Epididymal Epithelial Cell Involution Following a Single Intraperitoneal Administration of Ethane Dimethanesulfonate in the Goat (Capra hircus)

• Published in: Toxicology and applied pharmacology Vol. 175; no. 1; pp. 19 - 27
• Main Authors: Onyango, D.W., Wango, E.O., Werner, G.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 15.08.2001; Elsevier
• Subjects: Animals; Biological and medical sciences; Capra hircus; Carcinogenesis, carcinogens and anticarcinogens; Chemical agents; degeneration; EDS; epididymis; Epididymis - cytology; Epididymis - drug effects; epithelium; Epithelium - drug effects; Epithelium - physiology; ethane dimethanesulfonate; Goats; Infusions, Parenteral; Male; Medical sciences; Mesylates - pharmacology; Tumors; epithelium; epididymis; EDS; degeneration; Intraperitoneal administration; Toxicity; Single dose; Leydig cell; Vertebrata; Epididymis; Mammalia; Histopathology; Ultrastructure; Animal; Epithelial cell; Goat; Artiodactyla; Male genital diseases; Ungulata

Ethane dimethanesulfonate (EDS) selectively destroys Leydig cells in rats and a few other smaller animal species but not in mice and quail. In the teleost fish, it stimulates testicular activity instead. It also causes formation of sperm granulomas, reduction of sperm fertilizing ability, and destru...