GSTA1 Genetic Variants and Conditioning Regimen: Missing Key Factors in Dosing Guidelines of Busulfan in Pediatric Hematopoietic Stem Cell Transplantation
•The methods currently used to calculate busulfan dose are influenced by the GSTA1 genotype.•GSTA1 genotypes influence is best expressed by grouped diplotypes according their potential expression capacity.•The incorporation of GSTA1 haplotypes as a covariate in a population pharmacokinetics model is...
Saved in:
Published in | Biology of blood and marrow transplantation Vol. 23; no. 11; pp. 1918 - 1924 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.11.2017
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Be the first to leave a comment!