State and Trait Anxiety Share Common Network Topological Mechanisms of Human Brain

• Published in: Frontiers in neuroinformatics Vol. 16; p. 859309
• Main Authors: Li, Yubin, Jiang, Lili
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 23.06.2022; Frontiers Media S.A
• Subjects: Anxiety; Behavior; Brain; Brain architecture; centrality; Cognitive ability; Efficiency; human brain; Information processing; MRI; Neural networks; Neuroscience; Temporal variations
• ISSN: 1662-5196; 1662-5196
• DOI: 10.3389/fninf.2022.859309

Anxiety is a future-oriented unpleasant and negative mental state induced by distant and potential threats. It could be subdivided into momentary state anxiety and stable trait anxiety, which play a complex and combined role in our mental and physical health. However, no studies have systematically investigated whether these two different dimensions of anxiety share a common or distinct topological mechanism of human brain network. In this study, we used macroscale human brain morphological similarity network and functional connectivity network as well as their spatial and temporal variations to explore the topological properties of state and trait anxiety. Our results showed that state and trait anxiety were both negatively correlated with the coefficient of variation of nodal efficiency in the left frontal eyes field of volume network; state and trait anxiety were both positively correlated with the median and mode of pagerank centrality distribution in the right insula for both static and dynamic functional networks. In summary, our study confirmed that state and trait anxiety shared common human brain network topological mechanisms in the insula and the frontal eyes field, which were involved in preliminary cognitive processing stage of anxiety. Our study also demonstrated that the common brain network topological mechanisms had high spatiotemporal robustness and would enhance our understanding of human brain temporal and spatial organization.