GSTA1 Genetic Variants and Conditioning Regimen: Missing Key Factors in Dosing Guidelines of Busulfan in Pediatric Hematopoietic Stem Cell Transplantation

• Published in: Biology of blood and marrow transplantation Vol. 23; no. 11; pp. 1918 - 1924
• Main Authors: Nava, Tiago, Rezgui, Mohamed A., Uppugunduri, Chakradhara R.S., Curtis, Patricia Huezo-Diaz, Théoret, Yves, Duval, Michel, Daudt, Liane E., Ansari, Marc, Krajinovic, Maja, Bittencourt, Henrique
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2017
• Subjects: Busulfan; Busulfan - pharmacokinetics; Busulfan - therapeutic use; Child, Preschool; Children; Dosing guidelines; Female; Genetic Variation - genetics; Glutathione Transferase - genetics; Glutathione Transferase - metabolism; GSTA1; Hematopoietic Stem Cell Transplantation - methods; Humans; Infant; Male; Pharmacogenetics; Pharmacokinetics; Transplantation Conditioning - methods; Pharmacogenetics; Busulfan; Children; Dosing guidelines; Pharmacokinetics; GSTA1

•The methods currently used to calculate busulfan dose are influenced by the GSTA1 genotype.•GSTA1 genotypes influence is best expressed by grouped diplotypes according their potential expression capacity.•The incorporation of GSTA1 haplotypes as a covariate in a population pharmacokinetics model is...