Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction - Steel, Richard J.; O'Connell, Maria A.; Searcey, Mark (Bioorganic & medicinal chemistry letters, 2018)
Keywords: Chemistry; Chemistry, Medicinal; Chemistry, Organic; Dose-Response Relationship, Drug; Fluorocarbons - chemistry; Fluorocarbons - pharmacology; Hexafluorobenzene; Humans; Keap1; Kelch-Like ECH-Associated Protein 1 - antagonists & inhibitors; Kelch-Like ECH-Associated Protein 1 - metabolism; Life Sciences & Biomedicine; Macrocyclic Compounds - chemical synthesis; Macrocyclic Compounds - chemistry; Macrocyclic Compounds - pharmacology; Molecular Structure; NF-E2-Related Factor 2 - antagonists & inhibitors; NF-E2-Related Factor 2 - metabolism; Nrf2; Peptide; Peptides - chemistry; Peptides - pharmacology; Pharmacology & Pharmacy; Physical Sciences; Protein-protein interaction; Science & Technology; Structure-Activity Relationship; Keap1; Hexafluorobenzene; Protein-protein interaction; Nrf2; Peptide; KEAP1-NRF2 INTERACTION; DISCOVERY; GENE; INTERFACE; PATHWAY; UPDATE; PROVIDES; BINDING