Caps Off to Poxviruses

• Published in: Cell host & microbe Vol. 17; no. 3; pp. 287 - 289
• Main Author: Silverman, Robert H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.03.2015
• Subjects: Animals; Endoribonucleases - metabolism; Exoribonucleases - metabolism; Host-Pathogen Interactions; Humans; Immunity, Innate; Microtubule-Associated Proteins - metabolism; RNA, Double-Stranded - metabolism; Vaccinia virus - enzymology; Vaccinia virus - immunology; Vaccinia virus - physiology; Virus Replication

In this issue of Cell Host & Microbe, Liu et al. (2015) and Burgess and Mohr (2015) describe how two poxvirus mRNA decapping enzymes hijack a host 5′-to-3′-exoribonuclease to evade antiviral innate immunity by limiting accumulation of double-stranded RNA. In this issue of Cell Host & Microbe...