Maximal tear secretion evoked by controlled stimulation of corneal sensory nerves in healthy individuals and dry eye subjects

• Published in: The ocular surface Vol. 27; pp. 80 - 88
• Main Authors: Merino, María L., Belmonte, Javier, Rosas, José, Acosta, M. Carmen, Gallar, Juana, Belmonte, Carlos
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023
• Subjects: Adult; Carbon Dioxide; Cornea; Corneal nerve stimulation; Dry eye disease; Dry Eye Syndromes - diagnosis; Eye exploration; Humans; Sensory nerves; Sjogren's Syndrome - diagnosis; Sjögren's syndrome; Tear glands; Tear secretion; Tearing; Tears - physiology; Tearing; Tear secretion; Sjögren's syndrome; Corneal nerve stimulation; Sensory nerves; Eye exploration; Dry eye disease; Tear glands

To measure, the tear flow changes evoked in healthy subjects and dry eye disease (DED) patients by controlled sensory stimulation of the eye surface with i-Onion™, a new stimulation device. Sensory corneal nerves were stimulated with an instrument (i-Onion™) that ejects puffs of CO2 gas (99.9%) at 2...