume: 36 start-page: D402 year: 2008 end-page: D408 ident: bib29 publication-title: BioMagResBank. Nucleic Acids Res contributor: fullname: Lin – volume: 105 start-page: 1422 year: 2017 end-page: 1431 ident: bib5 article-title: Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments publication-title: J Biomed Mater Res B Appl Biomater contributor: fullname: Hartl – volume: 24 start-page: 827 year: 2016 end-page: 834 ident: bib19 article-title: Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients publication-title: Osteoarthr Cartil contributor: fullname: Harper – volume: 86 start-page: 9887 year: 2014 end-page: 9894 ident: bib24 article-title: Precision high-throughput proton NMR spectroscopy of human urine, serum, and plasma for large-scale metabolic phenotyping publication-title: Anal Chem contributor: fullname: Lewis – volume: 7 start-page: 142 year: 2006 ident: bib27 article-title: Centering, scaling, and transformations: improving the biological information content of metabolomics data publication-title: BMC Genomics contributor: fullname: van der Werf – volume: 2012 start-page: 698709 year: 2012 ident: bib1 article-title: The global economic cost of osteoarthritis: how the UK compares publication-title: Arthritis contributor: fullname: Cobb – volume: 11 year: 2014 ident: bib8 article-title: Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons publication-title: PLoS Med contributor: fullname: Kangas – volume: 91 start-page: 95 year: 2009 end-page: 101 ident: bib4 article-title: Gait mechanics influence healthy cartilage morphology and osteoarthritis of the knee publication-title: J Bone Joint Surg Am contributor: fullname: Scanlan – volume: 189 start-page: 266 year: 2001 end-page: 274 ident: bib34 article-title: Proteoglycans of the extracellular matrix and growth control publication-title: J Cell Physiol contributor: fullname: Schonherr – volume: 260 start-page: 144 year: 2015 end-page: 160 ident: bib46 article-title: Can NMR solve some significant challenges in metabolomics? publication-title: J Magn Reson contributor: fullname: Raftery – volume: 2019 start-page: 8169172 year: 2019 ident: bib41 article-title: Osteoarthritic synovial fluid modulates cell phenotype and metabolic behavior in vitro publication-title: Stem Cell Int contributor: fullname: Almeida – volume: 47 start-page: 399 year: 2015 end-page: 409 ident: bib50 article-title: Diagnostic potential of inflammatory markers in septic arthritis and periprosthetic joint infections: a clinical study with 719 patients publication-title: Infectious Diseases contributor: fullname: Scherer – volume: 453 start-page: 396 year: 2008 end-page: 400 ident: bib9 article-title: Human metabolic phenotype diversity and its association with diet and blood pressure publication-title: Nature contributor: fullname: Chan – volume: 24 start-page: 374 year: 2016 end-page: 381 ident: bib43 article-title: Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage publication-title: Osteoarthr Cartil contributor: fullname: Kraus – volume: 61 start-page: 407 year: 1979 end-page: 416 ident: bib36 article-title: Metabolic activity of articular cartilage in osteoarthritis. An in vitro study publication-title: Journal of Bone and Joint Surgery - Series A contributor: fullname: Oegema – volume: 16 start-page: S1 year: 2008 end-page: S3 ident: bib2 article-title: Current concepts in the pathogenesis of osteoarthritis publication-title: Osteoarthr Cartil contributor: fullname: Abramson – volume: 12 start-page: 24 year: 2016 ident: bib14 article-title: Metabolomic analysis of human synovial fluid and plasma reveals that phosphatidylcholine metabolism is associated with both osteoarthritis and diabetes mellitus publication-title: Metabolomics contributor: fullname: Randell – volume: 21 start-page: 85 year: 2008 end-page: 88 ident: bib22 article-title: 1H NMR investigation of normal and osteoarthritic synovial fluid in the horse publication-title: Vet Comp Orthop Traumatol contributor: fullname: Francioso – volume: 2015 start-page: 684794 year: 2015 ident: bib17 article-title: Serum metabolites as potential biomarkers for diagnosis of knee osteoarthritis publication-title: Dis Markers contributor: fullname: Chen – volume: 77 start-page: 1282 year: 2005 end-page: 1289 ident: bib30 article-title: Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets publication-title: Anal Chem contributor: fullname: Hudson – volume: 13 start-page: 762 year: 2005 end-page: 768 ident: bib11 article-title: Identification of an urinary metabolite profile associated with osteoarthritis publication-title: Osteoarthritis Cartilage contributor: fullname: Dragomir – volume: 41 start-page: D801 year: 2013 end-page: D807 ident: bib28 article-title: HMDB 3.0—the human Metabolome database in 2013 publication-title: Nucleic Acids Res contributor: fullname: Liu – volume: 81 start-page: 56 year: 2009 end-page: 66 ident: bib25 article-title: Recursive segment-wise peak alignment of biological (1)h NMR spectra for improved metabolic biomarker recovery publication-title: Anal Chem contributor: fullname: Holmes – volume: 75 start-page: 145 year: 2015 end-page: 151 ident: bib6 article-title: Lysosomal enzymes in serum and synovial fluid in patients with osteoarthritis publication-title: Scand J Clin Lab Investig contributor: fullname: Braszkiewicz – volume: 17 start-page: 223 year: 1999 end-page: 231 ident: bib21 article-title: Comparative study of normal and osteoarthritic canine synovial fluid using 500 MHz publication-title: J Orthpaedic Res contributor: fullname: Marshall – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib32 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J R Stat Soc Ser B contributor: fullname: Hochberg – volume: 9 start-page: 1410 year: 2014 end-page: 1417 ident: bib10 article-title: Serum metabolomic profiling and incident CKD among African Americans publication-title: Clin J Am Soc Nephrol contributor: fullname: Boerwinkle – volume: 21 start-page: 449 year: 1989 end-page: 501 ident: bib45 article-title: High resolution proton magnetic resonance spectroscopy of biological fluids publication-title: Prog Nucl Magn Reson Spectrosc contributor: fullname: Wilson – year: 2014 ident: bib13 article-title: A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential contributor: fullname: Xie – volume: 4 start-page: 715 year: 2004 end-page: 728 ident: bib40 article-title: Mitochondrial dysfunction in osteoarthritis publication-title: Mitochondrion contributor: fullname: Maneiro – volume: 93 start-page: 2242 year: 2011 end-page: 2248 ident: bib48 article-title: Diagnosis of periprosthetic joint infection: the utility of a simple yet unappreciated enzyme publication-title: J Bone Jt. Surg contributor: fullname: Ghanem – volume: 39 start-page: 1996 year: 2006 end-page: 2004 ident: bib3 article-title: Three-dimensional dynamic hip contact area and pressure distribution during activities of daily living publication-title: J Biomech contributor: fullname: Chao – volume: 13 start-page: 19 year: 2001 end-page: 27 ident: bib37 article-title: 1H and 13C HR-MAS NMR investigations on native and enzymatically digested bovine nasal cartilage publication-title: Magma contributor: fullname: Arnold – volume: 21 start-page: 363 year: 2015 end-page: 370 ident: bib42 article-title: Correlation of bone morphogenetic protein-2 levels in serum and synovial fluid with disease severity of knee osteoarthritis publication-title: Med Sci Monit : international medical journal of experimental and clinical research contributor: fullname: Yin – volume: 16 start-page: 1425 year: 2017 end-page: 1435 ident: bib16 article-title: Cartilaginous metabolomic study reveals potential mechanisms of osteophyte formation in osteoarthritis publication-title: J Proteome Res contributor: fullname: Zhang – volume: 627 start-page: 324 year: 1980 end-page: 331 ident: bib39 article-title: Extracellular matrix metabolism by chondrocytes 7. Evidence that L-glutamine is an essential amino acid for chondrocytes and other connective tissue cells publication-title: Biochim Biophys Acta Gen Subj contributor: fullname: Lowther – volume: 87 start-page: 1921 year: 2005 end-page: 1927 ident: bib49 article-title: Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty publication-title: J Bone Joint Surg Am contributor: fullname: Liu – volume: 4 year: 2014 ident: bib18 article-title: Classification of osteoarthritis phenotypes by metabolomics analysis publication-title: BMJ Open contributor: fullname: Randell – year: 2009 ident: bib23 article-title: Surgical Exposures in Orthopaedics : The Anatomic Approach contributor: fullname: Buckley – volume: 69 start-page: 1227 year: 2010 end-page: 1231 ident: bib12 article-title: Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis publication-title: Ann Rheum Dis contributor: fullname: Illig – volume: 69 start-page: 1227 year: 2010 ident: 10.1016/j.joca.2019.07.017_bib12 article-title: Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis publication-title: Ann Rheum Dis doi: 10.1136/ard.2009.120857 contributor: fullname: Zhai – volume: 105 start-page: 1422 year: 2017 ident: 10.1016/j.joca.2019.07.017_bib5 article-title: Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments publication-title: J Biomed Mater Res B Appl Biomater doi: 10.1002/jbm.b.33663 contributor: fullname: Galandakova – volume: 21 start-page: 63 year: 2013 ident: 10.1016/j.joca.2019.07.017_bib47 article-title: The role of metabolomics in osteoarthritis research publication-title: J Am Acad Orthop Surg doi: 10.5435/JAAOS-21-01-63 contributor: fullname: Adams – volume: 75 start-page: 145 year: 2015 ident: 10.1016/j.joca.2019.07.017_bib6 article-title: Lysosomal enzymes in serum and synovial fluid in patients with osteoarthritis publication-title: Scand J Clin Lab Investig doi: 10.3109/00365513.2014.992946 contributor: fullname: Olszewska-Slonina – volume: 4 year: 2014 ident: 10.1016/j.joca.2019.07.017_bib18 article-title: Classification of osteoarthritis phenotypes by metabolomics analysis publication-title: BMJ Open doi: 10.1136/bmjopen-2014-006286 contributor: fullname: Zhang – volume: 47 start-page: 399 year: 2015 ident: 10.1016/j.joca.2019.07.017_bib50 article-title: Diagnostic potential of inflammatory markers in septic arthritis and periprosthetic joint infections: a clinical study with 719 patients publication-title: Infectious Diseases doi: 10.3109/00365548.2015.1006674 contributor: fullname: Lenski – volume: 24 start-page: 827 year: 2016 ident: 10.1016/j.joca.2019.07.017_bib19 article-title: Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2015.12.004 contributor: fullname: Zhang – volume: 84 start-page: 605 year: 2017 ident: 10.1016/j.joca.2019.07.017_bib15 article-title: Metabolite profiles of synovial fluid change with the radiographic severity of knee osteoarthritis publication-title: Jt Bone Spine doi: 10.1016/j.jbspin.2016.05.018 contributor: fullname: Kim – volume: 21 start-page: 363 year: 2015 ident: 10.1016/j.joca.2019.07.017_bib42 article-title: Correlation of bone morphogenetic protein-2 levels in serum and synovial fluid with disease severity of knee osteoarthritis publication-title: Med Sci Monit : international medical journal of experimental and clinical research doi: 10.12659/MSM.892160 contributor: fullname: Liu – volume: 61 start-page: 407 year: 1979 ident: 10.1016/j.joca.2019.07.017_bib36 article-title: Metabolic activity of articular cartilage in osteoarthritis. An in vitro study publication-title: Journal of Bone and Joint Surgery - Series A doi: 10.2106/00004623-197961030-00017 contributor: fullname: Thompson – volume: 77 start-page: 1282 year: 2005 ident: 10.1016/j.joca.2019.07.017_bib30 article-title: Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets publication-title: Anal Chem doi: 10.1021/ac048630x contributor: fullname: Cloarec – volume: 2012 start-page: 698709 year: 2012 ident: 10.1016/j.joca.2019.07.017_bib1 article-title: The global economic cost of osteoarthritis: how the UK compares publication-title: Arthritis doi: 10.1155/2012/698709 contributor: fullname: Chen – volume: 39 start-page: 1996 year: 2006 ident: 10.1016/j.joca.2019.07.017_bib3 article-title: Three-dimensional dynamic hip contact area and pressure distribution during activities of daily living publication-title: J Biomech doi: 10.1016/j.jbiomech.2005.06.026 contributor: fullname: Yoshida – volume: 17 start-page: 223 year: 1999 ident: 10.1016/j.joca.2019.07.017_bib21 article-title: Comparative study of normal and osteoarthritic canine synovial fluid using 500 MHz 1H magnetic resonance spectroscopy publication-title: J Orthpaedic Res doi: 10.1002/jor.1100170211 contributor: fullname: Damyanovich – volume: 4 start-page: 715 year: 2004 ident: 10.1016/j.joca.2019.07.017_bib40 article-title: Mitochondrial dysfunction in osteoarthritis publication-title: Mitochondrion doi: 10.1016/j.mito.2004.07.022 contributor: fullname: Blanco – volume: 12 start-page: 24 year: 2016 ident: 10.1016/j.joca.2019.07.017_bib14 article-title: Metabolomic analysis of human synovial fluid and plasma reveals that phosphatidylcholine metabolism is associated with both osteoarthritis and diabetes mellitus publication-title: Metabolomics doi: 10.1007/s11306-015-0937-x contributor: fullname: Zhang – volume: 78 start-page: 4281 year: 2006 ident: 10.1016/j.joca.2019.07.017_bib26 article-title: Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics publication-title: Anal Chem doi: 10.1021/ac051632c contributor: fullname: Dieterle – volume: 41 start-page: D801 year: 2013 ident: 10.1016/j.joca.2019.07.017_bib28 article-title: HMDB 3.0—the human Metabolome database in 2013 publication-title: Nucleic Acids Res doi: 10.1093/nar/gks1065 contributor: fullname: Wishart – volume: 81 start-page: 56 year: 2009 ident: 10.1016/j.joca.2019.07.017_bib25 article-title: Recursive segment-wise peak alignment of biological (1)h NMR spectra for improved metabolic biomarker recovery publication-title: Anal Chem doi: 10.1021/ac8011544 contributor: fullname: Veselkov – volume: 4 year: 2013 ident: 10.1016/j.joca.2019.07.017_bib31 article-title: Statistical methods for the analysis of high-throughput metabolomics data publication-title: Comput Struct Biotechnol J doi: 10.5936/csbj.201301009 contributor: fullname: Bartel – volume: 13 start-page: 762 year: 2005 ident: 10.1016/j.joca.2019.07.017_bib11 article-title: Identification of an urinary metabolite profile associated with osteoarthritis publication-title: Osteoarthritis Cartilage doi: 10.1016/j.joca.2005.04.005 contributor: fullname: Lamers – volume: 57 start-page: 289 year: 1995 ident: 10.1016/j.joca.2019.07.017_bib32 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J R Stat Soc Ser B doi: 10.1111/j.2517-6161.1995.tb02031.x contributor: fullname: Benjamini – volume: 87 start-page: 1921 year: 2005 ident: 10.1016/j.joca.2019.07.017_bib49 article-title: Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty publication-title: J Bone Joint Surg Am doi: 10.2106/00004623-200509000-00003 contributor: fullname: Di Cesare – volume: 91 start-page: 95 issue: Suppl 1 year: 2009 ident: 10.1016/j.joca.2019.07.017_bib4 article-title: Gait mechanics influence healthy cartilage morphology and osteoarthritis of the knee publication-title: J Bone Joint Surg Am doi: 10.2106/JBJS.H.01408 contributor: fullname: Andriacchi – volume: 453 start-page: 396 year: 2008 ident: 10.1016/j.joca.2019.07.017_bib9 article-title: Human metabolic phenotype diversity and its association with diet and blood pressure publication-title: Nature doi: 10.1038/nature06882 contributor: fullname: Holmes – volume: 6 start-page: 861 year: 1992 ident: 10.1016/j.joca.2019.07.017_bib35 article-title: Proteoglycans: many forms and many functions publication-title: FASEB J doi: 10.1096/fasebj.6.3.1740236 contributor: fullname: Hardingham – volume: 16 start-page: 1425 year: 2017 ident: 10.1016/j.joca.2019.07.017_bib16 article-title: Cartilaginous metabolomic study reveals potential mechanisms of osteophyte formation in osteoarthritis publication-title: J Proteome Res doi: 10.1021/acs.jproteome.6b00676 contributor: fullname: Xu – volume: 13 start-page: 19 year: 2001 ident: 10.1016/j.joca.2019.07.017_bib37 article-title: 1H and 13C HR-MAS NMR investigations on native and enzymatically digested bovine nasal cartilage publication-title: Magma contributor: fullname: Schiller – volume: 21 start-page: 85 year: 2008 ident: 10.1016/j.joca.2019.07.017_bib22 article-title: 1H NMR investigation of normal and osteoarthritic synovial fluid in the horse publication-title: Vet Comp Orthop Traumatol doi: 10.3415/VCOT-06-12-0101 contributor: fullname: Lacitignola – year: 2009 ident: 10.1016/j.joca.2019.07.017_bib23 contributor: fullname: Hoppenfeld – volume: 12 year: 2017 ident: 10.1016/j.joca.2019.07.017_bib7 article-title: Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype publication-title: PLoS One doi: 10.1371/journal.pone.0175109 contributor: fullname: Snelling – volume: 68 start-page: 1869 year: 2016 ident: 10.1016/j.joca.2019.07.017_bib44 article-title: Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort study publication-title: Arthritis & rheumatology (Hoboken, N.J.) doi: 10.1002/art.39707 contributor: fullname: Reyes – volume: 189 start-page: 266 year: 2001 ident: 10.1016/j.joca.2019.07.017_bib34 article-title: Proteoglycans of the extracellular matrix and growth control publication-title: J Cell Physiol doi: 10.1002/jcp.10030 contributor: fullname: Kresse – volume: 93 start-page: 2242 year: 2011 ident: 10.1016/j.joca.2019.07.017_bib48 article-title: Diagnosis of periprosthetic joint infection: the utility of a simple yet unappreciated enzyme publication-title: J Bone Jt. Surg doi: 10.2106/JBJS.J.01413 contributor: fullname: Parvizi – year: 2014 ident: 10.1016/j.joca.2019.07.017_bib13 contributor: fullname: Qiu – volume: 9 start-page: 1410 year: 2014 ident: 10.1016/j.joca.2019.07.017_bib10 article-title: Serum metabolomic profiling and incident CKD among African Americans publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.11971113 contributor: fullname: Yu – volume: 2015 start-page: 684794 year: 2015 ident: 10.1016/j.joca.2019.07.017_bib17 article-title: Serum metabolites as potential biomarkers for diagnosis of knee osteoarthritis publication-title: Dis Markers doi: 10.1155/2015/684794 contributor: fullname: Zhang – ident: 10.1016/j.joca.2019.07.017_bib20 doi: 10.1146/annurev.anchem.1.031207.113026 – volume: 7 start-page: 142 year: 2006 ident: 10.1016/j.joca.2019.07.017_bib27 article-title: Centering, scaling, and transformations: improving the biological information content of metabolomics data publication-title: BMC Genomics doi: 10.1186/1471-2164-7-142 contributor: fullname: van den Berg – year: 2002 ident: 10.1016/j.joca.2019.07.017_bib38 article-title: Amino acids are made from intermediates of the citric acid cycle and other major pathways contributor: fullname: Berg – volume: 627 start-page: 324 year: 1980 ident: 10.1016/j.joca.2019.07.017_bib39 article-title: Extracellular matrix metabolism by chondrocytes 7. Evidence that L-glutamine is an essential amino acid for chondrocytes and other connective tissue cells publication-title: Biochim Biophys Acta Gen Subj doi: 10.1016/0304-4165(80)90463-8 contributor: fullname: Handley – volume: 21 start-page: 449 year: 1989 ident: 10.1016/j.joca.2019.07.017_bib45 article-title: High resolution proton magnetic resonance spectroscopy of biological fluids publication-title: Prog Nucl Magn Reson Spectrosc doi: 10.1016/0079-6565(89)80008-1 contributor: fullname: Nicholson – volume: 2019 start-page: 8169172 year: 2019 ident: 10.1016/j.joca.2019.07.017_bib41 article-title: Osteoarthritic synovial fluid modulates cell phenotype and metabolic behavior in vitro publication-title: Stem Cell Int contributor: fullname: de Sousa – volume: 16 start-page: S1 issue: Suppl 3 year: 2008 ident: 10.1016/j.joca.2019.07.017_bib2 article-title: Current concepts in the pathogenesis of osteoarthritis publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2008.06.025 contributor: fullname: Krasnokutsky – volume: 36 start-page: D402 year: 2008 ident: 10.1016/j.joca.2019.07.017_bib29 publication-title: BioMagResBank. Nucleic Acids Res doi: 10.1093/nar/gkm957 contributor: fullname: Ulrich – volume: 11 year: 2014 ident: 10.1016/j.joca.2019.07.017_bib8 article-title: Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons publication-title: PLoS Med doi: 10.1371/journal.pmed.1001606 contributor: fullname: Fischer – volume: 86 start-page: 9887 year: 2014 ident: 10.1016/j.joca.2019.07.017_bib24 article-title: Precision high-throughput proton NMR spectroscopy of human urine, serum, and plasma for large-scale metabolic phenotyping publication-title: Anal Chem doi: 10.1021/ac5025039 contributor: fullname: Dona – volume: 30 start-page: 893 year: 2014 ident: 10.1016/j.joca.2019.07.017_bib33 article-title: MetaboNetworks, an interactive Matlab-based toolbox for creating, customizing and exploring sub-networks from KEGG publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt612 contributor: fullname: Posma – volume: 24 start-page: 374 year: 2016 ident: 10.1016/j.joca.2019.07.017_bib43 article-title: Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2015.09.003 contributor: fullname: Catterall – volume: 260 start-page: 144 year: 2015 ident: 10.1016/j.joca.2019.07.017_bib46 article-title: Can NMR solve some significant challenges in metabolomics? publication-title: J Magn Reson doi: 10.1016/j.jmr.2015.07.014 contributor: fullname: Nagana Gowda |
SSID | ssj0003110 |
Score | 2.4001472 |
Snippet | The hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected in the... OBJECTIVEThe hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1768 |
SubjectTerms | Metabolic profiling Metabonomics NMR Osteoarthritis Synovial fluid |
Title | Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles |
URI | https://dx.doi.org/10.1016/j.joca.2019.07.017 https://www.ncbi.nlm.nih.gov/pubmed/31491490 https://search.proquest.com/docview/2286944289 |
Volume | 27 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKkRAXxJvlsTISBxAK28SOnXBrC9VC2T0ARXuzbGdCU1pn1d1F6oVfwo9lJnEqIQEHJEtRHFt2PGPPjDzzDWPPcq9VXSubpBbVNymdTJz1kPha5rkWlc41BSfP5mp6JN8v8sUW2x9iYcitMp79_ZnendaxZhJXc7JsmsknNGYE3fKhCkJ4kwS7TdieFMS32Ls8jfFbj0igREKtY-BM7-N1gvKC3LvKDsCzS1r2R-H0N-WzE0IHN9mNqD3y3X6Ct9gWhNvs2izej99hP9_EfCe4-3kTOGp3nJzGo2cWb2t-3Cy5DRX_FgD46iK035EDeX26aSrqQTEfLS7AcQd29JpbHgjx2J7zM_s1UMQjRwO9JZgO4M_ns48veBesSaCY7fKCd3C1NM4ZrJG_TrF9TAu-usuODt5-3p8mMf9C4nFnr5PMFZWw1hbK-VIKSC2UToLMhZe6QLp6V2eiygpVlZXC2hywZLqWAkntnbjHtkMb4AHjuqpBuTR1ugAJVVFIr5R2ZSoAtIVsxF4OC2-WPcyGGfzPTgyRyRCZzI42SKYRywfamN-YxaAc-Ge_pwMhDe4iuhqxAdrNymT4E6VEU6wcsfs9hS_nIdCIxLLz8D9HfcSu01vvA_OYba_PN_AENZm1G7Mrr36kY3Z1d-_L4Qd6vjuczscdA_8CySD4zw |
link.rule.ids | 315,786,790,3525,4521,24144,27602,27957,27958,45620,45698,45714,45909 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKkYAL4s2Wl5E4gFC0m9ixE25QqLbQ3QO00t4sO57Q9OGsurtI_S_8WGYSpxIScEDyybFlxzOehzzzDWOv8kqrulY2SS2ab1I6mThbQVLVMs-18DrXlJw8m6vpkfy8yBdbbHfIhaGwyij7e5neSevYM46nOV42zfgbOjOCXvnQBCG8SXWNXZd5OSHW3l98uBLH-LGHJFAioeExc6YP8jpBhUHxXWWH4NlVLfujdvqb9dlpob077HY0H_n7fod32RaEe-zGLD6Q32c_P8aCJ3j9eRM4mnecosZjaBZva37cLLkNnp8GAL66DO0PZEFen20aTzMo6aPFEzju0I7eccsDQR7bC35uvwdKeeToobeE0wH89Xz29Q3vsjUJFbNdXvIOr5bWOYc1MtgZjo91wVcP2NHep8PdaRILMCQVXu11krnCC2ttoVxVSgGphdJJkLmopC6QsJWrM-GzQvnSK-zNAVumaymQ1pUTD9l2aAM8Zlz7GpRLU6cLkOCLQlZKaVemAkBbyEbs7XDwZtnjbJghAO3EEJkMkclMtEEyjVg-0Mb8xi0GFcE_570cCGnwGtHbiA3QblYmw58oJfpi5Yg96il8tQ-BXiS2yc5_rvqC3Zwezg7Mwf78yxN2i770ATFP2fb6YgPP0KxZu-cd2_4C-jD31w |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Differences+in+the+composition+of+hip+and+knee+synovial+fluid+in+osteoarthritis%3A+a+nuclear+magnetic+resonance+%28NMR%29+spectroscopy+study+of+metabolic+profiles&rft.jtitle=Osteoarthritis+and+cartilage&rft.au=Akhbari%2C+P&rft.au=Jaggard%2C+M+K&rft.au=Boulang%C3%A9%2C+C+L&rft.au=Vaghela%2C+U&rft.date=2019-12-01&rft.eissn=1522-9653&rft.volume=27&rft.issue=12&rft.spage=1768&rft_id=info:doi/10.1016%2Fj.joca.2019.07.017&rft_id=info%3Apmid%2F31491490&rft.externalDocID=31491490 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1063-4584&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1063-4584&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1063-4584&client=summon |